Selective Inhibition of Hypoxia-Inducible Factor 1α Ameliorates Adipose Tissue Dysfunction
Open accessAbstract
Hypoxia-inducible factor 1α (HIF1α) induction in adipocytes is a critical component of the "fibrotic response," directly linked to metabolic dysfunction in adipose tissues under hypoxic conditions. We reasoned that inhibition of HIF1α may ameliorate the negative aspects of the obesity-associated fat pad expansion. We used the selective HIF1α inhibitor PX-478, whose effectiveness has previously been established in tumor models. We demonstrate that PX-478 treatment effectively suppresses the high-fat-diet (HFD)-induced HIF1α activation in adipose tissue. HIF1α inhibition causes a reduction of weight gain in mice on an HFD but not on a chow diet. Treatment increases energy expenditure and prompts resistance to HFD-mediated deterioration of metabolic parameters. Moreover, PX-478-treated mice have reduced fibrosis and fewer inflammatory infiltrates in their adipose tissues. We confirm the metabolic effects obtained with PX-478 treatment using an adipose tissue-specific, doxycycline-inducible dominant negative HIF1α mutant (dn-HIF1α). Consistent with the pharmacological results, genetic inhibition of endogenous HIF1α activity prompts similar metabolic improvements in HFD-fed mice. Collectively, our results demonstrate that HIF1α inhibition in the adipocyte leads to significant metabolic improvements, suggesting that selective HIF1α inhibition in adipose tissue may be an effective therapeutic avenue in the context of metabolic dysfunction.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Overexpression of dominant-negative HIF-1α or pharmacologic inhibition of HIF-1α significantly reduced adipose tissue fibrosis and improved adipose tissue function in mice fed a high-fat diet.
“Conversely, either overexpression of a dominant-negative HIF-1α or pharmacologic inhibition of HIF-1α significantly reduced AT fibrosis and improved AT function in mice fed a HFD (85).”
From The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. (2017) · cites this paper as [85]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041 · see citing works
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199 · see citing works
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760 · see citing works
Targeting HIF-1 for cancer therapy
Semenza, G. L. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1187 · Cited by 6,717 · cited 1× · see citing works
“The heterodimers bind to genomic hypoxia response elements (HREs) and transactivate a wide variety of genes, including genes whose protein products are involved in cell survival, glycolysis, erythropoiesis, and angiogenesis (18, 19).”
BackgroundIvan, M., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M., Salic, A., Asara, J. M., Lane, W. S., & Kaelin Jr., W. G. (2001) · Science · doi:10.1126/science.1059817 · Cited by 4,735 · see citing works
A conserved family of prolyl-4-hydroxylases that modify HIF
Bruick, R. K., & McKnight, S. L. (2001) · Science · doi:10.1126/science.1066373 · Cited by 2,549 · see citing works
Adipokines: inflammation and the pleiotropic role of white adipose tissue
Trayhurn, P., & Wood, I. S. (2004) · British Journal of Nutrition · doi:10.1079/bjn20041213 · Cited by 2,210 · see citing works
Adipose tissue remodeling and obesity
Sun, K., Kusminski, C. M., & Scherer, P. E. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45887 · Cited by 1,941 · see citing works
Self-citationSalceda, S., & Caro, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.36.22642 · Cited by 1,674 · see citing works
Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation
Hosogai, N., Fukuhara, A., Oshima, K., Miyata, Y., Tanaka, S., Segawa, K., Furukawa, S., Tochino, Y., Komuro, R., Matsuda, M., et al. (2007) · Diabetes · doi:10.2337/db06-0911 · Cited by 1,257 · see citing works
Minireview: The Adipocyte—At the Crossroads of Energy Homeostasis, Inflammation, and Atherosclerosis
Rajala, M. W., & Scherer, P. E. (2003) · Endocrinology · doi:10.1210/en.2003-0580 · Cited by 1,204 · see citing works
Self-citationMetabolic Dysregulation and Adipose Tissue Fibrosis: Role of Collagen VI
Khan, T., Muise, E. S., Iyengar, P., Wang, Z. V., Chandalia, M., Abate, N., Zhang, B. B., Bonaldo, P., Chua, S., & Scherer, P. E. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01300-08 · Cited by 1,053 · see citing works
Self-citationHypoxia-Inducible Factor 1α Induces Fibrosis and Insulin Resistance in White Adipose Tissue
Halberg, N., Khan, T., Trujillo, M. E., Wernstedt-Asterholm, I., Attie, A. D., Sherwani, S., Wang, Z. V., Landskroner-Eiger, S., Dineen, S., Magalang, U. J., et al. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00192-09 · Cited by 896 · see citing works
Self-citationYe, J., Gao, Z., Yin, J., & He, Q. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00435.2007 · Cited by 840 · see citing works
Weyer, C., Foley, J. E., Bogardus, C., Tataranni, P. A., & Pratley, R. E. (2000) · Diabetologia · doi:10.1007/s001250051560 · Cited by 799 · see citing works
Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth.
