Ageing and gut microbes: Perspectives for health maintenance and longevity

Biagi, Elena; Candela, Marco; Turroni, Silvia; Garagnani, Paolo; Franceschi, Claudio; Brigidi, Patrizia

doi:10.1016/j.phrs.2012.10.005

Cited by 276Gut microbiota and healthProbiotics and Fermented FoodsMicrobial Metabolites in Food Biotechnology

Ageing and gut microbes: Perspectives for health maintenance and longevity

Biagi, Elena, Candela, Marco, Turroni, Silvia, Garagnani, Paolo, Franceschi, Claudio, Brigidi, Patrizia·2013·Pharmacological Research

DOI 10.1016/j.phrs.2012.10.005

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Abstract

The ageing process affects the human gut microbiota phylogenetic composition and its interaction with the immune system. Age-related gut microbiota modifications are associated with immunosenescence and inflamm-ageing in a sort of self-sustaining loop, which allows the placement of gut microbiota unbalances among both the causes and the effects of the inflamm-ageing process. Even if, up to now, the link between gut microbiota and the ageing process is only partially understood, the gut ecosystem shows the potential to become a promising target for strategies able to contribute to the health status of older people. In this context, the consumption of pro/prebiotics may be useful in both prevention and treatment of age-related pathophysiological conditions, such as recovery and promotion of immune functions, i.e. adjuvant effect for influenza vaccine, and prevention and/or alleviation of common "winter diseases", as well as constipation and Clostridium difficile-associated diarrhoea. Moreover, being involved in different mechanisms which concur in counteracting inflammation, such as down-regulation of inflammation-associated genes and improvement of colonic mucosa conditions, probiotics have the potentiality to be involved in the promotion of longevity.

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The increase with age in pro-inflammatory pathobionts and decrease in immune-modulatory species may promote and sustain inflammatory disorders.
“The increase with age in pro-inflammatory pathobionts and the decrease in immune-modulatory species may promote and sustain inflammatory disorders [86].”
From Evolution of the immune system in humans from infancy to old age (2015) · cites this paper as [86]
Reduced bacterial diversity in the gut has been correlated with Clostridium difficile-associated diarrhoea, a major complication for the elderly in hospitals.
“Thus reduced bacterial diversity in the gut has been correlated with Clostridium difficile-associated diarrhoea, a major complication for the elderly in hospitals [86].”
From Evolution of the immune system in humans from infancy to old age (2015) · cites this paper as [86]

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Human intestinal microbiota: cross-talk with the host and its potential role in colorectal cancer
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Oral supplementation with Lactobacillus delbrueckii subsp. bulgaricus 8481 enhances systemic immunity in elderly subjects
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Probiotics modulate the Bifidobacterium microbiota of elderly nursing home residents
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Contribution of the Intestinal Microbiota to Human Health: From Birth to 100 Years of Age
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The biology of aging: 1985–2010 and beyond
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Lactobacillus plantarum CECT7315 and CECT7316 stimulate immunoglobulin production after influenza vaccination in elderly.
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Consumption of Bifidobacterium lactis LKM512 yogurt reduces gut mutagenicity by increasing gut polyamine contents in healthy adult subjects
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Gut microbiota as a candidate for lifespan extension: an ecological/evolutionary perspective targeted on living organisms as metaorganisms
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Oral administration of live Bifidobacterium substrains isolated from healthy centenarians enhanced immune function in BALB/c mice
Yang, H., Liu, S., Ibrahim, S. A., Zhao, L., Jiang, J., Sun, W.-F., & Ren, F. (2009) · Nutrition Research · doi:10.1016/j.nutres.2009.03.010 · Cited by 71 · see citing works
Gut microbiota of healthy elderly NSAID users is selectively modified with the administration of Lactobacillus acidophilus NCFM and lactitol
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Clostridium Difficile Infection in Older Adults: A Review and Update on Its Management
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Immunosenescence and Anti-Immunosenescence Therapies: The Case of Probiotics
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Drug metabolome of the Simvastatin formed by human intestinal microbiota in vitro
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Dynamics of fecal microbiota in hospitalized elderly fed probiotic LKM512 yogurt
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Efficacy of Lactic Acid Bacteria (LAB) supplement in management of constipation among nursing home residents
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Statin therapy and the elderly: SAGE advice?
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Probiotics-induced increase of large intestinal luminal polyamine concentration may promote longevity
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Sorted by citations

