Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury

Fiji: an open-source platform for biological-image analysis

Schindelin, J., Arganda-Carreras, I., Frise, E., Kaynig, V., Longair, M., Pietzsch, T., Preibisch, S., Rueden, C., Saalfeld, S., Schmid, B., et al. (2012) · Nature Methods · doi:10.1038/nmeth.2019 · Cited by 66,890 · see citing works

Macrophages in Tissue Repair, Regeneration, and Fibrosis

Wynn, T. A., & Vannella, K. M. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.015 · Cited by 4,481 · see citing works

Alternative Activation of Macrophages: An Immunologic Functional Perspective

Martinez, F. O., Helming, L., & Gordon, S. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132532 · Cited by 2,745 · see citing works

Conditional gene targeting in macrophages and granulocytes using LysMcre mice

Clausen, B. E., Burkhardt, C., Reith, W., Renkawitz, R., & Förster, I. (1999) · Transgenic Research · doi:10.1023/a:1008942828960 · Cited by 2,143 · see citing works

Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities

Bäck, M., Yurdagul, A., Tabas, I., Öörni, K., & Kovanen, P. T. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0169-2 · Cited by 1,341 · see citing works

Metabolism via Arginase or Nitric Oxide Synthase: Two Competing Arginine Pathways in Macrophages

Rath, M., ller, I. M. ⁄., Kropf, P., Closs, E. I., & Munder, M. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00532 · Cited by 1,271 · see citing works

HuR and mRNA stability

Brennan, C. M., & Steitz*, J. A. (2001) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000854 · Cited by 1,095 · see citing works

Phagocytosis of apoptotic cells in homeostasis

Arandjelovic, S., & Ravichandran, K. S. (2015) · Nature Immunology · doi:10.1038/ni.3253 · Cited by 959 · see citing works

Arginase-1–Expressing Macrophages Suppress Th2 Cytokine–Driven Inflammation and Fibrosis

Pesce, J. T., Ramalingam, T. R., Mentink-Kane, M. M., Wilson, M. S., El Kasmi, K. C., Smith, A. M., Thompson, R. W., Cheever, A. W., Murray, P. J., & Wynn, T. A. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000371 · Cited by 816 · see citing works

Macrophage Dysfunction Impairs Resolution of Inflammation in the Wounds of Diabetic Mice

Khanna, S., Biswas, S., Shang, Y., Collard, E., Azad, A., Kauh, C., Bhasker, V., Gordillo, G. M., Sen, C. K., & Roy, S. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009539 · Cited by 694 · see citing works

CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis

Kojima, Y., Volkmer, J.-P., McKenna, K., Civelek, M., Lusis, A. J., Miller, C. L., Direnzo, D., Nanda, V., Ye, J., Connolly, A. J., et al. (2016) · Nature · doi:10.1038/nature18935 · Cited by 683 · see citing works

Apoptotic Cells Promote Their Own Clearance and Immune Tolerance through Activation of the Nuclear Receptor LXR

A-González, N., Bensinger, S. J., Hong, C., Beceiro, S., Bradley, M. N., Zelcer, N., Deniz, J. M., Ramírez, C. M., Díaz, M., Gallardo, G., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.06.018 · Cited by 679 · see citing works

Exploring RNA transcription and turnover in vivo by using click chemistry

Jao, C. Y., & Salic, A. (2008) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0808480105 · Cited by 673 · see citing works

Monocyte-macrophages and T cells in atherosclerosis

Tabas, I., & Lichtman, A. H. (2017) · Immunity · doi:10.1016/j.immuni.2017.09.008 · Cited by 646 · see citing works

Macrophage subsets in atherosclerosis

Chinetti, G., Colin, S., & Staels, B. (2014) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2014.173 · Cited by 646 · see citing works

RBPmap: a web server for mapping binding sites of RNA-binding proteins

Paz, I., Kosti, I., Ares, M., Cline, M., & Mandel‐Gutfreund, Y. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku406 · Cited by 572 · see citing works

Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators

Dalli, J., & Serhan, C. N. (2012) · Blood · doi:10.1182/blood-2012-04-423525 · Cited by 556 · see citing works

Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair

Zhang, S., Weinberg, S., DeBerge, M., Gainullina, A., Schipma, M., Kinchen, J. M., Ben-Sahra, I., Gius, D. R., Yvan-Charvet, L., Chandel, N. S., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2018.12.004 · Cited by 485 · see citing works

Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages

Kawane, K., Ohtani, M., Miwa, K., Kizawa, T., Kanbara, Y., Yoshioka, Y., Yoshikawa, H., & Nagata, S. (2006) · Nature · doi:10.1038/nature05245 · Cited by 470 · see citing works

Uptake of apoptotic cells drives the growth of a pathogenic trypanosome in macrophages

Freire-de-Lima, C. G., Nascimento, D. O., Soares, M. B. P., Bozza, P. T., Castro-Faria-Neto, H. C., Mello, F. G. D., DosReis, G. A., & Lopes, M. F. (2000) · Nature · doi:10.1038/35003208 · Cited by 455 · see citing works

Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance

An, J., Muoio, D. M., Shiota, M., Fujimoto, Y., Cline, G. W., Shulman, G. I., Koves, T. R., Stevens, R., Millington, D., & Newgard, C. B. (2004) · Nature Medicine · doi:10.1038/nm995 · Cited by 450 · see citing works

Burying the Dead

Vandivier, R. W., Henson, P. M., & Douglas, I. S. (2006) · CHEST Journal · doi:10.1378/chest.129.6.1673 · Cited by 450 · see citing works

Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution

Proto, J. D., Doran, A. C., Gusarova, G., Yurdagul, A., Sozen, E., Subramanian, M., Islam, M. N., Rymond, C. C., Du, J., Hook, J., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.07.015 · Cited by 441 · see citing works

Clearance of apoptotic cells by phagocytes

Erwig, L.-P., & Henson, P. M. (2008) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4402184 · Cited by 422 · see citing works

An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques

Fredman, G., Hellmann, J., Proto, J. D., Kuriakose, G., Colas, R. A., Dorweiler, B., Connolly, E. S., Solomon, R., Jones, D. M., Heyer, E. J., et al. (2016) · Nature Communications · doi:10.1038/ncomms12859 · Cited by 411 · see citing works

Living on the Edge: Efferocytosis at the Interface of Homeostasis and Pathology

Morioka, S., Maueröder, C., & Ravichandran, K. S. (2019) · Immunity · doi:10.1016/j.immuni.2019.04.018 · Cited by 391 · see citing works

Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation

Puleston, D. J., Buck, M. D., Geltink, R. I. K., Kyle, R. L., Caputa, G., O’Sullivan, D., Cameron, A. M., Castoldi, Â., Musa, Y., Kabat, A. M., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.05.003 · Cited by 391 · see citing works

Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release

Morioka, S., Perry, J. S. A., Raymond, M. H., Medina, C. B., Zhu, Y., Zhao, L., Serbulea, V., Önengüt-Gümüşcü, S., Leitinger, N., Kucenas, S., et al. (2018) · Nature · doi:10.1038/s41586-018-0735-5 · Cited by 370 · see citing works

Mitochondrial fission promotes the continued clearance of apoptotic cells by macrophages

Wang, Y., Subramanian, M., Yurdagul, A., Barbosa-Lorenzi, V. C., Cai, B., de Juan-Sanz, J., Ryan, T. A., Nomura, M., Maxfield, F. R., & Tabas, I. (2017) · Cell · doi:10.1016/j.cell.2017.08.041 · Cited by 364 · see citing works

Modulation of Macrophage Efferocytosis in Inflammation

Johnson, D. K., Frasch, S. C., Fernandez-Boyanapalli, R. F., Henson, P. M., & Bratton, D. L. (2011) · Frontiers in Immunology · doi:10.3389/fimmu.2011.00057 · Cited by 346 · see citing works

STAT6/Arg1 promotes microglia/macrophage efferocytosis and inflammation resolution in stroke mice

Cai, W., Dai, X., Chen, J., Zhao, J., Xu, M., Zhang, L., Yang, B., Zhang, W., Rocha, M., Nakao, T., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.131355 · Cited by 317 · see citing works

Arginase-1 and Ym1 are markers for murine, but not human, alternatively activated myeloid cells

Raes, G., Van den Bergh, R., De Baetselier, P., & Ghassabeh, G. H. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.11.6561 · Cited by 302 · see citing works

Mechanisms and Consequences of Defective Efferocytosis in Atherosclerosis

Yurdagul, A., Doran, A. C., Cai, B., Fredman, G., & Tabas, I. A. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2017.00086 · Cited by 300 · see citing works

MerTK receptor cleavage promotes plaque necrosis and defective resolution in atherosclerosis

Cai, B., Thorp, E. B., Doran, A. C., Sansbury, B. E., Daemen, M. J. A. P., Dorweiler, B., Spite, M., Fredman, G., & Tabas, I. (2017) · Journal of Clinical Investigation · doi:10.1172/jci90520 · Cited by 262 · see citing works

Metabolic regulation of macrophage phenotype and function

Saha, S., Shalova, I. N., & Biswas, S. K. (2017) · Immunological Reviews · doi:10.1111/imr.12603 · Cited by 252 · see citing works

Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein

Park, D., Han, C. Z., Elliott, M. R., Kinchen, J. M., Trampont, P. C., Das, S., Collins, S., Lysiak, J. J., Hoehn, K. L., & Ravichandran, K. S. (2011) · Nature · doi:10.1038/nature10340 · Cited by 248 · see citing works

Mechanisms and consequences of efferocytosis in advanced atherosclerosis

Thorp, E., & Tabas, I. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0209115 · Cited by 231 · see citing works

IL-10–producing macrophages preferentially clear early apoptotic cells

Xu, W., Roos, A., Schlagwein, N., Woltman, A. M., Daha, M. R., & van Kooten, C. (2006) · Blood · doi:10.1182/blood-2005-10-4144 · Cited by 225 · see citing works

Macrophage Apoptosis and Efferocytosis in the Pathogenesis of Atherosclerosis

Linton, M. F., Babaev, V. R., Huang, J., Linton, E. F., Tao, H., & Yancey, P. G. (2016) · Circulation Journal · doi:10.1253/circj.cj-16-0924 · Cited by 225 · see citing works

Ornithine decarboxylase regulates M1 macrophage activation and mucosal inflammation via histone modifications

Hardbower, D. M., Asim, M., Luis, P. B., Singh, K., Barry, D. P., Yang, C., Steeves, M. A., Cleveland, J. L., Schneider, C. G., Piazuelo, M. B., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1614958114 · Cited by 219 · see citing works

ABCA1 and ABCG1 Protect Against Oxidative Stress–Induced Macrophage Apoptosis During Efferocytosis

Yvan-Charvet, L., Pagler, T. A., Seimon, T. A., Thorp, E., Welch, C. L., Witztum, J. L., Tabas, I., & Tall, A. R. (2010) · Circulation Research · doi:10.1161/circresaha.110.217281 · Cited by 217 · see citing works

Immunity to Helminths: Resistance, Regulation, and Susceptibility to Gastrointestinal Nematodes

Grencis, R. K. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120218 · Cited by 207 · see citing works

LAAT-1 Is the Lysosomal Lysine/Arginine Transporter That Maintains Amino Acid Homeostasis

Liu, B., Du, H., Rutkowski, R., Gartner, A., & Wang, X. (2012) · Science · doi:10.1126/science.1220281 · Cited by 195 · see citing works

The hypusine-containing translation factor eIF5A

Dever, T. E., Gutierrez, E., & Shin, B. (2014) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2014.939608 · Cited by 178 · see citing works

“Of Mice and Men”: Arginine Metabolism in Macrophages

Thomas, A. C., & Mattila, J. T. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00479 · Cited by 175 · see citing works

MerTK signaling in macrophages promotes the synthesis of inflammation resolution mediators by suppressing CaMKII activity

Cai, B., Kasikara, C., Doran, A. C., Ramakrishnan, R., Birge, R. B., & Tabas, I. (2018) · Science Signaling · doi:10.1126/scisignal.aar3721 · Cited by 175 · see citing works

Boosting Inflammation Resolution in Atherosclerosis

Fredman, G., & Tabas, I. A. (2017) · American Journal Of Pathology · doi:10.1016/j.ajpath.2017.01.018 · Cited by 173 · see citing works

Requirement for Rho GTPases and PI 3-kinases during apoptotic cell phagocytosis by macrophages

Leverrier, Y., & Ridley, A. J. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00047-1 · Cited by 164 · see citing works

Resolution of acute inflammation bridges the gap between innate and adaptive immunity

