Oxidative stress and calcium dysregulation by palmitate in type 2 diabetes

Ly, Luong Dai; Xu, Shanhua; Choi, Seong-Kyung; Ha, Chae-Myeong; Thoudam, Themis; Cha, Seung-Kuy; Wiederkehr, Andreas; Wollheim, Claes B; Lee, In-Kyu; Park, Kyu-Sang

doi:10.1038/emm.2016.157

Cited by 379Endoplasmic Reticulum Stress and DiseaseMitochondrial Function and PathologyIon Channels and Receptors

Oxidative stress and calcium dysregulation by palmitate in type 2 diabetes

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Ly, Luong Dai, Xu, Shanhua, Choi, Seong-Kyung, Ha, Chae-Myeong, Thoudam, Themis, Cha, Seung-Kuy, Wiederkehr, Andreas, Wollheim, Claes B +2 more·2017·Experimental & Molecular Medicine

DOI 10.1038/emm.2016.157PMC PMC5336562

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Abstract

Free fatty acids (FFAs) are important substrates for mitochondrial oxidative metabolism and ATP synthesis but also cause serious stress to various tissues, contributing to the development of metabolic diseases. CD36 is a major mediator of cellular FFA uptake. Inside the cell, saturated FFAs are able to induce the production of cytosolic and mitochondrial reactive oxygen species (ROS), which can be prevented by co-exposure to unsaturated FFAs. There are close connections between oxidative stress and organellar Ca2+ homeostasis. Highly oxidative conditions induced by palmitate trigger aberrant endoplasmic reticulum (ER) Ca2+ release and thereby deplete ER Ca2+ stores. The resulting ER Ca2+ deficiency impairs chaperones of the protein folding machinery, leading to the accumulation of misfolded proteins. This ER stress may further aggravate oxidative stress by augmenting ER ROS production. Secondary to ER Ca2+ release, cytosolic and mitochondrial matrix Ca2+ concentrations can also be altered. In addition, plasmalemmal ion channels operated by ER Ca2+ depletion mediate persistent Ca2+ influx, further impairing cytosolic and mitochondrial Ca2+ homeostasis. Mitochondrial Ca2+ overload causes superoxide production and functional impairment, culminating in apoptosis. This vicious cycle of lipotoxicity occurs in multiple tissues, resulting in β-cell failure and insulin resistance in target tissues, and further aggravates diabetic complications. High levels of the fatty acid palmitate cause cell death and exacerbate the complications of type 2 diabetes. Kyu-Sang Park at Yonsei University Wonju College of Medicine and colleagues review the molecular mechanisms responsible for palmitate-induced toxicity. The transmembrane protein CD36 mediates the uptake of palmitate into cells where it triggers the production of reactive oxygen species (ROS). Overproduction of ROS interferes with the cell's protein-processing organelle, the endoplasmic reticulum (ER), leading to damaged misfolded proteins and to ER calcium loss. This loss further damages protein folding and increases ROS production. Moreover, it causes an influx of calcium into mitochondria, the cell's power plants, and ultimately results in cell death. Therapeutic agents that inhibit CD36, reduce ROS production or prevent ER calcium loss could break this toxic cycle and contribute to the treatment of type 2 diabetes.

