Dealing with danger in the CNS: the response of the immune system to injury

Glutamate neurotoxicity and diseases of the nervous system

Choi, D. W. (1988) · Neuron · doi:10.1016/0896-6273(88)90162-6 · Cited by 8,152 · see citing works

Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013

(2015) · The Lancet · doi:10.1016/s0140-6736(14)61682-2 · Cited by 7,439 · see citing works

Neutrophil Emigration in the Skin, Lungs, and Peritoneum: Different Requirements for CD11/CD18 Revealed by CD18-deficient Mice

Mizgerd, J. P., Kubo, H., Kutkoski, G. J., Bhagwan, S. D., Scharffetter-Kochanek, K., Beaudet, A. L., & Doerschuk, C. M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.8.1357 · Cited by 7,332 · see citing works

Macrophage activation and polarization: nomenclature and experimental guidelines

Murray, P. J., Allen, J. E., Biswas, S. K., Fisher, E. A., Gilroy, D. W., Goerdt, S., Gordon, S., Hamilton, J. A., Ivashkiv, L. B., Lawrence, T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.008 · Cited by 6,337 · see citing works

Macrophage plasticity and polarization: in vivo veritas

Sica, A., & Mantovani, A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59643 · Cited by 6,335 · see citing works

Alternative activation of macrophages

Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189 · see citing works

Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

Nimmerjahn, A., Kirchhoff, F., & Helmchen, F. (2005) · Science · doi:10.1126/science.1110647 · Cited by 5,827 · see citing works

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M. F., Conway, S. J., Ng, L. G., Stanley, E. R., et al. (2010) · Science · doi:10.1126/science.1194637 · Cited by 5,175 · see citing works

The M1 and M2 paradigm of macrophage activation: Time for reassessment

Martinez, F. O., & Gordon, S. (2014) · F1000Prime Reports · doi:10.12703/p6-13 · Cited by 4,689 · see citing works

Structural and functional features of central nervous system lymphatic vessels

Louveau, A., Smirnov, I., Keyes, T. J., Eccles, J. D., Rouhani, S. J., Peske, J. D., Derecki, N. C., Castle, D., Mandell, J. W., Lee, K. S., et al. (2015) · Nature · doi:10.1038/nature14432 · Cited by 4,413 · see citing works

Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

Scaffidi, P., Misteli, T., & Bianchi, M. E. (2002) · Nature · doi:10.1038/nature00858 · Cited by 4,221 · see citing works

The Danger Model: A Renewed Sense of Self

Matzinger, P. (2002) · Science · doi:10.1126/science.1071059 · Cited by 4,205 · see citing works

ATP mediates rapid microglial response to local brain injury in vivo

Davalos, D., Grutzendler, J., Yang, G., Kim, J. V., Zuo, Y., Jung, S., Littman, D. R., Dustin, M. L., & Gan, W.-B. (2005) · Nature Neuroscience · doi:10.1038/nn1472 · Cited by 3,913 · see citing works

Circulating mitochondrial DAMPs cause inflammatory responses to injury

Zhang, Q., Raoof, M., Chen, Y., Sumi, Y., Sursal, T., Junger, W., Brohi, K., Itagaki, K., & Hauser, C. J. (2010) · Nature · doi:10.1038/nature08780 · Cited by 3,812 · see citing works

IL-33, an Interleukin-1-like Cytokine that Signals via the IL-1 Receptor-Related Protein ST2 and Induces T Helper Type 2-Associated Cytokines

Schmitz, J., Owyang, A. M., Oldham, E. R., Song, Y., Murphy, E., McClanahan, T. K., Zurawski, G., Moshrefi, M., Qin, J., Li, X., et al. (2005) · Immunity · doi:10.1016/j.immuni.2005.09.015 · Cited by 3,701 · see citing works

Regulation of Wound Healing by Growth Factors and Cytokines

WERNER, S., & GROSE, R. (2003) · Physiological Reviews · doi:10.1152/physrev.2003.83.3.835 · Cited by 3,629 · see citing works

Resveratrol Reduces the Proinflammatory Effects and Lipopolysaccharide- Induced Expression of HMGB1 and TLR4 in RAW264.7 Cells

Yang, Y., Li, S., Yang, Q., Shi, Y., Zheng, M., Liu, Y., Chen, F., Song, G., Xu, H., Wan, T., et al. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000358696 · Cited by 3,262 · see citing works

Sterile inflammation: sensing and reacting to damage

Chen, G. Y., & Nuñez, G. (2010) · Nature Reviews Immunology · doi:10.1038/nri2873 · Cited by 3,051 · see citing works

Monocyte recruitment during infection and inflammation

Shi, C., & Pamer, E. G. (2011) · Nature Reviews Immunology · doi:10.1038/nri3070 · Cited by 3,015 · see citing works

Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

Bauernfeind, F. G., Horvath, G. L., Stutz, A., Alnemri, E. S., MacDonald, K. L., Speert, D. P., Fernandes‐Alnemri, T., Wu, J., Monks, B. G., Fitzgerald, K. A., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901363 · Cited by 3,006 · see citing works

Activation and regulation of the inflammasomes

Latz, E., Xiao, T. S., & Stutz, A. (2013) · Nature Reviews Immunology · doi:10.1038/nri3452 · Cited by 2,884 · see citing works

DAMPs, PAMPs and alarmins: all we need to know about danger

Bianchi, M. E. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0306164 · Cited by 2,794 · see citing works

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

Hornung, V., Ablasser, A., Charrel-Dennis, M., Bauernfeind, F., Horvath, G., Caffrey, D. R., Latz, E., & Fitzgerald, K. A. (2009) · Nature · doi:10.1038/nature07725 · Cited by 2,627 · see citing works

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

Butovsky, O., Jedrychowski, M. P., Moore, C. S., Cialic, R., Lanser, A. J., Gabriely, G., Koeglsperger, T., Dake, B., Wu, P. M., Doykan, C. E., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3599 · Cited by 2,543 · see citing works

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

Halle, A., Hornung, V., Petzold, G. C., Stewart, C. R., Monks, B. G., Reinheckel, T., Fitzgerald, K. A., Latz, E., Moore, K. J., & Golenbock, D. T. (2008) · Nature Immunology · doi:10.1038/ni.1636 · Cited by 2,441 · see citing works

Toll Pathway-Dependent Blockade of CD4+CD25+ T Cell-Mediated Suppression by Dendritic Cells

Pasare, C., & Medzhitov, R. (2003) · Science · doi:10.1126/science.1078231 · Cited by 2,327 · see citing works

Inflammasomes in health and disease

Strowig, T., Henao-Mejia, J., Elinav, E., & Flavell, R. (2012) · Nature · doi:10.1038/nature10759 · Cited by 2,230 · see citing works

Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

Xue, J., Schmidt, S. V., Sander, J., Draffehn, A., Krebs, W., Quester, I., De Nardo, D., Gohel, T. D., Emde, M., Schmidleithner, L., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.01.006 · Cited by 2,210 · see citing works

Regulation of Adaptive Immunity by the Innate Immune System

Iwasaki, A., & Medzhitov, R. M. (2010) · Science · doi:10.1126/science.1183021 · Cited by 2,139 · see citing works

Identification of Two Distinct Macrophage Subsets with Divergent Effects Causing either Neurotoxicity or Regeneration in the Injured Mouse Spinal Cord

Kigerl, K. A., Gensel, J. C., Ankeny, D. P., Alexander, J. K., Donnelly, D. J., & Popovich, P. G. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3257-09.2009 · Cited by 2,130 · see citing works

Immune Signaling by RIG-I-like Receptors

Loo, Y.-M., & Gale, M. (2011) · Immunity · doi:10.1016/j.immuni.2011.05.003 · Cited by 1,875 · see citing works

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

Fernandes-Alnemri, T., Yu, J.-W., Datta, P., Wu, J., & Alnemri, E. S. (2009) · Nature · doi:10.1038/nature07710 · Cited by 1,831 · see citing works

Neutrophil Function: From Mechanisms to Disease

Amulic, B., Cazalet, C., Hayes, G. L., Metzler, K. D., & Zychlinsky, A. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-074942 · Cited by 1,695 · see citing works

Inflammation and wound healing: the role of the macrophage

Koh, T. J., & DiPietro, L. A. (2011) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399411001943 · Cited by 1,667 · see citing works

Origin and functions of tissue macrophages

Epelman, S., Lavine, K. J., & Randolph, G. J. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.013 · Cited by 1,585 · see citing works

The immune system evolved to discriminate infectious nonself from noninfectious self

Janeway, C. A. (1992) · Immunology Today · doi:10.1016/0167-5699(92)90198-g · Cited by 1,343 · see citing works

Neutrophil kinetics in health and disease

Summers, C., Rankin, S. M., Condliffe, A. M., Singh, N., Peters, A. M., & Chilvers, E. R. (2010) · Trends in Immunology · doi:10.1016/j.it.2010.05.006 · Cited by 1,237 · see citing works

Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation

McDonald, B., Pittman, K., Menezes, G. B., Hirota, S. A., Slaba, I., Waterhouse, C. C. M., Beck, P. L., Muruve, D. A., & Kubes, P. (2010) · Science · doi:10.1126/science.1195491 · Cited by 1,210 · see citing works

T‐lymphocyte entry into the central nervous system

Hickey, W. F., Hsu, B. L., & Kimura, H. (1991) · Journal of Neuroscience Research · doi:10.1002/jnr.490280213 · Cited by 1,176 · see citing works

Leukocyte Infiltration, Neuronal Degeneration, and Neurite Outgrowth after Ablation of Scar-Forming, Reactive Astrocytes in Adult Transgenic Mice

Bush, T. G., Puvanachandra, N., Horner, C. H., Polito, A., Ostenfeld, T., Svendsen, C. N., Mucke, L., Johnson, M. H., & Sofroniew, M. V. (1999) · Neuron · doi:10.1016/s0896-6273(00)80781-3 · Cited by 1,116 · see citing works

Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye.