Newson, J., Stables, M. J., Karra, E., Vargas, F. A., Quezada, S. A., Motwani, M. P., Mack, M., Yona, S., Audzevich, T., & Gilroy, D. W. (2014) · Blood · doi:10.1182/blood-2014-03-562710 · Cited by 159 · see citing works

Identification and Validation of Novel Small Molecule Disruptors of HuR-mRNA Interaction

Wu, X., Lan, L., Wilson, D. M., Marquez, R. T., Tsao, W.-C., Gao, P., Roy, A., Turner, B. A., McDonald, P., Tunge, J. A., et al. (2015) · ACS Chemical Biology · doi:10.1021/cb500851u · Cited by 147 · see citing works

STAT6 induces expression of Gas6 in macrophages to clear apoptotic neutrophils and resolve inflammation

Nepal, S., Tiruppathì, C., Tsukasaki, Y., Farahany, J., Mittal, M., Rehman, J., Prockop, D. J., & Malik, A. B. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1821601116 · Cited by 136 · see citing works

Apoptotic Cells Induce a Phosphatidylserine-Dependent Homeostatic Response from Phagocytes

Kiss, R. S., Elliott, M. R., Ma, Z., Marcel, Y. L., & Ravichandran, K. S. (2006) · Current Biology · doi:10.1016/j.cub.2006.09.043 · Cited by 119 · see citing works

Regression of Atherosclerosis Is Characterized by Broad Changes in the Plaque Macrophage Transcriptome

Feig, J. E., Vengrenyuk, Y., Reiser, V., Wu, C., Statnikov, A., Aliferis, C. F., Garabedian, M. J., Fisher, E. A., & Puig, O. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039790 · Cited by 118 · see citing works

Apoptotic cells trigger a membrane-initiated pathway to increase ABCA1

Fond, A. M., Lee, C. S., Schulman, I. G., Kiss, R. S., & Ravichandran, K. S. (2015) · Journal of Clinical Investigation · doi:10.1172/jci80300 · Cited by 114 · see citing works

ENU mutagenesis identifies mice with mitochondrial branched-chain aminotransferase deficiency resembling human maple syrup urine disease

Wu, J.-Y., Kao, H., Li, S., Stevens, R., Hillman, S. L., Millington, D. S., & Chen, Y.-T. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19574 · Cited by 104 · see citing works

The Protectin PCTR1 Is Produced by Human M2 Macrophages and Enhances Resolution of Infectious Inflammation

Ramon, S., Dalli, J., Sanger, J. M., Winkler, J. W., Aursnes, M., Tungen, J. E., Hansen, T. V., & Serhan, C. N. (2016) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.12.012 · Cited by 101 · see citing works

Ex Vivo and In Vitro Effect of Serum Amyloid A in the Induction of Macrophage M2 Markers and Efferocytosis of Apoptotic Neutrophils

Sun, L., Zhou, H., Zhu, Z., Qian, Y., Wang, L., Liang, Q., & Ye, R. D. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402164 · Cited by 90 · see citing works

The Requirement for Polyamines for Intestinal Epithelial Cell Migration Is Mediated through Rac1

Ray, R. M., McCormack, S. A., Covington, C., Viar, M. J., Zheng, Y., & Johnson, L. R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208741200 · Cited by 86 · see citing works

The Rac-FRET Mouse Reveals Tight Spatiotemporal Control of Rac Activity in Primary Cells and Tissues

Johnsson, A., Dai, Y., Nobis, M., Baker, M. J., McGhee, E. J., Walker, S. A., Schwarz, J. P., Kadir, S. R., Morton, J. P., Myant, K., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.02.024 · Cited by 86 · see citing works

GEFs: Dual regulation of Rac1 signaling

Marei, H., & Malliri, A. (2016) · Small GTPases · doi:10.1080/21541248.2016.1202635 · Cited by 77 · see citing works

Myc‐nick promotes efferocytosis through M2 macrophage polarization during resolution of inflammation

Zhong, X., Lee, H., Kim, S. H., Park, S., Kim, W., Cha, Y., & Surh, Y. (2018) · The FASEB Journal · doi:10.1096/fj.201800223r · Cited by 61 · see citing works

Genomics of Foam Cells and Nonfoamy Macrophages From Rabbits Identifies Arginase-I as a Differential Regulator of Nitric Oxide Production

Thomas, A. C., Sala‐Newby, G. B., Ismail, Y., Johnson, J. L., Pasterkamp, G., & Newby, A. C. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000256470.23842.94 · Cited by 61 · see citing works

Identification of Macrophage Arginase I as a New Candidate Gene of Atherosclerosis Resistance

Teupser, D., Burkhardt, R., Wilfert, W., Haffner, I., Nebendahl, K., & Thiery, J. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000195791.83380.4c · Cited by 61 · see citing works

Correlation of Polyamine and Growth Responses to N 1,N 11-Diethylnorspermine in Primary Fetal Fibroblasts Derived from Transgenic Mice Overexpressing Spermidine/SpermineN 1-Acetyltransferase

Alhonen, L. I., Karppinen, A., Uusi‐Oukari, M., Vujcic, S., Korhonen, V., Halmekytö, M., Kramer, D. L., Hines, R., Jänne, J., & Porter, C. W. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.4.1964 · Cited by 55 · see citing works

LC3-associated phagocytosis in microbial pathogenesis

Schille, S. A., Crauwels, P., Bohn, R., Bagola, K., Walther, P., & van Zandbergen, G. (2017) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2017.10.014 · Cited by 47 · see citing works

Impairment of macrophage function by inhibitors of ornithine decarboxylase activity

KIERSZENBAUM, F., Wirth, J. J., McCann, P. P., & Sjoerdsma, A. (1987) · Infection and Immunity · doi:10.1128/iai.55.10.2461-2464.1987 · Cited by 42 · see citing works

Effects of High Fat Feeding and Diabetes on Regression of Atherosclerosis Induced by Low-Density Lipoprotein Receptor Gene Therapy in LDL Receptor-Deficient Mice

Willecke, F., Yuan, C., Oka, K., Chan, L., Hu, Y., Barnhart, S., Bornfeldt, K., Goldberg, I. J., & Fisher, E. A. A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0128996 · Cited by 40 · see citing works

Hematopoietic arginase 1 deficiency results in decreased leukocytosis and increased foam cell formation but does not affect atherosclerosis

Ren, B., Kampen, E. V., van Berkel, T. J. C., Cruickshank, S. M., & Eck, M. V. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.11.018 · Cited by 25 · see citing works

Activation of Dbl restores migration in polyamine-depleted intestinal epithelial cells via Rho-GTPases