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ROS accumulation triggers damaging cascades: a decrease in mitochondrial membrane potential, activation of caspases 3/7, apoptosis, and ER stress and inflammation via NF-κB.
“ROS accumulation triggers damaging cascades: a decrease in mitochondrial membrane potential, activation of caspases 3/7, apoptosis, and ER stress and inflammation via NF-κB [90,152,153,154,155].”
From The HepG2 Cell Line as a Model for Studying Metabolic Dysfunction-Associated Steatotic Liver Disease (2026) · cites this paper as [153]
The 'Mitochondrial dysfunction by palmitate' section (page unavailable) reports mitochondrial depolarization, caspase activation, apoptosis, and a role for mitochondrial ROS in ER stress and cell death. It does not identify caspases 3/7. The 'Pancreatic beta cell failure and diabetes' section (page unavailable) links palmitate to NF-κB activation and mild inflammation in human islets, but does not establish that ROS triggers inflammation through NF-κB. (LLM, conf=0.86)
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Activation of the Drosophila MLK by Ceramide Reveals TNF-α and Ceramide as Agonists of Mammalian MLK3
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Inhibition of NAPDH Oxidase 2 (NOX2) Prevents Oxidative Stress and Mitochondrial Abnormalities Caused by Saturated Fat in Cardiomyocytes
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Essential Role of Mitochondrial Ca2+ Uniporter in the Generation of Mitochondrial pH Gradient and Metabolism-Secretion Coupling in Insulin-releasing Cells
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Palmitate induces reactive oxygen species production and β‐cell dysfunction by activating nicotinamide adenine dinucleotide phosphate oxidase through S rc signaling
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Protein tyrosine phosphatase 1B inhibition ameliorates palmitate-induced mitochondrial dysfunction and apoptosis in skeletal muscle cells
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Defining the role of DAG, mitochondrial function, and lipid deposition in palmitate-induced proinflammatory signaling and its counter-modulation by palmitoleate
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Disorders of Protein Misfolding: Alpha-1-Antitrypsin Deficiency as Prototype
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Oleic/Palmitate Induces Apoptosis in Human Articular Chondrocytes via Upregulation of NOX4 Expression and ROS Production.
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Supplement of TCA cycle intermediates protects against high glucose/palmitate-induced INS-1 beta cell death
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Effect of NAD on PARP-mediated insulin sensitivity in oleic acid treated hepatocytes
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Targeting Molecular Chaperones for the Treatment of Cystic Fibrosis: Is It a Viable Approach?
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Role of Minerals and Trace Elements in Diabetes and Insulin Resistance
Dubey, P., Thakur, V., & Chattopadhyay, M. (2020) · Nutrients · doi:10.3390/nu12061864 · Cited by 407 · see citing works
Particulate matter 2.5 damages skin cells by inducing oxidative stress, subcellular organelle dysfunction, and apoptosis
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The Role of Oxidative Stress in Pancreatic β Cell Dysfunction in Diabetes
Eguchi, N., Vaziri, N. D., Dafoe, D. C., & Ichii, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041509 · Cited by 354 · see citing works
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Fatty Acid-Induced Lipotoxicity in Pancreatic Beta-Cells During Development of Type 2 Diabetes
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Changes in Plasma Free Fatty Acids Associated with Type-2 Diabetes
Sobczak, A. I. S., Blindauer, C. A., & Stewart, A. J. (2019) · Nutrients · doi:10.3390/nu11092022 · Cited by 306 · see citing works
KIM-1 mediates fatty acid uptake by renal tubular cells to promote progressive diabetic kidney disease