Ryan, H. E., Poloni, M., McNulty, W., Elson, D., Gassmann, M., Arbeit, J. M., & Johnson, R. S. (2000) · PubMed · Cited by 786 · see citing works
Reduced Adipose Tissue Oxygenation in Human Obesity
Pasarica, M., Sereda, O. R., Redman, L. M., Albarado, D. C., Hymel, D. T., Roan, L. E., Rood, J. C., Burk, D. H., & Smith, S. R. (2009) · Diabetes · doi:10.2337/db08-1098 · Cited by 786 · see citing works
Regulation of the Hypoxia-inducible Transcription Factor 1α by the Ubiquitin-Proteasome Pathway
Kallio, P. J., Wilson, W. J., O’Brien, S. L., Makino, Y., & Poellinger, L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.10.6519 · Cited by 754 · see citing works
Hypoxia, Clonal Selection, and the Role of HIF-1 in Tumor Progression
Semenza, G. L. (2000) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230091169186 · Cited by 657 · see citing works
Adipocyte Turnover: Relevance to Human Adipose Tissue Morphology
Arner, E., Westermark, P. O., Spalding, K. L., Britton, T., Rydén, M., Frisén, J., Bernard, S., & Arner, P. (2010) · Diabetes · doi:10.2337/db09-0942 · Cited by 645 · see citing works
HIF-1 as a target for drug development
Giaccia, A., Siim, B. G., & Johnson, R. S. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1199 · Cited by 631 · see citing works
Development of high fat diet-induced obesity and leptin resistance in C57Bl/6J mice
Lin, S., Thomas, T. C., Storlien, L., & Huang, X. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801209 · Cited by 591 · see citing works
Rausch, M. E., Weisberg, S., Vardhana, P., & Tortoriello, D. V. (2008) · International Journal of Obesity · doi:10.1038/sj.ijo.0803744 · Cited by 585 · see citing works
Emerging role of adipose tissue hypoxia in obesity and insulin resistance
Ye, J. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.229 · Cited by 539 · see citing works
Suppression of tumor growth through disruption of hypoxia-inducible transcription
Kung, A. L., Wang, S., Klco, J. M., Kaelin, W. G., & Livingston, D. M. (2000) · Nature Medicine · doi:10.1038/82146 · Cited by 502 · see citing works
Aragonés, J., Schneider, M. A., Geyte, K. V., Fraisl, P., Dresselaers, T., Mazzone, M., Dirkx, R., Zacchigna, S., Lemieux, H., Jeoung, N. H., et al. (2008) · Nature Genetics · doi:10.1038/ng.2007.62 · Cited by 472 · see citing works
Dichotomous effects of VEGF-A on adipose tissue dysfunction
Sun, K., Asterholm, I. W., Kusminski, C. M., Bueno, A. C., Wang, Z. V., Pollard, J. W., Brekken, R. A., & Scherer, P. E. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200447109 · Cited by 417 · see citing works
Self-citationWang, B., Wood, I. S., & Trayhurn, P. (2007) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-007-0301-8 · Cited by 392 · see citing works
Oxygen, a source of life and stress
Brahimi-Horn, M. C., & Pouysségur, J. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.06.018 · Cited by 383 · see citing works
Obesity Decreases Perioperative Tissue Oxygenation
Kabon, B., Nagele, A., Reddy, D., Eagon, C., Fleshman, J. W., Sessler, D. I., & Kurz, A. (2004) · Anesthesiology · doi:10.1097/00000542-200402000-00015 · Cited by 376 · see citing works
Brennan, A. M., & Mantzoros, C. S. (2006) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0196 · Cited by 374 · see citing works
Role of hypoxia in obesity-induced disorders of glucose and lipid metabolism in adipose tissue.
Yin, J., Gao, Z., He, Q., Zhou, D., Guo, Z., & Ye, J. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90760.2008 · Cited by 319 · see citing works
Krishnan, J., Danzer, C. F., Simka, T., Ukropec, J., Walter, K., Kumpf, S., Mirtschink, P., Ukropcová, B., Gašperíková, D., Pedrazzini, T., et al. (2012) · Genes & Development · doi:10.1101/gad.180406.111 · Cited by 316 · see citing works
Virtanen, K. A., Lönnroth, P., Parkkola, R., Peltoniemi, P., Asola, M., Viljanen, T., Tolvanen, T., Knuuti, J., Rönnemaa, T., Huupponen, R., et al. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.87.8.3902 · Cited by 315 · see citing works
Hypoxia inducible factor-1α as a cancer drug target
Powis, G., & Kirkpatrick, L. (2004) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.647.3.5 · Cited by 311 · see citing works
Adipose tissue, insulin action and vascular disease: inflammatory signals
Yudkin, J. S. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802496 · Cited by 311 · cited 1× · see citing works
“The development of inflammation in adipose tissue has been linked to many other metabolic syndromes (55, 56).”
BackgroundHypoxia inducible factor as a cancer drug target.
Welsh, S., & Powis, G. (2003) · Current Cancer Drug Targets · doi:10.2174/1568009033481732 · Cited by 309 · see citing works
Koh, M. Y., Spivak-Kroizman, T., Venturini, S., Welsh, S., Williams, R. R., Kirkpatrick, D. L., & Powis, G. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-07-0463 · Cited by 309 · see citing works
Welsh, S. J., Williams, R. R., Kirkpatrick, L., Paine-Murrieta, G. D., & Powis, G. (2004) · PubMed · Cited by 280 · see citing works
Jiang, C., Qu, A., Matsubara, T., Chanturiya, T., Jou, W., Gavrilova, O., Shah, Y. M., & Gonzalez, F. J. (2011) · Diabetes · doi:10.2337/db11-0174 · Cited by 268 · see citing works
Welsh, S., Williams, R., Kirkpatrick, L., Paine-Murrieta, G., & Powis, G. (2004) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.233.3.3 · Cited by 240 · see citing works
Gene regulation under low oxygen: holding your breath for transcription
Rocha, S. (2007) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2007.06.005 · Cited by 219 · see citing works
Loss of Skeletal Muscle HIF-1α Results in Altered Exercise Endurance
Mason, S. D., Howlett, R. A., Kim, M. J., Olfert, I. M., Hogan, M. C., McNulty, W., Hickey, R. P., Wagner, P. D., Kahn, C. R., Giordano, F. J., et al. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020288 · Cited by 210 · see citing works
Systemic Fate of the Adipocyte-Derived Factor Adiponectin
Halberg, N., Schraw, T., Wang, Z. V., Kim, J., Yi, J., Hamilton, M. P., Luby‐Phelps, K., & Scherer, P. E. (2009) · Diabetes · doi:10.2337/db08-1750 · Cited by 198 · see citing works
Self-citationTranscriptional Activation of the Human Leptin Gene in Response to Hypoxia
Ambrosini, G., Nath, A. K., Sierra-Honigmann, M. R., & Flores-Riveros, J. R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205172200 · Cited by 188 · see citing works
Hypoxia-inducible factor-1alpha mediates hypoxia-induced delayed neuronal death that involves p53.
