Muoio, Deborah M.

Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance

Koves, T. R., Ussher, J. R., Noland, R. C., Slentz, D., Mosedale, M., Ilkayeva, O., Bain, J., Stevens, R., Dyck, J. R. B., Newgard, C. B., et al. (2008) · Cell Metabolism

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 1,990

Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes

Muoio, D. M., & Newgard, C. B. (2008) · Nature Reviews Molecular Cell Biology

Pancreatic function and diabetesMetabolism, Diabetes, and Cancer

Cited by 1,177

Energy metabolism in uncoupling protein 3 gene knockout mice

Vidal-Puig, A. J., Grujic, D., Zhang, C.-Y., Hagen, T., Boss, O., Ido, Y., Szczepanik, A., Wade, J., Mootha, V., Cortright, R., et al. (2000) · Journal of Biological Chemistry

Mitochondrial Function and PathologyAdipose Tissue and Metabolism

Cited by 677

Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury

Yurdagul, A., Subramanian, M., Wang, X., Crown, S. B., Ilkayeva, O. R., Darville, L., Kolluru, G. K., Rymond, C. C., Gerlach, B. D., Zheng, Z., et al. (2020) · Cell Metabolism

Phagocytosis and Immune RegulationCell death mechanisms and regulation

Cited by 525

Peroxisome Proliferator-activated Receptor-γ Co-activator 1α-mediated Metabolic Remodeling of Skeletal Myocytes Mimics Exercise Training and Reverses Lipid-induced Mitochondrial Inefficiency

Koves, T. R., Li, P., An, J., Akimoto, T., Slentz, D., Ilkayeva, O., Dohm, G. L., Yan, Z., Newgard, C. B., & Muoio, D. M. (2005) · Journal of Biological Chemistry

Adipose Tissue and MetabolismMetabolism, Diabetes, and Cancer

Cited by 464

Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance

An, J., Muoio, D. M., Shiota, M., Fujimoto, Y., Cline, G. W., Shulman, G. I., Koves, T. R., Stevens, R., Millington, D., & Newgard, C. B. (2004) · Nature Medicine

Lipid metabolism and biosynthesisDiet, Metabolism, and Disease

Cited by 450

Metabolic Inflexibility: When Mitochondrial Indecision Leads to Metabolic Gridlock

Muoio, D. M. (2014) · Cell

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 438

Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans

Hulver, M. W., Berggren, J. R., Carper, M. J., Miyazaki, M., Ntambi, J. M., Hoffman, E. P., Thyfault, J. P., Stevens, R., Dohm, G. L., Houmard, J. A., et al. (2005) · Cell Metabolism

Lipid metabolism and biosynthesisCancer, Lipids, and Metabolism

Cited by 384

Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility

Muoio, D. M., Noland, R. C., Kovalik, J.-P., Seiler, S. E., Davies, M. N., DeBalsi, K. L., Ilkayeva, O. R., Stevens, R. D., Kheterpal, I., Zhang, J., et al. (2012) · Cell Metabolism

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 372

Obesity-related derangements in metabolic regulation

Muoio, D. M., & Newgard, C. B. (2006) · Annual Review of Biochemistry

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 345

Lipid-Induced Mitochondrial Stress and Insulin Action in Muscle

Muoio, D. M., & Neufer, P. D. (2012) · Cell Metabolism

Metabolism, Diabetes, and CancerMitochondrial Function and Pathology

Cited by 343

SIRT4 is a lysine deacylase that controls leucine metabolism and insulin secretion

Anderson, K. A., Huynh, F. K., Fisher-Wellman, K., Stuart, J. D., Peterson, B. S., Douros, J. D., Wagner, G. R., Thompson, J. W., Madsen, A. S., Green, M. F., et al. (2017) · Cell Metabolism

Sirtuins and Resveratrol in MedicineAutophagy in Disease and Therapy

Cited by 326

Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control

Noland, R. C., Koves, T. R., Seiler, S. E., Lum, H., Lust, R. M., Ilkayeva, O., Stevens, R. D., Hegardt, F. G., & Muoio, D. M. (2009) · Journal of Biological Chemistry