Medawar, P. B. (1948) · PubMed · Cited by 1,084 · see citing works

The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP

Lee, G., Subramanian, N., Kim, A. I., Aksentijevich, I. A., Goldbach‐Mansky, R. T., Sacks, D. B., Germain, R. N., Kastner, D. L., & Chae, J. J. (2012) · Nature · doi:10.1038/nature11588 · Cited by 1,077 · see citing works

Innate immunity in the central nervous system

Ransohoff, R. M., & Brown, M. A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci58644 · Cited by 1,034 · see citing works

IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor <i>in vivo</i>

Carriere, V., Roussel, L., Ortega, N., Lacorre, D.-A., Americh, L., Aguilar, L., Bouche, G., & Girard, J.-P. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606854104 · Cited by 966 · see citing works

Neuronal and Glial Apoptosis after Traumatic Spinal Cord Injury

Liu, X., Xu, X., Hu, R., Du, C., Zhang, S. X., Mcdonald, J. W., Dong, H.-X., Wu, Y. J., Fan, G., Jacquin, M., et al. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-14-05395.1997 · Cited by 943 · see citing works

Tissue-specific signals control reversible program of localization and functional polarization of macrophages

Okabe, Y., & Medzhitov, R. (2014) · Cell · doi:10.1016/j.cell.2014.04.016 · Cited by 884 · see citing works

Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy

Moalem‐Taylor, G., Leibowitz‐Amit, R., Yoles, E., Mor, F., Cohen, I. R., & Schwartz, M. (1999) · Nature Medicine · doi:10.1038/4734 · Cited by 882 · see citing works

In vivo labeling with 2H2O reveals a human neutrophil lifespan of 5.4 days

Pillay, J., den Braber, I., Vrisekoop, N., Kwast, L. M., de Boer, R. J., Borghans, J. A. M., Tesselaar, K., & Koenderman, L. (2010) · Blood · doi:10.1182/blood-2010-01-259028 · Cited by 873 · see citing works

ATP Release Guides Neutrophil Chemotaxis via P2Y2 and A3 Receptors

Chen, Y., Corriden, R., Inoue, Y., Yip, L., Hashiguchi, N., Zinkernagel, A. S., Nizet, V., Insel, P. A., & JUNGER, W. G. (2006) · Science · doi:10.1126/science.1132559 · Cited by 858 · see citing works

A Review: Inflammatory Process in Alzheimer's Disease, Role of Cytokines

Rubio-Perez, J. M., & Morillas-Ruiz, J. M. (2012) · The Scientific World JOURNAL · doi:10.1100/2012/756357 · Cited by 841 · see citing works

Incidence of Traumatic Brain Injury in the United States, 2003

Rutland-Brown, W., Langlois, J. A., Thomas, K. E., & Xi, Y. L. (2006) · Journal of Head Trauma Rehabilitation · doi:10.1097/00001199-200611000-00009 · Cited by 836 · see citing works

HIN-200 Proteins Regulate Caspase Activation in Response to Foreign Cytoplasmic DNA

Roberts, T. L., Idris, A., Dunn, J. A., Kelly, G., Burnton, C. M., Hodgson, S., Hardy, L., Garceau, V., Sweet, M. J., Ross, I. L., et al. (2009) · Science · doi:10.1126/science.1169841 · Cited by 830 · see citing works

Macrophages are required for adult salamander limb regeneration

Godwin, J. W., Pinto, A. R., & Rosenthal, N. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1300290110 · Cited by 829 · see citing works

Regulation of learning and memory by meningeal immunity: a key role for IL-4

Derecki, N. C., Cardani, A. N., Yang, C. H., Quinnies, K. M., Crihfield, A., Lynch, K. R., & Kipnis, J. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20091419 · Cited by 800 · see citing works

Implantation of stimulated homologous macrophages results in partial recovery of paraplegic rats

Rapalino, O., Lazarov-Spiegler, O., Agranov, E., Velan, G. J., Yoles, E., Fraidakis, M., Soloman, A., Gepstein, R., Katz, A., Belkin, M., et al. (1998) · Nature Medicine · doi:10.1038/nm0798-814 · Cited by 788 · see citing works

Infiltrating Blood-Derived Macrophages Are Vital Cells Playing an Anti-inflammatory Role in Recovery from Spinal Cord Injury in Mice

Shechter, R., London, A., Varol, C., Raposo, C., Cusimano, M., Yovel, G., Rolls, A., Mack, M., Pluchino, S., Martino, G., et al. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000113 · Cited by 770 · see citing works

Free Radical Pathways in CNS Injury

LEWÉN, A., MATZ, P., & CHAN, P. H. (2000) · Journal of Neurotrauma · doi:10.1089/neu.2000.17.871 · Cited by 759 · see citing works

Tumor necrosis factor alpha: A link between neuroinflammation and excitotoxicity

Olmos, G., & Lladó, J. (2014) · Mediators of Inflammation · doi:10.1155/2014/861231 · Cited by 730 · see citing works

The Role of Excitotoxicity in Neurodegenerative Disease

Doble, A. (1999) · Pharmacology &amp; Therapeutics · doi:10.1016/s0163-7258(98)00042-4 · Cited by 723 · see citing works

The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1

Cayrol, C., & Girard, J.-P. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812690106 · Cited by 707 · see citing works

Depletion of Hematogenous Macrophages Promotes Partial Hindlimb Recovery and Neuroanatomical Repair after Experimental Spinal Cord Injury

Popovich, P. G., Guan, Z., Wei, P. Y., Huitinga, I., van Rooijen, N., & Stokes, B. T. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7118 · Cited by 692 · see citing works

Recruitment of Beneficial M2 Macrophages to Injured Spinal Cord Is Orchestrated by Remote Brain Choroid Plexus

Shechter, R., Miller, O., Yovel, G., Rosenzweig, N., London, A., Ruckh, J., Kim, K.-W., Klein, E., Kalchenko, V., Bendel, P., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.02.012 · Cited by 683 · see citing works

Role of Microglia in Neurotrauma

Loane, D. J., & Byrnes, K. R. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2010.07.002 · Cited by 657 · see citing works

TNF and increased intracellular iron alter macrophage polarization to a detrimental M1 phenotype in the injured spinal cord

Kroner, A., Greenhalgh, A. D., Zarruk, J. G., Passos dos Santos, R., Gaestel, M., & David, S. (2014) · Neuron · doi:10.1016/j.neuron.2014.07.027 · Cited by 655 · see citing works

IL-33 is a crucial amplifier of innate rather than acquired immunity

Oboki, K., Ohno, T., Kajiwara, N., Arae, K., Morita, H., Ishii, A., Nambu, A., Abe, T., Kiyonari, H., Matsumoto, K., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003059107 · Cited by 655 · see citing works

Microglia Induce Motor Neuron Death via the Classical NF-κB Pathway in Amyotrophic Lateral Sclerosis

Frakes, A. E., Ferraiuolo, L., Haidet-Phillips, A. M., Schmelzer, L., Braun, L., Miranda, C. J., Ladner, K. J., Bevan, A. K., Foust, K. D., Godbout, J. P., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.01.013 · Cited by 638 · see citing works

Inflammasomes in the CNS

Walsh, J. G., Muruve, D. A., & Power, C. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3638 · Cited by 637 · see citing works

Selective and Specific Macrophage Ablation Is Detrimental to Wound Healing in Mice

Mirza, R., DiPietro, L. A., & Koh, T. J. (2009) · The American Journal of Pathology · doi:10.2353/ajpath.2009.090248 · Cited by 616 · see citing works

Wild-type microglia arrest pathology in a mouse model of Rett syndrome

Derecki, N. C., Cronk, J. C., Lu, Z., Xu, E., Abbott, S. B. G., Guyenet, P. G., & Kipnis, J. (2012) · Nature · doi:10.1038/nature10907 · Cited by 607 · see citing works

IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G

Lefrançais, E., Roga, S., Gautier, V., de Peredo, A. G., Monsarrat, B., Girard, J., & Cayrol, C. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1115884109 · Cited by 598 · see citing works

Activated Macrophages and Microglia Induce Dopaminergic Sprouting in the Injured Striatum and Express Brain-Derived Neurotrophic Factor and Glial Cell Line-Derived Neurotrophic Factor

Batchelor, P., Liberatore, G. T., Wong, J. Y. F., Porritt, M. J., Frerichs, F., Donnan, G. A., & Howells, D. W. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-05-01708.1999 · Cited by 576 · see citing works

Transcranial amelioration of inflammation and cell death after brain injury.

Roth, T. L., Nayak, D., Atanasijevic, T., Koretsky, A. P., Latour, L. L., & McGavern, D. B. (2014) · Nature · doi:10.1038/nature12808 · Cited by 574 · see citing works

Secondary Cell Death and the Inflammatory Reaction After Dorsal Hemisection of the Rat Spinal Cord

Dusart, I., & Schwab, M. (1994) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1994.tb00983.x · Cited by 567 · see citing works

Decoding Cell Death Signals in Inflammation and Immunity

Zitvogel, L., Kepp, O., & Kroemer, G. (2010) · Cell · doi:10.1016/j.cell.2010.02.015 · Cited by 558 · see citing works

Maternal infection and immune involvement in autism

Patterson, P. H. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2011.03.001 · Cited by 520 · see citing works

Endogenous ligands of TLR2 and TLR4: agonists or assistants?

Erridge, C. (2010) · Journal of Leukocyte Biology · doi:10.1189/jlb.1209775 · Cited by 519 · see citing works

Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells

Yin, Y., Henzl, M. T., Lorber, B., Nakazawa, T., Thomas, T. T., Jiang, F., Langer, R., & Benowitz, L. I. (2006) · Nature Neuroscience · doi:10.1038/nn1701 · Cited by 516 · see citing works

Cellular signalling of the receptor for advanced glycation end products (RAGE)

Xie, J., Méndez, J. D., Méndez-Valenzuela, V., & Aguilar-Hernández, M. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.06.013 · Cited by 515 · see citing works

Wound Macrophages as Key Regulators of Repair

Brancato, S. K., & Albina, J. E. (2011) · The American Journal of Pathology · doi:10.1016/j.ajpath.2010.08.003 · Cited by 508 · see citing works

Acute Inflammatory Response in Spinal Cord Following Impact Injury

Carlson, S. L., Parrish, M. E., Springer, J. E., Doty, K. D., & Dossett, L. (1998) · Experimental Neurology · doi:10.1006/exnr.1998.6785 · Cited by 495 · see citing works

Liaisons dangereuses: P2X7 and the inflammasome

Di Virgilio, F. (2007) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2007.07.002 · Cited by 493 · see citing works

Protective and therapeutic role for αB-crystallin in autoimmune demyelination

Ousman, S., Tomooka, B. H., van Noort, J., Wawrousek, E., O'Conner, K., Hafler, D., Sobel, R., Robinson, W., & Steinman, L. (2007) · Nature · doi:10.1038/nature05935 · Cited by 491 · see citing works

Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status

Vogel, D. Y., Vereyken, E. J., Glim, J. E., Heijnen, P. D., Moeton, M., van der Valk, P., Amor, S., Teunissen, C. E., van Horssen, J., & Dijkstra, C. D. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-35 · Cited by 479 · see citing works

Microglia/Macrophage Polarization Dynamics in White Matter after Traumatic Brain Injury