Halterman, M. W., Miller, C. C., & Federoff, H. J. (1999) · PubMed Central · doi:10.1523/jneurosci.19-16-06818.1999 · Cited by 184 · see citing works
Chen, J., Zhao, S., Nakada, K., Kuge, Y., Tamaki, N., Okada, F., Wang, J., 進藤, 正., Higashino, F., Takeda, K., et al. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63924-7 · Cited by 170 · see citing works
Wang, Z. V., Deng, Y., Wang, Q. A., Sun, K., & Scherer, P. E. (2010) · Endocrinology · doi:10.1210/en.2010-0136 · Cited by 156 · see citing works
Self-citationNovel particulate spin probe for targeted determination of oxygen in cells and tissues
Pandian, R. P., Parinandi, N. L., Ilangovan, G., Zweier, J. L., & Kuppusamy, P. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00496-9 · Cited by 150 · see citing works
Wang, B., Wood, I. S., & Trayhurn, P. (2008) · Journal of Endocrinology · doi:10.1677/joe-08-0156 · Cited by 147 · see citing works
Sun, X., Kanwar, J. R., Leung, E. Y., Lehnert, K., Wang, D., & Krissansen, G. W. (2001) · Gene Therapy · doi:10.1038/sj.gt.3301388 · Cited by 146 · see citing works
Palayoor, S. T., Mitchell, J. B., Cerna, D., DeGraff, W., John‐Aryankalayil, M., & Coleman, C. N. (2008) · International Journal of Cancer · doi:10.1002/ijc.23807 · Cited by 132 · see citing works
Jordan, B. F., Runquist, M. L., Raghunand, N., Baker, A. F., Williams, R. R., Kirkpatrick, L., Powis, G., & Gillies, R. J. (2005) · Neoplasia · doi:10.1593/neo.04628 · Cited by 129 · see citing works
Hypoxia inducible factor-1: a novel target for cancer therapy
Belozerov, V. E., & Meir, E. G. V. (2005) · Anti-Cancer Drugs · doi:10.1097/01.cad.0000180116.85912.69 · Cited by 117 · see citing works
HIF-1α in endurance training: suppression of oxidative metabolism
Mason, S. D., Rundqvist, H., Papandreou, I., Duh, R., McNulty, W., Howlett, R. A., Olfert, I. M., Sundberg, C. J., Denko, N. C., Poellinger, L., et al. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00335.2007 · Cited by 114 · see citing works
Schwartz, D. L., Powis, G., Thitai-Kumar, A., He, Y., Bankson, J. A., Williams, R. R., Lemos, R., Oh, J., Volgin, A., Soghomonyan, S., et al. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-08-0981 · Cited by 99 · see citing works
A novel approach to cancer therapy using PX-478 as a HIF-1α inhibitor
Lee, K., & Kim, H. M. (2011) · Archives of Pharmacal Research · doi:10.1007/s12272-011-1021-3 · Cited by 95 · see citing works
Schwartz, D. L., Bankson, J. A., Lemos, R., Lai, S. Y., Thittai, A. K., He, Y., Hostetter, G. H., Demeure, M. J., Hoff, D. D. V., & Powis, G. (2010) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-09-0768 · Cited by 94 · see citing works
Methods for Noninvasive Imaging of Tissue Hypoxia
Vikram, D. S., Zweier, J. L., & Kuppusamy, P. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1717 · Cited by 92 · see citing works
Jacoby, J. J., Erez, B., Korshunova, M. V., Williams, R. R., Furutani, K., Takahashi, O., Kirkpatrick, L., Lippman, S. M., Powis, G., O'Reilly, M. S., et al. (2010) · Journal of Thoracic Oncology · doi:10.1097/jto.0b013e3181dc211f · Cited by 84 · see citing works
HIF-1α is necessary to support gluconeogenesis during liver regeneration
Tajima, T., Goda, N., Fujiki, N., Hishiki, T., Nishiyama, Y., Senoo‐Matsuda, N., Shimazu, M., Soga, T., Yoshimura, Y., Johnson, R. S., et al. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.07.115 · Cited by 66 · see citing works
Jordan, B. F., Black, K., Robey, I., Runquist, M. L., Powis, G., & Gillies, R. J. (2005) · NMR in Biomedicine · doi:10.1002/nbm.977 · Cited by 45 · see citing works
Khan, M., Mohan, I. K., Kutala, V. K., Kotha, S. R., Parinandi, N. L., Hamlin, R. L., & Kuppusamy, P. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2155 · Cited by 43 · see citing works
Self-citationOxygen and oxygenation in stem-cell therapy for myocardial infarction
Khan, M., Kwiatkowski, P. A., Rivera, B. K., & Kuppusamy, P. (2010) · Life Sciences · doi:10.1016/j.lfs.2010.06.013 · Cited by 31 · see citing works
Self-citationInhibitors of hypoxia-inducible factor-1 signaling.