Introduction to the human gut microbiota
Thursby, E., & Juge, N. (2017) · Biochemical Journal · doi:10.1042/bcj20160510 · Cited by 3,600 · see citing works
Evolution of the immune system in humans from infancy to old age
Simon, A. K., Hollander, G. A., & McMichael, A. (2015) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2014.3085 · Cited by 1,796 · see citing works
“The increase with age in pro-inflammatory pathobionts and the decrease in immune-modulatory species may promote and sustain inflammatory disorders [86].”
Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism
Gao, J., Xu, K., Liu, H., Liu, G., Bai, M., Peng, C., Li, T., & Yin, Y. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00013 · Cited by 1,313 · see citing works
“Changes in microbiota composition are connected to immunosenescence and inflammation in older individuals (Franceschi et al., 2000; Biagi et al., 2013; Cheng et al., 2013).”
Background
Microbiota and neurodevelopmental windows: implications for brain disorders
Borre, Y. E., O’Keeffe, G. W., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2014) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.05.002 · Cited by 1,089 · see citing works
The neuropharmacology of butyrate: the bread and butter of the microbiota-gut-brain axis
Stilling, R. M., van de Wouw, M., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.06.011 · Cited by 891 · see citing works
Immunity in Drosophila melanogaster — from microbial recognition to whole-organism physiology
Buchon, N. S., Silverman, N. S., & Cherry, S. R. (2014) · Nature reviews. Immunology · doi:10.1038/nri3763 · Cited by 868 · see citing works
Gut microbes from the phylogenetically diverse genus Eubacterium and their various contributions to gut health
Mukherjee, A., Lordan, C., Ross, R. P., & Cotter, P. D. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1802866 · Cited by 703 · see citing works
Gut microbiome and aging: physiological and mechanistic insights
Nagpal, R., Mainali, R., Ahmadi, S., Wang, S., Singh, R., Kavanagh, K., Kitzman, D. W., Kushugulova, A., Marotta, F., & Yadav, H. (2018) · Nutrition and Healthy Aging · doi:10.3233/nha-170030 · Cited by 670 · see citing works
“717 Since prebiotics are ‘favorite’ foods for probiotics, 718 combining them as “synbiotics” for preventive as 719 well as therapeutic health effects could be envis720 aged for better gut and overall health [46, 163].”
Background
Immunosenescence and inflammaging in the aging process: age-related diseases or longevity?
Santoro, A., Bientinesi, E., & Monti, D. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101422 · Cited by 603 · see citing works
Nutrition, immunity and COVID-19
Calder, P. C. (2020) · BMJ Nutrition Prevention & Health · doi:10.1136/bmjnph-2020-000085 · Cited by 587 · see citing works
The Interplay between the Gut Microbiome and the Immune System in the Context of Infectious Diseases throughout Life and the Role of Nutrition in Optimizing Treatment Strategies
Wiertsema, S. P., van Bergenhenegouwen, J., Garssen, J., & Knippels, L. M. J. (2021) · Nutrients · doi:10.3390/nu13030886 · Cited by 558 · see citing works
“Especially in elderly care facilities, where infections spread easily among residents, preventing infections is crucial [35].”
Background
Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the role of nutrition
Calder, P. C., Bosco, N., Bourdet‐Sicard, R., Capuron, L., Delzenne, N. M., Dore, J. M., Franceschi, C., Lehtinen, M. J., Recker, T., Salvioli, S., et al. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.09.001 · Cited by 498 · see citing works
“…of gut microbiota composition among elderly with a concomitant reduced biodiversity and compromised stability, with an increase in pathobionts and a decrease in healthy promoting bacteria such as bifidobacteria (Arboleya et al., 2016; Biagi et al., 2013, 2010; O’Toole and Jeffery, 2015).”
Self-citation
Can physical activity ameliorate immunosenescence and thereby reduce age-related multi-morbidity?
Duggal, N. A., Niemiro, G., Harridge, S. D. R., Simpson, R. J., & Lord, J. M. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-019-0177-9 · Cited by 436 · see citing works
Immunology of aging: the birth of inflammaging
Fulop, T., Larbi, A., Pawelec, G., Khalil, A., Cohen, A. A., Hirokawa, K., Witkowski, J. M., & Franceschi, C. (2021) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-021-08899-6 · Cited by 464 · see citing works
