Franceschi, Claudio

A meta-analysis of genome-wide association studies identifies multiple longevity genes

Deelen, J., Evans, D. S., Arking, D. E., Tesi, N., Nygaard, M., Liu, X., Wojczynski, M. K., Biggs, M. L., van der Spek, A., Atzmon, G., et al. (2019) · Nature Communications

Genetic Associations and EpidemiologyGenetics, Aging, and Longevity in Model Organisms

Cited by 370

A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages

Bellizzi, D., Rose, G., Cavalcante, P., Covello, G., Dato, S., De Rango, F., Greco, V., Maggiolini, M., Feraco, E., Mari, V., et al. (2005) · Genomics

Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model Organisms

Cited by 367

Expansion of cytotoxic CD8 + CD28 − T cells in healthy ageing people, including centenarians

FAGNONI, F. F., VESCOVINI, R., MAZZOLA, M., BOLOGNA, G., NIGRO, E., LAVAGETTO, G., FRANCESCHI, C., PASSERI, M., & SANSONI, P. (1996) · Immunology

T-cell and B-cell ImmunologyImmune Cell Function and Interaction

Cited by 362

Functional metagenomic profiling of intestinal microbiome in extreme ageing

Rampelli, S., Candela, M., Turroni, S., Biagi, E., Collino, S., Franceschi, C., O'Toole, P. W., & Brigidi, P. (2013) · Aging

Gut microbiota and healthOral microbiology and periodontitis research

Cited by 359

Aging and Parkinson's Disease: Inflammaging, neuroinflammation and biological remodeling as key factors in pathogenesis

Calabrese, V., Santoro, A., Monti, D., Crupi, R., Di Paola, R., Latteri, S., Cuzzocrea, S., Zappia, M., Giordano, J., Calabrese, E. J., et al. (2018) · Free Radical Biology and Medicine

Parkinson's Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 356

Correction: Through Ageing, and Beyond: Gut Microbiota and Inflammatory Status in Seniors and Centenarians

Biagi, E., Nylund, L., Candela, M., Ostan, R., Bucci, L., Pini, E., Nikkïla, J., Monti, D., Satokari, R., Franceschi, C., et al. (2010) · PLoS ONE

Gut microbiota and healthOral microbiology and periodontitis research

Cited by 345

Inflammaging as a Major Characteristic of Old People: Can It Be Prevented or Cured?

Franceschi, C. (2008) · Nutrition Reviews

Genetics, Aging, and Longevity in Model OrganismsImmune Response and Inflammation

Cited by 342

The network and the remodeling theories of aging: historical background and new perspectives

Franceschi, C., Valensin, S., Bonafè, M., Paolisso, G., Yashin, A. I., Monti, D., & De Benedictis, G. (2000) · Experimental Gerontology

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 335

Inflamm-ageing

Cevenini, E., Monti, D., & Franceschi, C. (2013) · Current Opinion in Clinical Nutrition and Metabolic Care

Genetics, Aging, and Longevity in Model OrganismsNutrition and Health in Aging

Cited by 317

Decreased epigenetic age of PBMCs from Italian semi-supercentenarians and their offspring

Horvath, S., Pirazzini, C., Bacalini, M. G., Gentilini, D., Di Blasio, A. M., Delledonne, M., Mari, D., Arosio, B., Monti, D., Passarino, G., et al. (2015) · Aging

Epigenetics and DNA MethylationGenetics, Aging, and Longevity in Model Organisms

Cited by 316

Immunobiography and the heterogeneity of immune responses in the elderly: A focus on inflammaging and trained immunity

Franceschi, C., Salvioli, S., Garagnani, P., de Eguileor, M., Monti, D., & Capri, M. (2017) · Frontiers in Immunology

Immune responses and vaccinationsImmune Response and Inflammation

Cited by 290

Identification of a geographic area characterized by extreme longevity in the Sardinia island: The AKEA study

Poulain, M., Pes, G. M., Grasland, C., Carru, C., Ferrucci, L., Baggio, G., Franceschi, C., & Deiana, L. (2004) · Experimental Gerontology

Insurance, Mortality, Demography, Risk ManagementGenetics, Aging, and Longevity in Model Organisms

Cited by 286

Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly

Rose, G., Dato, S., Altomare, K., Bellizzi, D., Garasto, S., Greco, V, Passarino, G., Feraco, E., Mari, V, Barbi, C., et al. (2003) · Experimental Gerontology

Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model Organisms

Cited by 282

Ageing and gut microbes: Perspectives for health maintenance and longevity

Biagi, E., Candela, M., Turroni, S., Garagnani, P., Franceschi, C., & Brigidi, P. (2013) · Pharmacological Research

Gut microbiota and healthProbiotics and Fermented Foods

Cited by 276

Metabolic Signatures of Extreme Longevity in Northern Italian Centenarians Reveal a Complex Remodeling of Lipids, Amino Acids, and Gut Microbiota Metabolism

Collino, S., Montoliu, I., Martin, F.-P. J., Scherer, M., Mari, D., Salvioli, S., Bucci, L., Ostan, R., Monti, D., Biagi, E., et al. (2013) · PLoS ONE

Metabolomics and Mass Spectrometry StudiesGenetics, Aging, and Longevity in Model Organisms

Cited by 270

Calorie restriction in humans inhibits the PI 3 K/AKT pathway and induces a younger transcription profile

Mercken, E. M., Crosby, S. D., Lamming, D. W., JeBailey, L., Krzysik‐Walker, S., Villareal, D. T., Capri, M., Franceschi, C., Zhang, Y., Becker, K., et al. (2013) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsMuscle Physiology and Disorders

Cited by 261

Reconfiguration of DNA methylation in aging

Zampieri, M., Ciccarone, F., Calabrese, R., Franceschi, C., Bürkle, A., & Caiafa, P. (2015) · Mechanisms of Ageing and Development

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 254

Gut microbiota changes in the extreme decades of human life: a focus on centenarians

Santoro, A., Ostan, R., Candela, M., Biagi, E., Brigidi, P., Capri, M., & Franceschi, C. (2018) · Cellular and Molecular Life Sciences

Gut microbiota and healthGenetics, Aging, and Longevity in Model Organisms

Cited by 250

Age-related differences in the expression of circulating microRNAs: miR-21 as a new circulating marker of inflammaging

Olivieri, F., Spazzafumo, L., Santini, G., Lazzarini, R., Albertini, M. C., Rippo, M. R., Galeazzi, R., Abbatecola, A. M., Marcheselli, F., Monti, D., et al. (2012) · Mechanisms of Ageing and Development

MicroRNA in disease regulationTelomeres, Telomerase, and Senescence

Cited by 248

Cytomegalovirus Infection: A Driving Force in Human T Cell Immunosenescence

KOCH, S., LARBI, A., ÖZCELIK, D., SOLANA, R., GOUTTEFANGEAS, C., ATTIG, S., WIKBY, A., STRINDHALL, J., FRANCESCHI, C., & PAWELEC, G. (2007) · Annals of the New York Academy of Sciences

Cytomegalovirus and herpesvirus researchHerpesvirus Infections and Treatments

Cited by 242

Human Aging and Longevity Are Characterized by High Levels of Mitokines

Conte, M., Ostan, R., Fabbri, C., Santoro, A., Guidarelli, G., Vitale, G., Mari, D., Sevini, F., Capri, M., Sandri, M., et al. (2019) · The Journals of Gerontology: Series A

GDF15 and Related BiomarkersFibroblast Growth Factor Research

Cited by 219

Fibroblast cultures from healthy centenarians have an active proteasome

Chondrogianni, N., Petropoulos, I., Franceschi, C., Friguet, B., & Gonos, E. S. (2000) · Experimental Gerontology

Genetics, Aging, and Longevity in Model OrganismsUbiquitin and proteasome pathways

Cited by 200

Novel loci and pathways significantly associated with longevity

Zeng, Y., Nie, C., Min, J., Liu, X., Li, M., Chen, H., Xu, H., Wang, M., Ni, T., Li, Y., et al. (2016) · Scientific Reports

Genetic Associations and EpidemiologyGenetics, Aging, and Longevity in Model Organisms

Cited by 195

Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study

Beekman, M., Blanché, H., Perola, M., Hervonen, A., Bezrukov, V., Sikora, E., Flachsbart, F., Christiansen, L., De Craen, A. J. M., Kirkwood, T. B. L., et al. (2013) · Aging Cell

Genetic Associations and EpidemiologyGenetics, Aging, and Longevity in Model Organisms

Cited by 190