LKB1 drives stasis and C/EBP-mediated reprogramming to an alveolar type II fate in lung cancer
Open accessAbstract
LKB1 is among the most frequently altered tumor suppressors in lung adenocarcinoma. Inactivation of Lkb1 accelerates the growth and progression of oncogenic KRAS-driven lung tumors in mouse models. However, the molecular mechanisms by which LKB1 constrains lung tumorigenesis and whether the cancer state that stems from Lkb1 deficiency can be reverted remains unknown. To identify the processes governed by LKB1 in vivo, we generated an allele which enables Lkb1 inactivation at tumor initiation and subsequent Lkb1 restoration in established tumors. Restoration of Lkb1 in oncogenic KRAS-driven lung tumors suppressed proliferation and led to tumor stasis. Lkb1 restoration activated targets of C/EBP transcription factors and drove neoplastic cells from a progenitor-like state to a less proliferative alveolar type II cell-like state. We show that C/EBP transcription factors govern a subset of genes that are induced by LKB1 and depend upon NKX2-1. We also demonstrate that a defining factor of the alveolar type II lineage, C/EBPα, constrains oncogenic KRAS-driven lung tumor growth in vivo. Thus, this key tumor suppressor regulates lineage-specific transcription factors, thereby constraining lung tumor development through enforced differentiation.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
LKB1 loss promotes tumorigenesis by reprogramming epigenetic states, facilitating lineage plasticity and promoting metastasis.
“Beyond its role regulating metabolism via AMPK, LKB1 loss promotes tumorigenesis by reprogramming epigenetic states, facilitating lineage plasticity and promoting metastasis22,67–70.”
From LKB1 regulates JNK-dependent stress signaling and apoptotic dependency of KRAS-mutant lung cancers (2025) · cites this paper as [70]
The Introduction reports that Lkb1 deletion accelerates lung tumor growth, and the Results describe loss of alveolar type II differentiation and the emergence of other neoplastic cell states after Lkb1 inactivation. The Discussion says inactivation imparts epigenetic plasticity, but calls for further study of its mechanisms. This paper does not establish that LKB1 loss promotes metastasis; it discusses testing Lkb1 restoration within metastases as future work. Page numbers are unavailable in our copy. (LLM, conf=0.86)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106 · see citing works
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625 · see citing works
Cytoscape: A software Environment for integrated models of biomolecular interaction networks
Shannon, P., Markiel, A., Ozier, O., Baliga, N. S., Wang, J. T., Ramage, D., Amin, N., Schwikowski, B., & Ideker, T. (2003) · Genome Research · doi:10.1101/gr.1239303 · Cited by 51,888 · see citing works
STAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709 · see citing works
limma powers differential expression analyses for RNA-sequencing and microarray studies
Ritchie, M. E., Phipson, B., Wu, D., Hu, Y., Law, C. W., Shi, W., & Smyth, G. K. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv007 · Cited by 40,458 · see citing works
clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters
Yu, G., Wang, L.-G., Han, Y., & He, Q.-Y. (2012) · OMICS: A Journal of Integrative Biology · doi:10.1089/omi.2011.0118 · Cited by 36,259 · see citing works
Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219 · see citing works
RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome
Li, B., & Dewey, C. N. (2011) · BMC Bioinformatics · doi:10.1186/1471-2105-12-323 · Cited by 22,179 · see citing works
Comprehensive Integration of Single-Cell Data
Stuart, T., Butler, A., Hoffman, P., Hafemeister, C., Papalexi, E., Mauck, W. M., Hao, Y., Stoeckius, M., Smibert, P., & Satija, R. (2019) · Cell · doi:10.1016/j.cell.2019.05.031 · Cited by 15,453 · see citing works
Heinz, S., Benner, C., Spann, N., Bertolino, E., Lin, Y. C., Laslo, P., Cheng, J. X., Murre, C., Singh, H., & Glass, C. K. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.05.004 · Cited by 13,382 · see citing works
Complex heatmaps reveal patterns and correlations in multidimensional genomic data
Gu, Z., Eils, R., & Schlesner, M. (2016) · Bioinformatics · doi:10.1093/bioinformatics/btw313 · Cited by 10,122 · see citing works
Vogelstein, B., Papadopoulos, N., Velculescu, V. E., Zhou, S., Diaz, L. A., & Kinzler, K. W. (2013) · Science · doi:10.1126/science.1235122 · Cited by 7,863 · see citing works
A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
Madisen, L., Zwingman, T. A., Sunkin, S. M., Oh, S. W., Zariwala, H. A., Gu, H., Ng, L. L., Palmiter, R. D., Hawrylycz, M. J., Jones, A. R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2467 · Cited by 6,907 · see citing works
Comprehensive molecular profiling of lung adenocarcinoma
The Cancer Genome Atlas Research Network (2014) · Nature · doi:10.1038/nature13385 · Cited by 5,732 · see citing works
