Sexton, Patrick M.

International Union of Pharmacology. XXXII. The Mammalian Calcitonin Gene-Related Peptides, Adrenomedullin, Amylin, and Calcitonin Receptors

Poyner, D. R., Sexton, P. M., Marshall, I., Smith, D. M., Quirion, R., Born, W., Muff, R., Fischer, J. A., & Foord, S. M. (2002) · Pharmacological Reviews

Neuropeptides and Animal PhysiologyIon Channels and Receptors

Cited by 804

Emerging paradigms in GPCR allostery: implications for drug discovery

Wootten, D., Christopoulos, A., & Sexton, P. M. (2013) · Nature Reviews Drug Discovery

Receptor Mechanisms and SignalingNeuroscience and Neuropharmacology Research

Cited by 498

Multiple Amylin Receptors Arise from Receptor Activity-Modifying Protein Interaction with the Calcitonin Receptor Gene Product

Christopoulos, G., Perry, K. J., Morfis, M., Tilakaratne, N., Gao, Y., Fraser, N. J., Main, M. J., Foord, S. M., & Sexton, P. M. (1999) · Molecular Pharmacology

Neuropeptides and Animal PhysiologyReceptor Mechanisms and Signaling

Cited by 486

Muscarinic acetylcholine receptors: novel opportunities for drug development

Kruse, A. C., Kobilka, B. K., Gautam, D., Sexton, P. M., Christopoulos, A., & Wess, J. (2014) · Nature Reviews Drug Discovery

Receptor Mechanisms and SignalingNeuroscience and Neuropharmacology Research

Cited by 437

Glucagon-Like Peptide-1 and Its Class B G Protein–Coupled Receptors: A Long March to Therapeutic Successes

Graaf, C. D., Donnelly, D., Wootten, D., Lau, J., Sexton, P. M., Miller, L. J., Ahn, J.-M., Liao, J., Fletcher, M. M., Yang, D., et al. (2016) · Pharmacological Reviews

Receptor Mechanisms and SignalingDiabetes Treatment and Management

Cited by 403

GPCR modulation by RAMPs

Hay, D. L., Poyner, D. R., & Sexton, P. M. (2006) · Pharmacology & Therapeutics

Receptor Mechanisms and SignalingNeuropeptides and Animal Physiology

Cited by 239

Novel Allosteric Modulators of G Protein-coupled Receptors

Gentry, P. R., Sexton, P. M., & Christopoulos, A. (2015) · Journal of Biological Chemistry

Receptor Mechanisms and SignalingNeuroscience and Neuropharmacology Research

Cited by 199

Receptor Activity-Modifying Proteins Differentially Modulate the G Protein-Coupling Efficiency of Amylin Receptors

Morfis, M., Tilakaratne, N., Furness, S. G. B., Christopoulos, G., Werry, T. D., Christopoulos, A., & Sexton, P. M. (2008) · Endocrinology

Receptor Mechanisms and SignalingNeuropeptides and Animal Physiology

Cited by 134

Identification of brain isoforms of the rat calcitonin receptor.

Sexton, P. M., Houssami, S., Hilton, J. M., O'Keeffe, L. M., Center, R. J., Gillespie, M. T., Darcy, P., & Findlay, D. M. (1993) · Molecular Endocrinology

Neuropeptides and Animal PhysiologyReceptor Mechanisms and Signaling

Cited by 134

Ligand-Dependent Modulation of G Protein Conformation Alters Drug Efficacy

Furness, S. G. B., Liang, Y.-L., Nowell, C. J., Halls, M. L., Wookey, P. J., Dal Maso, E., Inoue, A., Christopoulos, A., Wootten, D., & Sexton, P. M. (2016) · Cell

Receptor Mechanisms and SignalingProtein Kinase Regulation and GTPase Signaling

Cited by 134

Allostery and biased agonism at class B G protein-coupled receptors

Wootten, D., Miller, L. J., Koole, C., Christopoulos, A., & Sexton, P. M. (2017) · Chemical Reviews

Receptor Mechanisms and SignalingNeuropeptides and Animal Physiology

Cited by 112

G Protein–Coupled Receptors Targeting Insulin Resistance, Obesity, and Type 2 Diabetes Mellitus

Riddy, D. M., Delerive, P., Summers, R. J., Sexton, P. M., & Langmead, C. J. (2018) · Pharmacological Reviews

Receptor Mechanisms and SignalingDiabetes Treatment and Management

Cited by 108

Prolonged Calcitonin Receptor Signaling by Salmon, but Not Human Calcitonin, Reveals Ligand Bias

Andreassen, K. V., Hjuler, S. T., Furness, S. G., Sexton, P. M., Christopoulos, A., Nosjean, O., Karsdal, M. A., & Henriksen, K. (2014) · PLoS ONE

Receptor Mechanisms and SignalingNeuropeptides and Animal Physiology

Cited by 89

Calcitonin receptor antibodies in the identification of osteoclasts

Quinn, J. M. W., Morfis, M., Lam, M. H. C., Elliott, J., Kartsogiannis, V, Williams, E. D., Gillespie, M. T., Martin, T. J., & Sexton, P. M. (1999) · Bone

Bone Metabolism and DiseasesBone health and osteoporosis research

Cited by 85

Cryptic pocket formation underlies allosteric modulator selectivity at muscarinic GPCRs

Hollingsworth, S. A., Kelly, B., Valant, C., Michaelis, J. A., Mastromihalis, O., Thompson, G., Venkatakrishnan, A. J., Hertig, S., Scammells, P. J., Sexton, P. M., et al. (2019) · Nature Communications

Receptor Mechanisms and SignalingNeuroscience and Neuropharmacology Research

Cited by 73

Fine Tuning Muscarinic Acetylcholine Receptor Signaling Through Allostery and Bias

van der Westhuizen, E. T., Choy, K. H. C., Valant, C., McKenzie-Nickson, S., Bradley, S. J., Tobin, A. B., Sexton, P. M., & Christopoulos, A. (2021) · Frontiers in Pharmacology

Receptor Mechanisms and SignalingNeuroscience and Neuropharmacology Research

Cited by 63

Mini ReviewCalcitonin

Findlay, D. M., & Sexton, P. M. (2004) · Growth Factors

Parathyroid Disorders and TreatmentsNeuropeptides and Animal Physiology

Cited by 54

Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics

Vuckovic, Z., Wang, J., Pham, V., Mobbs, J. I., Belousoff, M. J., Bhattarai, A., Burger, W. A., Thompson, G., Yeasmin, M., Nawaratne, V., et al. (2023) · eLife

Receptor Mechanisms and SignalingNeuroscience and Neuropharmacology Research

Cited by 34

Calcitonin

Findlay, D. M., Sexton, P. M., & Martin, T. J. (2016) · Endocrinology: Adult and Pediatric

Parathyroid Disorders and TreatmentsBone health and osteoporosis research

Cited by 2