Selective Inhibition of Hypoxia-Inducible Factor 1α Ameliorates Adipose Tissue Dysfunction
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Hypoxia-inducible factor 1α (HIF1α) induction in adipocytes is a critical component of the "fibrotic response," directly linked to metabolic dysfunction in adipose tissues under hypoxic conditions. We reasoned that inhibition of HIF1α may ameliorate the negative aspects of the obesity-associated fat pad expansion. We used the selective HIF1α inhibitor PX-478, whose effectiveness has previously been established in tumor models. We demonstrate that PX-478 treatment effectively suppresses the high-fat-diet (HFD)-induced HIF1α activation in adipose tissue. HIF1α inhibition causes a reduction of weight gain in mice on an HFD but not on a chow diet. Treatment increases energy expenditure and prompts resistance to HFD-mediated deterioration of metabolic parameters. Moreover, PX-478-treated mice have reduced fibrosis and fewer inflammatory infiltrates in their adipose tissues. We confirm the metabolic effects obtained with PX-478 treatment using an adipose tissue-specific, doxycycline-inducible dominant negative HIF1α mutant (dn-HIF1α). Consistent with the pharmacological results, genetic inhibition of endogenous HIF1α activity prompts similar metabolic improvements in HFD-fed mice. Collectively, our results demonstrate that HIF1α inhibition in the adipocyte leads to significant metabolic improvements, suggesting that selective HIF1α inhibition in adipose tissue may be an effective therapeutic avenue in the context of metabolic dysfunction.
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Overexpression of dominant-negative HIF-1α or pharmacologic inhibition of HIF-1α significantly reduced adipose tissue fibrosis and improved adipose tissue function in mice fed a high-fat diet.
“Conversely, either overexpression of a dominant-negative HIF-1α or pharmacologic inhibition of HIF-1α significantly reduced AT fibrosis and improved AT function in mice fed a HFD (85).”
From The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. (2017) · cites this paper as [85]
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- Authors
- Sun, K., Halberg, N., Khan, M., Magalang, U. J., & Scherer, P. E.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- The Ohio State University (US)
- The Ohio State University Wexner Medical Center (US)
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2013-03-01
- Volume
- 33
- Issue
- 5
- Pages
- 904-917
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- PMC
- PMC3623075
- OpenAlex
- W2155306967
- Cited by
- 231
- References
- 66
- Citations by year
- 2026: 9 · 2025: 13 · 2024: 15 · 2023: 25 · 2022: 22 · 2021: 15 · 2020: 21 · 2019: 15 · 2018: 21 · 2017: 11 · 2016: 19 · 2015: 14 · 2014: 24 · 2013: 7
- FWCI
- 10.78
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular and Cellular Biology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ohio State University
- University of Texas Southwestern Medical Center
- National Institutes of Health
- National Heart, Lung, and Blood Institute (HL-093463, R01HL093463)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK 55758, R01DK055758, RC1DK086629, P01DK088761)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- hypoxia-inducible factor-1α, PX-478, adipose tissue dysfunction, obesity, high-fat diet, adipose tissue fibrosis, energy expenditure, adipose tissue inflammation, metabolic dysfunction
- MeSH terms
- Adipose Tissue, Animals, Digoxin, Energy Metabolism, Fatty Liver, Glucose Tolerance Test, Liver, Male, Mice, Inbred C57BL, Mice, Transgenic, Mustard Compounds, Mutation, Oxygen, Phenylpropionates, Weight Gain, Up-Regulation, Mice, Hypoxia-Inducible Factor 1, alpha Subunit, Diet, High-Fat
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