Wang, G., Zhang, J., Hu, X., Zhang, L., Mao, L., Jiang, X., Liou, A. K.-F., Leak, R. K., Gao, Y., & Chen, J. (2013) · Journal of Cerebral Blood Flow &amp; Metabolism · doi:10.1038/jcbfm.2013.146 · Cited by 473 · see citing works

Neuronal Intrinsic Mechanisms of Axon Regeneration

Liu, K., Tedeschi, A., Park, K. K., & He, Z. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113723 · Cited by 458 · see citing works

Steroids for acute spinal cord injury

Bracken, M. B. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001046.pub2 · Cited by 455 · see citing works

The High Mobility Group (Hmg) Boxes of the Nuclear Protein Hmg1 Induce Chemotaxis and Cytoskeleton Reorganization in Rat Smooth Muscle Cells

Degryse, B., Bonaldi, T., Scaffidi, P., Müller, S., Resnati, M., Sanvito, F., Arrigoni, G., & Bianchi, M. E. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.152.6.1197 · Cited by 451 · see citing works

Denervated Schwann Cells Attract Macrophages by Secretion of Leukemia Inhibitory Factor (LIF) and Monocyte Chemoattractant Protein-1 in a Process Regulated by Interleukin-6 and LIF

Tofaris, G., Patterson, P., Jessen, K., & Mirsky, R. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06696.2002 · Cited by 403 · see citing works

Toll-Dependent Control Mechanisms of CD4 T Cell Activation

Pasare, C., & Medzhitov, R. M. (2004) · Immunity · doi:10.1016/j.immuni.2004.10.006 · Cited by 386 · see citing works

Macrophage depletion impairs oligodendrocyte remyelination following lysolecithin-induced demyelination

Kotter, M. R., Setzu, A., Sim, F. J., Van Rooijen, N., & Franklin, R. J. M. (2001) · Glia · doi:10.1002/glia.1085 · Cited by 385 · see citing works

Oligodendroglial apoptosis occurs along degenerating axons and is associated with FAS and p75 expression following spinal cord injury in the rat

Casha, S., Yu, W. R., & Fehlings, M. G. (2001) · Neuroscience · doi:10.1016/s0306-4522(00)00538-8 · Cited by 381 · see citing works

Brain-derived neurotrophic factor in astrocytes, oligodendrocytes, and microglia/macrophages after spinal cord injury.

Dougherty, K. D., Dreyfus, C., & Black, I. (2000) · Neurobiology of Disease · doi:10.1006/nbdi.2000.0318 · Cited by 373 · see citing works

HMGB1 acts on microglia Mac1 to mediate chronic neuroinflammation that drives progressive neurodegeneration

Gao, H.-M., Zhou, H., Zhang, F., Wilson, B. C., Kam, W., & Hong, J.-S. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3732-10.2011 · Cited by 369 · see citing works

Passive or Active Immunization with Myelin Basic Protein Promotes Recovery from Spinal Cord Contusion

Hauben, E., Butovsky, O., Nevo, U., Yoles, E., Moalem‐Taylor, G., Agranov, E., Mor, F., Leibowitz‐Amit, R., Pevsner, E., AKSELROD, S., et al. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-17-06421.2000 · Cited by 367 · see citing works

The Glia-Derived Alarmin IL-33 Orchestrates the Immune Response and Promotes Recovery following CNS Injury

Gadani, S. P., Walsh, J. T., Smirnov, I., Zheng, J., & Kipnis, J. (2015) · Neuron · doi:10.1016/j.neuron.2015.01.013 · Cited by 359 · see citing works

Protective Autoimmunity Is a Physiological Response to CNS Trauma

Yoles, E., Hauben, E., Palgi, O., Agranov, E., Gothilf, A., Cohen, A., Kuchroo, V. K., Cohen, I. R., Weiner, H. L., & Schwartz, M. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-11-03740.2001 · Cited by 344 · see citing works

A Molecular Platform in Neurons Regulates Inflammation after Spinal Cord Injury

de Rivero Vaccari, J. P., Lotocki, G., Marcillo, A. E., Dietrich, W. D., & Keane, R. W. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.0157-08.2008 · Cited by 332 · see citing works

Another Barrier to Regeneration in the CNS: Activated Macrophages Induce Extensive Retraction of Dystrophic Axons through Direct Physical Interactions

Horn, K. P., Busch, S. A., Hawthorne, A. L., van Rooijen, N., & Silver, J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2488-08.2008 · Cited by 332 · see citing works

Immunologic Privilege in the Central Nervous System and the Blood–Brain Barrier

Muldoon, L. L., Alvarez, J. I., Begley, D. J., Boado, R. J., del Zoppo, G. J., Doolittle, N. D., Engelhardt, B., Hallenbeck, J. M., Lonser, R. R., Ohlfest, J. R., et al. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.153 · Cited by 327 · see citing works

Mutant superoxide dismutase 1-induced IL-1β accelerates ALS pathogenesis

Meissner, F., Molawi, K., & Zychlinsky, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002396107 · Cited by 319 · see citing works

Therapeutic Neutralization of the NLRP1 Inflammasome Reduces the Innate Immune Response and Improves Histopathology after Traumatic Brain Injury

de Rivero Vaccari, J. P., Lotocki, G., Alonso, O. F., Bramlett, H. M., Dietrich, W. D., & Keane, R. W. (2009) · Journal of Cerebral Blood Flow &amp; Metabolism · doi:10.1038/jcbfm.2009.46 · Cited by 312 · see citing works

Temporal–Spatial Pattern of Acute Neuronal and Glial Loss after Spinal Cord Contusion

Grossman, S. D., Rosenberg, L. J., & Wrathall, J. R. (2001) · Experimental Neurology · doi:10.1006/exnr.2001.7628 · Cited by 310 · see citing works

Serum Proteins Bypass the Blood-Brain Fluid Barriers for Extracellular Entry to the Central Nervous System

Broadwell, R. D., & Sofroniew, M. V. (1993) · Experimental Neurology · doi:10.1006/exnr.1993.1059 · Cited by 310 · see citing works

IL ‐33 attenuates EAE by suppressing IL ‐17 and IFN ‐γ production and inducing alternatively activated macrophages

Jiang, H., Milovanović, M., Allan, D., Niedbała, W., Besnard, A., Fukada, S. Y., Alves-Filho, J. C., Togbe, D., Goodyear, C. S., Linington, C., et al. (2012) · European Journal of Immunology · doi:10.1002/eji.201141947 · Cited by 307 · see citing works

Immunology of relapse and remission in multiple sclerosis.

Steinman, L. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120227 · Cited by 307 · see citing works

Interleukin 33 as a Mechanically Responsive Cytokine Secreted by Living Cells

Kakkar, R. K., Hei, H., Dobner, S., & Lee, R. T. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.298703 · Cited by 297 · see citing works

Localizing central nervous system immune surveillance: Meningeal antigen‐presenting cells activate T cells during experimental autoimmune encephalomyelitis

Kivisäkk, P., Imitola, J., Rasmussen, S. O., Elyaman, W., Zhu, B., Ransohoff, R. M., & Khoury, S. J. (2008) · Annals of Neurology · doi:10.1002/ana.21379 · Cited by 287 · see citing works

A Therapeutic Vaccine Approach to Stimulate Axon Regeneration in the Adult Mammalian Spinal Cord

Huang, D. W., McKerracher, L. J., Braun, P. E., & David, S. (1999) · Neuron · doi:10.1016/s0896-6273(00)81118-6 · Cited by 287 · see citing works

Expression of the NLRP3 Inflammasome in Cerebral Cortex After Traumatic Brain Injury in a Rat Model

Liu, H., Li, W., Chen, Z.-R., Hu, Y.-C., Zhang, D.-D., Shen, W., Zhou, M., Zhu, L., & Hang, C. (2013) · Neurochemical Research · doi:10.1007/s11064-013-1115-z · Cited by 276 · see citing works

Traumatic Brain Injury Pathophysiology and Treatments: Early, Intermediate, and Late Phases Post-Injury

Algattas, H., & Huang, J. H. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms15010309 · Cited by 270 · see citing works

Neuroprotective autoimmunity: Naturally occurring CD4 + CD25 + regulatory T cells suppress the ability to withstand injury to the central nervous system

Kipnis, J., Mizrahi, T., Hauben, E., Shaked, I., Shevach, E. M., & Schwartz, M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.232565399 · Cited by 265 · see citing works

Blockade of interleukin‐6 receptor suppresses reactive astrogliosis and ameliorates functional recovery in experimental spinal cord injury

Okada, S., Nakamura, M., Mikami, Y., Shimazaki, T., Mihara, M., Ohsugi, Y., Iwamoto, Y., Yoshizaki, K., Kishimoto, T., Toyama, Y., et al. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20044 · Cited by 264 · see citing works

Activated Macrophage/Microglial Cells Can Promote the Regeneration of Sensory Axons into the Injured Spinal Cord

Prewitt, C. M., Niesman, I. R., Kane, C. J. M., & Houlé, J. D. (1997) · Experimental Neurology · doi:10.1006/exnr.1997.6694 · Cited by 260 · see citing works

Concept of autoimmunity following spinal cord injury: Possible roles for T lymphocytes in the traumatized central nervous system

Popovich, P. G., Stokes, B. T., & Whitacre, C. C. (1996) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19960815)45:4 · Cited by 249 · see citing works

Pro-cognitive properties of T cells

Kipnis, J., Gadani, S., & Derecki, N. C. (2012) · Nature Reviews Immunology · doi:10.1038/nri3280 · Cited by 246 · see citing works

Clinical experience using incubated autologous macrophages as a treatment for complete spinal cord injury: Phase I study results

Knoller, N., Auerbach, G., Fulga, V., Zelig, G., Attias, J., Bakimer, R., Marder, J. B., Yoles, E., Belkin, M., Schwartz, M., et al. (2005) · Journal of Neurosurgery Spine · doi:10.3171/spi.2005.3.3.0173 · Cited by 245 · see citing works

Traumatic brain injury in aged animals increases lesion size and chronically alters microglial/macrophage classical and alternative activation states

Kumar, A., Stoica, B. A., Sabirzhanov, B., Burns, M. P., Faden, A. I., & Loane, D. J. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.11.013 · Cited by 244 · see citing works

Inflammatory pathways of seizure disorders

Marchi, N., Granata, T., & Janigro, D. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.11.002 · Cited by 241 · see citing works

Anti–high mobility group box‐1 antibody therapy for traumatic brain injury

Okuma, Y., Liu, K., Wake, H., Zhang, J., Maruo, T., Date, I., Yoshino, T., Ohtsuka, A., Otani, N., Tomura, S., et al. (2012) · Annals of Neurology · doi:10.1002/ana.23602 · Cited by 236 · see citing works