Aran, D., Looney, A. P., Liu, L., Wu, E., Fong, V., Hsu, A., Chak, S., Naikawadi, R. P., Wolters, P. J., Abate, A. R., et al. (2019) · Nature Immunology · doi:10.1038/s41590-018-0276-y · Cited by 4,984 · see citing works
GREAT improves functional interpretation of cis-regulatory regions
McLean, C. Y., Bristor, D., Hiller, M., Clarke, S. L., Schaar, B. T., Lowe, C. B., Wenger, A. M., & Bejerano, G. (2010) · Nature Biotechnology · doi:10.1038/nbt.1630 · Cited by 4,502 · see citing works
The single-cell transcriptional landscape of mammalian organogenesis
Cao, J., Spielmann, M., Qiu, X., Huang, X., Ibrahim, D. M., Hill, A. J., Zhang, F., Mundlos, S., Christiansen, L., Steemers, F. J., et al. (2019) · Nature · doi:10.1038/s41586-019-0969-x · Cited by 4,490 · see citing works
La Manno, G., Soldatov, R., Zeisel, A., Braun, E., Hochgerner, H., Petukhov, V., Lidschreiber, K., Kastriti, M. E., Lönnerberg, P., Furlan, A., et al. (2018) · Nature · doi:10.1038/s41586-018-0414-6 · Cited by 4,118 · see citing works
Differential analyses for RNA-seq: transcript-level estimates improve gene-level inferences
Soneson, C., Love, M. I., & Robinson, M. D. (2015) · F1000Research · doi:10.12688/f1000research.7563.1 · Cited by 3,929 · see citing works
Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris
The Tabula Muris Consortium, coordination, O., coordination, L., processing, O. C. A., sequencing, L. P. A., analysis, C. D., annotation, C. T., Writing group, Supplemental text writing group, & Principal investigators (2018) · Nature · doi:10.1038/s41586-018-0590-4 · Cited by 3,326 · see citing works
GEOquery: a bridge between the Gene Expression Omnibus (GEO) and BioConductor
Davis, S. R., & Meltzer, P. S. (2007) · Bioinformatics · doi:10.1093/bioinformatics/btm254 · Cited by 3,287 · see citing works
Generalizing RNA velocity to transient cell states through dynamical modeling
Bergen, V., Lange, M., Peidli, S., Wolf, F. A., & Theis, F. J. (2020) · Nature Biotechnology · doi:10.1038/s41587-020-0591-3 · Cited by 2,951 · see citing works
MSFragger: ultrafast and comprehensive peptide identification in mass spectrometry–based proteomics
Kong, A. T., Leprevost, F. D. V., Avtonomov, D. M., Mellacheruvu, D., & Nesvizhskii, A. I. (2017) · Nature Methods · doi:10.1038/nmeth.4256 · Cited by 2,344 · see citing works
Enrichment Map: A Network-Based Method for Gene-Set Enrichment Visualization and Interpretation
Merico, D., Isserlin, R., Stueker, O., Emili, A., & Bader, G. D. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013984 · Cited by 2,235 · see citing works
The LKB1-AMPK pathway: metabolism and growth control in tumour suppression
Shackelford, D. B., & Shaw, R. J. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2676 · Cited by 1,943 · see citing works
Self-citationAnalysis of lung tumor initiation and progression using conditional expression of oncogenic K-rasPreprint
Jackson, E. L., Willis, N. A., Mercer, K. L., Bronson, R. T., Crowley, D. G., Montoya, R., Jacks, T., & Tuveson, D. A. (2001) · Genes & Development · doi:10.1101/gad.943001 · Cited by 1,877 · see citing works
McCarthy, D. J., Campbell, K. R., Lun, A. T. L., & Wills, Q. F. (2017) · Bioinformatics · doi:10.1093/bioinformatics/btw777 · Cited by 1,852 · see citing works
Restoration of p53 function leads to tumour regression in vivo
Ventura, A., Kirsch, D. G., McLaughlin, M. E., Tuveson, D. A., Grimm, J., Lintault, L., Newman, J., Reczek, E. E., Weissleder, R., & Jacks, T. (2007) · Nature · doi:10.1038/nature05541 · Cited by 1,820 · see citing works
Effects of an Rb mutation in the mouse
Jacks, T., Fazeli, A., Schmitt, E. M., Bronson, R. T., Goodell, M. A., & Weinberg, R. A. (1992) · Nature · doi:10.1038/359295a0 · Cited by 1,755 · see citing works
<i>STK11/LKB1</i> Mutations and PD-1 Inhibitor Resistance in <i>KRAS</i> -Mutant Lung Adenocarcinoma
Skoulidis, F., Goldberg, M. E., Greenawalt, D. M., Hellmann, M. D., Awad, M. M., Gainor, J. F., Schrock, A. B., Hartmaier, R. J., Trabucco, S. E., Gay, L., et al. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-0099 · Cited by 1,641 · see citing works
Mapping the Mouse Cell Atlas by Microwell-Seq
Han, X., Wang, R., Zhou, Y., Fei, L., Sun, H., Lai, S., Saadatpour, A., Zhou, Z., Chen, H., Ye, F., et al. (2018) · Cell · doi:10.1016/j.cell.2018.02.001 · Cited by 1,597 · see citing works
CCAAT/enhancer-binding proteins: structure, function and regulation
Ramji, D. P., & Foka, P. (2002) · Biochemical Journal · doi:10.1042/bj20020508 · Cited by 1,401 · see citing works
Reconstructing lineage hierarchies of the distal lung epithelium using single-cell RNA-seq
Treutlein, B., Brownfield, D. G., Wu, A. R., Neff, N. F., Mantalas, G. L., Espinoza, F. H., Desai, T. J., Krasnow, M. A., & Quake, S. R. (2014) · Nature · doi:10.1038/nature13173 · Cited by 1,342 · see citing works
Lessons from the Cancer Genome
Garraway, L. A., & Lander, E. S. (2013) · Cell · doi:10.1016/j.cell.2013.03.002 · Cited by 1,322 · see citing works
Schwenk, F., Baron, U., & Rajewsky, K. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.24.5080 · Cited by 1,289 · see citing works
A compendium of mutational cancer driver genes
