Kelleher, Neil L.

Top-down characterization of endogenous protein complexes with native proteomics

Skinner, O. S., Haverland, N. A., Fornelli, L., Melani, R. D., Do Vale, L. H. F., Seckler, H. S., Doubleday, P. F., Schachner, L. F., Srzentić, K., Kelleher, N. L., et al. (2018) · Nature Chemical Biology

Advanced Proteomics Techniques and ApplicationsMass Spectrometry Techniques and Applications

Cited by 155

Accurate Sequence Analysis of a Monoclonal Antibody by Top-Down and Middle-Down Orbitrap Mass Spectrometry Applying Multiple Ion Activation Techniques

Fornelli, L., Srzentić, K., Huguet, R., Mullen, C., Sharma, S., Zabrouskov, V., Fellers, R. T., Durbin, K. R., Compton, P. D., & Kelleher, N. L. (2018) · Analytical Chemistry

Mass Spectrometry Techniques and ApplicationsAdvanced Proteomics Techniques and Applications

Cited by 150

The Blood Proteoform Atlas: A reference map of proteoforms in human hematopoietic cells

Melani, R. D., Gerbasi, V. R., Anderson, L. C., Sikora, J. W., Toby, T. K., Hutton, J. E., Butcher, D. S., Negrão, F., Seckler, H. S., Srzentić, K., et al. (2022) · Science

Advanced Proteomics Techniques and ApplicationsAdvanced Biosensing Techniques and Applications

Cited by 140

Quantitation and Identification of Thousands of Human Proteoforms below 30 kDa

Durbin, K. R., Fornelli, L., Fellers, R. T., Doubleday, P. F., Narita, M., & Kelleher, N. L. (2016) · Journal of Proteome Research

Advanced Proteomics Techniques and ApplicationsMass Spectrometry Techniques and Applications

Cited by 111

Precise characterization of KRAS4b proteoforms in human colorectal cells and tumors reveals mutation/modification cross-talk

Ntai, I., Fornelli, L., DeHart, C. J., Hutton, J. E., Doubleday, P. F., LeDuc, R. D., van Nispen, A. J., Fellers, R. T., Whiteley, G., Boja, E. S., et al. (2018) · Proceedings of the National Academy of Sciences

Advanced Proteomics Techniques and ApplicationsProtein Kinase Regulation and GTPase Signaling

Cited by 108

The emerging process of Top Down mass spectrometry for protein analysis: biomarkers, protein-therapeutics, and achieving high throughput

Kellie, J. F., Tran, J. C., Lee, J. E., Ahlf, D. R., Thomas, H. M., Ntai, I., Catherman, A. D., Durbin, K. R., Zamdborg, L., Vellaichamy, A., et al. (2010) · Molecular BioSystems

Advanced Proteomics Techniques and ApplicationsMass Spectrometry Techniques and Applications

Cited by 99

High-Throughput Analysis of Intact Human Proteins Using UVPD and HCD on an Orbitrap Mass Spectrometer

Cleland, T. P., DeHart, C. J., Fellers, R. T., VanNispen, A. J., Greer, J. B., LeDuc, R. D., Parker, W. R., Thomas, P. M., Kelleher, N. L., & Brodbelt, J. S. (2017) · Journal of Proteome Research

Advanced Proteomics Techniques and ApplicationsMass Spectrometry Techniques and Applications

Cited by 96

Optimizing capillary electrophoresis for top‐down proteomics of 30–80 kDa proteins

Li, Y., Compton, P. D., Tran, J. C., Ntai, I., & Kelleher, N. L. (2014) · PROTEOMICS

Advanced Proteomics Techniques and ApplicationsMicrofluidic and Capillary Electrophoresis Applications

Cited by 95

Proton Transfer Charge Reduction Enables High-Throughput Top-Down Analysis of Large Proteoforms

Huguet, R., Mullen, C., Srzentić, K., Greer, J. B., Fellers, R. T., Zabrouskov, V., Syka, J. E. P., Kelleher, N. L., & Fornelli, L. (2019) · Analytical Chemistry

Advanced Proteomics Techniques and ApplicationsMass Spectrometry Techniques and Applications

Cited by 94

Identification and Characterization of Human Proteoforms by Top-Down LC-21 Tesla FT-ICR Mass Spectrometry

Anderson, L. C., DeHart, C. J., Kaiser, N. K., Fellers, R. T., Smith, D. F., Greer, J. B., LeDuc, R. D., Blakney, G. T., Thomas, P. M., Kelleher, N. L., et al. (2017) · Journal of Proteome Research

Advanced Proteomics Techniques and ApplicationsMass Spectrometry Techniques and Applications

Cited by 94

Evaluation of the Compact High-Field Orbitrap for Top-Down Proteomics of Human Cells

Ahlf, D. R., Compton, P. D., Tran, J. C., Early, B. P., Thomas, P. M., & Kelleher, N. L. (2012) · Journal of Proteome Research

Advanced Proteomics Techniques and ApplicationsMass Spectrometry Techniques and Applications

Cited by 89

Advancing Top-down Analysis of the Human Proteome Using a Benchtop Quadrupole-Orbitrap Mass Spectrometer

Fornelli, L., Durbin, K. R., Fellers, R. T., Early, B. P., Greer, J. B., LeDuc, R. D., Compton, P. D., & Kelleher, N. L. (2017) · Journal of Proteome Research

