Shackelford, David B.

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

Gwinn, D. M., Shackelford, D. B., Egan, D. F., Mihaylova, M. M., Mery, A., Vasquez, D. S., Turk, B. E., & Shaw, R. J. (2008) · Molecular Cell

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

Cited by 3,849

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

Egan, D. F., Shackelford, D. B., Mihaylova, M. M., Gelino, S., Kohnz, R. A., Mair, W., Vasquez, D. S., Joshi, A., Gwinn, D. M., Taylor, R., et al. (2011) · Science

Autophagy in Disease and TherapyMetabolism, Diabetes, and Cancer

Cited by 2,600

The LKB1-AMPK pathway: metabolism and growth control in tumour suppression

Shackelford, D. B., & Shaw, R. J. (2009) · Nature Reviews Cancer

Metabolism, Diabetes, and CancerPI3K/AKT/mTOR signaling in cancer

Cited by 1,943

LKB1 Inactivation Dictates Therapeutic Response of Non-Small Cell Lung Cancer to the Metabolism Drug Phenformin

Shackelford, D. B., Abt, E., Gerken, L., Vasquez, D. S., Seki, A., Leblanc, M., Wei, L., Fishbein, M. C., Czernin, J., Mischel, P. S., et al. (2013) · Cancer Cell

Metabolism, Diabetes, and CancerCancer, Hypoxia, and Metabolism

Cited by 585

Loss of the Tumor Suppressor LKB1 Promotes Metabolic Reprogramming of Cancer Cells via HIF-1α

Faubert, B., Vincent, E. E., Griss, T., Samborska, B., Izreig, S., Svensson, R. U., Mamer, O. A., Avizonis, D., Shackelford, D. B., Shaw, R. J., et al. (2014) · Proceedings of the National Academy of Sciences

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 278

In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer

Momcilovic, M., Jones, A., Bailey, S. T., Waldmann, C. M., Li, R., Lee, J. T., Abdelhady, G., Gomez, A., Holloway, T., Schmid, E., et al. (2019) · Nature

Cancer, Hypoxia, and MetabolismMitochondrial Function and Pathology

Cited by 214

Sodium-glucose transporter 2 is a diagnostic and therapeutic target for early-stage lung adenocarcinoma

Scafoglio, C. R., Villegas, B., Abdelhady, G., Bailey, S. T., Liu, J., Shirali, A. S., Wallace, W. D., Magyar, C. E., Grogan, T. R., Elashoff, D., et al. (2018) · Science Translational Medicine

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 176

Targeted inhibition of EGFR and glutaminase induces metabolic crisis in EGFR mutant lung cancer

Momcilovic, M., Bailey, S. T., Lee, J. T., Fishbein, M. C., Magyar, C., Braas, D., Graeber, T., Jackson, N. J., Czernin, J., Emberley, E., et al. (2017) · Cell Reports

Cancer, Hypoxia, and MetabolismLung Cancer Treatments and Mutations

Cited by 157

Targeting LKB1 in Cancer – Exposing and Exploiting Vulnerabilities

Momcilovic, M., & Shackelford, D. B. (2015) · British Journal of Cancer

PI3K/AKT/mTOR signaling in cancerCancer-related Molecular Pathways

Cited by 97

Heightening Energetic Stress Selectively Targets LKB1-Deficient Non–Small Cell Lung Cancers

Momcilovic, M., McMickle, R., Abt, E., Seki, A., Simko, S. A., Magyar, C., Stout, D. B., Fishbein, M. C., Walser, T. C., Dubinett, S. M., et al. (2015) · Cancer Research

PI3K/AKT/mTOR signaling in cancerLung Cancer Treatments and Mutations

Cited by 46

LKB1 drives stasis and C/EBP-mediated reprogramming to an alveolar type II fate in lung cancer

Murray, C. W., Brady, J. J., Han, M., Cai, H., Tsai, M. K., Pierce, S. E., Cheng, R., Demeter, J., Feldser, D. M., Jackson, P. K., et al. (2022) · Nature Communications

Lung Cancer Research StudiesLung Cancer Treatments and Mutations

Cited by 22

Asparagine signals mitochondrial respiration and can be targeted to impair tumour growth

Krall, A. S., Mullen, P. J., Surjono, F., Momcilovic, M., Schmid, E. W., Halbrook, C. J., Thambundit, A., Mittelman, S. D., Lyssiotis, C. A., Shackelford, D. B., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory)

Cancer, Hypoxia, and MetabolismPI3K/AKT/mTOR signaling in cancer

Cited by 5