Martínez-Jiménez, F., Muiños, F., Sentís, I., Deu-Pons, J., Reyes-Salazar, I., Arnedo-Pac, C., Mularoni, L., Pich, O., Bonet, J., Kranas, H., et al. (2020) · Nature reviews. Cancer · doi:10.1038/s41568-020-0290-x · Cited by 1,278 · see citing works
Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis
Lee, E. Y.-H. P., Chang, C.-Y., Hu, N., Wang, Y.-C. J., Lai, C., Herrup, K., Lee, W., & Bradley, A. (1992) · Nature · doi:10.1038/359288a0 · Cited by 1,264 · see citing works
Kimura, S., Hara, Y., Pineau, T., Fernández‐Salguero, P. M., Fox, C. H., Ward, J. M., & Gonzalez, F. J. (1996) · Genes & Development · doi:10.1101/gad.10.1.60 · Cited by 1,221 · see citing works
Ron, D., & Habener, J. F. (1992) · Genes & Development · doi:10.1101/gad.6.3.439 · Cited by 1,156 · see citing works
Alveolar progenitor and stem cells in lung development, renewal and cancer
Desai, T., Brownfield, D., & Krasnow, M. A. (2014) · Nature · doi:10.1038/nature12930 · Cited by 1,066 · see citing works
LKB1 modulates lung cancer differentiation and metastasis
Ji, H., Ramsey, M. R., Hayes, D. N., Fan, C., McNamara, K., Kozlowski, P., Torrice, C., Wu, M. C., Shimamura, T., Perera, S. A., et al. (2007) · Nature · doi:10.1038/nature06030 · Cited by 1,064 · see citing works
Jonkers, J., Meuwissen, R. L. J., van der Gulden, H. M. L., Peterse, H. L., van der Valk, M., & Berns, A. J. M. (2001) · Nature Genetics · doi:10.1038/ng747 · Cited by 1,053 · see citing works
Principles of Tumor Suppression
Sherr, C. J. (2004) · Cell · doi:10.1016/s0092-8674(03)01075-4 · Cited by 1,028 · see citing works
Co-occurring genomic alterations in non-small-cell lung cancer biology and therapy
Skoulidis, F., & Heymach, J. V. (2019) · Nature Reviews Cancer · doi:10.1038/s41568-019-0179-8 · Cited by 1,019 · see citing works
Requirement for a functional Rb-1 gene in murine development
Clarke, A. R., Maandag, E. R., van ROON, M. A., van der Lugt, N. M. T., van der Valk, M., Hooper, M., Berns, A. J. M., & Rielef, H. T. (1992) · Nature · doi:10.1038/359328a0 · Cited by 1,006 · see citing works
Preparing for the First Breath: Genetic and Cellular Mechanisms in Lung Development
Morrisey, E. E., & Hogan, B. L. M. (2010) · Developmental Cell · doi:10.1016/j.devcel.2009.12.010 · Cited by 967 · see citing works
Skoulidis, F., Byers, L. A., Diao, L., Papadimitrakopoulou, V. A., Tong, P., Izzo, J., Behrens, C., Kadara, H., Parra, E. R., Canales, J. R., et al. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-14-1236 · Cited by 936 · see citing works
Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase
DuPage, M. J. P., Dooley, A. L., & Jacks, T. (2009) · Nature Protocols · doi:10.1038/nprot.2009.95 · Cited by 862 · see citing works
Proteome-wide identification of ubiquitin interactions using UbIA-MS
Zhang, X.-F., Smits, A. H., van Tilburg, G. B. A., Ovaa, H., Huber, W. K., & Vermeulen, M. (2018) · Nature Protocols · doi:10.1038/nprot.2017.147 · Cited by 813 · see citing works
Weinstein, I. B., & Joe, A. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-3293 · Cited by 805 · see citing works
Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor
Zacharias, W. J., Frank, D. B., Zepp, J. A., Morley, M. P., Alkhaleel, F. A., Kong, J., Zhou, S., Cantu, E., & Morrisey, E. E. (2018) · Nature · doi:10.1038/nature25786 · Cited by 742 · see citing works
Single-cell Wnt signaling niches maintain stemness of alveolar type 2 cells
Nabhan, A. N., Brownfield, D., Harbury, P. B., Krasnow, M. A., & Desai, T. (2018) · Science · doi:10.1126/science.aam6603 · Cited by 731 · see citing works
Strunz, M., Simon, L. M., Ansari, M., Kathiriya, J. J., Angelidis, I., Mayr, C. H., Tsidiridis, G., Lange, M., Mattner, L. F., Yee, M., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17358-3 · Cited by 710 · see citing works
Mechanisms of Disease: oncogene addiction—a rationale for molecular targeting in cancer therapy
Weinstein, I. B., & Joe, A. K. (2006) · Nature Clinical Practice Oncology · doi:10.1038/ncponc0558 · Cited by 708 · see citing works
Ageing hallmarks exhibit organ-specific temporal signatures
Schaum, N., Lehallier, B., Hahn, O., Pálovics, R., Hosseinzadeh, S., Lee, S. E., Sit, R., Lee, D. P., Losada, P. M., Zardeneta, M. E., et al. (2020) · Nature · doi:10.1038/s41586-020-2499-y · Cited by 671 · see citing works
Stem cell fate in cancer growth, progression and therapy resistance
Lytle, N. K., Barber, A. G., & Reya, T. (2018) · Nature reviews. Cancer · doi:10.1038/s41568-018-0056-x · Cited by 645 · see citing works
Koyama, S., Akbay, E. A., Li, Y. Y., Aref, A. R., Skoulidis, F., Herter-Sprie, G. S., Buczkowski, K. A., Liu, Y., Awad, M. M., Denning, W. L., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-1439 · Cited by 640 · see citing works
An atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomics
Angelidis, I., Simon, L. M., Fernandez, I. E., Strunz, M., Mayr, C. H., Greiffo, F. R., Tsitsiridis, G., Ansari, M., Graf, E., Strom, T.-M., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08831-9 · Cited by 637 · see citing works
Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung.