Depletion of Ly6G/Gr-1 Leukocytes after Spinal Cord Injury in Mice Alters Wound Healing and Worsens Neurological Outcome

Stirling, D. P., Liu, S., Kubes, P., & Yong, V. W. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4918-08.2009 · Cited by 234 · see citing works

P2X7-Like Receptor Activation in Astrocytes Increases Chemokine Monocyte Chemoattractant Protein-1 Expression via Mitogen-Activated Protein Kinase

Panenka, W. J., Jijon, H. B., Herx, L., Armstrong, J. N., Feighan, D., Wei, T., Yong, V. W., Ransohoff, R. M., & MacVicar, B. A. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07135.2001 · Cited by 233 · see citing works

Multiple Sclerosis: Deeper Understanding of Its Pathogenesis Reveals New Targets for Therapy

Steinman, L., Martinꝉ, R., Bernard, C. C. A., Conlon, P. J., & Oksenberg, J. R. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142913 · Cited by 230 · see citing works

Contrasting the Glial Response to Axon Injury in the Central and Peripheral Nervous Systems

Lutz, A. B., & Barres, B. A. (2014) · Developmental Cell · doi:10.1016/j.devcel.2013.12.002 · Cited by 229 · see citing works

Cutting Edge: Critical Role for Mesothelial Cells in Necrosis-Induced Inflammation through the Recognition of IL-1α Released from Dying Cells

Eigenbrod, T., Park, J.-H., Harder, J., Iwakura, Y., & Núñez, G. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.12.8194 · Cited by 228 · see citing works

Degeneration of spared axons following partial white matter lesion: implications for optic nerve neuropathies.

Yoles, E., & Schwartz, M. (1998) · Experimental Neurology · doi:10.1006/exnr.1998.6811 · Cited by 228 · see citing works

Production and functions of IL-33 in the central nervous system

Yasuoka, S., Kawanokuchi, J., Parajuli, B., Jin, S., Doi, Y., Noda, M., Sonobe, Y., Takeuchi, H., Mizuno, T., & Suzumura, A. (2011) · Brain Research · doi:10.1016/j.brainres.2011.02.045 · Cited by 222 · see citing works

Changes in blood–brain barrier permeability to large and small molecules following traumatic brain injury in mice

Habgood, M. D., Bye, N., Dziegielewska, K. M., Ek, C. J., Lane, M. A., Potter, A., Morganti‐Kossmann, C., & Saunders, N. R. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05275.x · Cited by 220 · see citing works

Neuroprotection and progenitor cell renewal in the injured adult murine retina requires healing monocyte-derived macrophages

London, A., Itskovich, E., Benhar, I., Kalchenko, V., Mack, M., Jung, S., & Schwartz, M. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20101202 · Cited by 213 · see citing works

Induction of IL-33 expression and activity in central nervous system glia

Hudson, C. A., Christophi, G. P., Gruber, R. C., Wilmore, J. R., Lawrence, D. A., & Massa, P. T. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.1207830 · Cited by 213 · see citing works

Neutrophils Express Oncomodulin and Promote Optic Nerve Regeneration

Kurimoto, T., Yin, Y., Habboub, G., Gilbert, H.-Y., Li, Y., Nakao, S., Hafezi‐Moghadam, A., & Benowitz, L. I. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5511-12.2013 · Cited by 210 · see citing works

High-resolution intravital imaging reveals that blood-derived macrophages but not resident microglia facilitate secondary axonal dieback in traumatic spinal cord injury

Evans, T. A., Barkauskas, D. S., Myers, J., Hare, E. G., You, J., Ransohoff, R. M., Huang, A. Y.-C., & Silver, J. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.01.013 · Cited by 209 · see citing works

MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4.

Walsh, J. T., Hendrix, S., Boato, F., Smirnov, I., Zheng, J., Lukens, J. R., Gadani, S. P., Hechler, D., Gölz, G., Rosenberger, K., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci76210 · Cited by 208 · see citing works

Inflammation and spinal cord injury: Infiltrating leukocytes as determinants of injury and repair processes

Trivedi, A. A., Olivas, A. D., & Noble‐Haeusslein, L. J. (2006) · Clinical Neuroscience Research · doi:10.1016/j.cnr.2006.09.007 · Cited by 205 · see citing works

Tumor-Associated Macrophages in the Cutaneous SCC Microenvironment Are Heterogeneously Activated

Pettersen, J. S., Fuentes‐Duculan, J., Suárez‐Fariñas, M., Pierson, K. C., Pitts-Kiefer, A., Fan, L., Belkin, D. A., Wang, C. Q. F., Bhuvanendran, S., Johnson-Huang, L. M., et al. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.9 · Cited by 205 · see citing works

Oxidant stress in mitochondrial DNA damage, autophagy and inflammation in atherosclerosis

Ding, Z., Liu, S., Wang, X., Khaidakov, M., Dai, Y., & Mehta, J. L. (2013) · Scientific Reports · doi:10.1038/srep01077 · Cited by 204 · see citing works

Hyperuricemia-induced NLRP3 activation of macrophages contributes to the progression of diabetic nephropathy

Kim, S.-M., Lee, S. H., Kim, Y., Kim, S.-Y., Seo, J.-W., Choi, Y., Kim, D.-J., Jeong, K. H., Lee, T., Ihm, C., et al. (2015) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00637.2014 · Cited by 202 · see citing works

Pathophysiology of astroglial purinergic signalling

Franke, H., Verkhratsky, A., Burnstock, G., & Illés, P. (2012) · Purinergic Signalling · doi:10.1007/s11302-012-9300-0 · Cited by 200 · see citing works

HMGB1: The jack‐of‐all‐trades protein is a master DNA repair mechanic

Lange, S. S., & Vásquez, K. M. (2009) · Molecular Carcinogenesis · doi:10.1002/mc.20544 · Cited by 196 · see citing works

P2X 4 Receptors Influence Inflammasome Activation after Spinal Cord Injury

Vaccari, J. P. D. R., Bastien, D., Yurcisin, G., Pineau, I., Dietrich, W. D., Koninck, Y. D., Keane, R. W., & Lacroix, S. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.4930-11.2012 · Cited by 185 · see citing works

Traumatic brain injury induces macrophage subsets in the brain

Hsieh, C. L., Kim, C. C., Ryba, B. E., Niemi, E. C., Bando, J. K., Locksley, R. M., Liu, J., Nakamura, M. C., & Seaman, W. E. (2013) · European Journal of Immunology · doi:10.1002/eji.201243084 · Cited by 179 · see citing works

Essay 1: The Danger Model in Its Historical Context

Matzinger, P. (2001) · Scandinavian Journal of Immunology · doi:10.1046/j.1365-3083.2001.00974.x · Cited by 178 · see citing works

Role of the liver in regulating numbers of circulating neutrophils

Shi, J., Gilbert, G. E., Kokubo, Y., & Ohashi, T. (2001) · Blood · doi:10.1182/blood.v98.4.1226 · Cited by 178 · see citing works

IL-1 family cytokines trigger sterile inflammatory disease

Lukens, J. R., Gross, J. M., & Kanneganti, T. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00315 · Cited by 172 · see citing works

Endogenous antibodies promote rapid myelin clearance and effective axon regeneration after nerve injury

Vargas, M. E., Watanabe, J., Singh, S. J., Robinson, W. H., & Barres, B. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001948107 · Cited by 168 · see citing works

Macrophagic and microglial responses after focal traumatic brain injury in the female rat

Turtzo, L., Lescher, J., Janes, L., Dean, D. D., Budde, M. D., & Frank, J. A. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-82 · Cited by 167 · see citing works

Taking Advantage of the Systemic Immune System to Cure Brain Diseases

Yong, V. W., & Rivest, S. (2009) · Neuron · doi:10.1016/j.neuron.2009.09.035 · Cited by 165 · see citing works

Evidence for Prolonged Release of Excitatory Amino Acids in Severe Human Head Trauma

Bullock, R. M., Zauner, A., Myseros, J. S., Marmarou, A., Woodward, J. J., & Young, H. F. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb16586.x · Cited by 161 · see citing works

Microglia and macrophages differentially modulate cell death after brain injury caused by oxygen‐glucose deprivation in organotypic brain slices

Girard, S., Brough, D., López‐Castejón, G., Giles, J. A., Rothwell, N. J., & Allan, S. M. (2013) · Glia · doi:10.1002/glia.22478 · Cited by 161 · see citing works

Exacerbation of Facial Motoneuron Loss after Facial Nerve Transection in Severe Combined Immunodeficient (scid) Mice

Serpe, C. J., Kohm, A. P., Huppenbauer, C. B., Sanders, V. M., & Jones, K. J. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-11-j0004.1999 · Cited by 160 · see citing works

Features of skin-coincubated macrophages that promote recovery from spinal cord injury

Bomstein, Y., Marder, J. B., Vitner, K., Smirnov, I., Lisaey, G., Butovsky, O., Fulga, V., & Yoles, E. (2003) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(03)00260-1 · Cited by 155 · see citing works

Nasal Vaccination with Myelin Oligodendrocyte Glycoprotein Reduces Stroke Size by Inducing IL-10-Producing CD4+ T Cells

Frenkel, D., Huang, Z., Maron, R., Koldzic, D. N., Hancock, W. W., Moskowitz, M. A., & Weiner, H. L. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.12.6549 · Cited by 147 · see citing works

Interleukin-33 treatment reduces secondary injury and improves functional recovery after contusion spinal cord injury

Pomeshchik, Y., Kidin, I., Korhonen, P., Savchenko, E., Jaronen, M., Lehtonen, Š., Wojciechowski, S., Kanninen, K. M., Koıstınaho, J., & Malm, T. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.08.002 · Cited by 143 · see citing works

Autologous incubated macrophage therapy in acute, complete spinal cord injury: results of the phase 2 randomized controlled multicenter trial

Lammertse, D. P., Jones, L., Charlifue, S. W., Kirshblum, S., Apple, D. F., Ragnarsson, K. T., Falci, S. P., Heary, R. F., Choudhri, T. F., Jenkins, A. L., et al. (2012) · Spinal Cord · doi:10.1038/sc.2012.39 · Cited by 142 · see citing works

Complement C3 and C5 play critical roles in traumatic brain cryoinjury: blocking effects on neutrophil extravasation by C5a receptor antagonist

Sewell, D. L., Nacewicz, B. M., Liu, F., Macvilay, S., Erdei, A., Lambris, J. D., Sándor, M., & Fábry, Z. (2004) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2004.06.003 · Cited by 139 · see citing works

CD4-Positive T Cell-Mediated Neuroprotection Requires Dual Compartment Antigen Presentation

Byram, S. C., Carson, M. J., DeBoy, C. A., Serpe, C. J., Sanders, V. M., & Jones, K. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5276-03.2004 · Cited by 132 · see citing works

Selective Proinflammatory Activation of Astrocytes by High-Mobility Group Box 1 Protein Signaling

Pedrazzi, M., Patrone, M., Passalacqua, M., Ranzato, E., Colamassaro, D., Sparatore, B., Pontremoli, S., & Melloni, E. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.12.8525 · Cited by 132 · see citing works

Immune-Based Therapy for Spinal Cord Repair: Autologous Macrophages and Beyond

Schwartz, M., & Yoles, E. (2006) · Journal of Neurotrauma · doi:10.1089/neu.2006.23.360 · Cited by 131 · see citing works

Rapid Tumor Necrosis Factor α-Induced Exocytosis of Glutamate Receptor 2-Lacking AMPA Receptors to Extrasynaptic Plasma Membrane Potentiates Excitotoxicity

Leonoudakis, D., Zhao, P., & Beattie, E. C. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5159-07.2008 · Cited by 131 · see citing works

Nitric oxide via macrophage iNOS induces apoptosis following traumatic spinal cord injury

Satake, K., Matsuyama, Y., Kamiya, M., Kawakami, H., Iwata, H., Adachi, K., & Kiuchi, K. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00253-9 · Cited by 130 · see citing works

CNS sterile injury: just another wound healing?