Self-citation
PGRP-SC2 Promotes Gut Immune Homeostasis to Limit Commensal Dysbiosis and Extend Lifespan
Guo, L., Karpac, J., Tran, S. L., & Jasper, H. (2014) · Cell · doi:10.1016/j.cell.2013.12.018 · Cited by 463 · see citing works
“, 2011, 2012) indicate that such interventions may be able to also allay age-related pathologies and increase health and lifespan in humans (Biagi et al., 2013; Ottaviani et al., 2011).”
Vaccination in the elderly: The challenge of immune changes with aging
Ciabattini, A., Nardini, C., Santoro, F., Garagnani, P., Franceschi, C., & Medaglini, D. (2018) · Seminars in Immunology · doi:10.1016/j.smim.2018.10.010 · Cited by 411 · see citing works
Self-citation
The aging gut microbiome and its impact on host immunity
Bosco, N., & Noti, M. (2021) · Genes and Immunity · doi:10.1038/s41435-021-00126-8 · Cited by 418 · see citing works
Application of metagenomics in the human gut microbiome
Wang, W., Xu, S., Ren, Z., Tao, L., Jiang, J., & Zheng, S. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i3.803 · Cited by 400 · see citing works
Functional metagenomic profiling of intestinal microbiome in extreme ageing
Rampelli, S., Candela, M., Turroni, S., Biagi, E., Collino, S., Franceschi, C., O'Toole, P. W., & Brigidi, P. (2013) · Aging · doi:10.18632/aging.100623 · Cited by 359 · see citing works
“Pathobionts are minor microbiota opportunists able to thrive in inflamed conditions, sustaining and nurturing the physiological inflammation [14].”
BackgroundSelf-citation
Alzheimer’s disease and gut microbiota
Hu, X., Wang, T., & Jin, F. (2016) · Science China Life Sciences · doi:10.1007/s11427-016-5083-9 · Cited by 371 · see citing works
Inflammaging decreases adaptive and innate immune responses in mice and humans
Frasca, D., & Blomberg, B. B. (2016) · Biogerontology · doi:10.1007/s10522-015-9578-8 · Cited by 357 · see citing works
“This altered microbiota composition is associated with increased serum levels of pro-inflammatory mediators such as IL-6 and IL-8 (Biagi et al. 2013, 2010).”
Gut microbiota and aging
Ling, Z., Liu, X., Cheng, Y., Yan, X., & Wu, S. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1867054 · Cited by 366 · see citing works
“Recent studies suggested that maintenance of a “youthful” or “healthy” gut microbiota architecture during aging may delay or limit immunosenescence (Biagi et al. 2013).”
Background
The integration of inflammaging in age-related diseases
Fülöp, T., Witkowski, J. M., Olivieri, F., & Larbi, A. (2018) · Seminars in Immunology · doi:10.1016/j.smim.2018.09.003 · Cited by 356 · see citing works
Understanding the gastrointestinal tract of the elderly to develop dietary solutions that prevent malnutrition
Rémond, D., Shahar, D., Gille, D., Pinto, P., Kachal, J., Peyron, M., dos Santos, C. D., Walther, B., Bordoni, A., Dupont, D., et al. (2015) · OncoTarget · doi:10.18632/oncotarget.4030 · Cited by 299 · see citing works
“A reduced biodiversity and compromised stability of the intestinal microbiota is often observed in elderly when compared to younger subjects [148].”
Background
Nonalcoholic fatty liver disease and aging: Epidemiology to management
Bertolotti, M. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i39.14185 · Cited by 309 · see citing works
Nutrition and the gut microbiome in the elderly
Salazar, N., Valdés-Varela, L., González, S., Gueimonde, M., & de los Reyes-Gavilán, C. G. (2017) · Gut Microbes · doi:10.1080/19490976.2016.1256525 · Cited by 282 · see citing works
African fermented foods and probiotics
Franz, C. M. A. P., Huch, M., Mathara, J. M., Abriouel, H., Benomar, N., Reid, G., Gálvez, A., & Holzapfel, W. H. (2014) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2014.08.033 · Cited by 265 · see citing works
“…are showing, these organisms are integral to all aspects of human and animal development, longevity and ultimate survival (de Vos and de Vos, 2012; Hughes, 2012; Trivedi, 2012; Biagi et al., 2013; de Vos and Nieuwdorp, 2013; Fang and Evans, 2013; Loscalzo, 2013; Pennisi, 2013; Reid et al., 2013b).”
Background
Post-COVID-19 acute sarcopenia: physiopathology and management
Piotrowicz, K., Gąsowski, J., Michel, J., & Veronese, N. (2021) · Aging Clinical and Experimental Research · doi:10.1007/s40520-021-01942-8 · Cited by 251 · see citing works
Alzheimer’s disease and gut microbiota modifications: The long way between preclinical studies and clinical evidence