Sánchez‐Céspedes, M., Parrella, P., Esteller, M., Nomoto, S., Trink, B., Engles, J. M., Westra, W. H., Herman, J. G., & Sidransky, D. (2002) · PubMed · Cited by 626 · see citing works
Rapid Colorectal Adenoma Formation Initiated by Conditional Targeting of the Apc Gene
Shibata, H., Toyama, K., Shioya, H., Ito, M., Hirota, M., Hasegawa, S., Matsumoto, H., Takano, H., Akiyama, T., Toyoshima, K., et al. (1997) · Science · doi:10.1126/science.278.5335.120 · Cited by 605 · see citing works
Widespread recombinase expression using FLPeR (Flipper) mice
Farley, F. W., Soriano, P. M., Steffen, L. S., & Dymecki, S. M. (2000) · genesis · doi:10.1002/1526-968x(200011/12)28:3/4 · Cited by 602 · see citing works
Phenotypic Plasticity: Driver of Cancer Initiation, Progression, and Therapy Resistance
Gupta, P. B., Pastushenko, I., Skibinski, A., Blanpain, C., & Kuperwasser, C. (2018) · Cell stem cell · doi:10.1016/j.stem.2018.11.011 · Cited by 596 · see citing works
Shackelford, D. B., Abt, E., Gerken, L., Vasquez, D. S., Seki, A., Leblanc, M., Wei, L., Fishbein, M. C., Czernin, J., Mischel, P. S., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2012.12.008 · Cited by 585 · see citing works
Self-citationChoi, J., Park, J.-E., Tsagkogeorga, G., Yanagita, M., Koo, B., Han, N., & Lee, J. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.06.020 · Cited by 569 · see citing works
Kobayashi, Y., Tata, A., Konkimalla, A., Katsura, H., Lee, R. F., Ou, J., Banovich, N. E., Kropski, J. A., & Tata, P. R. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-0542-8 · Cited by 559 · see citing works
Dow, L. E., O’Rourke, K. P., Simon, J. M., Tschaharganeh, D. F., van Es, J. H., Clevers, H. C., & Lowe, S. W. (2015) · Cell · doi:10.1016/j.cell.2015.05.033 · Cited by 549 · see citing works
Suppression of STING Associated with LKB1 Loss in KRAS-Driven Lung Cancer
Kitajima, S., Ivanova, E., Guo, S., Yoshida, R., Campisi, M., Sundararaman, S. K., Tange, S., Mitsuishi, Y., Thai, T. C., Masuda, S., et al. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-0689 · Cited by 526 · see citing works
Bohinski, R. J., Lauro, R. D., & Whitsett, J. A. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.9.5671 · Cited by 524 · see citing works
Crowell, H. L., Soneson, C., Germain, P.-L., Calini, D., Collin, L., Raposo, C., Malhotra, D., & Robinson, M. D. (2020) · Nature Communications · doi:10.1038/s41467-020-19894-4 · Cited by 515 · see citing works
Transcriptional Control of Lung Morphogenesis
Maeda, Y., Davé, V., & Whitsett, J. A. (2007) · Physiological Reviews · doi:10.1152/physrev.00028.2006 · Cited by 473 · see citing works
Suppression of lung adenocarcinoma progression by Nkx2-1
Winslow, M. M., Dayton, T. L., Verhaak, R. G. W., Kim-Kiselak, C., Snyder, E. L., Feldser, D. M., Hubbard, D. D., DuPage, M. J., Whittaker, C. A., Hoersch, S., et al. (2011) · Nature · doi:10.1038/nature09881 · Cited by 467 · see citing works
Self-citationDefects in Tracheoesophageal and Lung Morphogenesis inNkx2.1(−/−) Mouse Embryos
Minoo, P., Su, G., Drum, H., Bringas, P., & Kimura, S. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9234 · Cited by 461 · see citing works
Yuan, S., Norgard, R. J., & Stanger, B. Z. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0015 · Cited by 458 · see citing works
A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response
Chen, Z., Cheng, K., Walton, Z., Wang, Y., Ebi, H., Shimamura, T., Liu, Y., Tupper, T., Ouyang, J., Li, J., et al. (2012) · Nature · doi:10.1038/nature10937 · Cited by 446 · see citing works
Kao, H., Downes, M., Ordentlich, P., & Evans, R. M. (2000) · Genes & Development · doi:10.1101/gad.14.1.55 · Cited by 424 · see citing works
Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation
Bardeesy, N. M., Sinha, M., Hezel, A. F., Signoretti, S., Hathaway, N. A., Sharpless, N. E., Loda, M. F., Carrasco, D. R., & DePinho, R. A. (2002) · Nature · doi:10.1038/nature01045 · Cited by 418 · see citing works
Zambelli, F., Pesole, G., & Pavesi, G. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp464 · Cited by 402 · see citing works
Nerlov, C. (2007) · Trends in Cell Biology · doi:10.1016/j.tcb.2007.07.004 · Cited by 396 · see citing works
Integrating genetic and non-genetic determinants of cancer evolution by single-cell multi-omics
Nam, A. S., Chaligné, R., & Landau, D. A. (2020) · Nature Reviews Genetics · doi:10.1038/s41576-020-0265-5 · Cited by 381 · see citing works
Girard, L., Zöchbauer‐Müller, S., Virmani, A. K., Gazdar, A. F., & Minna, J. D. (2000) · PubMed · Cited by 344 · see citing works
CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells
Kim, J., Hu, Z., Cai, L., Li, K., Choi, E., Faubert, B., Bezwada, D., Rodriguez-Canales, J., Villalobos, P., Lin, Y.-F., et al. (2017) · Nature · doi:10.1038/nature22359 · Cited by 325 · see citing works
Huang, E. Y., Zhang, J., Miska, E. A., Guenther, M. G., Kouzarides, T., & Lazar, M. A. (2000) · Genes & Development · doi:10.1101/gad.14.1.45 · Cited by 325 · see citing works
Cloonan, S. M., & Choi, A. M. K. (2016) · Journal of Clinical Investigation · doi:10.1172/jci81113 · Cited by 322 · see citing works
The Peutz-Jegher Gene Product LKB1 Is a Mediator of p53-Dependent Cell Death
Karuman, P., Gozani, O., Odze, R. D., Zhou, X., Zhu, H., Shaw, R. J., Brien, T. P., Bozzuto, C. D., Ooi, D. L.-Y., Cantley, L. C., et al. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00258-1 · Cited by 321 · see citing works
Stress-Induced Binding of the Transcription Factor CHOP to a Novel DNA Control Element
Ubeda, M., Wang, X.-Z., Zinszner, H., Wu, I., Habener, J. F., & Ron, D. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.4.1479 · Cited by 310 · see citing works
Vascular Abnormalities and Deregulation of VEGF in Lkb1 -Deficient Mice
Ylikorkala, A., Rossi, D. J., Korsisaari, N., Luukko, K., Alitalo, K. K., Henkemeyer, M. J., & Mäkelä, T. P. (2001) · Science · doi:10.1126/science.1062074 · Cited by 299 · see citing works
Molecular stop signs: regulation of cell-cycle arrest by C/EBP transcription factors
Johnson, P. F. (2005) · Journal of Cell Science · doi:10.1242/jcs.02459 · Cited by 288 · see citing works
Genetic and non-genetic clonal diversity in cancer evolution
Black, J. R., & McGranahan, N. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-021-00336-2 · Cited by 287 · see citing works
Loss of the Tumor Suppressor LKB1 Promotes Metabolic Reprogramming of Cancer Cells via HIF-1α
Faubert, B., Vincent, E. E., Griss, T., Samborska, B., Izreig, S., Svensson, R. U., Mamer, O. A., Avizonis, D., Shackelford, D. B., Shaw, R. J., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1312570111 · Cited by 278 · see citing works