Belozerov, V. E., & Meir, E. G. V. (2006) · PubMed · Cited by 21 · see citing works
Flagged first, then by citations
1 of the 66 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- [16]16. Ivan M, Kondo K, Yang H, Kim W, Valiando J, Ohh M, Salic A, Asara JM, Lane WS, Kaelin WG., Jr 2001. HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 292: 464–468 [DOI] [PubMed] [Google Scholar]
Cited by
Sorted by citations
Inflammation in obesity, diabetes, and related disorders
Rohm, T. V., Meier, D. T., Olefsky, J. M., & Donath, M. Y. (2022) · Immunity · doi:10.1016/j.immuni.2021.12.013 · Cited by 2,066 · see citing works
Adipose-tissue plasticity in health and disease
Sakers, A. P., Siqueira, M. K. D., Seale, P., & Villanueva, C. J. (2022) · Cell · doi:10.1016/j.cell.2021.12.016 · Cited by 1,111 · see citing works
Fibrosis and adipose tissue dysfunction.
Sun, K., Tordjman, J., Clément, K., & Scherer, P. E. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.06.016 · Cited by 960 · see citing works
Self-citationA single-cell atlas of human and mouse white adipose tissue
Emont, M. P., Jacobs, C., Essene, A. L., Pant, D., Tenen, D., Colleluori, G., Di Vincenzo, A., Jørgensen, A. M., Dashti, H., Stefek, A., et al. (2022) · Nature · doi:10.1038/s41586-022-04518-2 · Cited by 840 · see citing works
Obesity and cancer—mechanisms underlying tumour progression and recurrence
Park, J., Morley, T. S., Kim, M. G., Clegg, D. J., & Scherer, P. E. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.94 · Cited by 808 · see citing works
Self-citationThe ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis.
Crewe, C., An, Y. A., & Scherer, P. E. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88883 · Cited by 732 · see citing works
Self-citationTargeting adipose tissue in the treatment of obesity-associated diabetes
Kusminski, C. M., Bickel, P. E., & Scherer, P. E. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.75 · Cited by 678 · see citing works
Self-citationFuster, J. J., Ouchi, N., Gokce, N., & Walsh, K. X. (2016) · Circulation Research · doi:10.1161/circresaha.115.306885 · Cited by 688 · see citing works
Lee, Y. S., Kim, J.-W., Osborne, O., Oh, D. Y., Sasik, R., Schenk, S., Chen, A., Chung, H., Murphy, A., Watkins, S. M., et al. (2014) · Cell · doi:10.1016/j.cell.2014.05.012 · Cited by 598 · see citing works
The cell biology of fat expansion
Rutkowski, J. M., Stern, J. H., & Scherer, P. E. (2015) · Journal of Cell Biology · doi:10.1083/jcb.201409063 · Cited by 541 · see citing works
Self-citationHypoxia signaling in human health and diseases: implications and prospects for therapeutics
Luo, Z., Tian, M., Yang, G., Tan, Q., Chen, Y., Li, G., Zhang, Q., Li, Y., Wan, P., & Wu, J. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01080-1 · Cited by 499 · see citing works
Havis, E., & Duprez, D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051664 · Cited by 497 · see citing works
Mahajan, R., Lau, D. H., Brooks, A. G., SHIPP, N. J., Manavis, J., Wood, J. P. M., Finnie, J. W., Samuel, C. S., Royce, S. G., Twomey, D. J., et al. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.04.058 · Cited by 464 · see citing works
An Integrated View of Immunometabolism
Lee, Y. S., Wollam, J., & Olefsky, J. M. (2018) · Cell · doi:10.1016/j.cell.2017.12.025 · Cited by 450 · see citing works
Vascular rarefaction mediates whitening of brown fat in obesity
Shimizu, I., Aprahamian, T. R., Kikuchi, R., Shimizu, A., Papanicolaou, K. N., MacLauchlan, S., Maruyama, S., & Walsh, K. (2014) · Journal of Clinical Investigation · doi:10.1172/jci71643 · Cited by 425 · see citing works
The role of hypoxia-inducible factors in metabolic diseases
Gonzalez, F. J., Xie, C., & Jiang, C. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0096-z · Cited by 406 · see citing works
Metabolic adaptation and maladaptation in adipose tissue
Chouchani, E. T., & Kajimura, S. (2019) · Nature Metabolism · doi:10.1038/s42255-018-0021-8 · Cited by 397 · see citing works
Endotrophin triggers adipose tissue fibrosis and metabolic dysfunction
Sun, K., Park, J., Gupta, O. T., Holland, W. L., Auerbach, P., Zhang, N., Goncalves Marangoni, R., Nicoloro, S. M., Czech, M. P., Varga, J., et al. (2014) · Nature Communications · doi:10.1038/ncomms4485 · Cited by 364 · see citing works
Self-citationChronic tissue inflammation and metabolic diseasePreprint
Lee, Y. S., & Olefsky, J. M. (2021) · Genes & Development · doi:10.1101/gad.346312.120 · Cited by 354 · see citing works
Hypoxia-inducible factors and the regulation of lipid metabolism
Mylonis, I., Simos, G., & Paraskeva, E. (2019) · Cells · doi:10.3390/cells8030214 · Cited by 316 · see citing works
Cao, Y. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.08.008 · Cited by 331 · see citing works
Pathophysiological implications of hypoxia in human diseases