Mancuso, C., & Santangelo, R. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2017.12.009 · Cited by 232 · see citing works
“Indeed, a marked ncrease in Bacteroidetes has been described in the Irish elderly opulation, whereas the presence of this phylum remains quite onstant in the Italian elderly [43,53].”
Background
Human Inflammaging
Fülöp, T., Larbi, A., & Witkowski, J. M. (2019) · Gerontology · doi:10.1159/000497375 · Cited by 221 · see citing works
Revisiting Metchnikoff: Age-related alterations in microbiota-gut-brain axis in the mouse
Scott, K. A., Ida, M., Peterson, V. L., Prenderville, J. A., Moloney, G. M., Izumo, T., Murphy, K., Murphy, A., Ross, R. P., Stanton, C., et al. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.02.004 · Cited by 202 · see citing works
“Furthermore, the composition of the gut microbiota in both humans and laboratory animals varies across the lifespan (Rehman 2012, Biagi et al. 2013, Jeffery and O'Toole 2013, Langille et al. 2014, Lynch et al. 2015).”
The subgingival periodontal microbiota of the aging mouth
Feres, M., Teles, F., Teles, R. P., Figueiredo, L. C., & Faveri, M. (2016) · Periodontology 2000 · doi:10.1111/prd.12136 · Cited by 202 · see citing works
“There is growing evidence that the low-grade, chronic, systemic inflammation observed in aging (inflammaging) is an important risk factor for both morbidity and mortality in the elderly people (30), and inflammaging may be potentiated by products produced by the microbial communities existent in the human body, such a…”
Background
Age-Associated Changes in the Immune System and Blood–Brain Barrier Functions
Erickson, M. A., & Banks, W. A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071632 · Cited by 192 · see citing works
“For example, dietary changes may occur upon new residence in assisted living institutions [16].”
BackgroundResultInfluential
Human gut microbiota and healthy aging: Recent developments and future prospective
Kumar, M., Babaei, P., Ji, B., & Nielsen, J. (2016) · Nutrition and Healthy Aging · doi:10.3233/nha-150002 · Cited by 201 · see citing works
“[63] Biagi E, Candela M, Turroni S, Garagnani P, Franceschi C, Brigidi P.”
Background
Microbiota and Lifestyle: A Special Focus on Diet
Redondo-Useros, N., Nova, E., González-Zancada, N., Díaz, L. E., Gómez-Martínez, S., & Marcos, A. (2020) · Nutrients · doi:10.3390/nu12061776 · Cited by 189 · see citing works
Short Chain Fatty Acid Metabolism in Relation to Gut Microbiota and Genetic Variability
Meyers, G. R., Samouda, H., & Bohn, T. (2022) · Nutrients · doi:10.3390/nu14245361 · Cited by 193 · see citing works
ACE2 imbalance as a key player for the poor outcomes in COVID-19 patients with age-related comorbidities – Role of gut microbiota dysbiosis
Viana, S., Nunes, S., & Reis, F. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101123 · Cited by 193 · see citing works
Gut Dysbiosis and Muscle Aging: Searching for Novel Targets against Sarcopenia
Picca, A., Fanelli, F., Calvani, R., Mulè, G., Pesce, V., Sisto, A., Pantanelli, C., Bernabei, R., Landi, F., & Marzetti, E. (2018) · Mediators of Inflammation · doi:10.1155/2018/7026198 · Cited by 181 · see citing works
“These findings might explain, at least in part, why probiotics have been successfully implemented as strategies to treat respiratory and gastrointestinal infections and enhance responses to vaccinations in older people [106].”
Background
Gut bacteria Akkermansia is associated with reduced risk of obesity: evidence from the American Gut Project
Zhou, Q., Zhang, Y., Wang, X., Yang, R., Zhu, X., Zhang, Y., Chen, C., Yuan, H., Yang, Z., & Sun, L. (2020) · Nutrition & Metabolism · doi:10.1186/s12986-020-00516-1 · Cited by 175 · see citing works
“Many common factors such as age, sex, geography and ethnic origins shaped the gut microbiota [13, 20, 21], and were closely related to obesity.”
Background
Age-Associated Loss of Lamin-B Leads to Systemic Inflammation and Gut Hyperplasia
Chen, H., Zheng, X., & Zheng, Y. (2014) · Cell · doi:10.1016/j.cell.2014.10.028 · Cited by 168 · see citing works
“Interestingly, microbiota changes also occur in aging human intestine and have been linked to altered intestinal inflammatory states and diseases (Biagi et al., 2013; Cheng et al., 2013; Guinane and Cotter, 2013; Hopkins et al., 2002; Lozupone et al., 2012).”
The gut microbiota of centenarians: Signatures of longevity in the gut microbiota profile