Self-citationStage-specific sensitivity to p53 restoration during lung cancer progression
Feldser, D. M., Kostova, K. K., Winslow, M. M., Taylor, S. E., Cashman, C., Whittaker, C. A., Rivera, F. J. S., Resnick, R., Bronson, R. T., Hemann, M. T., et al. (2010) · Nature · doi:10.1038/nature09535 · Cited by 271 · see citing works
Self-citationMultiple cells-of-origin of mutant K-Ras–induced mouse lung adenocarcinoma
Sutherland, K. D., Song, J., Kwon, M. C., Proost, N., Zevenhoven, J., & Berns, A. J. M. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1319963111 · Cited by 267 · see citing works
Sox9 plays multiple roles in the lung epithelium during branching morphogenesis
Rockich, B. E., Hrycaj, S., Shih, H.-P., Nagy, M. S., Ferguson, M. A. H., Kopp, J. L., Sander, M., Wellik, D. M., & Spence, J. R. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1311847110 · Cited by 267 · see citing works
Chiou, S., Winters, I. P., Wang, J., Naranjo, S., Dudgeon, C., Tamburini, F. B., Brady Jennifer, J., Yang, D., Grüner, B. M., Chuang, C.-H., et al. (2015) · Genes & Development · doi:10.1101/gad.264861.115 · Cited by 267 · see citing works
Self-citationNkx2-1 Represses a Latent Gastric Differentiation Program in Lung Adenocarcinoma
Snyder, E. L., Watanabe, H., Magendantz, M., Hoersch, S., Chen, T. A., Wang, D. G., Crowley, D. G., Whittaker, C. A., Meyerson, M. M., Kimura, S., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.02.018 · Cited by 255 · see citing works
Diseases of Pulmonary Surfactant Homeostasis
Whitsett, J. A., Wert, S. E., & Weaver, T. E. (2015) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-012513-104644 · Cited by 251 · see citing works
Carretero, J., Shimamura, T., Rikova, K., Jackson, A. L., Wilkerson, M. D., Borgman, C. L., Buttarazzi, M., Sanofsky, B. A., McNamara, K. L., Brandstetter, K. A., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.04.026 · Cited by 243 · see citing works
A role for LKB1 gene in human cancer beyond the Peutz–Jeghers syndrome
Sánchez‐Céspedes, M. (2007) · Oncogene · doi:10.1038/sj.onc.1210594 · Cited by 233 · see citing works
In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer
Momcilovic, M., Jones, A., Bailey, S. T., Waldmann, C. M., Li, R., Lee, J. T., Abdelhady, G., Gomez, A., Holloway, T., Schmid, E., et al. (2019) · Nature · doi:10.1038/s41586-019-1715-0 · Cited by 214 · see citing works
Self-citationGuo, M., Du, Y., Gokey, J. J., Ray, S., Bell, S. M., Adam, M., Sudha, P., Perl, A. T., Deshmukh, H. S., Potter, S. S., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07770-1 · Cited by 201 · see citing works
The GSK3 Signaling Axis Regulates Adaptive Glutamine Metabolism in Lung Squamous Cell Carcinoma
Momcilovic, M., Bailey, S. T., Lee, J. T., Fishbein, M. C., Braas, D., Go, J. L., Graeber, T. G., Parlati, F., Demo, S. D., Li, R., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.04.002 · Cited by 182 · see citing works
Self-citationMitofusins regulate lipid metabolism to mediate the development of lung fibrosis
Chung, K., Hsu, C., Fan, L.-C., Huang, Z., Bhatia, D., Chen, Y., Hisata, S., Cho, S. J., Nakahira, K., Imamura, M., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11327-1 · Cited by 179 · see citing works
AMPK governs lineage specification through Tfeb-dependent regulation of lysosomesPreprint
Young, N. P., Kamireddy, A., Nostrand, J. L. V., Eichner, L. J., Shokhirev, M. N., Dayn, Y., & Shaw, R. J. (2016) · Genes & Development · doi:10.1101/gad.274142.115 · Cited by 177 · see citing works
Kim, H. S., Mendiratta, S., Kim, J., Pecot, C. V., Larsen, J. E., Zubovych, I., Seo, B. Y., Kim, J., Eskiocak, B., Chung, H., et al. (2013) · Cell · doi:10.1016/j.cell.2013.09.041 · Cited by 172 · see citing works
NRF2 Activation Promotes Aggressive Lung Cancer and Associates with Poor Clinical Outcomes
Singh, A., Daemen, A., Nickles, D., Jeon, S., Foreman, O., Sudini, K. R., Gnad, F., Lajoie, S., Gour, N., Mitzner, W., et al. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-1985 · Cited by 169 · see citing works
The AMPK-Related Kinases SIK1 and SIK3 Mediate Key Tumor-Suppressive Effects of LKB1 in NSCLC
Hollstein, P. E., Eichner, L. J., Brun, S. N., Kamireddy, A., Svensson, R. U., Vera, L. I., Ross, D. S., Rymoff, T. J., Hutchins, A., Galvez, H. M., et al. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-1261 · Cited by 168 · see citing works
C/EBPα Inhibits Cell Growth via Direct Repression of E2F-DP-Mediated Transcription
Slomiany, B. A., D'Arigo, K. L., Kelly, M. M., & Kurtz, D. T. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.16.5986-5997.2000 · Cited by 166 · see citing works
Identification of cancer initiating cells in K-Ras driven lung adenocarcinoma
Mainardi, S., Mijimolle, N., Francoz, S., Vicente‐Dueñas, C., Sánchez-Garcı́a, I., & Barbacid, M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1320383110 · Cited by 165 · see citing works
SIK1 Couples LKB1 to p53-Dependent Anoikis and Suppresses Metastasis
Cheng, H.-L. M., Liu, P., Wang, Z. C., Zou, L., Santiago, S., Garbitt, V. M., Gjoerup, O. V., Iglehart, J. D., Miron, A., Richardson, A. L., et al. (2009) · Science Signaling · doi:10.1126/scisignal.2000369 · Cited by 158 · see citing works
Chuang, C.-H., Greenside, P., Rogers, Z. N., Brady Jennifer, J., Yang, D., Ma, R. K., Caswell, D. R., Chiou, S., Winters, A. F., Grüner, B. M., et al. (2017) · Nature Medicine · doi:10.1038/nm.4285 · Cited by 151 · see citing works
Self-citationThe hexosamine biosynthesis pathway is a targetable liability in KRAS/LKB1 mutant lung cancer
Kim, J., Lee, H. M., Cai, F., Ko, B., Yang, C., Lieu, E. L., Muhammad, N., Rhyne, S., Li, K., Haloul, M., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-00316-0 · Cited by 143 · see citing works
C/EBPα is required for lung maturation at birth
Martis, P. C., Whitsett, J. A., Xu, Y. J., Perl, A. T., Wan, H., & Ikegami, M. (2006) · Development · doi:10.1242/dev.02273 · Cited by 141 · see citing works
Rogers, Z. N., McFarland, C. D., Winters, I. P., Naranjo, S., Chuang, C.-H., Petrov, D. A., & Winslow, M. M. (2017) · Nature Methods · doi:10.1038/nmeth.4297 · Cited by 139 · see citing works
Self-citationIg/EBP (C/EBPγ) is a transdominant negative inhibitor of C/EBP family transcriptional activators
Cooper, C. L., Henderson, A. J., Artandi, S. E., Avitahl, N., & Calame, K. L. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.21.4371 · Cited by 127 · see citing works
Down-regulation and antiproliferative role of C/EBPalpha in lung cancer.