Chen, P.-S., Chiu, W.-T., Hsu, P.-L., Lin, S.-C., Peng, I.-C., Wang, C.-Y., & Tsai, S.-J. (2020) · Journal of Biomedical Science · doi:10.1186/s12929-020-00658-7 · Cited by 318 · see citing works
Deciphering the cellular interplays underlying obesity-induced adipose tissue fibrosis
Marcelin, G., Silveira, A. L. M., Martins, L. B., Ferreira, A. V. M., & Clément, K. (2019) · Journal of Clinical Investigation · doi:10.1172/jci129192 · Cited by 274 · see citing works
Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targets
Zhao, Y., Xiong, W., Li, C., Zhao, R., Lu, H., Song, S., Zhou, Y., Hu, Y., Shi, B., & Ge, J. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01652-9 · Cited by 269 · see citing works
A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate
Wang, W., Ishibashi, J., Trefely, S., Shao, M., Cowan, A. J., Sakers, A. P., Lim, H., O’Connor, S., Doan, M. T., Cohen, P., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.05.005 · Cited by 225 · see citing works
Inhibition of Hif1α prevents both trauma-induced and genetic heterotopic ossification
Agarwal, S., Loder, S. J., Brownley, C., Cholok, D. J., Mangiavini, L., Li, J., Breuler, C. J., Hsieh, H. H. S., Li, S., Ranganathan, K., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1515397113 · Cited by 224 · see citing works
Adipose tissue angiogenesis: Impact on obesity and type-2 diabetes
Corvera, S., & Gealekman, O. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.06.003 · Cited by 211 · see citing works
Cohen, P., & Spiegelman, B. M. (2016) · Molecular Biology of the Cell · doi:10.1091/mbc.e15-10-0749 · Cited by 217 · see citing works
Adipose tissue and adipocyte dysregulation
Lafontan, M. (2013) · Diabetes & Metabolism · doi:10.1016/j.diabet.2013.08.002 · Cited by 217 · see citing works
Macrophage-inducible C-type lectin underlies obesity-induced adipose tissue fibrosis
Tanaka, M., Ikeda, K., Suganami, T., Komiya, C., Ochi, K., Shirakawa, I., Hamaguchi, M., Nishimura, S., Manabe, I., Matsuda, T., et al. (2014) · Nature Communications · doi:10.1038/ncomms5982 · Cited by 204 · see citing works
Hypoxia and Adipocyte Physiology: Implications for Adipose Tissue Dysfunction in Obesity
Trayhurn, P. (2014) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071812-161156 · Cited by 194 · see citing works
Adipose Tissue as an Endocrine Organ
McGown, C., Birerdinc, A., & Younossi, Z. M. (2013) · Clinics in Liver Disease · doi:10.1016/j.cld.2013.09.012 · Cited by 194 · see citing works
Hasegawa, Y., Ikeda, K., Chen, Y., Alba, D., Stifler, D. R., Shinoda, K., Hosono, T., Maretich, P., Yang, Y., Ishigaki, Y., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2017.12.005 · Cited by 181 · see citing works
Novel mechanisms in the pathogenesis of atrial fibrillation: practical applications
Lau, D. H., Schotten, U., Mahajan, R., Antic, N. A., Hatem, S. N., Pathak, R. K., Hendriks, J., Kalman, J. M., & Sanders, P. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv375 · Cited by 171 · see citing works
Hypoxia-inducible factors and diabetes
Gunton, J. E. (2020) · Journal of Clinical Investigation · doi:10.1172/jci137556 · Cited by 159 · see citing works
Brown adipose tissue derived VEGF-A modulates cold tolerance and energy expenditure
Sun, K., Kusminski, C. M., Luby‐Phelps, K., Spurgin, S. B., An, Y., Wang, Q. A., Holland, W. L., & Scherer, P. E. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.03.010 · Cited by 152 · see citing works
Self-citationZhang, X., Zhang, Y., Wang, P., Zhang, S., Dong, Y., Zeng, G., Yan, Y., Sun, L., Wu, Q., Liu, H., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.09.016 · Cited by 152 · see citing works
The many secret lives of adipocytes: implications for diabetes
Scherer, P. E. (2018) · Diabetologia · doi:10.1007/s00125-018-4777-x · Cited by 155 · see citing works
Self-citationBuechler, C., Krautbauer, S., & Eisinger, K. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i4.548 · Cited by 141 · see citing works
Decreased Adipose Tissue Oxygenation Associates with Insulin Resistance in Individuals with Obesity
Cifarelli, V., Beeman, S. C., Smith, G. I., Yoshino, J., Morozov, D., Beals, J. W., Kayser, B. D., Watrous, J. D., Jain, M., Patterson, B. W., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci141828 · Cited by 132 · see citing works
Iftikhar, I. H., Hoyos, C. M., Phillips, C. L., & Magalang, U. J. (2015) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.4610 · Cited by 126 · see citing works
Self-citationRole of Cellular Senescence in Type II Diabetes
Narasimhan, A., Flores, R. R., Robbins, P. D., & Niedernhofer, L. J. (2021) · Endocrinology · doi:10.1210/endocr/bqab136 · Cited by 133 · see citing works
Nonalcoholic fatty liver disease and obstructive sleep apnea
Aron‐Wisnewsky, J., Clément, K., & Pépin, J. (2016) · Metabolism · doi:10.1016/j.metabol.2016.05.004 · Cited by 128 · see citing works
Adipose Tissue Remodeling in Pathophysiology