Mori, Y., Ajay, A. K., Chang, J., Mou, S., Zhao, H., Kishi, S., Li, J., Brooks, C. R., Xiao, S., Woo, H., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.04.004 · Cited by 304 · see citing works
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Role of c-Jun N-terminal Kinase (JNK) in Obesity and Type 2 Diabetes
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Effects of Dietary n–3 and n–6 Polyunsaturated Fatty Acids in Inflammation and Cancerogenesis
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Monounsaturated Fatty Acids in Obesity-Related Inflammation
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Targeting Oxidative Stress for the Treatment of Liver Fibrosis
Luangmonkong, T., Suriguga, S., Mutsaers, H. A. M., Groothuis, G. M. M., Olinga, P., & Boersema, M. (2018) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/112_2018_10 · Cited by 248 · see citing works
Recent advances in reactive oxygen species scavenging nanomaterials for wound healing
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Thermosensitive Hydrogel Incorporating Prussian Blue Nanoparticles Promotes Diabetic Wound Healing via ROS Scavenging and Mitochondrial Function Restoration
Zhao, X., Liu, Y., Ma, R., Chen, J., Qiu, J., Du, S., Li, C., Wu, Z., Yang, X., Chen, Z., et al. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c24569 · Cited by 216 · see citing works
PDK4 augments ER-mitochondria contact to dampen skeletal muscle insulin signaling during obesity
Thoudam, T., Ha, C.-M., Leem, J., Chanda, D., Park, J.-S., Kim, H.-J., Jeon, J.-H., Choi, Y.-K., Liangpunsakul, S., Huh, Y. H., et al. (2019) · Diabetes · doi:10.2337/db18-0363 · Cited by 207 · see citing works
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Environmental Chemical Exposures and Mitochondrial Dysfunction: a Review of Recent Literature
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The risk of osteoarthritis with running and aging: a 5-year longitudinal study.
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Redox changes in obesity, metabolic syndrome, and diabetes
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Lipotoxicity and β-Cell Failure in Type 2 Diabetes: Oxidative Stress Linked to NADPH Oxidase and ER Stress
Vilas‐Boas, E. A., de Almeida, D. C., Roma, L. P., Ortis, F., & Carpinelli, Â. R. (2021) · Cells · doi:10.3390/cells10123328 · Cited by 143 · see citing works
Modulation of Cardiac Arrhythmogenesis by Epicardial Adipose Tissue
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Biotechnological production of omega-3 fatty acids: current status and future perspectives
Qin, J., Kurt, E., LBassi, T., Sa, L., & Xie, D. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1280296 · Cited by 139 · see citing works
Tanycytes Regulate Lipid Homeostasis by Sensing Free Fatty Acids and Signaling to Key Hypothalamic Neuronal Populations via FGF21 Secretion
Geller, S., Arribat, Y., Netzahualcoyotzi, C., Lagarrigue, S., Carneiro, L., Zhang, L., Amati, F., López‐Mejía, I. C., & Pellerin, L. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.08.004 · Cited by 108 · see citing works
Water Extract of Curcuma longa L. Ameliorates Non-Alcoholic Fatty Liver Disease
Mun, J., Kim, S., Yoon, H., You, Y., Kim, O., Choi, K., Lee, Y., Lee, J., Park, J., & Jun, W. (2019) · Nutrients · doi:10.3390/nu11102536 · Cited by 106 · see citing works
Pancreatic Beta-cell Dysfunction in Type 2 Diabetes
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Metabolic Effects of Metformin in the Failing Heart
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The Distinct Effects of Palmitic and Oleic Acid on Pancreatic Beta Cell Function: The Elucidation of Associated Mechanisms and Effector Molecules
Nemecz, M., Constantin, A. L., Dumitrescu, M., Alexandru, N., Filippi, A., Tanko, G., & Georgescu, A. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01554 · Cited by 94 · see citing works
Response to Persistent ER Stress in Plants: A Multiphasic Process That Transitions Cells from Prosurvival Activities to Cell Death
