Inflamm-ageing

NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses

Taganov, K. D., Boldin, M. P., Chang, K.-J., & Baltimore, D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605298103 · Cited by 4,317 · see citing works

Inflammatory Mechanisms in Obesity

Gregor, M. F., & Hotamisligil, G. S. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101322 · Cited by 3,754 · see citing works

Type 2 diabetes as an inflammatory disease

Donath, M. Y., & Shoelson, S. E. (2011) · Nature Reviews Immunology · doi:10.1038/nri2925 · Cited by 3,737 · see citing works

Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome

Vrieze, A., Van Nood, E., Holleman, F., Salojärvi, J., Kootte, R. S., Bartelsman, J. F. W. M., Dallinga–Thie, G. M., Ackermans, M. T., Serlie, M. J., Oozeer, R., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.06.031 · Cited by 2,913 · see citing works

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

Rodier, F., Coppé, J.-P., Patil, C. K., Hoeijmakers, W. A. M., Muñoz, D. P., Raza, S. R., Freund, A., Campeau, E., Davalos, A. R., & Campisi, J. (2009) · Nature Cell Biology · doi:10.1038/ncb1909 · Cited by 2,232 · see citing works

Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans

Franceschi, C., Capri, M., Monti, D., Giunta, S., Olivieri, F., Sevini, F., Panourgia, M. P., Invidia, L., Celani, L., Scurti, M., et al. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.11.016 · Cited by 2,087 · see citing works

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

Kuilman, T., Michaloglou, C., Vredeveld, L. C. W., Douma, S., van Doorn, R., Desmet, C. J., Aarden, L. A., Mooi, W. J., & Peeper, D. S. (2008) · Cell · doi:10.1016/j.cell.2008.03.039 · Cited by 2,086 · see citing works

Four faces of cellular senescence

Rodier, F., & Campisi, J. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201009094 · Cited by 2,016 · see citing works

Chemokine signaling via the CXCR2 receptor reinforces senescence

Acosta, J. C., O'Loghlen, A., Banito, A., Guijarro, M. V., Augert, A., Raguz, S., Fumagalli, M., Da Costa, M., Brown, C., Popov, N., et al. (2008) · Cell · doi:10.1016/j.cell.2008.03.038 · Cited by 1,801 · see citing works

The role of chondrocyte senescence in osteoarthritis

Price, J. S., Waters, J. G., Darrah, C., Pennington, C., Edwards, D. R., Donell, S. T., & Clark, I. M. (2002) · Aging Cell · doi:10.1046/j.1474-9728.2002.00008.x · Cited by 386 · see citing works

Differential expression of thymosin β‐10 by early passage and senescent vascular endothelium is modulated by VPF/VEGF: evidence for senescent endothelial cells <i>in vivo</i> at sites of atherosclerosis

VASILE, E., TOMITA, Y., BROWN, L. F., KOCHER, O., & DVORAK, H. F. (2001) · The FASEB Journal · doi:10.1096/fj.00-0051com · Cited by 232 · see citing works

Inflammaging: a new immune–metabolic viewpoint for age-related diseases

Franceschi, C., Garagnani, P., Parini, P., Giuliani, C., & Santoro, A. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0059-4 · Cited by 3,586 · see citing works

The Sleep-Immune Crosstalk in Health and Disease

Besedovsky, L., Lange, T., & Haack, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00010.2018 · Cited by 1,479 · see citing works

Mediterranean Diet intervention alters the gut microbiome in older people reducing frailty and improving health status: the NU-AGE 1-year dietary intervention across five European countries

Ghosh, T. S., Rampelli, S., Jeffery, I. B., Santoro, A., Neto, M., Capri, M., Giampieri, E., Jennings, A., Candela, M., Turroni, S., et al. (2020) · Gut · doi:10.1136/gutjnl-2019-319654 · Cited by 991 · see citing works

The metabolic roots of senescence: mechanisms and opportunities for intervention

Wiley, C. D., & Campisi, J. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00483-8 · Cited by 691 · see citing works

Interventions to slow aging in humans: are we ready?