Biagi, E., Rampelli, S., Turroni, S., Quercia, S., Candela, M., & Brigidi, P. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.12.013 · Cited by 166 · see citing works
Self-citation
The Role of the Gut Microbiota in the Pathogenesis of Parkinson's Disease
Yang, D., Zhao, D., Ali Shah, S. Z., Wu, W., Lai, M., Zhang, X., Li, J., Guan, Z., Zhao, H., Li, W., et al. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.01155 · Cited by 162 · see citing works
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Mediterranean diet and inflammaging within the hormesis paradigm
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Self-citation
Microbiota and aging
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Mechanisms of lung aging
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Role of the Microbiota in the Modulation of Vaccine Immune Responses
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Parkinson’s Disease: The Emerging Role of Gut Dysbiosis, Antibiotics, Probiotics, and Fecal Microbiota Transplantation
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“with higher levels of inflammatory mediators such as IL-6 and IL8.(78) Therefore it follows, altered gut microbiota in elderly may play a role in pathogenesis of PD via inflammaging.”
Background
Impact of personalized diet and probiotic supplementation on inflammation, nutritional parameters and intestinal microbiota – The “RISTOMED project”: Randomized controlled trial in healthy older people
Valentini, L., Pinto, A., Bourdel‐Marchasson, I., Ostan, R., Brigidi, P., Turroni, S., Hrelia, S., Hrelia, P., Bereswill, S., Fischer, A., et al. (2014) · Clinical Nutrition · doi:10.1016/j.clnu.2014.09.023 · Cited by 144 · see citing works
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BackgroundSelf-citation
Antioxidant Status and Gut Microbiota Change in an Aging Mouse Model as Influenced by Exopolysaccharide Produced by Lactobacillus plantarum YW11 Isolated from Tibetan Kefir
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The human intestinal microbiome at extreme ages of life. Dietary intervention as a way to counteract alterations
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“A higher proportion of Bacteroidetes and a reduced stability of the microbial community has been reported in the elderly Irish population, whereas the proportion of Bacteroidetes remains constant in Italian elderly (Biagi et al., 2013).”
Metagenomic Assembly: Overview, Challenges and Applications.
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“Major alterations are represented by [15]:”
Salivary nitrite production is elevated in individuals with a higher abundance of oral nitrate-reducing bacteria
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“Some microbes live 74 in symbiosis with their host and can significantly contribute to health [23], [24].”
Background
From lifetime to evolution: timescales of human gut microbiota adaptation
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BackgroundInfluentialSelf-citation
Colonic Transit Time Is a Driven Force of the Gut Microbiota Composition and Metabolism: In Vitro Evidence
Tottey, W., Feria-Gervasio, D., Gaci, N., Laillet, B., Pujos, E., Martin, J.-F., Sebedio, J.-L., Sion, B., Jarrige, J.-F., Alric, M., et al. (2017) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm16042 · Cited by 125 · see citing works
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“For example, with aging, the abundance and diversity of bifidobacteria decline (57), while bacteria including streptococci, staphylococci, enterococci, and enterobacteria increase (58).”
The Gut-Brain Axis: Two Ways Signaling in Parkinson’s Disease
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Method
Comparative analysis of the gut microbiota in centenarians and young adults shows a common signature across genotypically non-related populations
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Microbiomes other than the gut: inflammaging and age-related diseases
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“It has been proposed that the increase of pathobionts can be promoted by the low-grade inflammatory status at the level of the intestinal mucosa, which is part of the general process of inflammaging that accompanies the age advancement [44, 45].”
BackgroundSelf-citation
The nursing home elder microbiome stability and associations with age, frailty, nutrition and physical location