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Modulation of Autophagy Influences the Function and Survival of Human Pancreatic Beta Cells Under Endoplasmic Reticulum Stress Conditions and in Type 2 Diabetes
Bugliani, M., Mossuto, S., Grano, F., Suleiman, M., Marselli, L., Boggi, U., SIMONE, P. D., Eizirik, D. L., Cnop, M., Marchetti, P., et al. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00052 · Cited by 92 · see citing works
Contribution of Oxidative Stress and Impaired Biogenesis of Pancreatic β-Cells to Type 2 Diabetes
Ježek, P., Jabůrek, M., & Plecitá‐Hlavatá, L. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2018.7656 · Cited by 88 · see citing works
Nicotinamide Phosphoribosyltransferase Inhibitors Selectively Induce Apoptosis of AML Stem Cells by Disrupting Lipid Homeostasis
Subedi, A., Liu, Q., Ayyathan, D. M., Sharon, D. M., Cathelin, S., Hosseini, M., Xu, C., Voisin, V., Bader, G. D., D’Alessandro, A., et al. (2020) · Cell stem cell · doi:10.1016/j.stem.2021.06.004 · Cited by 88 · see citing works
Gut microbiota and probiotics intervention: A potential therapeutic target for management of cardiometabolic disorders and chronic kidney disease?
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Matrine attenuates endoplasmic reticulum stress and mitochondrion dysfunction in nonalcoholic fatty liver disease by regulating SERCA pathway
Gao, X., Guo, S., Zhang, S., Liu, A., Shi, L., & Zhang, Y. (2018) · Journal of Translational Medicine · doi:10.1186/s12967-018-1685-2 · Cited by 82 · see citing works
The Human Islet: Mini-Organ With Mega-Impact
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MiR-30 promotes fatty acid beta-oxidation and endothelial cell dysfunction and is a circulating biomarker of coronary microvascular dysfunction in pre-clinical models of diabetes
Veitch, S., Njock, M., Chandy, M., Siraj, M. A., Chi, L., Mak, H., Yu, K., Rathnakumar, K., Perez-Romero, C. A., Chen, Z., et al. (2022) · Cardiovascular Diabetology · doi:10.1186/s12933-022-01458-z · Cited by 82 · see citing works
Pathophysiological Mechanisms of Diabetes-Induced Macrovascular and Microvascular Complications: The Role of Oxidative Stress
Roy, B. (2025) · Medical Sciences · doi:10.3390/medsci13030087 · Cited by 89 · see citing works
Astragalosides IV protected the renal tubular epithelial cells from free fatty acids-induced injury by reducing oxidative stress and apoptosis
Chen, Q., Su, Y., Ju, Y., Ma, K., Li, W., & Li, W. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.09.049 · Cited by 76 · see citing works
Deficiency of the Circadian Clock Gene Bmal1 Reduces Microglial Immunometabolism
Wang, X., Wolff, S. E. C., Korpel, N. L., Milanova, I. V., Sandu, C., Rensen, P. C. N., Kooijman, S., Cassel, J., Kalsbeek, A., Boutillier, A., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.586399 · Cited by 77 · see citing works
Lipid-Induced Mechanisms of Metabolic Syndrome
Denisenko, Y., Kytikovа, O. Y., Novgorodtseva, T. P., Antonyuk, M. V., Gvozdenko, T. A., & Анатольевна, К. Т. (2020) · Journal of Obesity · doi:10.1155/2020/5762395 · Cited by 78 · see citing works
Integrative biology of extracellular vesicles in diabetes mellitus and diabetic complications
Liu, J., Zhang, Y., Tian, Y., Huang, W. C., Tong, N., & Fu, X. (2022) · Theranostics · doi:10.7150/thno.65778 · Cited by 72 · see citing works
Research progress on the mechanism of beta-cell apoptosis in type 2 diabetes mellitus
You, S., Zheng, J., Chen, Y., & Huang, H. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.976465 · Cited by 68 · see citing works
Enriched dietary saturated fatty acids induce trained immunity via ceramide production that enhances severity of endotoxemia and clearance of infection
Seufert, A. L., Hickman, J. W., Traxler, S. K., Peterson, R. M., Waugh, T. A., Lashley, S. J., Shulzhenko, N., Napier, R. J., & Napier, B. A. (2022) · eLife · doi:10.7554/elife.76744 · Cited by 67 · see citing works
Impaired fatty acid metabolism perpetuates lipotoxicity along the transition to chronic kidney injury