Ray, R. M., Bavaria, M. N., Bhattacharya, S., & Johnson, L. R. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00409.2010 · Cited by 12 · see citing works

A New Mouse Model of Mild Ornithine Transcarbamylase Deficiency (spf-j) Displays Cerebral Amino Acid Perturbations at Baseline and upon Systemic Immune Activation

Tarasenko, T. N., Rosas, O. R., Singh, L. N., Kristaponis, K., Vernon, H. J., & McGuire, P. J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0116594 · Cited by 11 · see citing works

Targeting inflammation in atherosclerosis — from experimental insights to the clinic

Soehnlein, O., & Libby, P. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00198-1 · Cited by 1,042 · see citing works

Amino Assets: How Amino Acids Support Immunity

Kelly, B. L., & Pearce, E. L. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.06.010 · Cited by 653 · see citing works

Macrophage-targeted nanomedicine for the diagnosis and treatment of atherosclerosis

Chen, W., Schilperoort, M., Cao, Y., Shi, J., Tabas, I. A., & Tao, W. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00629-x · Cited by 533 · see citing works

Drugging the efferocytosis process: concepts and opportunities

Mehrotra, P., & Ravichandran, K. S. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00470-y · Cited by 459 · see citing works

Myeloid Cell-Derived Arginase in Cancer Immune Response

Grzywa, T. M., Sosnowska, A., Matryba, P., Rydzyńska, Z., Jasiński, M., Nowis, D., & Gołąb, J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00938 · Cited by 434 · see citing works

Macrophages in intestinal homeostasis and inflammatory bowel disease

Hegarty, L. M., Jones, G., & Bain, C. C. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00769-0 · Cited by 371 · see citing works

Efferocytosis induces macrophage proliferation to help resolve tissue injury

Gerlach, B. D., Ampomah, P. B., Yurdagul, A., Liu, C., Lauring, M. C., Wang, X., Kasikara, C., Kong, N., Shi, J., Tao, W., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.10.015 · Cited by 360 · see citing works

Macrophage polarization and metabolism in atherosclerosis

Hou, P., Fang, J., Liu, Z., Shi, Y., Agostini, M., Bernassola, F., Bove, P., Candi, E., Rovella, V., Sica, G. S., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06206-z · Cited by 360 · see citing works

Metabolic orchestration of the wound healing response

Eming, S. A., Murray, P. J., & Pearce, E. J. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.07.017 · Cited by 319 · see citing works

Macrophage phenotypes and functions: resolving inflammation and restoring homeostasis

Rodríguez-Morales, P., & Franklin, R. A. (2023) · Trends in Immunology · doi:10.1016/j.it.2023.10.004 · Cited by 327 · see citing works

Phagocytosis of Apoptotic Cells in Resolution of Inflammation

Kourtzelis, I., Hajishengallis, G., & Chavakis, T. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00553 · Cited by 301 · see citing works

Foam Cells in Atherosclerosis: Novel Insights Into Its Origins, Consequences, and Molecular Mechanisms

Gui, Y., Zheng, H., & Cao, R. Y. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.845942 · Cited by 258 · see citing works

Intracellular and Intercellular Aspects of Macrophage Immunometabolism in Atherosclerosis

Tabas, I. A., & Bornfeldt, K. (2020) · Circulation Research · doi:10.1161/circresaha.119.315939 · Cited by 249 · see citing works

Macrophage immunometabolism in inflammatory bowel diseases: From pathogenesis to therapy

Pan, X., Zhu, Q., Pan, L., & Sun, J. T. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108176 · Cited by 251 · see citing works

More than just protein building blocks: how amino acids and related metabolic pathways fuel macrophage polarization

Kieler, M., Hofmann, M., & Schabbauer, G. (2021) · FEBS Journal · doi:10.1111/febs.15715 · Cited by 246 · see citing works

IL-33-induced metabolic reprogramming controls the differentiation of alternatively activated macrophages and the resolution of inflammation

Faas, M., Ipseiz, N., Ackermann, J. A., Culemann, S., Grüneboom, A., Schröder, F., Rothe, T., Scholtysek, C., Eberhardt, M., Böttcher, M., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.09.010 · Cited by 208 · see citing works

Programmed death of macrophages in atherosclerosis: mechanisms and therapeutic targets

Meyer, G. R. Y. D., Zurek, M., Puylaert, P., & Martinet, W. (2024) · Nature Reviews Cardiology · doi:10.1038/s41569-023-00957-0 · Cited by 214 · see citing works

Alveolar macrophages in tissue homeostasis, inflammation, and infection: evolving concepts of therapeutic targeting

Malainou, C., Abdin, S. M., Lachmann, N., Matt, U., & Herold, S. (2023) · Journal of Clinical Investigation · doi:10.1172/jci170501 · Cited by 210 · see citing works

Mechanisms of Macrophage Plasticity in the Tumor Environment: Manipulating Activation State to Improve Outcomes

Ricketts, T. D., Prieto‐Domínguez, N., Gowda, P. S., & Ubil, E. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.642285 · Cited by 181 · see citing works

The role of efferocytosis‐fueled macrophage metabolism in the resolution of inflammation

Schilperoort, M., Ngai, D., Sukka, S. R., Avrampou, K., Shi, H., & Tabas, I. A. (2023) · Immunological Reviews · doi:10.1111/imr.13214 · Cited by 181 · see citing works

Macrophages use apoptotic cell-derived methionine and DNMT3A during efferocytosis to promote tissue resolution

Ampomah, P. B., Cai, B., Sukka, S. R., Gerlach, B. D., Yurdagul, A., Wang, X., Kuriakose, G., Darville, L. N. F., Sun, Y., Sidoli, S., et al. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00551-7 · Cited by 176 · see citing works

Inflammation Resolution: Implications for Atherosclerosis

Doran, A. C. (2022) · Circulation Research · doi:10.1161/circresaha.121.319822 · Cited by 177 · see citing works

Efferocytosis in atherosclerosis

Adkar, S. S., & Leeper, N. J. (2024) · Nature Reviews Cardiology · doi:10.1038/s41569-024-01037-7 · Cited by 166 · see citing works

Lactate and IL6 define separable paths of inflammatory metabolic adaptation

Dichtl, S., Lindenthal, L., Zeitler, L., Behnke, K., Schlösser, D., Strobl, B., Scheller, J., Kasmi, K. C. E., & Murray, P. J. (2021) · Science Advances · doi:10.1126/sciadv.abg3505 · Cited by 163 · see citing works