Shechter, R., & Schwartz, M. (2012) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.11.007 · Cited by 128 · see citing works

Glial cell loss, proliferation and replacement in the contused murine spinal cord

Lytle, J. M., & Wrathall, J. R. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05390.x · Cited by 127 · see citing works

Defeating inhibition of regeneration by scar and myelin components

Fawcett, J. W., Schwab, M. E., Montani, L., Brazda, N., & Müller, H. W. (2012) · Handbook of clinical neurology · doi:10.1016/b978-0-444-52137-8.00031-0 · Cited by 126 · see citing works

Anti-IL-6-receptor antibody promotes repair of spinal cord injury by inducing microglia-dominant inflammation

Mukaino, M., Nakamura, M., Yamada, O., Okada, S., Morikawa, S., Renault-Mihara, F., Iwanami, A., Ikegami, T., Ohsugi, Y., Tsuji, O., et al. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2010.04.020 · Cited by 125 · see citing works

Neurotrophins regulate the function of cultured microglia

Nakajima, K., Kikuchi, Y., Ikoma, E., Honda, S., Ishikawa, M., Liu, Y., & Kohsaka, S. (1998) · Glia · doi:10.1002/(sici)1098-1136(199811)24:3 · Cited by 122 · see citing works

Activation of P2X₇ receptors induces CCL3 production in microglial cells through transcription factor NFAT

Kataoka, A., Tozaki‐Saitoh, H., Koga, Y., Tsuda, M., & Inoue, K. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05744.x · Cited by 121 · see citing works

Mechanisms of Mononuclear Phagocyte Recruitment in Alzheimers Disease

Hickman, S. E., & Khoury, J. E. (2010) · CNS &amp; Neurological Disorders - Drug Targets · doi:10.2174/187152710791011982 · Cited by 120 · see citing works

Monocyte recruitment and myelin removal are delayed following spinal cord injury in mice with CCR2 chemokine receptor deletion

Ma, M., Wei, T., Boring, L. F., Charo, I. F., Ransohoff, R. M., & Jakeman, L. B. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10269 · Cited by 118 · see citing works

Inflammasome-Derived IL-1β Regulates the Production of GM-CSF by CD4+ T Cells and γδ T Cells

Lukens, J. R., Barr, M., Chaplin, D., Chi, H., & Kanneganti, T. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103308 · Cited by 117 · see citing works

Time Course of Cerebral Edema after Traumatic Brain Injury in Rats: Effects of Riluzole and Mannitol

Bareyre, F. M., Wahl, F., McIntosh, T. K., & Stutzmann, J. M. (1997) · Journal of Neurotrauma · doi:10.1089/neu.1997.14.839 · Cited by 115 · see citing works

Deficiency of the chemokine receptor CXCR2 attenuates neutrophil infiltration and cortical damage following closed head injury

Semple, B. D., Bye, N., Ziebell, J. M., & Morganti-Kossmann, M. C. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.06.015 · Cited by 113 · see citing works

CD4+ T, but not CD8+ or B, lymphocytes mediate facial motoneuron survival after facial nerve transection

Serpe, C. J., Coers, S., Sanders, V. M., & Jones, K. J. (2003) · Brain Behavior and Immunity · doi:10.1016/s0889-1591(03)00028-x · Cited by 112 · see citing works

Toll-like receptor 2-mediated alternative activation of microglia is protective after spinal cord injury

Stirling, D. P., Cummins, K., Mishra, M. K., Teo, W., Yong, V. W., & Stys, P. K. (2013) · Brain · doi:10.1093/brain/awt341 · Cited by 111 · see citing works

Glycyrrhizin protects rat heart against ischemia-reperfusion injury through blockade of HMGB1-dependent phospho-JNK/Bax pathway

Zhai, C., Zhang, M.-Q., Zhang, Y., Xu, H., Wang, J., An, G., Wang, Y., & Li, L. (2012) · Acta Pharmacologica Sinica · doi:10.1038/aps.2012.112 · Cited by 110 · see citing works

Anti-TNF therapy in the injured spinal cord

Esposito, E., & Cuzzocrea, S. (2010) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2010.11.009 · Cited by 109 · see citing works

An Update on PYRIN Domain-Containing Pattern Recognition Receptors: From Immunity to Pathology

Ratsimandresy, R. A., Dorfleutner, A., & Stehlik, C. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00440 · Cited by 109 · see citing works

Glial scar and immune cell involvement in tissue remodeling and repair following acute CNS injuries

Rapôso, C., & Schwartz, M. (2014) · Glia · doi:10.1002/glia.22676 · Cited by 107 · see citing works

Mild traumatic brain injury from motor vehicle accidents: Factors associated with return to work

Ruffolo, C. F., Friedland, J., DAWSON, D. R., Colantonio, A., & Lindsay, P. H. (1999) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/s0003-9993(99)90275-7 · Cited by 105 · see citing works

Macrophage-induced neurotoxicity is mediated by glutamate and attenuated by glutaminase inhibitors and gap junction inhibitors

Yawata, I., Takeuchi, H., Doi, Y., Liang, J., Mizuno, T., & Suzumura, A. (2008) · Life Sciences · doi:10.1016/j.lfs.2008.03.010 · Cited by 103 · see citing works

Age-dependent change of HMGB1 and DNA double-strand break accumulation in mouse brain

Enokido, Y., Yoshitake, A., Ito, H., & Okazawa, H. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.08.108 · Cited by 94 · see citing works

Potential Repair of Rat Spinal Cord Injuries Using Stimulated Homologous Macrophages

Schwartz, M., Lazarov, O., Rapalino, O., Agranov, I., Velan, G., & Hadani, M. (1999) · Neurosurgery · doi:10.1097/00006123-199905000-00057 · Cited by 89 · see citing works

Mice, men and the relatives: cross-species studies underpin innate immunity

Bryant, C. E., & Monie, T. P. (2012) · Open Biology · doi:10.1098/rsob.120015 · Cited by 89 · see citing works

HMGB1 Contributes to Regeneration After Spinal Cord Injury in Adult Zebrafish

Fang, P., Pan, H., Lin, S. L., Zhang, W., Rauvala, H., Schachner, M., & Shen, Y. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8533-4 · Cited by 88 · see citing works

Riluzole for the treatment of acute traumatic spinal cord injury: rationale for and design of the NACTN Phase I clinical trial

Fehlings, M. G., Wilson, J. R., Frankowski, R. F., Toups, E. G., Aarabi, B., Harrop, J. S., Shaffrey, C. I., Harkema, S. J., Guest, J. D., Tator, C. H., et al. (2012) · Journal of Neurosurgery Spine · doi:10.3171/2012.4.aospine1259 · Cited by 88 · see citing works

“Tissue-repairing” blood-derived macrophages are essential for healing of the injured spinal cord: From skin-activated macrophages to infiltrating blood-derived cells?

Schwartz, M. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.01.010 · Cited by 87 · see citing works

A neutrophil elastase inhibitor (ONO‐5046) reduces neurologic damage after spinal cord injury in rats

Tonai, T., Shiba, K., Taketani, Y., Ohmoto, Y., Murata, K., Muraguchi, M., Ohsaki, H., Takeda, E., & Nishisho, T. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00488.x · Cited by 86 · see citing works

Effects of Therapeutic Hypothermia on Inflammasome Signaling after Traumatic Brain Injury

Tomura, S., Vaccari, J. P. D. R., Keane, R., Bramlett, H., & Dietrich, W. (2012) · Journal of Cerebral Blood Flow and Metabolism · doi:10.1038/jcbfm.2012.99 · Cited by 84 · see citing works

Inflammation-induced GDNF improves locomotor function after spinal cord injury

Hashimoto, M., Nitta, A., Fukumitsu, H., Nomoto, H., Shen, L., & Furukawa, S. (2005) · Neuroreport · doi:10.1097/00001756-200502080-00004 · Cited by 81 · see citing works

Glia Maturation Factor Induces Interleukin-33 Release from Astrocytes: Implications for Neurodegenerative Diseases

Kempuraj, D., Khan, M. M., Thangavel, R., Xiong, Z., Yang, E., & Zaheer, A. (2013) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-013-9439-7 · Cited by 79 · see citing works

High mobility group box 1 (HMGB1)

Yang, H., & Tracey, K. J. (2005) · Critical Care Medicine · doi:10.1097/01.ccm.0000187005.81616.a9 · Cited by 76 · see citing works

High-Mobility Group Box-1 and Its Receptors Contribute to Proinflammatory Response in the Acute Phase of Spinal Cord Injury in Rats

Chen, K., Uchida, K., Nakajima, H., Yayama, T., Hirai, T., Guerrero, A., Kobayashi, S., Ma, W., Liu, S., Zhu, P., et al. (2011) · Spine · doi:10.1097/brs.0b013e318203941c · Cited by 71 · see citing works

CXCL10 Is Required to Maintain T-Cell Populations and to Control Parasite Replication during Chronic Ocular Toxoplasmosis

Norose, K., Kikumura, A., Luster, A. D., Hunter, C. A., & Harris, T. H. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-5819 · Cited by 70 · see citing works

Defining antigen‐dependent stages of T cell migration from the blood to the central nervous system parenchyma

Archambault, A. S., Sim, J. E., Gimenez, M. A. T., & Russell, J. H. (2005) · European Journal of Immunology · doi:10.1002/eji.200425864 · Cited by 70 · see citing works