Rinaldi, A. M., Lazareth, H., Poindessous, V., Nemazanyy, I., Sampaio, J. L., Malpetti, D., Bignon, Y., Naesens, M., Rabant, M., Anglicheau, D., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.161783 · Cited by 64 · see citing works
Impacts of polypropylene microplastics on lipid profiles of mouse liver uncovered by lipidomics analysis and Raman spectroscopy
Liu, M., Mu, J., Wang, M., Hu, C., Ji, J., Wen, C., & Zhang, D. (2023) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2023.131918 · Cited by 64 · see citing works
Sources and triggers of oxidative damage in neurodegeneration
Angelova, P. R. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.07.003 · Cited by 64 · see citing works
From obesity to Alzheimer's disease through insulin resistance
Terzo, S., Amato, A., & Mulè, F. (2021) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2021.108026 · Cited by 63 · see citing works
Astragaloside IV attenuates myocardial dysfunction in diabetic cardiomyopathy rats through downregulation of CD36 ‐mediated ferroptosis
Li, X., Li, Z., Dong, X., Wu, Y., Li, B., Kuang, B., Chen, G., & Zhang, L. (2023) · Phytotherapy Research · doi:10.1002/ptr.7798 · Cited by 62 · see citing works
Mitochondrial dysfunction and endoplasmic reticulum stress in the promotion of fibrosis in obstructive nephropathy induced by unilateral ureteral obstruction
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Remodeling of Mitochondrial Plasticity: The Key Switch from NAFLD/NASH to HCC
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A Brief Review of the Mechanisms of β-Cell Dedifferentiation in Type 2 Diabetes
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Effects of anticancer drugs on the cardiac mitochondrial toxicity and their underlying mechanisms for novel cardiac protective strategies
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Ophiopogonin D alleviates diabetic myocardial injuries by regulating mitochondrial dynamics
Li, W., Ji, L., Tian, J., Tang, W., Shan, X., Zhao, P., Chen, H., Zhang, C., Xu, M. G., Lü, R., et al. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.113853 · Cited by 59 · see citing works
Two Birds One Stone: The Neuroprotective Effect of Antidiabetic Agents on Parkinson Disease—Focus on Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitors
Lin, K.-J., Wang, T., Chen, S., Lin, K.-L., Liou, C., Lan, M., Chuang, Y., Chuang, J., Wang, P., Lee, J., et al. (2021) · Antioxidants · doi:10.3390/antiox10121935 · Cited by 60 · see citing works
Protein aggregation: Consequences, mechanism, characterization and inhibitory strategies
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Molecular mechanisms of lipotoxicity-induced pancreatic β-cell dysfunction
Benito‐Vicente, A., Jebari‐Benslaiman, S., Galicia-García, U., Larrea, A., Uribe, K. B., & Martı́n, C. (2021) · International review of cytology · doi:10.1016/bs.ircmb.2021.02.013 · Cited by 57 · see citing works
Metabolites of Gut Microbiota and Possible Implication in Development of Diabetes Mellitus
Guo, Z., Pan, J., Zhu, H., & Chen, Z. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c07851 · Cited by 57 · see citing works
The Effect of Omega-3 Fatty Acids on Insulin Resistance
Sinha, S., Haque, M., Lugova, H., & Kumar, S. (2023) · Life · doi:10.3390/life13061322 · Cited by 55 · see citing works
Shaping of Innate Immune Response by Fatty Acid Metabolite Palmitate
Tzeng, H., Chyuan, I., & Chen, W.-Y. (2019) · Cells · doi:10.3390/cells8121633 · Cited by 50 · see citing works
A systematic review on the mechanisms of vitamin K effects on the complications of diabetes and pre‐diabetes
Karamzad, N., Maleki, V., Carson‐Chahhoud, K., Azizi, S., Sahebkar, A., & Gargari, B. P. (2019) · BioFactors · doi:10.1002/biof.1569 · Cited by 54 · see citing works
Spatially Resolved Metabolites in Stable and Unstable Human Atherosclerotic Plaques Identified by Mass Spectrometry Imaging
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Discovery of benzofuran-3(2H)-one derivatives as novel DRAK2 inhibitors that protect islet β-cells from apoptosis
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Lipotoxic Impairment of Mitochondrial Function in β-Cells: A Review