Auger, C., & Kajimura, S. (2022) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-042220-023633 · Cited by 123 · see citing works
Oxygen sensing and metabolic homeostasis
Palmer, B. F., & Clegg, D. J. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.08.001 · Cited by 117 · see citing works
Rahtu‐Korpela, L., Karsikas, S., Hörkkö, S., Sequeiros, R. T. B., Lammentausta, E., Mäkelä, K. A., Herzig, K., Walkinshaw, G., Kivirikko, K. I., Myllyharju, J., et al. (2014) · Diabetes · doi:10.2337/db14-0472 · Cited by 120 · see citing works
Knockdown of ANT2 reduces adipocyte hypoxia and improves insulin resistance in obesity
Seo, J. B., Riopel, M., Cabrales, P., Huh, J. Y., Bandyopadhyay, G. K., Andreyev, A. Y., Murphy, A. N., Beeman, S. C., Smith, G. I., Klein, S., et al. (2018) · Nature Metabolism · doi:10.1038/s42255-018-0003-x · Cited by 109 · see citing works
Suzuki, T. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i41.15087 · Cited by 110 · see citing works
Adipose tissue changes in obesity and the impact on metabolic function
Sam, S., & Mazzone, T. (2014) · Translational research · doi:10.1016/j.trsl.2014.05.008 · Cited by 111 · see citing works
Caputo, T., Gilardi, F., & Desvergne, B. (2017) · FEBS Letters · doi:10.1002/1873-3468.12742 · Cited by 112 · see citing works
Impact of obesity on cardiac metabolism, fibrosis, and function
Mahajan, R., Lau, D. H., & Sanders, P. (2014) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2014.09.005 · Cited by 109 · see citing works
The Implications of Obesity for Cardiac Arrhythmia Mechanisms and Management
Pathak, R. K., Mahajan, R., Lau, D. H., & Sanders, P. (2014) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2014.10.027 · Cited by 105 · see citing works
Warbrick, I., & Rabkin, S. W. (2019) · Obesity Reviews · doi:10.1111/obr.12828 · Cited by 97 · see citing works
Critical Role of Matrix Metalloproteinase 14 in Adipose Tissue Remodeling during Obesity
Li, X., Zhao, Y., Chen, C., Yang, L., Lee, H.-H., Wang, Z., Zhang, N., Kolonin, M. G., An, Z., Ge, X., et al. (2020) · Molecular and Cellular Biology · doi:10.1128/mcb.00564-19 · Cited by 108 · see citing works
Self-citationType 2 diabetes – An autoinflammatory disease driven by metabolic stress
Gonzalez, L. L., Garrie, K., & Turner, M. D. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.08.034 · Cited by 98 · see citing works
An update on immune dysregulation in obesity‐related insulin resistance
Daryabor, G., Kabelitz, D., & Kalantar, K. (2018) · Scandinavian Journal of Immunology · doi:10.1111/sji.12747 · Cited by 98 · see citing works
Gaspar, J. M., & Velloso, L. A. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00813 · Cited by 94 · see citing works
Obesity-related kidney disease: Beyond hypertension and insulin-resistance
Arabi, T. Z., Shafqat, A., Sabbah, B. N., Ashraf, N., Shah, H., Abdulkader, H. S., Razak, A., Sabbah, A. N., & Arabi, Z. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1095211 · Cited by 98 · see citing works
Pathologic HIF1α signaling drives adipose progenitor dysfunction in obesity
Shao, M., Hepler, C., Zhang, Q., Shan, B., Vishvanath, L., Henry, G. H., Zhao, S., An, Y., Wu, Y., Strand, D. W., et al. (2021) · Cell stem cell · doi:10.1016/j.stem.2020.12.008 · Cited by 87 · see citing works
Signaling pathways and intervention for therapy of type 2 diabetes mellitus
Cao, R. Y., Tian, H., Zhang, Y., Liu, G., Xu, H., Rao, G., Tian, Y., & Fu, X. (2023) · MedComm · doi:10.1002/mco2.283 · Cited by 94 · see citing works
The evolving functions of the vasculature in regulating adipose tissue biology in health and obesity
AlZaim, I., de Rooij, L. P. M. H., Sheikh, B. N., Börgeson, E., & Kalucka, J. M. (2023) · Nature Reviews Endocrinology · doi:10.1038/s41574-023-00893-6 · Cited by 90 · see citing works
Improved methodologies for the study of adipose biology: insights gained and opportunities ahead
Wang, Q. A., Scherer, P. E., & Gupta, R. K. (2014) · Journal of Lipid Research · doi:10.1194/jlr.r046441 · Cited by 87 · see citing works
Self-citationMicroglia activation in Niemann–Pick disease, type C1 is amendable to therapeutic intervention
Cougnoux, A., Drummond, R. A., Collar, A. L., Iben, J., Salman, A., Westgarth, H. J., Wassif, C. A., Cawley, N. X., Farhat, N. Y., Ozato, K., et al. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy112 · Cited by 85 · see citing works
Partial leptin deficiency confers resistance to diet-induced obesity in mice
Zhao, S., Li, N., Zhu, Y., Straub, L. G., Zhang, Z., Wang, M.-Y., Zhu, Q., Kusminski, C. M., Elmquist, J. K., & Scherer, P. E. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.100995 · Cited by 83 · see citing works
Self-citationm6A methylation promotes white-to-beige fat transition by facilitating Hif1a translation
Wu, R., Chen, Y., Liu, Y., Zhuang, L., Chen, W., Zeng, B., Liao, X., Guo, G., Wang, Y., & Wang, X. (2021) · EMBO Reports · doi:10.15252/embr.202052348 · Cited by 82 · see citing works
