Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription

Takahashi, Hidekazu; McCaffery, J. Michael; Irizarry, Rafael A.; Boeke, Jef D.

doi:10.1016/j.molcel.2006.05.040

Cited by 438Genomics and Chromatin DynamicsHistone Deacetylase Inhibitors ResearchNuclear Structure and Function

Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription

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Takahashi, Hidekazu, McCaffery, J. Michael, Irizarry, Rafael A., Boeke, Jef D.·2006·Molecular Cell

DOI 10.1016/j.molcel.2006.05.040

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Abstract

Metabolic enzymes rarely regulate informational processes like gene expression. Yeast acetyl-CoA synthetases (Acs1p and 2p) are exceptional, as they are important not only for carbon metabolism but also are shown here to supply the acetyl-CoA for histone acetylation by histone acetyltransferases (HATs). acs2-Ts mutants exhibit global histone deacetylation, transcriptional defects, and synthetic growth defects with HAT mutants at high temperatures. In glycerol with ethanol, Acs1p is an alternate acetyl-CoA source for HATs. Rapid deacetylation after Acs2p inactivation suggests nuclear acetyl-CoA synthesis is rate limiting for histone acetylation. Different histone lysines exhibit distinct deacetylation rates, with N-terminal tail lysines deacetylated rapidly and H3 lysine 56 slowly. Yeast mitochondrial and nucleocytosolic acetyl-CoA pools are biochemically isolated. Thus, acetyl-CoA metabolism is directly linked to chromatin regulation and may affect diverse cellular processes in which acetylation and metabolism intersect, such as disease states and aging.

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“Loss of function of these enzymes reduces histone acetylation, with global consequences on gene expression (Takahashi et al., 2006; Wellen et al., 2009).”
From Cellular Metabolism and Disease: What Do Metabolic Outliers Teach Us? (2012) · cites this paper as Takahashi et al., 2006

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Authors: Takahashi, H., McCaffery, J. M., Irizarry, R. A., & Boeke, J. D.
Affiliations: Johns Hopkins University (US)
Corresponding author: Boeke, Jef D.
ORCID: Takahashi, Hidekazu
McCaffery, J. Michael
Irizarry, Rafael A.
Boeke, Jef D.
Venue: Molecular Cell
Publisher: Elsevier BV
Published: 2006-07
Volume: 23
Issue: 2
Pages: 207-217
ISSN: 1097-2765 (ISSN-L)
DOI: 10.1016/j.molcel.2006.05.040
OpenAlex: W2038907283
Cited by: 438
References: 57
Citations by year: 2026: 10 · 2025: 17 · 2024: 19 · 2023: 29 · 2022: 26 · 2021: 34 · 2020: 19 · 2019: 27 · 2018: 22 · 2017: 27 · 2016: 29 · 2015: 30 · 2014: 34 · 2013: 21 · 2012: 24
FWCI: 4.62
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2573 d)
Locations: Molecular Cell (publishedVersion)
PubMed (publishedVersion)
Funders: Johns Hopkins University
National Ethnic Affairs Commission of the People's Republic of China
National Institutes of Health
National Institute of General Medical Sciences (R01GM062385, GM62385)
National Center for Research Resources (S10RR019409, RR020839, U54RR020839)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
Keywords: acetyl-CoA synthetase, histone acetylation, histone deacetylation, histone acetyltransferase, global transcription, acetyl-CoA metabolism, chromatin regulation, histone lysine acetylation, yeast, temperature-sensitive mutants, synthetic growth defect
MeSH terms: Acetate-CoA Ligase, Acetylation, Cell Nucleus, Coenzyme A Ligases, Cytosol, Histones, Mitochondria, Mutation, Transcription, Genetic, Signal Transduction, Saccharomyces cerevisiae Proteins, Histone Acetyltransferases

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Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription

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