Receptor for advanced glycation end-products (RAGE) activates divergent signaling pathways to augment neurite outgrowth of adult sensory neurons

Saleh, A. J., Smith, D. R., Tessler, L., Mateo, A. R., Martens, C., Schartner, E., der Ploeg, R. V., Toth, C. C., Zochodne, D. W., & Fernyhough, P. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.08.018 · Cited by 69 · see citing works

High Mobility Group Box-1 (HMGB1; Amphoterin) Is Required for Zebrafish Brain Development

Zhao, X., Kuja‐Panula, J., Rouhiainen, A., Chen, Y., Panula, P., & Rauvala, H. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.223834 · Cited by 69 · see citing works

The contribution of activated phagocytes and myelin degeneration to axonal retraction/dieback following spinal cord injury

McPhail, L. T., Stirling, D. P., Tetzlaff, W., Kwiecień, J. M., & Ramer, M. S. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03662.x · Cited by 66 · see citing works

Traumatic Injury and the Presence of Antigen Differentially Contribute to T-Cell Recruitment in the CNS

Ling, C., Sándor, M., Suresh, M., & Fábry, Z. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3502-05.2006 · Cited by 62 · see citing works

Reparixin, an Inhibitor of CXCR2 Function, Attenuates Inflammatory Responses and Promotes Recovery of Function after Traumatic Lesion to the Spinal Cord

Gorio, A., Madaschi, L., Zadra, G., Marfia, G., Cavalieri, B., Bertini, R., & Giulio, A. M. D. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.123679 · Cited by 59 · see citing works

Temporal and Spatial Dynamics of Peroxynitrite-Induced Oxidative Damage After Spinal Cord Contusion Injury

Carrico, K. M., Vaishnav, R., & Hall, E. D. (2009) · Journal of Neurotrauma · doi:10.1089/neu.2008-0870 · Cited by 58 · see citing works

Cell death, caspase activation, and HMGB1 release of porcine choroid plexus epithelial cells during Streptococcus suis infection in vitro

Tenenbaum, T., Eßmann, F., Adam, R., Seibt, A., Jänicke, R. U., Novotny, G. E. K., Galla, H., & Schroten, H. (2006) · Brain Research · doi:10.1016/j.brainres.2006.05.041 · Cited by 56 · see citing works

Complex cell-state changes revealed by single cell RNA sequencing of 76,149 microglia throughout the mouse lifespan and in the injured brain

Hammond, T. R., Dufort, C., Dissing-Olesen, L., Giera, S., Young, A., Wysoker, A., Walker, A. J., Segel, M., Nemesh, J., Saunders, A., et al. (2018) · doi:10.1101/406140 · Cited by 2,225 · see citing works

Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions

Qin, C., Yang, S., Chu, Y., Zhang, H., Pang, X., Chen, L., Zhou, L., Chen, M., Tian, D., & Wang, W. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01064-1 · Cited by 971 · see citing works

Cell transplantation therapy for spinal cord injury

Assinck, P., Duncan, G. J., Hilton, B. J., Plemel, J. R., & Tetzlaff, W. (2017) · Nature Neuroscience · doi:10.1038/nn.4541 · Cited by 941 · see citing works

Global brain inflammation in stroke

Shi, K., Tian, D., Li, Z.-G., Ducruet, A. F., Lawton, M. T., & Shi, F. (2019) · The Lancet Neurology · doi:10.1016/s1474-4422(19)30078-x · Cited by 921 · see citing works

The Biology of Regeneration Failure and Success After Spinal Cord Injury

Tran, A. P., Warren, P. M., & Silver, J. (2018) · Physiological Reviews · doi:10.1152/physrev.00017.2017 · Cited by 883 · see citing works

Revisiting the Mechanisms of CNS Immune Privilege

Louveau, A., Harris, T. H., & Kipnis, J. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.08.006 · Cited by 682 · see citing works

Inflammation after spinal cord injury: a review of the critical timeline of signaling cues and cellular infiltration

Hellenbrand, D. J., Quinn, C. M., Piper, Z. J., Morehouse, C. N., Fixel, J. A., & Hanna, A. S. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02337-2 · Cited by 663 · see citing works

Neutrophils in tissue injury and repair

Wang, J. (2018) · Cell and Tissue Research · doi:10.1007/s00441-017-2785-7 · Cited by 624 · see citing works

Inflammatory Response in the CNS: Friend or Foe?

Sochocka, M., Diniz, B. S., & Leszek, J. (2017) · Molecular Neurobiology · doi:10.1007/s12035-016-0297-1 · Cited by 573 · see citing works

The Meningeal Lymphatic System: A New Player in Neurophysiology

Da Mesquita, S., Fu, Z., & Kipnis, J. (2018) · Neuron · doi:10.1016/j.neuron.2018.09.022 · Cited by 479 · see citing works

Disrupting the blood–brain barrier by focused ultrasound induces sterile inflammation

Kovacs, Z. I., Kim, S., Jikaria, N., Qureshi, F., Milo, B., Lewis, B. K., Bresler, M., Burks, S. R., & Frank, J. A. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1614777114 · Cited by 458 · see citing works

NLRP3 inflammasome-driven pathways in depression: clinical and preclinical findings

Kaufmann, F. N., Costa, A. P., Ghisleni, G., Diaz, A. P., Rodrigues, A. L. S., Peluffo, H., & Kaster, M. P. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.03.002 · Cited by 370 · see citing works

Multifaceted interactions between adaptive immunity and the central nervous system

Kipnis, J. (2016) · Science · doi:10.1126/science.aag2638 · Cited by 376 · see citing works

IL-33 ameliorates Alzheimer's disease-like pathology and cognitive decline

Fu, A. K. Y., Hung, K.-W., Yuen, M. Y. F., Zhou, X., Mak, D. S. Y., Chan, I. C. W., Cheung, T. H., Zhang, B., Fu, W.-Y., Liew, F. Y., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1604032113 · Cited by 369 · see citing works

Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis.

Bolte, A. C., Dutta, A. B., Hurt, M. E., Smirnov, I., Kovacs, M. A., McKee, C. A., Ennerfelt, H. E., Shapiro, D., Nguyen, B. H., Frost, E. L., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18113-4 · Cited by 357 · see citing works

Monocyte-Derived Macrophages Contribute to Spontaneous Long-Term Functional Recovery after Stroke in Mice

Wattananit, S., Tornero, D., Graubardt, N., Memanishvili, T., Monni, E., Tatarishvili, J., Miskinyte, G., Ge, R., Ahlenius, H., Lindvall, O., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.4317-15.2016 · Cited by 354 · see citing works

Bioprinting: From Tissue and Organ Development to in Vitro Models

Mota, C., Camarero‐Espinosa, S., Baker, M., Wieringa, P., & Moroni, L. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00789 · Cited by 308 · see citing works

Myeloid Cells in the Central Nervous System

Herz, J., Filiano, A. J., Wiltbank, A. T., Yogev, N., & Kipnis, J. (2017) · Immunity · doi:10.1016/j.immuni.2017.06.007 · Cited by 332 · see citing works

Emerging Roles for the Immune System in Traumatic Brain Injury

McKee, C. A., & Lukens, J. R. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00556 · Cited by 265 · see citing works

Shaping Neuronal Fate: Functional Heterogeneity of Direct Microglia-Neuron Interactions

Cserép, C., Pósfai, B., & Dénes, Á. (2021) · Neuron · doi:10.1016/j.neuron.2020.11.007 · Cited by 256 · see citing works

Neurosteroids as regulators of neuroinflammation

Yılmaz, C., Karali, K., Fodelianaki, G., Gravanis, A., Chavakis, T., Charalampopoulos, I., & Alexaki, V. I. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100788 · Cited by 245 · see citing works

Brain-immune interactions in perinatal hypoxic-ischemic brain injury

Li, B., Concepcion, K. R., Meng, X., & Zhang, L. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.10.006 · Cited by 230 · see citing works

Peripherally derived macrophages modulate microglial function to reduce inflammation after CNS injury

Greenhalgh, A. D., Zarruk, J. G., Healy, L. M., Jesudasan, S. J. B., Jhelum, P., Salmon, C. K., Formanek, A., Russo, M. V., Antel, J. P., McGavern, D. B., et al. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2005264 · Cited by 212 · see citing works

Opening doors with ultrasound and microbubbles: Beating biological barriers to promote drug delivery

Deprez, J., Lajoinie, G. P. R., Engelen, Y., Smedt, S. C. D., & Lentacker, I. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.02.015 · Cited by 209 · see citing works

Brain Ischemia Suppresses Immunity in the Periphery and Brain via Different Neurogenic Innervations

Liu, Q., Jin, W.-N., Liu, Y., Shi, K., Sun, H., Zhang, F., Zhang, C., Gonzales, R. J., Sheth, K. N., Cava, A. L., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.02.015 · Cited by 207 · see citing works

Mechanisms of lysophosphatidylcholine‐induced demyelination: A primary lipid disrupting myelinopathy

Plemel, J. R., Michaels, N. J., Weishaupt, N., Caprariello, A. V., Keough, M. B., Rogers, J. A., Yukseloglu, A., Lim, J., Patel, V. V., Rawji, K. S., et al. (2018) · Glia · doi:10.1002/glia.23245 · Cited by 220 · see citing works

Cell death, clearance and immunity in the skeletal muscle

Sciorati, C., Rigamonti, E., Manfredi, A. A., & Rovere, P. Q. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2015.171 · Cited by 194 · see citing works

A DAMP-scavenging, IL-10-releasing hydrogel promotes neural regeneration and motor function recovery after spinal cord injury

Shen, H., Bai, X., Yang, C., Xue, W., You, Z., Wu, X., Ma, D., Shao, D., Leong, K. W., & Dai, J. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121279 · Cited by 191 · see citing works

Neuroinflammation and neurohormesis in the pathogenesis of Alzheimer’s disease and Alzheimer-linked pathologies: modulation by nutritional mushrooms

Salinaro, A. T., Pennisi, M., Paola, R. D., Scuto, M. C., Crupi, R., Cambria, M. T., Ontario, M. L., Tomasello, M., Uva, M. G., Maiolino, L., et al. (2018) · Immunity & Ageing · doi:10.1186/s12979-017-0108-1 · Cited by 170 · see citing works

Immunoadolescence: Neuroimmune development and adolescent behavior

Brenhouse, H. C., & Schwarz, J. M. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.05.035 · Cited by 153 · see citing works

Distinct myeloid cell subsets promote meningeal remodeling and vascular repair after mild traumatic brain injury