Extracellular Matrix (ECM) and Fibrosis in Adipose Tissue: Overview and Perspectives
Sun, K., Li, X., & Scherer, P. E. (2023) · Comprehensive physiology · doi:10.1002/cphy.c220020 · Cited by 154 · see citing works
Self-citationThe Adipocyte Acquires a Fibroblast-Like Transcriptional Signature in Response to a High Fat Diet
Jones, J. E. C., Rabhi, N., Orofino, J., Gamini, R., Perissi, V., Vernochet, C., & Farmer, S. R. (2020) · Scientific Reports · doi:10.1038/s41598-020-59284-w · Cited by 75 · see citing works
Li, X., Li, J., Wang, L., Li, A., Qiu, Z., Qi, L., Kou, J., Liu, K., Liu, B., & Huang, F. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13493 · Cited by 75 · see citing works
Alolga, R. N., Nuer-Allornuvor, G. F., Kuugbee, E. D., Yin, X., & Ma, G. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104630 · Cited by 73 · see citing works
HIF-1α inhibitor PX-478 preserves pancreatic β cell function in diabetes
Ilegems, E., Bryzgalova, G., Correia, J., Yesildag, B., Berra, E., Ruas, J., Pereira, T., & Berggren, P. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.aba9112 · Cited by 67 · see citing works
Kim, J. Y., Lee, H. J., Lee, S., Jung, Y. H., Yoo, D. Y., Hwang, I. K., Seong, J. K., Ryu, J. M., & Han, H. J. (2017) · Scientific Reports · doi:10.1038/s41598-017-04175-w · Cited by 72 · see citing works
Extracellular Matrix (ECM) and Fibrosis in Adipose Tissue: Overview and Perspectives
Sun, K., Li, X., & Scherer, P. E. (2023) · Comprehensive physiology · doi:10.1002/j.2040-4603.2023.tb00254.x · Cited by 71 · see citing works
Self-citationBalan, A. I., Halațiu, V.-B., & Scridon, A. (2024) · Antioxidants · doi:10.3390/antiox13010117 · Cited by 69 · see citing works
Hypoxia-regulated mechanisms in the pathogenesis of obesity and non-alcoholic fatty liver disease
Lefere, S., Steenkiste, C. V., Verhelst, X., Vlierberghe, H. V., Devisscher, L., & Geerts, A. M. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2222-1 · Cited by 68 · see citing works
The regulation of adipocyte growth in white adipose tissue
Li, Q., & Spalding, K. L. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1003219 · Cited by 72 · see citing works
GPS2 Deficiency Triggers Maladaptive White Adipose Tissue Expansion in Obesity via HIF1A Activation
Drareni, K., Ballaire, R., Barilla, S., Mathew, M. J., Toubal, A., Fan, R., Liang, N., Chollet, C., Huang, Z., Kondili, M., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.08.032 · Cited by 63 · see citing works
Wang, P., Zeng, G., Yan, Y., Zhang, S., Dong, Y., Zhang, Y., Zhang, X., Liu, H., Zhang, Z., Jiang, C., et al. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.10.001 · Cited by 65 · see citing works
Adipocyte Pseudohypoxia Suppresses Lipolysis and Facilitates Benign Adipose Tissue Expansion
Michailidou, Z., Morton, N. M., Moreno‐Navarrete, J. M., West, C. C., Stewart, K. J., Fernández‐Real, J. M., Schofield, C. J., Seckl, J. R., & Ratcliffe, P. J. (2014) · Diabetes · doi:10.2337/db14-0233 · Cited by 58 · see citing works
Divergent functions of endotrophin on different cell populations in adipose tissue
Zhao, Y., Gu, X., Zhang, N., Kolonin, M. G., An, Z., & Sun, K. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00314.2016 · Cited by 61 · see citing works
Self-citationSex-specific metabolic functions of adipose Lipocalin-2
Krishnan, K. C., Sabir, S., Shum, M., Meng, Y., Acín‐Pérez, R., Lang, J. M., Floyd, R. R., Vergnes, L., Seldin, M. M., Fuqua, B. K., et al. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.09.009 · Cited by 59 · see citing works
Adipose HIF-1α causes obesity by suppressing brown adipose tissue thermogenesis
Jun, J. C., Devera, R., Unnikrishnan, D. C., Shin, M., Bevans‐Fonti, S., Yao, Q., Rathore, A., Younas, H., Halberg, N., Scherer, P. E., et al. (2016) · Journal of Molecular Medicine · doi:10.1007/s00109-016-1480-6 · Cited by 57 · see citing works
Self-citationRegulation of glycolysis in brown adipocytes by HIF-1α
Basse, A. L., Isidor, M. S., Winther, S., Skjoldborg, N. B., Murholm, M., Andersen, E. S., Pedersen, S. B., Wolfrum, C., Quistorff, B., & Hansen, J. B. (2017) · Scientific Reports · doi:10.1038/s41598-017-04246-y · Cited by 55 · see citing works
Mody, N., & Mcilroy, G. D. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.07.012 · Cited by 55 · see citing works
Jang, J. E., Ko, M. S., Yun, J.-Y., Kim, M., Kim, J. H., Park, H. S., Kim, A.-R., Kim, H.-J., Kim, B. J., Ahn, Y. E., et al. (2016) · Diabetes · doi:10.2337/db15-1624 · Cited by 58 · see citing works
Regulation of obesity and insulin resistance by hypoxia-inducible factors
Kim, J., Ban, J.-J., Ruthenborg, R. J., & Cho, K. (2014) · Hypoxia · doi:10.2147/hp.s68771 · Cited by 52 · see citing works
ERα upregulates Phd3 to ameliorate HIF-1 induced fibrosis and inflammation in adipose tissue