Halmos, B., Huettner, C. S., Kocher, O. N., Ferenczi, K., Karp, D. D., & Tenen, D. G. (2002) · PubMed · Cited by 125 · see citing works
Mapping the in vivo fitness landscape of lung adenocarcinoma tumor suppression in mice
Rogers, Z. N., McFarland, C. D., Winters, I. P., Seoane, J. A., Brady Jennifer, J., Yoon, S. M., Curtis, C. N., Petrov, D. A., & Winslow, M. M. (2018) · Nature Genetics · doi:10.1038/s41588-018-0083-2 · Cited by 125 · see citing works
Self-citationBhatt, V. D., Khayati, K., Hu, Z. S., Lee, A. S., Kamran, W., Su, X., & Guo, J. Y. (2019) · Genes & Development · doi:10.1101/gad.320481.118 · Cited by 115 · see citing works
Epigenetic Modulation of Tumor Suppressor CCAAT/Enhancer Binding Protein α Activity in Lung Cancer
Tada, Y., Brena, R. M., Hackanson, B. W., Morrison, C., Otterson, G. A., & Plass, C. (2006) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djj093 · Cited by 114 · see citing works
LKB1 Is Recruited to the p21/WAF1 Promoter by p53 to Mediate Transcriptional Activation
Zeng, P.-Y., & Berger, S. L. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0999 · Cited by 112 · see citing works
An LKB1–SIK Axis Suppresses Lung Tumor Growth and Controls Differentiation
Murray, C. W., Brady, J. J., Tsai, M. K., Li, C., Winters, I. P., Tang, R., Andrejka, L., Ma, R. K., Kunder, C. A., Chu, P., et al. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-1237 · Cited by 111 · see citing works
Self-citationLao, Z., Raju, G. P., Bai, C. B., & Joyner, A. L. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.07.004 · Cited by 107 · see citing works
Little, D. R., Lynch, A. M., Yan, Y., Akiyama, H., Kimura, S., & Chen, J. (2021) · Nature Communications · doi:10.1038/s41467-021-22817-6 · Cited by 105 · see citing works
Myers, S. A., Rhoads, A., Cocco, A. R., Peckner, R., Haber, A. L., Schweitzer, L. D., Krug, K., Mani, D. R., Clauser, K. R., Rozenblatt–Rosen, O., et al. (2019) · Molecular & Cellular Proteomics · doi:10.1074/mcp.ra118.001259 · Cited by 103 · see citing works
Chen, S., Chen, J., Johnson, P. F., Muppala, V., & Lee, Y. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.19.7292-7299.2000 · Cited by 101 · see citing works
D’Alò, F., Johansen, L. M., Nelson, E. A., Radomska, H. S., Evans, E. K., Zhang, P., Nerlov, C., & Tenen, D. G. (2003) · Blood · doi:10.1182/blood-2003-02-0479 · Cited by 98 · see citing works
Transcriptional control of lung alveolar type 1 cell development and maintenance by NK homeobox 2-1
Little, D. R., Gerner-Mauro, K. N., Flodby, P., Crandall, E. D., Borok, Z., Akiyama, H., Kimura, S., Ostrin, E. J., & Chen, J. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1906663116 · Cited by 94 · see citing works
Kaufman, J. M., Amann, J. M., Park, K., Arasada, R. R., Li, H., Shyr, Y., & Carbone, D. P. (2014) · Journal of Thoracic Oncology · doi:10.1097/jto.0000000000000173 · Cited by 87 · see citing works
RB constrains lineage fidelity and multiple stages of tumour progression and metastasis
Walter, D. M., Yates, T. J., Ruiz-Torres, M., Kim-Kiselak, C., Gudiel, A. A., Deshpande, C. G., Wang, W., Cicchini, M., Stokes, K. L., Tobias, J. W., et al. (2019) · Nature · doi:10.1038/s41586-019-1172-9 · Cited by 85 · see citing works
Self-citationCamolotto, S. A., Pattabiraman, S., Mosbruger, T. L., Jones, A. D., Belova, V. K., Orstad, G., Streiff, M., Salmond, L., Stubben, C., Kaestner, K. H., et al. (2018) · eLife · doi:10.7554/elife.38579 · Cited by 82 · see citing works
Alveolar Epithelial Type II Cells Induce T Cell Tolerance to Specific Antigen
Lo, B., Hansen, S., Evans, K. S., Heath, J. K., & Wright, J. R. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.2.881 · Cited by 80 · see citing works
Bassères, D. S. D. S., Levantini, E., Ji, H., Monti, S., Elf, S., Dayaram, T., Fenyus, M. L., Kocher, O. N., Golub, T. R., Wong, K., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.3.1109-1123.2006 · Cited by 69 · see citing works
Mutation of Lkb1 and p53 Genes Exert a Cooperative Effect on Tumorigenesis
Wei, C., Amos, C. I., Stephens, L. C., Campos, I. M., Deng, J. M., Behringer, R. R., Rashid, A., & Frazier, M. L. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0716 · Cited by 66 · see citing works
Nagaraj, A. S., Lahtela, J., Hemmes, A., Pellinen, T. S., Blom, S., Devlin, J. R., Salmenkivi, K., Kallioniemi, O., Mäyränpää, M. I., Närhi, K. M., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2016.12.059 · Cited by 64 · see citing works
Targeting adhesion signaling in KRAS, LKB1 mutant lung adenocarcinoma