Analysis of the immune response to sciatic nerve injury identifies efferocytosis as a key mechanism of nerve debridement

Kalinski, A. L., Yoon, C., Huffman, L. D., Duncker, P. C., Kohen, R., Passino, R., Hafner, H., Johnson, C. N., Kawaguchi, R., Carbajal, K. S., et al. (2020) · eLife · doi:10.7554/elife.60223 · Cited by 160 · see citing works

Specialized pro-resolving mediators in vascular inflammation and atherosclerotic cardiovascular disease

Fredman, G., & Serhan, C. N. (2024) · Nature Reviews Cardiology · doi:10.1038/s41569-023-00984-x · Cited by 160 · see citing works

PFKFB2-mediated glycolysis promotes lactate-driven continual efferocytosis by macrophages

Schilperoort, M., Ngai, D., Katerelos, M., Power, D., & Tabas, I. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00736-8 · Cited by 145 · see citing works

HDL Function and Atherosclerosis: Reactive Dicarbonyls as Promising Targets of Therapy

Linton, M. F., Yancey, P. G., Tao, H., & Davies, S. S. (2023) · Circulation Research · doi:10.1161/circresaha.123.321563 · Cited by 155 · see citing works

Extracellular vesicles arising from apoptosis: forms, functions, and applications

Gregory, C. D., & Rimmer, M. P. (2023) · The Journal of Pathology · doi:10.1002/path.6138 · Cited by 140 · see citing works

Crosstalk Between Macrophages and Vascular Smooth Muscle Cells in Atherosclerotic Plaque Stability

Yurdagul, A. (2022) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.121.316233 · Cited by 137 · see citing works

Control of tumor-associated macrophage responses by nutrient acquisition and metabolism

Zhang, X., Ji, L., & Li, M. O. (2023) · Immunity · doi:10.1016/j.immuni.2022.12.003 · Cited by 134 · see citing works

Stiffness sensing via Piezo1 enhances macrophage efferocytosis and promotes the resolution of liver fibrosis

Wang, Y., Wang, J., Zhang, J., Wang, Y., Wang, Y., Kang, H., Zhao, W., Bai, W., Miao, N., & Wang, J. (2024) · Science Advances · doi:10.1126/sciadv.adj3289 · Cited by 131 · see citing works

Myeloid Cell PKM2 Deletion Enhances Efferocytosis and Reduces Atherosclerosis

Doddapattar, P., Dev, R., Ghatge, M., Patel, R. B., Jain, M. K., Dhanesha, N., Lentz, S. R., & Chauhan, A. K. (2022) · Circulation Research · doi:10.1161/circresaha.121.320704 · Cited by 126 · see citing works

TREM2 protects from atherosclerosis by limiting necrotic core formation

Piollet, M., Porsch, F., Rizzo, G., Kapser, F., Schulz, D., Kiss, M. G., Schlepckow, K., Morenas‐Rodríguez, E., Sen, M. O., Gropper, J., et al. (2024) · Nature Cardiovascular Research · doi:10.1038/s44161-024-00429-9 · Cited by 130 · see citing works

Microglial metabolic flexibility: emerging roles for lactate

Monsorno, K., Buckinx, A., & Paolicelli, R. C. (2022) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2021.12.001 · Cited by 112 · see citing works

Putting the brakes on phagocytosis: “don't-eat-me” signaling in physiology and disease

Kelley, S. M., & Ravichandran, K. S. (2021) · EMBO Reports · doi:10.15252/embr.202152564 · Cited by 110 · see citing works

Senescent cells suppress macrophage-mediated corpse removal via upregulation of the CD47-QPCT/L axis

Schloesser, D., Lindenthal, L., Sauer, J., Chung, K., Chavakis, T., Griesser, E., Baskaran, P., Maier-Habelsberger, U., Fundel‐Clemens, K., Schlotthauer, I., et al. (2022) · The Journal of Cell Biology · doi:10.1083/jcb.202207097 · Cited by 113 · see citing works

Trained immunity of alveolar macrophages enhances injury resolution via KLF4-MERTK-mediated efferocytosis

Chakraborty, S., Singh, A., Wang, L. X., Wang, X., Sanborn, M. A., Ye, Z., Maienschein‐Cline, M., Mukhopadhyay, A., Ganesh, B. B., Malik, A. B., et al. (2023) · The Journal of Experimental Medicine · doi:10.1084/jem.20221388 · Cited by 111 · see citing works

Efferocytosis reprograms the tumor microenvironment to promote pancreatic cancer liver metastasis

Astuti, Y., Raymant, M., Quaranta, V., Clarke, K., Abudula, M., Smith, O., Bellomo, G., Chandran-Gorner, V., Nourse, C., Halloran, C. M., et al. (2024) · Nature Cancer · doi:10.1038/s43018-024-00731-2 · Cited by 110 · see citing works

Metabolic adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments

Wang, Y., Trzeciak, A. J., Rojas, W. S., Saavedra, P. H. V., Chen, Y., Chirayil, R., Etchegaray, J. I., Lucas, C. D., Puleston, D. J., Keshari, K. R., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.12.005 · Cited by 107 · see citing works

First we eat, then we do everything else: The dynamic metabolic regulation of efferocytosis

Trzeciak, A. J., Wang, Y., & Perry, J. S. A. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.08.001 · Cited by 107 · see citing works

Non-canonical glutamine transamination sustains efferocytosis by coupling redox buffering to oxidative phosphorylation

Merlin, J., Ivanov, S., Dumont, A., Sergushichev, A., Gall, J., Stunault, M. I., Ayrault, M., Vaillant, N., Castiglione, A., Swain, A., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00471-y · Cited by 101 · see citing works

L-arginine metabolism inhibits arthritis and inflammatory bone loss

Cao, S., Li, Y., Song, R., Meng, X., Fuchs, M., Liang, C., Kachler, K., Meng, X., Wen, J., Schlötzer-Schrehardt, U. M., et al. (2023) · Annals of the Rheumatic Diseases · doi:10.1136/ard-2022-223626 · Cited by 100 · see citing works

Arginine: at the crossroads of nitrogen metabolism

Fung, T. S., Ryu, K. W., & Thompson, C. B. (2025) · The EMBO Journal · doi:10.1038/s44318-025-00379-3 · Cited by 109 · see citing works