Kim, M., Neinast, M. D., Frank, A. P., Sun, K., Park, J., Zehr, J. A., Vishvanath, L., Morselli, E., Amelotte, M., Palmer, B. F., et al. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.05.007 · Cited by 52 · see citing works
Self-citationYun, J.-W., Son, M.-J., Abdelmegeed, M. A., Banerjee, A., Morgan, T. R. M., Yoo, S.-H., & Song, B. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.08.030 · Cited by 49 · see citing works
Ballestri, S., Nascimbeni, F., Romagnoli, D., Baldelli, E., Targher, G., & Lonardo, A. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17030355 · Cited by 48 · see citing works
Lin, Q., & Yun, Z. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00039 · Cited by 47 · see citing works
Zhao, Y., Li, X., Yang, L., Eckel‐Mahan, K. L., Tong, Q., Gu, X., Kolonin, M. G., & Sun, K. (2018) · Molecular and Cellular Biology · doi:10.1128/mcb.00242-18 · Cited by 44 · see citing works
Self-citationLysyl oxidase and adipose tissue dysfunction
Pastel, E., Price, E., Sjöholm, K., McCulloch, L. J., Rittig, N. F., Liversedge, N., Knight, B., Møller, N., Svensson, P., & Kos, K. (2017) · Metabolism · doi:10.1016/j.metabol.2017.10.002 · Cited by 45 · see citing works
Adegunsoye, A., & Balachandran, J. S. (2015) · Mediators of Inflammation · doi:10.1155/2015/510105 · Cited by 43 · see citing works
Poblete, J. M. S., Ballinger, M. N., Bao, S., Alghothani, M., Nevado, J. B., Eubank, T. D., Christman, J. W., & Magalang, U. J. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00174.2019 · Cited by 44 · see citing works
Self-citationThe VHL/HIF Axis in the Development and Treatment of Pheochromocytoma/Paraganglioma
Song, P., Zhang, J., Tan, X., Huang, Y., Xu, J., Silk, N., Zhang, D., Liu, Q., & Jiang, J. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.586857 · Cited by 42 · see citing works
Mechanistic Insights into the Link between Obesity and Prostate Cancer
Adesunloye, B. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22083935 · Cited by 41 · see citing works
Obesity‐induced tissue alterations resist weight loss: A mechanistic review
Guardia, L. D., & Shin, A. C. (2024) · Diabetes Obesity and Metabolism · doi:10.1111/dom.15637 · Cited by 40 · see citing works
Enhancing adipose tissue plasticity: progenitor cell roles in metabolic health
Lecoutre, S., Rebière, C., Maqdasy, S., Lambert, M., Dussaud, S., Abatan, J. B., Dugail, I., Gautier, E. L., Clément, K., & Marcelin, G. (2025) · Nature Reviews Endocrinology · doi:10.1038/s41574-024-01071-y · Cited by 46 · see citing works
Immune Cells Gate White Adipose Tissue Expansion
Cox, A. R., Chernis, N., Masschelin, P. M., & Hartig, S. M. (2019) · Endocrinology · doi:10.1210/en.2019-00266 · Cited by 39 · see citing works
Pescador, N., Francisco, V., Vázquez, P., Esquinas-Román, E. M., González-Paramos, C., Valdecantos, M. P., García‐Martinez, I., Urrutia, A. A., Ruíz-Cañas, L., Escalona-Garrido, C., et al. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102171 · Cited by 39 · see citing works
Hypoxia inducible factor 1α inhibitor PX-478 reduces atherosclerosis in mice
Villa-Roel, N., Ryu, K., Gu, L., Esmerats, J. F., Kang, D. W., Kumar, S., & Jo, H. (2022) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2022.01.002 · Cited by 39 · see citing works
- Authors
- Sun, K., Halberg, N., Khan, M., Magalang, U. J., & Scherer, P. E.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- The Ohio State University (US)
- The Ohio State University Wexner Medical Center (US)
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2013-03-01
- Volume
- 33
- Issue
- 5
- Pages
- 904-917
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- PMC
- PMC3623075
- OpenAlex
- W2155306967
- Cited by
- 231
- References
- 66
- Citations by year
- 2026: 9 · 2025: 13 · 2024: 15 · 2023: 25 · 2022: 22 · 2021: 15 · 2020: 21 · 2019: 15 · 2018: 21 · 2017: 11 · 2016: 19 · 2015: 14 · 2014: 24 · 2013: 7
- FWCI
- 10.78
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular and Cellular Biology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ohio State University
- University of Texas Southwestern Medical Center
- National Institutes of Health
- National Heart, Lung, and Blood Institute (HL-093463, R01HL093463)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK 55758, R01DK055758, RC1DK086629, P01DK088761)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- hypoxia-inducible factor-1α, PX-478, adipose tissue dysfunction, obesity, high-fat diet, adipose tissue fibrosis, energy expenditure, adipose tissue inflammation, metabolic dysfunction
- MeSH terms
- Adipose Tissue, Animals, Digoxin, Energy Metabolism, Fatty Liver, Glucose Tolerance Test, Liver, Male, Mice, Inbred C57BL, Mice, Transgenic, Mustard Compounds, Mutation, Oxygen, Phenylpropionates, Weight Gain, Up-Regulation, Mice, Hypoxia-Inducible Factor 1, alpha Subunit, Diet, High-Fat
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