Longo, V. D., Antebi, A., Bartke, A., Barzilai, N., Brown‐Borg, H. M., Caruso, C., Curiel, T. J., Cabo, R., Franceschi, C., Gems, D., et al. (2015) · Aging Cell · doi:10.1111/acel.12338 · Cited by 592 · see citing works

Immunosenescence and inflammaging in the aging process: age-related diseases or longevity?

Santoro, A., Bientinesi, E., & Monti, D. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101422 · Cited by 603 · see citing works

Aging of the immune system: Focus on inflammation and vaccination

Pinti, M., Appay, V., Campisi, J., Frasca, D., Fülöp, T., Sauce, D., Larbi, A., Weinberger, B., & Cossarizza, A. (2016) · European Journal of Immunology · doi:10.1002/eji.201546178 · Cited by 439 · see citing works

Interleukin-6 and C-reactive protein, successful aging, and mortality: the PolSenior study

Puzianowska-Kuźnicka, M., Owczarz, M., Wieczorowska-Tobis, K., Nadrowski, P., Chudek, J., Slusarczyk, P., Skalska, A., Jonas, M., Franek, E., & Mossakowska, M. (2016) · Immunity &amp; Ageing · doi:10.1186/s12979-016-0076-x · Cited by 445 · see citing works

p16(Ink4a) and senescence-associated β-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli

Hall, B. M., Balan, V., Gleiberman, A. S., Strom, E., Krasnov, P., Virtuoso, L. P., Rydkina, E., Vujcic, S., Balan, K., Gitlin, I. I., et al. (2017) · Aging · doi:10.18632/aging.101268 · Cited by 407 · see citing works

Immunosenescence in aging: Between immune cells depletion and cytokines up-regulation

Ventura, M. T., Casciaro, M., Gangemi, S., & Buquicchio, R. (2017) · Clinical and Molecular Allergy · doi:10.1186/s12948-017-0077-0 · Cited by 389 · see citing works

Functional metagenomic profiling of intestinal microbiome in extreme ageing

Rampelli, S., Candela, M., Turroni, S., Biagi, E., Collino, S., Franceschi, C., O'Toole, P. W., & Brigidi, P. (2013) · Aging · doi:10.18632/aging.100623 · Cited by 359 · see citing works

Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells

Hall, B. M., Balan, V., Gleiberman, A. S., Strom, E., Krasnov, P., Virtuoso, L. P., Rydkina, E., Vujcic, S., Balan, K., Gitlin, I., et al. (2016) · Aging · doi:10.18632/aging.100991 · Cited by 357 · see citing works

Regulatory T Cells and the Immune Aging Process: A Mini-Review

Jagger, A., Shimojima, Y., Goronzy, J. J., & Weyand, C. M. (2014) · Gerontology · doi:10.1159/000355303 · Cited by 301 · see citing works

Ageing: from inflammation to cancer

Leonardi, G. C., Accardi, G., Monastero, R., Nicoletti, F., & Libra, M. (2018) · Immunity &amp; Ageing · doi:10.1186/s12979-017-0112-5 · Cited by 241 · see citing works

Vitamin C, Aging and Alzheimer’s Disease

Monacelli, F., Acquarone, E., Giannotti, C., Borghi, R., & Nencioni, A. (2017) · Nutrients · doi:10.3390/nu9070670 · Cited by 243 · see citing works

From inflammaging to healthy aging by dietary lifestyle choices: is epigenetics the key to personalized nutrition?

vel Szic, K. S., Declerck, K., Vidaković, M., & Vanden Berghe, W. (2015) · Clinical Epigenetics · doi:10.1186/s13148-015-0068-2 · Cited by 192 · see citing works

Skeletal muscle oxidative stress and inflammation in aging: Focus on antioxidant and anti-inflammatory therapy

Chen, M., Wang, Y., Deng, S., Lian, Z., & Yu, K. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.964130 · Cited by 187 · see citing works

Senescence promotes in vivo reprogramming through p16<scp>^INK</scp>^4a and <scp>IL</scp>‐6