Through the layers: how macrophages drive atherosclerosis across the vessel wall

Susser, L. I., & Rayner, K. J. (2022) · Journal of Clinical Investigation · doi:10.1172/jci157011 · Cited by 99 · see citing works

Efferocytosis-induced lactate enables the proliferation of pro-resolving macrophages to mediate tissue repair

Ngai, D., Schilperoort, M., & Tabas, I. A. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00921-9 · Cited by 99 · see citing works

The landscape of metabolic brain alterations in Alzheimer's disease

Batra, R., Arnold, M., Wörheide, M. A., Allen, M., Wang, X., Blach, C., Levey, A. I., Seyfried, N. T., Ertekin‐Taner, N., Bennett, D. A., et al. (2022) · Alzheimer s & Dementia · doi:10.1002/alz.12714 · Cited by 88 · see citing works

Targeting Efferocytosis in Inflammaging

Poon, I. K. H., & Ravichandran, K. S. (2023) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-032723-110507 · Cited by 92 · see citing works

Atherosclerosis Linked to Aberrant Amino Acid Metabolism and Immunosuppressive Amino Acid Catabolizing Enzymes

Zarić, B. L., Radovanović, J., Gluvic, Z. M., Stewart, A. J., Essack, M., Motwalli, O., Gojobori, T., & Isenović, E. R. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.551758 · Cited by 92 · see citing works

Cellular Responses to the Efferocytosis of Apoptotic Cells

Yin, C., & Heit, B. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.631714 · Cited by 92 · see citing works

De novo synthesis and salvage pathway coordinately regulate polyamine homeostasis and determine T cell proliferation and function

Wu, R., Chen, X., Kang, S., Wang, T., Gnanaprakasam, J. R., Yao, Y., Liu, L., Zheng, S. G., Fan, G., Burns, M. R., et al. (2020) · Science Advances · doi:10.1126/sciadv.abc4275 · Cited by 87 · see citing works

Down-regulated GAS6 impairs synovial macrophage efferocytosis and promotes obesity-associated osteoarthritis

Yao, Z., Qi, W., Zhang, H., Zhang, Z., Liu, L., Shao, Y., Zeng, H., Yin, J., Pan, H., Guo, X., et al. (2023) · eLife · doi:10.7554/elife.83069 · Cited by 88 · see citing works

Anti-Inflammatory Neutrophil Functions in the Resolution of Inflammation and Tissue Repair

Loh, W., & Vermeren, S. (2022) · Cells · doi:10.3390/cells11244076 · Cited by 87 · see citing works

Polyamine import and accumulation causes immunomodulation in macrophages engulfing apoptotic cells

McCubbrey, A. L., McManus, S. A., McClendon, J. D., Thomas, S. M., Chatwin, H. B., Reisz, J. A., D’Alessandro, A., Mould, K. J., Bratton, D. L., Henson, P. M., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2021.110222 · Cited by 81 · see citing works

Resolvin D1 Enhances Necroptotic Cell Clearance Through Promoting Macrophage Fatty Acid Oxidation and Oxidative Phosphorylation

Hosseini, Z., Marinello, M., Decker, C., Sansbury, B. E., Sadhu, S., Gerlach, B. D., Ramos, R. B., Adam, A. P., Spite, M. R., & Fredman, G. (2021) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.315758 · Cited by 79 · see citing works

Chronic exposure to carbon black ultrafine particles reprograms macrophage metabolism and accelerates lung cancer

Chang, C.-Y., You, R., Armstrong, D., Bandi, A., Cheng, Y.-T., Burkhardt, P. M., Becerra-Dominguez, L., Madison, M. C., Tung, H.-Y., Zeng, Z., et al. (2022) · Science Advances · doi:10.1126/sciadv.abq0615 · Cited by 79 · see citing works

After cell death: the molecular machinery of efferocytosis

Moon, B., Yang, S., Moon, H., Lee, J., & Park, D. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-01070-5 · Cited by 78 · see citing works

Macrophage and Neutrophil Dysfunction in Diabetic Wounds

Clayton, S. M., Shafikhani, S. H., & Soulika, A. M. (2024) · Advances in Wound Care · doi:10.1089/wound.2023.0149 · Cited by 83 · see citing works

Efferocytosis drives a tryptophan metabolism pathway in macrophages to promote tissue resolution

Sukka, S. R., Ampomah, P. B., Darville, L. N. F., Ngai, D., Wang, X., Kuriakose, G., Xiao, Y., Shi, J., Koomen, J. M., McCusker, R. H., et al. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01115-7 · Cited by 82 · see citing works

Live cell tracking of macrophage efferocytosis during Drosophila embryo development in vivo

Raymond, M. H., Davidson, A. J., Shen, Y., Tudor, D. R., Lucas, C. D., Morioka, S., Perry, J. S. A., Krapivkina, J., Perrais, D., Schumacher, L. J., et al. (2022) · Science · doi:10.1126/science.abl4430 · Cited by 77 · see citing works

Organoids transplantation attenuates intestinal ischemia/reperfusion injury in mice through L-Malic acid-mediated M2 macrophage polarization

Zhang, F.-L., Hu, Z., Wang, Y., Zhang, W., Zhou, B., Sun, Q., Lin, Z., & Liu, K. (2023) · Nature Communications · doi:10.1038/s41467-023-42502-0 · Cited by 75 · see citing works

Activating Macrophage Continual Efferocytosis via Microenvironment Biomimetic Short Fibers for Reversing Inflammation in Bone Repair

Wang, H., Zhang, Y., Zhang, Y., Li, C., Zhang, M., Wang, J., Zhang, Y., Du, Y., Cui, W., & Chen, W. (2024) · Advanced Materials · doi:10.1002/adma.202402968 · Cited by 76 · see citing works

Macrophage Responses to Environmental Stimuli During Homeostasis and Disease

Rasheed, A., & Rayner, K. J. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab004 · Cited by 79 · see citing works

Polyamine Immunometabolism: Central Regulators of Inflammation, Cancer and Autoimmunity

Chia, T.-Y., Zolp, A. J., & Miska, J. M. (2022) · Cells · doi:10.3390/cells11050896 · Cited by 75 · see citing works

Macrophages recycle phagocytosed bacteria to fuel immunometabolic responses

Lesbats, J., Brillac, A., Reisz, J. A., Mukherjee, P., Lhuissier, C., Fernández-Monreal, M., Dupuy, J.-W., Sequeira, A., Tioli, G., De La Calle Arregui, C., et al. (2025) · Nature · doi:10.1038/s41586-025-08629-4 · Cited by 74 · see citing works