Gilbert‐Ross, M., Konen, J. M., Koo, J., Shupe, J. A., Robinson, B. S., Wiles, W. G., Huang, C., Martin, W. D., Behera, M., Smith, G. H., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.90487 · Cited by 57 · see citing works
C/EBPα is required for pulmonary cytoprotection during hyperoxia
Xu, Y. J., Saegusa, C., Schehr, A., Grant, S. N., Whitsett, J. A., & Ikegami, M. (2009) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00094.2009 · Cited by 52 · see citing works
Targeted BMI1 inhibition impairs tumor growth in lung adenocarcinomas with low CEBPα expression
Yong, K. J., Bassères, D. S. D. S., Welner, R. S., Zhang, W. C., Yang, H. H., Yan, B., Alberich-Jordà, M., Zhang, J., de Figueiredo‐Pontes, L. L., Battelli, C., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad6066 · Cited by 51 · see citing works
A Functional Taxonomy of Tumor Suppression in Oncogenic KRAS–Driven Lung Cancer
Cai, H., Chew, S. K., Li, C., Tsai, M. K., Andrejka, L., Murray, C. W., Hughes, N. W., Shuldiner, E. G., Ashkin, E. L., Tang, R., et al. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-1325 · Cited by 50 · see citing works
Self-citationPTEN action in leukaemia dictated by the tissue microenvironment
Miething, C., Scuoppo, C., Bosbach, B., Appelmann, I., Nakitandwe, J., Ma, J., Wu, G., Lintault, L., Auer, M., Premsrirut, P. K., et al. (2014) · Nature · doi:10.1038/nature13239 · Cited by 45 · see citing works
A systems approach to mapping transcriptional networks controlling surfactant homeostasis
Xu, Y. J., Zhang, M., Wang, Y., Kadambi, P., Davé, V., Lu, L. J., & Whitsett, J. A. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-451 · Cited by 34 · see citing works
Recombinase-based conditional and reversible gene regulation via XTR alleles
Robles-Oteíza, C., Taylor, S., Yates, T. J., Cicchini, M., Lauderback, B., Cashman, C. R., Burds, A. A., Winslow, M. M., Jacks, T., & Feldser, D. M. (2015) · Nature Communications · doi:10.1038/ncomms9783 · Cited by 30 · see citing works
Self-citationOff and back-on again: a tumor suppressor’s tale
Acosta, J., Wang, W., & Feldser, D. M. (2018) · Oncogene · doi:10.1038/s41388-018-0186-3 · Cited by 14 · see citing works
Self-citationLKB1 signaling in advancing cell differentiation
Udd, L., & Mäkelä, T. P. (2011) · Familial Cancer · doi:10.1007/s10689-011-9441-2 · Cited by 12 · see citing works
Nagaraj, A. S., Lahtela, J., Hemmes, A., Mäyränpää, M. I., Salmenkivi, K., Närhi, K. M., & Verschuren, E. W. (2016) · European Journal of Cancer · doi:10.1016/s0959-8049(16)61312-6 · Cited by 8 · see citing works
HDAC3 regulates senescence and lineage specificity in non-small cell lung cancerPreprint
Eichner, L. J., Curtis, S. D., Brun, S. N., Baumgart, J. T., Ross, D. S., Rymoff, T. J., & Shaw, R. J. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.10.14.338590 · Cited by 7 · see citing works
Flagged first, then by citations
3 of the 146 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Liu, M., Gu, L., Zhang, Y., Li, Y., Zhang, L., Xin, Y., Wang, Y., & Xu, Z. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.217025 · Cited by 57 · see citing works
Epithelial-mesenchymal transition in cancer stemness and heterogeneity: updated
Mortezaee, K., Majidpoor, J., & Kharazinejad, E. (2022) · Medical Oncology · doi:10.1007/s12032-022-01801-0 · Cited by 38 · see citing works
Lineage plasticity and histological transformation: tumor histology as a spectrum
Li, X., Gardner, E. E., Molina‐Pinelo, S., Wilhelm, C., Mu, P., & Quintanal-Villalonga, À. (2025) · Cell Research · doi:10.1038/s41422-025-01180-x · Cited by 31 · see citing works
The role of STK11/LKB1 in cancer biology: implications for ovarian tumorigenesis and progression
Kang, J., Gallucci, S., Pan, J., Oakhill, J. S., & Sanij, E. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1449543 · Cited by 21 · see citing works
Posttranslational regulation of liver kinase B1 in human cancer
Hu, L., Liu, M., Tang, B., Li, Q., Pan, B., Xu, C. S., & Lin, H. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.104570 · Cited by 17 · see citing works
LKB1 regulates JNK-dependent stress signaling and apoptotic dependency of KRAS-mutant lung cancers
Li, C., Syed, M. U., Nimbalkar, A., Shen, Y., Vieira, M. D., Fraser, C., Inde, Z., Qin, X., Ouyang, J., Kreuzer, J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-58753-y · Cited by 11 · see citing works
“Beyond its role regulating metabolism via AMPK, LKB1 loss promotes tumorigenesis by reprogramming epigenetic states, facilitating lineage plasticity and promoting metastasis 22,67 – 70 .”