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CD47 and thrombospondin-1 regulation of mitochondria, metabolism, and diabetes
Roberts, D. D., & Isenberg, J. S. (2021) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00175.2021 · Cited by 48 · see citing works
In vitro evaluation by PCA and AHP of potential antidiabetic properties of lactic acid bacteria isolated from traditional fermented food
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High Dietary Fat Consumption Impairs Axonal Mitochondrial Function In Vivo
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Phosphoinositides and intracellular calcium signaling: novel insights into phosphoinositides and calcium coupling as negative regulators of cellular signaling
Oh, B. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-01067-0 · Cited by 47 · see citing works
Biochemical and molecular evidence on the role of vaspin in early detection of the insulin resistance in a rat model of high-fat diet and use of diazinon
Maghsoudi, A. S., Hassani, S., Momtaz, S., Shadboorestan, A., Ganjali, M. R., Ghahremani, M. H., Hosseini, R., Norouzi, P., & Abdollahi, M. R. (2018) · Toxicology · doi:10.1016/j.tox.2018.10.014 · Cited by 45 · see citing works
Astragaloside IV inhibits palmitate-mediated oxidative stress and fibrosis in human glomerular mesangial cells via downregulation of CD36 expression
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NADPH Oxidases Connecting Fatty Liver Disease, Insulin Resistance and Type 2 Diabetes: Current Knowledge and Therapeutic Outlook
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Type 2 Diabetes and Alzheimer’s Disease: The Emerging Role of Cellular Lipotoxicity
Marrano, N., Biondi, G., Borrelli, A., Rella, M., Zambetta, T., Gioia, L. D., Caporusso, M., Logroscino, G., Perrini, S., Giorgino, F., et al. (2023) · Biomolecules · doi:10.3390/biom13010183 · Cited by 44 · see citing works
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Authors: Ly, L. D., Xu, S., Choi, S.-K., Ha, C.-M., Thoudam, T., Cha, S.-K., Wiederkehr, A., Wollheim, C. B., Lee, I.-K., & Park, K.-S.
Affiliations: Yonsei University (KR)
Kyungpook National University Hospital (KR)
University of Geneva (CH)
Corresponding author: Park, Kyu-Sang
ORCID: Choi, Seong-Kyung
Ha, Chae-Myeong
Thoudam, Themis
Cha, Seung-Kuy
Wiederkehr, Andreas
Wollheim, Claes B
Lee, In-Kyu
Park, Kyu-Sang
Venue: Experimental & Molecular Medicine
Publisher: Springer Science and Business Media LLC
Published: 2017-02-03
Volume: 49
Issue: 2
Pages: e291-e291
ISSN: 1226-3613 (ISSN-L)
2092-6413
DOI: 10.1038/emm.2016.157
PMC: PMC5336562
OpenAlex: W2584561009
Cited by: 378
References: 161
Citations by year: 2026: 30 · 2025: 44 · 2024: 36 · 2023: 53 · 2022: 42 · 2021: 60 · 2020: 39 · 2019: 35 · 2018: 32 · 2017: 5
FWCI: 3.57
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0 (tdm)
creativecommons.org/licenses/by-nc-sa/4.0 (vor)
Locations: Experimental & Molecular Medicine (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion, cc-by-nc-sa)
PubMed (publishedVersion)
Archive ouverte UNIGE (University of Geneva) (publishedVersion, other-oa)
Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
Funders: Korea Health Industry Development Institute (HI16C1501)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords: palmitate, lipotoxicity, type 2 diabetes, oxidative stress, calcium homeostasis, CD36, free fatty acids, reactive oxygen species, endoplasmic reticulum calcium depletion, endoplasmic reticulum stress, protein misfolding, mitochondrial calcium overload, apoptosis, beta-cell failure, insulin resistance, unsaturated fatty acids
MeSH terms: Animals, Calcium, Diabetes Mellitus, Type 2, Endoplasmic Reticulum, Fatty Acids, Nonesterified, Humans, Mitochondria, Palmitic Acids, Reactive Oxygen Species, Oxidative Stress, CD36 Antigens, Insulin-Secreting Cells, Endoplasmic Reticulum Stress

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Oxidative stress and calcium dysregulation by palmitate in type 2 diabetes

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