Mitochondrial Fragmentation Promotes Inflammation Resolution Responses in Macrophages via Histone Lactylation

Susser, L. I., Nguyen, M.-A., Geoffrion, M., Emerton, C., Ouimet, M. I., Khacho, M., & Rayner, K. J. (2023) · Molecular and Cellular Biology · doi:10.1080/10985549.2023.2253131 · Cited by 72 · see citing works

RBP–RNA interactions in the control of autoimmunity and autoinflammation

Liu, J., & Cao, X. (2023) · Cell Research · doi:10.1038/s41422-022-00752-5 · Cited by 73 · see citing works

Research progress on macrophage polarization during osteoarthritis disease progression: a review

Yin, X., Wang, Q., Tang, Y., Wang, T., Zhang, Y., & Yu, T. (2024) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-024-05052-9 · Cited by 71 · see citing works

Dysregulated cellular metabolism in atherosclerosis: mediators and therapeutic opportunities

Stroope, C., Nettersheim, F. S., Coon, B. G., Finney, A. C., Schwartz, M. A., Ley, K. F., Rom, O., & Yurdagul, A. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01015-w · Cited by 72 · see citing works

Macrophages and T cells in metabolic disorder-associated cancers

Taranto, D., Kloosterman, D., & Akkari, L. (2024) · Nature Reviews. Cancer · doi:10.1038/s41568-024-00743-1 · Cited by 67 · see citing works

Loss of myeloid cell-specific SIRPα, but not CD47, attenuates inflammation and suppresses atherosclerosis

Singla, B., Lin, H., Ahn, W., Xu, J., Ma, Q., Sghayyer, M., Dong, K., Cherian‐Shaw, M., Zhou, J., Huo, Y., et al. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab369 · Cited by 70 · see citing works

Specialized Pro-Resolving Mediators Mitigate Cancer-Related Inflammation: Role of Tumor-Associated Macrophages and Therapeutic Opportunities

Lavy, M., Gauttier, V., Poirier, N., Barillé‐Nion, S., & Blanquart, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.702785 · Cited by 65 · see citing works

Efferocytosis of SARS-CoV-2-infected dying cells impairs macrophage anti-inflammatory functions and clearance of apoptotic cells

Salina, A. C. G., dos-Santos, D., Rodrigues, T. S., Fortes-Rocha, M., Filho, E. G. F., Alzamora-Terrel, D. L., de Castro, Í. M. S., Fraga‐Silva, T. F. D. C., de Lima, M. H., Nascimento, D. C., et al. (2022) · eLife · doi:10.7554/elife.74443 · Cited by 67 · see citing works

Magnetic Resonance Imaging Nanoprobe Quantifies Nitric Oxide for Evaluating M1/M2 Macrophage Polarization and Prognosis of Cancer Treatments

Liu, X., Wang, M., Jiang, Y., Zhang, X., Shi, C., Zeng, F., Qin, Y., Ye, J., Hu, J., & Zhou, Z. (2023) · ACS Nano · doi:10.1021/acsnano.3c05627 · Cited by 64 · see citing works

Potential Mechanisms and Effects of Efferocytosis in Atherosclerosis

Wang, L., Li, H., Tang, Y., & Yao, P. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.585285 · Cited by 62 · see citing works

Sigma-1 receptor-regulated efferocytosis by infiltrating circulating macrophages/microglial cells protects against neuronal impairments and promotes functional recovery in cerebral ischemic stroke

Zhang, G., Li, Q., Tao, W., Qin, P., Chen, J., Yang, H., Chen, J., Liu, H., Dai, Q., & Zhen, X. (2023) · Theranostics · doi:10.7150/thno.77088 · Cited by 62 · see citing works

Cardiac macrophages and emerging roles for their metabolism after myocardial infarction

Thorp, E. B. (2023) · Journal of Clinical Investigation · doi:10.1172/jci171953 · Cited by 64 · see citing works

Macrophage angiotensin-converting enzyme reduces atherosclerosis by increasing peroxisome proliferator-activated receptor α and fundamentally changing lipid metabolism

Cao, D., Khan, Z., Li, X., Saito, S., Bernstein, E. A., Victor, A. R., Ahmed, F., Hoshi, A., Veiras, L. C., Shibata, T., et al. (2023) · Cardiovascular Research · doi:10.1093/cvr/cvad082 · Cited by 60 · see citing works

SIRT3 Regulates Clearance of Apoptotic Cardiomyocytes by Deacetylating Frataxin

Gao, J., Huang, C., Kong, L., Zhou, W., Sun, M., Wei, T., & Shen, W. (2023) · Circulation Research · doi:10.1161/circresaha.123.323160 · Cited by 60 · see citing works

Targeted macrophage phagocytosis by Irg1/itaconate axis improves the prognosis of intracerebral hemorrhagic stroke and peritonitis

Luo, Z., Sheng, Z., Hu, L., Shi, L., Tian, Y., Zhao, X., Yang, W., Xiao, Z., Shen, D., Wu, W., et al. (2024) · EBioMedicine · doi:10.1016/j.ebiom.2024.104993 · Cited by 60 · see citing works

Mitochondria orchestrate macrophage effector functions in atherosclerosis

Dumont, A., Lee, M., Barouillet, T., Murphy, A. J., & Yvan‐Charvet, L. (2020) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2020.100922 · Cited by 59 · see citing works

Wnt signaling enhances macrophage responses to IL-4 and promotes resolution of atherosclerosis

Weinstock, A., Rahman, K., Yaacov, O., Nishi, H., Menon, P., Nikain, C. A., Garabedian, M. L., Pena, S., Akbar, N., Sansbury, B. E., et al. (2021) · eLife · doi:10.7554/elife.67932 · Cited by 57 · see citing works

Efferocytosis in the Central Nervous System

Zhao, J., Zhang, W., Wu, T., Wang, H., Mao, J., Liu, J., Zhou, Z., Lin, X., Yan, H., & Wang, Q. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.773344 · Cited by 56 · see citing works

JAML promotes acute kidney injury mainly through a macrophage-dependent mechanism

Huang, W. C., Wang, B.-O., Hou, Y., Fu, Y., Cui, S., Zhu, J., Zhan, X.-Y., Li, R., Tang, W., Wu, J., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.158571 · Cited by 55 · see citing works

Multiomic analyses uncover immunological signatures in acute and chronic coronary syndromes