Advanced Proteomics Techniques and ApplicationsMass Spectrometry Techniques and Applications

Cited by 88

Measurement of Individual Ions Sharply Increases the Resolution of Orbitrap Mass Spectra of Proteins

Kafader, J. O., Melani, R. D., Senko, M. W., Makarov, A. A., Kelleher, N. L., & Compton, P. D. (2019) · Analytical Chemistry

Mass Spectrometry Techniques and ApplicationsAdvanced Proteomics Techniques and Applications

Cited by 87

A comprehensive pipeline for translational top-down proteomics from a single blood draw

Toby, T. K., Fornelli, L., Srzentić, K., DeHart, C. J., Levitsky, J., Friedewald, J., & Kelleher, N. L. (2019) · Nature Protocols

Advanced Proteomics Techniques and ApplicationsMass Spectrometry Techniques and Applications

Cited by 86

STORI Plots Enable Accurate Tracking of Individual Ion Signals

Kafader, J. O., Beu, S. C., Early, B. P., Melani, R. D., Durbin, K. R., Zabrouskov, V., Makarov, A. A., Maze, J. T., Shinholt, D. L., Yip, P. F., et al. (2019) · Journal of the American Society for Mass Spectrometry

Mass Spectrometry Techniques and ApplicationsMetabolomics and Mass Spectrometry Studies

Cited by 85

Mapping Proteoforms and Protein Complexes From King Cobra Venom Using Both Denaturing and Native Top-down Proteomics

Melani, R. D., Skinner, O. S., Fornelli, L., Domont, G. B., Compton, P. D., & Kelleher, N. L. (2016) · Molecular & Cellular Proteomics

Advanced Proteomics Techniques and ApplicationsVenomous Animal Envenomation and Studies

Cited by 85

Putting humpty dumpty back together again: what does protein quantification mean in bottom-up proteomics?

Plubell, D. L., Käll, L., Webb-Robertson, B.-J., Bramer, L. M., Ives, A., Kelleher, N. L., Smith, L. M., Montine, T. J., Wu, C. C., & MacCoss, M. J. (2022) · Journal of Proteome Research

Advanced Proteomics Techniques and ApplicationsAdvanced Biosensing Techniques and Applications

Cited by 85

The C-Score: A Bayesian Framework to Sharply Improve Proteoform Scoring in High-Throughput Top Down Proteomics

LeDuc, R. D., Fellers, R. T., Early, B. P., Greer, J. B., Thomas, P. M., & Kelleher, N. L. (2014) · Journal of Proteome Research

Advanced Proteomics Techniques and ApplicationsMass Spectrometry Techniques and Applications

Cited by 85

Individual Ion Mass Spectrometry Enhances the Sensitivity and Sequence Coverage of Top-Down Mass Spectrometry

Kafader, J. O., Durbin, K. R., Melani, R. D., Des Soye, B. J., Schachner, L. F., Senko, M. W., Compton, P. D., & Kelleher, N. L. (2020) · Journal of Proteome Research

Mass Spectrometry Techniques and ApplicationsAdvanced Proteomics Techniques and Applications

Cited by 76

Unabridged Analysis of Human Histone H3 by Differential Top-Down Mass Spectrometry Reveals Hypermethylated Proteoforms from MMSET/NSD2 Overexpression

Zheng, Y., Fornelli, L., Compton, P. D., Sharma, S., Canterbury, J., Mullen, C., Zabrouskov, V., Fellers, R. T., Thomas, P. M., Licht, J. D., et al. (2016) · Molecular & Cellular Proteomics

Advanced Proteomics Techniques and ApplicationsGenomics and Chromatin Dynamics

Cited by 73

Top Down Mass Spectrometry of <60-kDa Proteins from Methanosarcina acetivorans Using Quadrupole FTMS with Automated Octopole Collisionally Activated Dissociation

Patrie, S. M., Ferguson, J. T., Robinson, D. E., Whipple, D., Rother, M., Metcalf, W. W., & Kelleher, N. L. (2006) · Molecular & Cellular Proteomics

Advanced Proteomics Techniques and ApplicationsMass Spectrometry Techniques and Applications

Cited by 62

A Cell-Based Approach to the Human Proteome Project

Kelleher, N. L. (2012) · Journal of the American Society for Mass Spectrometry

Advanced Proteomics Techniques and ApplicationsMass Spectrometry Techniques and Applications

Cited by 55

Proteoform‐Selective Imaging of Tissues Using Mass Spectrometry**

Yang, M., Hu, H., Su, P., Thomas, P. M., Camarillo, J. M., Greer, J. B., Early, B. P., Fellers, R. T., Kelleher, N. L., & Laskin, J. (2022) · Angewandte Chemie International Edition

Mass Spectrometry Techniques and ApplicationsAdvanced Proteomics Techniques and Applications

Cited by 54

Native vs Denatured: An in Depth Investigation of Charge State and Isotope Distributions

Kafader, J. O., Melani, R. D., Schachner, L. F., Ives, A. N., Patrie, S. M., Kelleher, N. L., & Compton, P. D. (2020) · Journal of the American Society for Mass Spectrometry

Mass Spectrometry Techniques and ApplicationsAdvanced Proteomics Techniques and Applications

Cited by 51