Russo, M. V., Latour, L. L., & McGavern, D. B. (2018) · Nature Immunology · doi:10.1038/s41590-018-0086-2 · Cited by 149 · see citing works

Characterization of meningeal type 2 innate lymphocytes and their response to CNS injury

Gadani, S. P., Smirnov, I., Wiltbank, A. T., Overall, C. C., & Kipnis, J. (2016) · The Journal of Experimental Medicine · doi:10.1084/jem.20161982 · Cited by 148 · see citing works

Neuroprotective Potentials of Marine Algae and Their Bioactive Metabolites: Pharmacological Insights and Therapeutic Advances

Hannan, M. A., Dash, R., Haque, M. N., Mohibbullah, M., Sohag, A. A. M., Rahman, M. A., Uddin, M. J., Alam, M., & Moon, I. S. (2020) · Marine Drugs · doi:10.3390/md18070347 · Cited by 152 · see citing works

High Mobility Group Box 1 is a novel pathogenic factor and a mechanistic biomarker for epilepsy

Ravizza, T., Terrone, G., Salamone, A., Frigerio, F., Balosso, S., Antoine, D. J., & Vezzani, A. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.10.008 · Cited by 129 · see citing works

Nitric Oxide: Exploring the Contextual Link with Alzheimer’s Disease

Asiimwe, N., Yeo, S. G., Kim, M.-S., Jung, J., & Jeong, N. Y. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/7205747 · Cited by 125 · see citing works

Innate immune cells and C-Reactive protein in acute First-Episode psychosis and schizophrenia: relationship to psychopathology and treatment

Steiner, J., Frodl, T., Schiltz, K., Dobrowolny, H., Jacobs, R., Fernandes, B. S., Guest, P. C., Meyer-Lotz, G., Borucki, K., Bahn, S., et al. (2019) · Schizophrenia Bulletin · doi:10.1093/schbul/sbz068 · Cited by 123 · see citing works

Filling the gaps on stroke research: Focus on inflammation and immunity

Levard, D., Buendía, I., Lanquetin, A., Glavan, M., Vivien, D., & Rubio, M. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.09.025 · Cited by 120 · see citing works

Advances in Biomaterial‐Based Spinal Cord Injury Repair

Shen, H., Fan, C., You, Z., Xiao, Z., Zhao, Y., & Dai, J. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202110628 · Cited by 119 · see citing works

T Cells as an Emerging Target for Chronic Pain Therapy

Laumet, G. O., Ma, J., Robison, A. J., Kumari, S., Heijnen, C. J., & Kavelaars, A. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00216 · Cited by 111 · see citing works

Adult oligodendrocyte progenitor cells – Multifaceted regulators of the CNS in health and disease

Fernández-Castañeda, A., & Gaultier, A. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.01.005 · Cited by 111 · see citing works

Secondary effects on brain physiology caused by focused ultrasound-mediated disruption of the blood–brain barrier

Todd, N., Angolano, C., Ferran, C. J., Devor, A., Borsook, D., & McDannold, N. J. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.05.040 · Cited by 111 · see citing works

Neuroimmunological therapies for treating spinal cord injury: Evidence and future perspectives

Chio, J. C. T., Xu, K. J., Popovich, P. G., David, S., & Fehlings, M. G. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113704 · Cited by 108 · see citing works

Infiltration and persistence of lymphocytes during late-stage cerebral ischemia in middle cerebral artery occlusion and photothrombotic stroke models

Feng, Y., Liao, S., Wei, C., Jia, D., Wood, K., Liu, Q., Wang, X., Shi, F., & Jin, W. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-1017-0 · Cited by 106 · see citing works

Macrophagic and microglial complexity after neuronal injury

Mesquida-Veny, F., del Rı́o, J. A., & Hervera, A. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101970 · Cited by 104 · see citing works

Role of microglia in spinal cord injury

Kroner, A., & Almanza, J. R. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.134370 · Cited by 100 · see citing works

Cerebrospinal Fluid–Basic Concepts Review

Czarniak, N., Kamińska, J., Matowicka-Karna, J., & Koper‐Lenkiewicz, O. M. (2023) · Biomedicines · doi:10.3390/biomedicines11051461 · Cited by 99 · see citing works

Brain injury instructs bone marrow cellular lineage destination to reduce neuroinflammation

Shi, S. X.-Y., Shi, K., & Liu, Q. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abc7029 · Cited by 91 · see citing works

The immune system in traumatic brain injury

Plesnila, N. (2015) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2015.10.008 · Cited by 80 · see citing works

Macrophage migration inhibitory factor facilitates prostaglandin E2 production of astrocytes to tune inflammatory milieu following spinal cord injury

Zhang, Y., Zhou, Y., Chen, S., Hu, Y., Zhu, Z., Wang, Y., Du, N., Song, T., Yang, Y., Guo, A., et al. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1468-6 · Cited by 77 · see citing works

Dectin-1 limits autoimmune neuroinflammation and promotes myeloid cell-astrocyte crosstalk via Card9-independent expression of Oncostatin M

Deerhake, M. E., Danzaki, K., Inoue, M., Cardakli, E. D., Nonaka, T., Aggarwal, N., Barclay, W. E., Ji, R., & Shinohara, M. L. (2021) · Immunity · doi:10.1016/j.immuni.2021.01.004 · Cited by 74 · see citing works

Focused ultrasound with microbubbles induces sterile inflammatory response proportional to the blood brain barrier opening: Attention to experimental conditions

Kovacs‐Balint, Z., Burks, S. R., & Frank, J. A. (2018) · Theranostics · doi:10.7150/thno.24181 · Cited by 77 · see citing works

A possible role of microglia-derived nitric oxide by lipopolysaccharide in activation of astroglial pentose-phosphate pathway via the Keap1/Nrf2 system

Iizumi, T., Takahashi, S., Mashima, K., Minami, K., Izawa, Y., Abe, T., Hishiki, T., Suematsu, M., Kajimura, M., & Suzuki, N. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0564-0 · Cited by 76 · see citing works

Neutrophil Decoys with Anti‐Inflammatory and Anti‐Oxidative Properties Reduce Secondary Spinal Cord Injury and Improve Neurological Functional Recovery

Bi, Y., Duan, W., Chen, J., You, T., Li, S., Jiang, W., Li, M., Wang, G., Pan, X., Wu, J., et al. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202102912 · Cited by 73 · see citing works

Positive effects of intermittent fasting in ischemic stroke

Fann, D., Ng, G., Poh, L., & Arumugam, T. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.01.014 · Cited by 66 · see citing works

Blood–brain barrier opening by intracarotid artery hyperosmolar mannitol induces sterile inflammatory and innate immune responses

Burks, S. R., Kersch, C. N., Witko, J. A., Pagel, M. A., Sundby, M., Muldoon, L. L., Neuwelt, E. A., & Frank, J. A. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2021915118 · Cited by 73 · see citing works

MRI and histological evaluation of pulsed focused ultrasound and microbubbles treatment effects in the brain

Kovacs‐Balint, Z., Tu, T., Sundby, M., Qureshi, F. M., Lewis, B. K., Jikaria, N. R., Burks, S. R., & Frank, J. A. (2018) · Theranostics · doi:10.7150/thno.24512 · Cited by 71 · see citing works

Fluid proteomics of CSF and serum reveal important neuroinflammatory proteins in blood–brain barrier disruption and outcome prediction following severe traumatic brain injury: a prospective, observational study

Lindblad, C., Pin, E., Just, D., Nimer, F. A., Nilsson, P., Bellander, B., Svensson, M. A., Piehl, F., & Thelin, E. P. (2021) · Critical Care · doi:10.1186/s13054-021-03503-x · Cited by 70 · see citing works

Temporal single-cell atlas of non-neuronal retinal cells reveals dynamic, coordinated multicellular responses to central nervous system injury

Benhar, I., Ding, J., Yan, W., Whitney, I. E., Jacobi, A., Sud, M., Burgin, G., Shekhar, K., Tran, N. M., Wang, C., et al. (2023) · Nature Immunology · doi:10.1038/s41590-023-01437-w · Cited by 70 · see citing works

Effects of astrocytes and microglia on neuroinflammation after spinal cord injury and related immunomodulatory strategies

Pang, Q.-M., Chen, S., Xu, Q.-J., Zhang, M., Liang, D.-F., Fu, S.-P., Jiang, Y. P., Liu, Z.-L., Zhang, Q., & Zhang, T. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108754 · Cited by 70 · see citing works

Ethanol-Induced Neurodegeneration and Glial Activation in the Developing Brain

Saito, M., Chakraborty, G., Hui, M., Masiello, K., & Saito, M. (2016) · Brain Sciences · doi:10.3390/brainsci6030031 · Cited by 69 · see citing works

The Role of NF-κB Triggered Inflammation in Cerebral Ischemia

Jover‐Mengual, T., Hwang, J.-Y., Byun, H.-R., Court-Vazquez, B. L., Centeno, J. M., Burguete, M. C., & Zukin, R. S. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.633610 · Cited by 69 · see citing works

Immune response after central nervous system injury

Salvador, A. F., & Kipnis, J. (2022) · Seminars in Immunology · doi:10.1016/j.smim.2022.101629 · Cited by 69 · see citing works

Neuroinflammation, Early-Life Adversity, and Brain Development

Andersen, S. L. (2022) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000325 · Cited by 70 · see citing works

Neutrophil Count Is Associated With Reduced Gray Matter and Enlarged Ventricles in First-Episode Psychosis

Núñez, C., Stephan‐Otto, C., Usall, J., Bioque, M., Lobo, A., González-Pinto, A. M., Pina‐Camacho, L., Vieta, E., Castro‐Fornieles, J., Rodríguez–Jiménez, R., et al. (2018) · Schizophrenia Bulletin · doi:10.1093/schbul/sby113 · Cited by 68 · see citing works

Macrophage migration inhibitory factor facilitates production of CCL5 in astrocytes following rat spinal cord injury

Zhou, Y., Guo, W., Zhu, Z., Hu, Y., Wang, Y., Zhang, X., Wang, W., Du, N., Song, T., Yang, K., et al. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1297-z · Cited by 68 · see citing works

The alarmin interleukin-1α triggers secondary degeneration through reactive astrocytes and endothelium after spinal cord injury

Bretheau, F., Castellanos-Molina, A., Bélanger, D., Kusik, M., Mailhot, B., Boisvert, A., Vallières, N., Lessard, M., Gunzer, M., Liu, X., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33463-x · Cited by 67 · see citing works

Microglia and astrocyte activation is region‐dependent in the α‐synuclein mouse model of Parkinson's disease

Basurco, L., Abellanas, M. A., Ayerra, L., Conde, E., Vinueza‐Gavilanes, R., Luquin, E., Vales, Á., Vilas, A., Martín‐Úriz, P. S., Tamayo, I., et al. (2022) · Glia · doi:10.1002/glia.24295 · Cited by 64 · see citing works