Pekayvaz, K., Losert, C., Knottenberg, V., Gold, C., van Blokland, I. V., Oelen, R., Groot, H. E., Benjamins, J. W., Brambs, S., Kaiser, R. W. J., et al. (2024) · Nature Medicine · doi:10.1038/s41591-024-02953-4 · Cited by 59 · see citing works

Comparative Review of Microglia and Monocytes in CNS Phagocytosis

Andoh, M., & Koyama, R. (2021) · Cells · doi:10.3390/cells10102555 · Cited by 52 · see citing works

Resolution therapy: Harnessing efferocytic macrophages to trigger the resolution of inflammation

Saas, P., Vetter, M., Maraux, M., Bonnefoy, F., & Perruche, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1021413 · Cited by 52 · see citing works

Spatially Resolved Metabolites in Stable and Unstable Human Atherosclerotic Plaques Identified by Mass Spectrometry Imaging

Seeley, E. H., Liu, Z., Yuan, S. S., Stroope, C., Cockerham, E. D., Rashdan, N. A., Delgadillo, L. F., Finney, A. C., Kumar, D., Das, S. R., et al. (2023) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.122.318684 · Cited by 51 · see citing works

ODC (Ornithine Decarboxylase)-Dependent Putrescine Synthesis Maintains MerTK (MER Tyrosine-Protein Kinase) Expression to Drive Resolution

Yurdagul, A., Kong, N., Gerlach, B. D., Wang, X., Ampomah, P. B., Kuriakose, G., Tao, W., Shi, J., & Tabas, I. A. (2021) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.315622 · Cited by 51 · see citing works

Deficiency of macrophage PHACTR1 impairs efferocytosis and promotes atherosclerotic plaque necrosis

Kasikara, C., Schilperoort, M., Gerlach, B. D., Xue, C., Wang, X., Zheng, Z., Kuriakose, G., Dorweiler, B., Zhang, H., Fredman, G., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci145275 · Cited by 51 · see citing works

Induction of osteoblast apoptosis stimulates macrophage efferocytosis and paradoxical bone formation

Batoon, L., Koh, A. J., Millard, S. M., Grewal, J., Choo, F. M., Kannan, R., Kinnaird, A., Avey, M., Teslya, T., Pettit, A. R., et al. (2024) · Bone Research · doi:10.1038/s41413-024-00341-9 · Cited by 51 · see citing works

LC3-associated phagocytosis (LAP): a potentially influential mediator of efferocytosis-related tumor progression and aggressiveness

Asare, P. F., Roscioli, E., Hurtado, P. R., Tran, H. B., Mah, C. Y., & Hodge, S. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01298 · Cited by 50 · see citing works

Suppression of IL-1β promotes beneficial accumulation of fibroblast-like cells in atherosclerotic plaques in clonal hematopoiesis

Fidler, T. P., Dunbar, A. J., Kim, E., Hardaway, B., Pauli, J., Xue, C., Abramowicz, S., Xiao, T., O’Connor, K., Sachs, N., et al. (2024) · Nature Cardiovascular Research · doi:10.1038/s44161-023-00405-9 · Cited by 49 · see citing works

Lysosomes in the immunometabolic reprogramming of immune cells in atherosclerosis

Bonacina, F., Zhang, X., Manel, N., Yvan‐Charvet, L., Razani, B., & Norata, G. D. (2024) · Nature Reviews Cardiology · doi:10.1038/s41569-024-01072-4 · Cited by 50 · see citing works

Macrophage ALDH2 (Aldehyde Dehydrogenase 2) Stabilizing Rac2 Is Required for Efferocytosis Internalization and Reduction of Atherosclerosis Development

Zhang, J., Zhao, X., Guo, Y., Liu, Z., Wei, S., Yuan, Q., Shang, H., Sang, W., Cui, S., Xu, T., et al. (2022) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.121.317204 · Cited by 49 · see citing works

Efferocytes release extracellular vesicles to resolve inflammation and tissue injury via prosaposin-GPR37 signaling

Bhattacharya, P., Dhawan, U. K., Hussain, M. T., Singh, P., Bhagat, K. K., Singhal, A., Austin‐Williams, S., Sengupta, S., & Subramanian, M. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112808 · Cited by 46 · see citing works

Amino Acid Metabolism and Atherosclerotic Cardiovascular Disease

Anand, S. K., Governale, T.-A., Zhang, X., Razani, B., Yurdagul, A., Pattillo, C. B., & Rom, O. (2024) · American Journal Of Pathology · doi:10.1016/j.ajpath.2023.12.006 · Cited by 46 · see citing works

Macrophage Efferocytosis in Cardiac Pathophysiology and Repair

Li, Y., Li, Q., & Fan, G. (2020) · Shock · doi:10.1097/shk.0000000000001625 · Cited by 46 · see citing works

Phagocytosis converts infiltrated monocytes to microglia-like phenotype in experimental brain ischemia

Ju, H., Park, K. W., Kim, I., Cave, J. W., & Cho, S. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02552-5 · Cited by 45 · see citing works

Efferocytosis by macrophages in physiological and pathological conditions: regulatory pathways and molecular mechanisms

Sheng, Y.-R., Hu, W.-T., Chen, S.-M., & Zhu, X.-Y. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1275203 · Cited by 41 · see citing works

Boosting arginine metabolism to regress atherosclerosis?

Giannarelli, C. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.abb0793 · Cited by 1 · see citing works

Appetite for Arginine: Metabolic Control of Macrophage Hunger

Puleston, D. J., & Pearce, E. L. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.02.005 · Cited by 7 · see citing works

Efferocyte‐Derived MCTRs Metabolically Prime Macrophages for Continual Efferocytosis via Rac1‐Mediated Activation of Glycolysis

Koenis, D. S., Matteis, R. D., Rajeeve, V., Cutillas, P. R., & Dalli, J. (2023) · Advanced Science · doi:10.1002/advs.202304690 · Cited by 21 · see citing works

The role of efferocytosis‐fueled macrophage metabolism in the resolution of inflammation

Schilperoort, M., Ngai, D., Sukka, S. R., Avrampou, K., Shi, H., & Tabas, I. A. (2023) · Immunological Reviews · doi:10.1111/imr.13214 · Cited by 181 · see citing works

Abstract 2068: Novel Mechanisms Underlying The Role Of Ornithine Decarboxylase In Inflammation Resolution And Atherosclerosis Regression

Kumar, D., Pandit, R., & Yurdagul, A. (2024) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvb.44.suppl_1.2068