Minor, A. C., Couser, E., & Eichner, L. J. (2025) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2025.06.008 · Cited by 13 · see citing works
HALO: hierarchical causal modeling for single cell multi-omics data
Mao, H. H., Jia, M., Di, M. E., Valenzi, E., Cai, X. T., Singh, H., Lafyatis, R., Zhang, K., & Benos, P. V. (2025) · Nature Communications · doi:10.1038/s41467-025-63921-1 · Cited by 10 · see citing works
A phase II trial of mTORC1/2 inhibition in STK11 deficient non small cell lung cancer
Middleton, G., Robbins, H. L., Fletcher, P., Savage, J., Mehmi, M., Summers, Y., Greystoke, A., Steele, N., Popat, S., Jain, P., et al. (2025) · npj Precision Oncology · doi:10.1038/s41698-025-00838-4 · Cited by 7 · see citing works
Liver kinase B1 ( LKB1 ) regulates the epigenetic landscape of mouse pancreatic beta cells
Haberman, N., Cheung, R., Pizza, G., Cvetešić, N., Nagy, D., Maude, H., Blázquez, L., Lenhard, B., Cebola, I., Rutter, G. A., et al. (2024) · The FASEB Journal · doi:10.1096/fj.202401078r · Cited by 4 · see citing works
Polarity in respiratory development, homeostasis and disease
Tilston-Lünel, A., & Varelas, X. (2023) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2023.02.004 · Cited by 3 · see citing works
Murine models of lung adenocarcinoma: Valuable tools for preclinical investigation
Shang, W., Lai, C., Luo, S., & Chen, L. (2025) · Gene · doi:10.1016/j.gene.2025.149802 · Cited by 3 · see citing works
Pillai, R., Rashidfarrokhi, A., Hao, Y., Wu, W., Mancini, M. C. S., Karadal-Ferrena, B., Dimitriadoy, S. G., Cross, M., Yeaton, A. H., Huang, S. M., et al. (2026) · Cancer Discovery · doi:10.1158/2159-8290.cd-25-0470 · Cited by 3 · see citing works
Mével‐Aliset, M., Radu, A. G., Allard, J., Blanchet, S., Montellier, E., Hainaut, P. L., Rossignol, R., Torch, S., Orsi, G. A., & Thibert, C. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.151571 · Cited by 2 · see citing works
Hebert, J. D., Tang, Y. J., Szamecz, M., Andrejka, L., Lopez, S. S., Petrov, D. A., Boross, G. Z., & Winslow, M. M. (2025) · Molecular Biology and Evolution · doi:10.1093/molbev/msaf023 · Cited by 3 · see citing works
Self-citationMulti-Target Neural Differentiation (MTND) Therapeutic Cocktail to Suppress Brain Tumor
Hu, X., Xie, J., Yang, Y., Qiu, Z., Lu, W., Lin, X., & Xu, B. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241512329 · Cited by 2 · see citing works
Combinatorial in vivo genome editing identifies widespread epistasis during lung tumorigenesisPreprint
Hebert, J. D., Tang, Y. J., Andrejka, L., Lopez, S. S., Petrov, D. A., Boross, G. Z., & Winslow, M. M. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.03.07.583981 · Cited by 2 · see citing works
Self-citationSmall molecule activation of the tumor suppressor kinase LKB1Preprint
Song, L., Mitchell, D. C., Liu, J., Wang, L., Wang, Z., He, C., Ding, L., Adler, M. J., Turnham, R. E., Kellett, T., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.17.628051 · Cited by 2 · see citing works
Yan, P., Jiang, W., Xue, X., Hou, T., Wang, J., Huang, D., Chen, L., Inuzuka, H., Dai, X., & Wei, W. (2026) · Cancer Letters · doi:10.1016/j.canlet.2026.218678 · Cited by 1 · see citing works
Small-molecule activation of the tumor suppressor kinase LKB1 via the pseudokinase STRAD
Song, L., Mitchell, D. C., Liu, J., Leak, L. B., Turnham, R. E., Wang, L., Wang, Z., He, C., Ding, L., Adler, M., et al. (2026) · Cell chemical biology · doi:10.1016/j.chembiol.2026.07.013 · Cited by 3 · see citing works
LKB1 regulates JNK-dependent stress signaling and apoptotic dependency of KRAS -mutant lung cancersPreprint
Li, C., Syed, M. U., Nimbalkar, A., Shen, Y., Fraser, C., Inde, Z., Qin, X., Ouyang, J., Kreuzer, J., Clark, S. E., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.09.29.510137 · Cited by 1 · see citing works
Wang, X., Zhang, B. G., Sun, C., Huang, M., Huang, W., Zhang, B., Zhang, X., Ren, X., Luo, L., Liang, H., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.09.717383
- Authors
- Murray, C. W., Brady, J. J., Han, M., Cai, H., Tsai, M. K., Pierce, S. E., Cheng, R., Demeter, J., Feldser, D. M., Jackson, P. K., Shackelford, D. B., & Winslow, M. M.
- Affiliations
- Stanford Medicine (US)
- University of California, Los Angeles (US)
- University of Pennsylvania (US)
- Corresponding author
- Winslow, Monte M.
- ORCID
- Venue
- Nature Communications
- Published
- 2022-02-28
- Volume
- 13
- Issue
- 1
- Pages
- 1090-1090
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC8885825
- OpenAlex
- W4214768247
- Cited by
- 22
- References
- 146
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 5 · 2023: 3 · 2022: 2
- FWCI
- 1.88
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- U.S. Department of Health & Human Services | NIH | National Cancer Institute (NIH R01-CA175336, NIH R01-CA207133, NIH R01-CA230919, NIH F32-CA189659, NIH R01-CA208642)
- U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIH 5T32GM007276)
- U.S. Department of Defense (LCRP W81XWH-18-1-0295)
- Topics
- Health Sciences › Medicine › Oncology › Lung Cancer Research Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Treatments and Mutations
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- LKB1, lung adenocarcinoma, C/EBP transcription factors, C/EBPα, TTF-1, lineage reprogramming, tumor suppressor restoration, oncogenic KRAS, tumor differentiation
- MeSH terms
- Animals, Lung Neoplasms, Transcription Factors, Gene Expression Regulation, Neoplastic, Proto-Oncogene Proteins p21(ras), Cell Line, Tumor, Mice, AMP-Activated Protein Kinases, Carcinogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review