Dual roles of interleukin-33 in cognitive function by regulating central nervous system inflammation

Rao, X., Hua, F., Zhang, L., Lin, Y., Fang, P., Chen, S., Ying, J., & Wang, X. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03570-w · Cited by 64 · see citing works

Emerging targets for reprograming the immune response to promote repair and recovery of function after spinal cord injury

Brennan, F. H., & Popovich, P. G. (2018) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000550 · Cited by 62 · see citing works

Inflammatory Regulation of CNS Barriers After Traumatic Brain Injury: A Tale Directed by Interleukin-1

Garnett, C. N., Watson, J. B., Higgins, E. K., Quan, N., & Bachstetter, A. D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.688254 · Cited by 60 · see citing works

In vivo imaging of sterile microglial activation in rat brain after disrupting the blood-brain barrier with pulsed focused ultrasound: [18F]DPA-714 PET study

Sinharay, S., Tu, T., Kovacs‐Balint, Z., Schreiber-Stainthorp, W., Sundby, M., Zhang, X., Papadakis, G. Z., Reid, W. C., Frank, J. A., & Hammoud, D. A. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1543-z · Cited by 60 · see citing works

Beyond host defense and tissue injury: the emerging role of neutrophils in tissue repair

Rizo-Téllez, S. A., & Filep, J. G. (2024) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00652.2023 · Cited by 62 · see citing works

Systemic Interleukin-4 Administration after Spinal Cord Injury Modulates Inflammation and Promotes Neuroprotection

Lima, R., Monteiro, S., Lopes, J., Barradas, P. S., Vasconcelos, N., Gomes, E. D., Assunção-Silva, R. C., Teixeira, F. G., Morais, M., Sousa, N., et al. (2017) · Pharmaceuticals · doi:10.3390/ph10040083 · Cited by 60 · see citing works

Combined Blockade of Interleukin-1α and -1β Signaling Protects Mice from Cognitive Dysfunction after Traumatic Brain Injury

Newell, E. A., Todd, B. P., Mahoney, J., Pieper, A., Ferguson, P., & Bassuk, A. (2018) · eNeuro · doi:10.1523/eneuro.0385-17.2018 · Cited by 55 · see citing works

Age and Diet Affect Genetically Separable Secondary Injuries that Cause Acute Mortality Following Traumatic Brain Injury in Drosophila

Katzenberger, R. J., Ganetzky, B., & Wassarman, D. A. (2016) · G3 Genes Genomes Genetics · doi:10.1534/g3.116.036194 · Cited by 57 · see citing works

Regulation of neuroimmune processes by damage- and resolution-associated molecular patterns

Klegeris, A. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.293134 · Cited by 56 · see citing works

Advances in Biomarker-Guided Therapy for Pediatric- and Adult-Onset Neuroinflammatory Disorders: Targeting Chemokines/Cytokines

Pranzatelli, M. R. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00557 · Cited by 56 · see citing works

Melatonin alleviates intestinal injury, neuroinflammation and cognitive dysfunction caused by intestinal ischemia/reperfusion

Yang, B., Zhang, L., Chen, Y., Bai, Y., Jia, J., Feng, J., Liu, K., & Zhou, J. F. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106596 · Cited by 55 · see citing works

The cerebral endothelial cell as a key regulator of inflammatory processes in sterile inflammation

Ludewig, P., Winneberger, J., & Magnus, T. U. (2018) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2018.10.012 · Cited by 55 · see citing works

Dwellers and Trespassers: Mononuclear Phagocytes at the Borders of the Central Nervous System

Ivan, D. C., Walthert, S., Berve, K., Steudler, J., & Locatelli, G. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.609921 · Cited by 53 · see citing works

Controlled extracellular vesicles release from aminoguanidine nanoparticle-loaded polylysine hydrogel for synergistic treatment of spinal cord injury

Wang, S., Wang, R., Chen, J., Yang, B., Shu, J., Cheng, F., Tao, Y., Shi, K., Wang, C., Wang, J., et al. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.09.026 · Cited by 53 · see citing works

Acute Neuroinflammatory Response in the Substantia Nigra Pars Compacta of Rats after a Local Injection of Lipopolysaccharide

Flores-Martinez, Y. M., Fernandez-Parrilla, M. A., Ayala-Dávila, J., Reyes-Corona, D., Blanco-Álvarez, V. M., Soto-Rojas, L. O., Luna-Herrera, C., González-Barrios, J. A., León‐Chávez, B. A., Gutiérrez-Castillo, M. E., et al. (2018) · Journal of Immunology Research · doi:10.1155/2018/1838921 · Cited by 53 · see citing works

Age-dependent immune and lymphatic responses after spinal cord injury

Salvador, A. F., Dykstra, T., Rustenhoven, J., Gao, W., Blackburn, S. M., Bhasiin, K., Dong, M. Q., Guimarães, R. M., Gonuguntla, S., Smirnov, I., et al. (2023) · Neuron · doi:10.1016/j.neuron.2023.04.011 · Cited by 51 · see citing works

Mechanisms of Stem Cell Therapy in Spinal Cord Injuries

Shinozaki, M., Nagoshi, N., Nakamura, M., & Okano, H. (2021) · Cells · doi:10.3390/cells10102676 · Cited by 53 · see citing works

Inflammatory response of microglia to prions is controlled by sialylation of PrPSc

Srivastava, S., Katorcha, E., Makarava, N., Barrett, J. P., Loane, D. J., & Baskakov, I. V. (2018) · Scientific Reports · doi:10.1038/s41598-018-29720-z · Cited by 47 · see citing works

The Interaction Between NF-κB and Estrogen in Alzheimer’s Disease

Mishra, P., Davies, D. A., & Albensi, B. C. (2023) · Molecular Neurobiology · doi:10.1007/s12035-022-03152-3 · Cited by 51 · see citing works

A Delay between Motor Cortex Lesions and Neuronal Transplantation Enhances Graft Integration and Improves Repair and Recovery

Péron, S., Droguerre, M., Debarbieux, F. C., Ballout, N., Benoit‐Marand, M., Francheteau, M., Brot, S., Rougon, G. N., Jaber, M., & Gaillard, A. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.2936-16.2017 · Cited by 47 · see citing works

Regulatory Role of Mesenchymal Stem Cells on Secondary Inflammation in Spinal Cord Injury

Pang, Q.-M., Chen, S.-Y., Fu, S.-P., Zhou, H., Zhang, Q., Ao, J., Luo, X.-P., & Zhang, T. (2022) · Journal of Inflammation Research · doi:10.2147/jir.s349572 · Cited by 48 · see citing works

Smart hybrid nanomaterials for chronic infections: microbiome-responsive and sustainable therapeutic platforms

Singh, H., Balusamy, S. R., Sukweenadhi, J., Saravanan, M., Mohanprasanth, A., Mijakovic̀, I., & Singh, P. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03712-4 · Cited by 46 · see citing works

Drosophila as a Model to Study Brain Innate Immunity in Health and Disease

Lye, S. H., & Chtarbanova, S. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123922 · Cited by 44 · see citing works

Stem Cell Therapy for Modulating Neuroinflammation in Neuropathic Pain

Joshi, H. P., Jo, H. J., Kim, Y. H., An, S. B., Park, C., & Han, I. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094853 · Cited by 45 · see citing works

Axonal regeneration in zebrafish spinal cord

Ghosh, S., & Hui, S. P. (2018) · Regeneration · doi:10.1002/reg2.99 · Cited by 43 · see citing works

IFP35, a novel DAMP, aggravates neuroinflammation following acute ischemic stroke via TLR4/NF-κB/NLRP3 signaling

Zhang, M., Guo, B., Zhang, X., Han, D., Lv, L., Yan, X., Su, C., Chai, D., Zhao, N., Yan, X., et al. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03492-6 · Cited by 46 · see citing works

Multiple Sclerosis and Aging: The Dynamics of Demyelination and Remyelination

Correale, J. D., & Ysrraelit, M. C. (2022) · ASN NEURO · doi:10.1177/17590914221118502 · Cited by 42 · see citing works

A comprehensive review on the neuroprotective potential of resveratrol in ischemic stroke

Owjfard, M., Rahimian, Z., Karimi, F., Borhani‐Haghighi, A., & Mallahzadeh, A. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e34121 · Cited by 42 · see citing works

Advancements and mechanisms of stem cell-based therapies for spinal cord injury in animals

Mili, B., & Choudhary, O. P. (2024) · International Journal of Surgery · doi:10.1097/js9.0000000000001074 · Cited by 41 · see citing works

Alarmins and central nervous system inflammation in HIV ‐associated neurological disorders

Gougeon, M. (2016) · Journal of Internal Medicine · doi:10.1111/joim.12570 · Cited by 41 · see citing works

Proteomics and bioinformatics reveal insights into neuroinflammation in the acute to subacute phases in rat models of spinal cord contusion injury

Yao, X., Liu, Z., Chen, J., Huang, Z., Liu, J., Sun, B., Zhu, Q. A., Ding, R., & Chen, J. (2021) · The FASEB Journal · doi:10.1096/fj.202100081rr · Cited by 41 · see citing works

Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesisPreprint

Bolte, A. C., Hurt, M. E., Smirnov, I., Kovacs, M. A., McKee, C. A., Natale, N. R., Ennerfelt, H. E., Frost, E. L., Lammert, C. R., Kipnis, J., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/817023 · Cited by 41 · see citing works

Modelling human pathology of traumatic brain injury in animal models

Risling, M., Smith, D. H., Stein, T. D., Thelin, E. P., Zanier, E. R., Ankarcrona, M., & Nilsson, P. (2019) · Journal of Internal Medicine · doi:10.1111/joim.12909 · Cited by 43 · see citing works

Salutary effect of autoimmune T cells after central nervous system injury

Schwartz, M. (2001) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8297-2_4

Immune response after central nervous system injury

Salvador, A. F., & Kipnis, J. (2022) · Seminars in Immunology · doi:10.1016/j.smim.2022.101629 · Cited by 69 · see citing works

Beneficial Autoimmune T Cells and Posttraumatic Neuroprotection

Schwartz, M. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb05400.x · Cited by 21 · see citing works

Immune Response and CNS Injury

Gregson, N. A. (2019) · CRC Press eBooks · doi:10.1201/9780429124839-3 · Cited by 1 · see citing works

Beyond immune privilege: the brain as a dynamic immunological interface

Kobeissy, F. H., & Salzet, M. (2026) · Cell Death and Disease · doi:10.1038/s41419-026-08561-z · Cited by 9 · see citing works