Scherer, Philipp E.

Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity

Unger, R. H., & Scherer, P. E. (2010) · Trends in Endocrinology & Metabolism

Adipokines, Inflammation, and Metabolic DiseasesRegulation of Appetite and Obesity

Cited by 436

Direct Insulin and Leptin Action on Pro-opiomelanocortin Neurons Is Required for Normal Glucose Homeostasis and Fertility

Hill, J. W., Elias, C. F., Fukuda, M., Williams, K. W., Berglund, E. D., Holland, W. L., Cho, Y.-R., Chuang, J.-C., Xu, Y., Choi, M., et al. (2010) · Cell Metabolism

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

Cited by 391

JNK1 but not JNK2 promotes the development of steatohepatitis in mice

Schattenberg, J. M., Singh, R., Wang, Y., Lefkowitch, J. H., Rigoli, R. M., Scherer, P. E., & Czaja, M. J. (2006) · Hepatology

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 384

Endotrophin triggers adipose tissue fibrosis and metabolic dysfunction

Sun, K., Park, J., Gupta, O. T., Holland, W. L., Auerbach, P., Zhang, N., Goncalves Marangoni, R., Nicoloro, S. M., Czech, M. P., Varga, J., et al. (2014) · Nature Communications

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 364

Adipocyte-derived endotrophin promotes malignant tumor progression

Park, J., & Scherer, P. E. (2012) · Journal of Clinical Investigation

Immune cells in cancerTGF-β signaling in diseases

Cited by 350

Myofibroblasts in murine cutaneous fibrosis originate from adiponectin-positive intradermal progenitors

Marangoni, R. G., Korman, B. D., Wei, J., Wood, T. A., Graham, L. V., Whitfield, M. L., Scherer, P. E., Tourtellotte, W. G., & Varga, J. (2015) · Arthritis & Rheumatology

Systemic Sclerosis and Related DiseasesDupuytren's Contracture and Treatments

Cited by 337

Fat apoptosis through targeted activation of caspase 8: a new mouse model of inducible and reversible lipoatrophy

Pajvani, U. B., Trujillo, M. E., Combs, T. P., Iyengar, P., Jelicks, L., Roth, K. A., Kitsis, R. N., & Scherer, P. E. (2005) · Nature Medicine

Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

Cited by 322

Diabetes and apoptosis: lipotoxicity

Kusminski, C. M., Shetty, S., Orci, L., Unger, R. H., & Scherer, P. E. (2009) · Apoptosis

Diabetes, Cardiovascular Risks, and LipoproteinsLipid metabolism and biosynthesis

Cited by 302

Obese adipocytes show ultrastructural features of stressed cells and die of pyroptosis

Giordano, A., Murano, I., Mondini, E., Perugini, J., Smorlesi, A., Severi, I., Barazzoni, R., Scherer, P. E., & Cinti, S. (2013) · Journal of Lipid Research

Adipokines, Inflammation, and Metabolic DiseasesInflammasome and immune disorders

Cited by 297

Hepatocyte Toll-like receptor 4 regulates obesity-induced inflammation and insulin resistance

Jia, L., Vianna, C. R., Fukuda, M., Berglund, E. D., Liu, C., Tao, C., Sun, K., Liu, T., Harper, M. J., Lee, C. E., et al. (2014) · Nature Communications

Adipokines, Inflammation, and Metabolic DiseasesImmune Response and Inflammation

Cited by 294

Specific hepatic sphingolipids relate to insulin resistance, oxidative stress, and inflammation in nonalcoholic steatohepatitis

Apostolopoulou, M., Gordillo, R., Koliaki, C., Gancheva, S., Jelenik, T., De Filippo, E., Herder, C., Markgraf, D., Jankowiak, F., Esposito, I., et al. (2018) · Diabetes Care

Liver Disease Diagnosis and TreatmentSphingolipid Metabolism and Signaling

Cited by 284

Adiponectin, driver or passenger on the road to insulin sensitivity?

Ye, R., & Scherer, P. E. (2013) · Molecular Metabolism

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 251

Adiponectin, Cardiovascular Function, and Hypertension

Wang, Z. V., & Scherer, P. E. (2008) · Hypertension

Adipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and Adiposity

Cited by 247

Obesity, Diabetes, and Cardiovascular Diseases: A Compendium

Scherer, P. E., & Hill, J. A. (2016) · Circulation Research

Diabetes, Cardiovascular Risks, and LipoproteinsCardiovascular Function and Risk Factors

Cited by 237

Selective Inhibition of Hypoxia-Inducible Factor 1α Ameliorates Adipose Tissue Dysfunction

Sun, K., Halberg, N., Khan, M., Magalang, U. J., & Scherer, P. E. (2013) · Molecular and Cellular Biology

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 231

Immunologic and endocrine functions of adipose tissue: implications for kidney disease

Zhu, Q., & Scherer, P. E. (2018) · Nature Reviews Nephrology

Adipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and Adiposity

Cited by 200

Chronic intermittent hypoxia induces atherosclerosis via activation of adipose angiopoietin-like 4

Drager, L. F., Yao, Q., Hernandez, K. L., Shin, M.-K., Bevans-Fonti, S., Gay, J., Sussan, T. E., Jun, J. C., Myers, A. C., Olivecrona, G., et al. (2013) · American Journal of Respiratory and Critical Care Medicine

Obstructive Sleep Apnea ResearchLipid metabolism and disorders

Cited by 175

Progressive loss of β-cell function leads to worsening glucose tolerance in first-degree relatives of subjects with type 2 diabetes

Cnop, M., Vidal, J., Hull, R. L., Utzschneider, K. M., Carr, D. B., Schraw, T., Scherer, P. E., Boyko, E. J., Fujimoto, W. Y., & Kahn, S. E. (2007) · Diabetes Care

Pancreatic function and diabetesDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 174

The transcriptional response of the islet to pregnancy in mice

Rieck, S., White, P., Schug, J., Fox, A. J., Smirnova, O., Gao, N., Gupta, R. K., Wang, Z. V., Scherer, P. E., Keller, M. P., et al. (2009) · Molecular Endocrinology

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 160

Enhanced metabolic flexibility associated with elevated adiponectin levels

Asterholm, I. W., & Scherer, P. E. (2010) · The American Journal of Pathology

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 157

Brain Adipocytokine Action and Metabolic Regulation

Ahima, R. S., Qi, Y., Singhal, N. S., Jackson, M. B., & Scherer, P. E. (2006) · Diabetes

Adipokines, Inflammation, and Metabolic DiseasesRegulation of Appetite and Obesity

Cited by 150

Proangiogenic Contribution of Adiponectin toward Mammary Tumor Growth In vivo

Landskroner-Eiger, S., Qian, B., Muise, E. S., Nawrocki, A. R., Berger, J. P., Fine, E. J., Koba, W., Deng, Y., Pollard, J. W., & Scherer, P. E. (2009) · Clinical Cancer Research

Angiogenesis and VEGF in CancerAdipokines, Inflammation, and Metabolic Diseases

Cited by 145

The Multifaceted Roles of Adipose Tissue—Therapeutic Targets for Diabetes and Beyond: The 2015 Banting Lecture

Scherer, P. E. (2016) · Diabetes

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 133

Transforming obesity: The advancement of multi-receptor drugs

Kusminski, C. M., Perez-Tilve, D., Müller, T. D., DiMarchi, R. D., Tschöp, M. H., & Scherer, P. E. (2024) · Cell

Pharmacology and Obesity TreatmentDiabetes Treatment and Management

Cited by 126