Metabolism and Genetic DisordersAdipose Tissue and Metabolism

Cited by 317

Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression

Stoltzman, C. A., Peterson, C. W., Breen, K. T., Muoio, D. M., Billin, A. N., & Ayer, D. E. (2008) · Proceedings of the National Academy of Sciences

Metabolism, Diabetes, and CancerCancer, Hypoxia, and Metabolism

Cited by 283

Peripheral metabolic actions of leptin

Muoio, D. M., & Lynis Dohm, G. (2002) · Best Practice & Research Clinical Endocrinology & Metabolism

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 183

Intramuscular triacylglycerol and insulin resistance: guilty as charged or wrongly accused?

Muoio, D. M. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 137

Insulin-stimulated cardiac glucose oxidation is increased in high-fat diet-induced obese mice lacking malonyl CoA decarboxylase

Ussher, J. R., Koves, T. R., Jaswal, J. S., Zhang, L., Ilkayeva, O., Dyck, J. R. B., Muoio, D. M., & Lopaschuk, G. D. (2009) · Diabetes

Cardiovascular Function and Risk FactorsCancer, Lipids, and Metabolism

Cited by 135

Skeletal muscle adaptation to fatty acid depends on coordinated actions of the PPARs and PGC1α: implications for metabolic disease

Muoio, D. M., & Koves, T. R. (2007) · Applied Physiology, Nutrition, and Metabolism

Peroxisome Proliferator-Activated ReceptorsAdipose Tissue and Metabolism

Cited by 129

Metabolic profiling of PPARα −/− mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation

Makowski, L., Noland, R. C., Koves, T. R., Xing, W., Ilkayeva, O. R., Muehlbauer, M. J., Stevens, R. D., & Muoio, D. M. (2009) · The FASEB Journal

Peroxisome Proliferator-Activated ReceptorsMetabolism and Genetic Disorders

Cited by 113

Carnitine revisited: potential use as adjunctive treatment in diabetes

Power, R. A., Hulver, M. W., Zhang, J. Y., Dubois, J., Marchand, R. M., Ilkayeva, O., Muoio, D. M., & Mynatt, R. L. (2007) · Diabetologia

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 113

The STEDMAN project: biophysical, biochemical and metabolic effects of a behavioral weight loss intervention during weight loss, maintenance, and regain

Lien, L. F., Haqq, A. M., Arlotto, M., Slentz, C. A., Muehlbauer, M. J., McMahon, R. L., Rochon, J., Gallup, D., Bain, J. R., Ilkayeva, O., et al. (2009) · OMICS: A Journal of Integrative Biology

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 97

Contraction of insulin-resistant muscle normalizes insulin action in association with increased mitochondrial activity and fatty acid catabolism

Thyfault, J. P., Cree, M. G., Zheng, D., Zwetsloot, J. J., Tapscott, E. B., Koves, T. R., Ilkayeva, O., Wolfe, R. R., Muoio, D. M., & Dohm, G. L. (2007) · American Journal of Physiology-Cell Physiology

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 87

A high-fat diet elicits differential responses in genes coordinating oxidative metabolism in skeletal muscle of lean and obese individuals

Boyle, K. E., Canham, J. P., Consitt, L. A., Zheng, D., Koves, T. R., Gavin, T. P., Holbert, D., Neufer, P. D., Ilkayeva, O., Muoio, D. M., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism

Peroxisome Proliferator-Activated ReceptorsAdipose Tissue and Metabolism

Cited by 79

The Effect of Sex Steroid Hormones on Substrate Oxidation during Prolonged Submaximal Exercise in Women.

Hackney, A. C., Muoio, D., & Meyer, W. R. (2000) · The Japanese Journal of Physiology

Cardiovascular and exercise physiologyMuscle metabolism and nutrition

Cited by 38