Mosteiro, L., Pantoja, C., de Martino, A., & Serrano, M. (2018) · Aging Cell · doi:10.1111/acel.12711 · Cited by 182 · see citing works

ROLE of IGF-1 System in the Modulation of Longevity: Controversies and New Insights From a Centenarians’ Perspective

Vitale, G., Pellegrino, G., Vollery, M., & Hofland, L. J. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00027 · Cited by 166 · see citing works

The inflammatory markers CRP, IL-6, and IL-10 are associated with cognitive function—data from the Berlin Aging Study II

Tegeler, C., O'Sullivan, J. L., Bucholtz, N., Goldeck, D., Pawelec, G., Steinhagen-Thiessen, E., & Demuth, I. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.10.039 · Cited by 163 · see citing works

4-hydroxynonenal-mediated signaling and aging

Zhang, H., & Forman, H. J. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.11.032 · Cited by 114 · see citing works

Are Nutrition-Related Knowledge and Attitudes Reflected in Lifestyle and Health Among Elderly People? A Study Across Five European Countries

Jeruszka-Bielak, M., Kollajtis-Dolowy, A., Santoro, A., Ostan, R., Berendsen, A. A. M., Jennings, A., Meunier, N., Marseglia, A., Caumon, E., Gillings, R., et al. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00994 · Cited by 110 · see citing works

The role of low-grade inflammation and metabolic flexibility in aging and nutritional modulation thereof: a systems biology approach

Calçada, D., Vianello, D., Giampieri, E., Sala, C., Castellani, G., de Graaf, A., Kremer, B., van Ommen, B., Feskens, E., Santoro, A., et al. (2014) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2014.01.004 · Cited by 97 · see citing works

Nutrition, diet and immunosenescence

Maijó, M., Clements, S. J., Ivory, K., Nicoletti, C., & Carding, S. R. (2014) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2013.12.003 · Cited by 85 · see citing works

Treatment of obesity in older persons—A systematic review

Haywood, C., & Sumithran, P. (2019) · Obesity Reviews · doi:10.1111/obr.12815 · Cited by 84 · see citing works

A parallel randomized trial on the effect of a healthful diet on inflammageing and its consequences in European elderly people: Design of the NU-AGE dietary intervention study

Berendsen, A., Santoro, A., Pini, E., Cevenini, E., Ostan, R., Pietruszka, B., Rolf, K., Cano, N., Caille, A., Lyon-Belgy, N., et al. (2013) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2013.10.002 · Cited by 82 · see citing works

Probiotic Bacteria for Healthier Aging: Immunomodulation and Metabolism of Phytoestrogens

Landete, J. M., Gaya, P., Rodríguez, E., Langa, S., Peirotén, Á., Medina, M., & Arqués, J. L. (2017) · BioMed Research International · doi:10.1155/2017/5939818 · Cited by 76 · see citing works

Small intestinal permeability in older adults

Valentini, L., Ramminger, S., Haas, V., Postrach, E., Werich, M., Fischer, A., Koller, M., Swidsinski, A., Bereswill, S., Lochs, H., et al. (2014) · Physiological Reports · doi:10.1002/phy2.281 · Cited by 73 · see citing works

Interplay of good bacteria and central nervous system: cognitive aspects and mechanistic considerations

Salami, M. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.613120 · Cited by 67 · see citing works

Trends in Natural Nutrients for Oxidative Stress and Cell Senescence

Omidifar, N., moghadami, M., Mousavi, S. M., Hashemi, S. A., Gholami, A., Shokripour, M., & Sohrabi, Z. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/7501424 · Cited by 36 · see citing works

Inflammaging and Cardiovascular Risk in Old Women

Moscucci, F., Baratta, F., Bucciarelli, V., Mattioli, A. V., Pinti, M., Zanini, G., Sciomer, S., Gallina, S., Piccirillo, G., & Desideri, G. (2025) · High Blood Pressure &amp; Cardiovascular Prevention · doi:10.1007/s40292-025-00758-1 · Cited by 8 · see citing works