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Flexibility of Gut Microbiota in Ageing Individuals during Dietary Fiber Long‐Chain Inulin Intake
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Reduced microbial diversity in adult survivors of childhood acute lymphoblastic leukemia and microbial associations with increased immune activation
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Precision nutrition and the microbiome part II: potential opportunities and pathways to commercialisation
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“In Part I of this review we discussed the elderly (> 65 years) microbiota which is generally characterised by a reduction in microbial diversity, a decrease in species associated with short chain fatty acid (SCFA) production, especially butyrate, an increase in opportunistic pathogens [95,96] and even greater inter-in…”
Background
A comparison of intestinal integrity, digestive function, and egg quality in laying hens with different ages
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Bladder cancer, inflammageing and microbiomes
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“This stability is maintained until older age (> 65), when the microbiome stability and function beings to decline (10, 11).”
Background
Maintenance of a healthy trajectory of the intestinal microbiome during aging: A dietary approach
Candela, M., Biagi, E., Brigidi, P., O’Toole, P. W., & de Vos, W. M. (2013) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2013.12.004 · Cited by 85 · see citing works
“This enario, in the context of the growing perception of the strategic le of the IM for human health and wellbeing, imposes the eservation of the IM-host mutualistic interaction along human ing as a paradigm of a healthy aging (Biagi et al., 2013).”
BackgroundInfluentialSelf-citation
Effect of prebiotics on the fecal microbiota of elderly volunteers after dietary supplementation of Bacillus coagulans GBI-30, 6086
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Is inflammageing influenced by the microbiota in the aged gut? A systematic review
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“However, several studies have reported major alterations in immune responses of the aged gut in both humans and non-human animal models (Dicarlo et al., 2009; Biagi et al., 2013; Larbi et al., 2008; Simioni et al., 2007).”
Background
Nutrition and Healthy Aging: Prevention and Treatment of Gastrointestinal Diseases
Cristina, N. M., & D’Alba, L. (2021) · Nutrients · doi:10.3390/nu13124337 · Cited by 77 · see citing works
Design and Investigation of PolyFermS In Vitro Continuous Fermentation Models Inoculated with Immobilized Fecal Microbiota Mimicking the Elderly Colon
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Dysbiosis of gut microbiota in inflammatory bowel disease: Current therapies and potential for microbiota-modulating therapeutic approaches
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“Since there is a large body of evidence suggesting that SCFAs play a major role in metabolic activities and act as immune mediators, alterations in microbiota may explain the observed increase in inflammatory-ageing that occurs in the GI tract of elderly individuals [27].”
Background
Primate microbiomes over time: Longitudinal answers to standing questions in microbiome research
Björk, J. R., Dasari, M. R., Grieneisen, L., & Archie, E. A. (2019) · American Journal of Primatology · doi:10.1002/ajp.22970 · Cited by 74 · see citing works
“Similarly, while the prevailing view is that gut microbial diversity declines in old age (Biagi et al., 2013; Voreades, Kozil, & Weir, 2014), several recent studies find that diversity either does not change or increases in the elderly compared with younger adults (Biagi et al., 2016; Bian et al.,…”
Age-Related Hearing Loss: The Link between Inflammaging, Immunosenescence, and Gut Dysbiosis
Kociszewska, D., & Vlajkovic, S. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137348 · Cited by 77 · see citing works
“However, the elderly have a diminished population of Firmicutes and atypical Bacteriodetes/Firmicutes ratios [155] with a predominant population of Bacteriodetes [156].”
BackgroundInfluential
Gut Microbiome in Down Syndrome
Biagi, E., Candela, M., Centanni, M., Consolandi, C., Rampelli, S., Turroni, S., Severgnini, M., Peano, C., Ghezzo, A., Scurti, M., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112023 · Cited by 66 · see citing works
Self-citation
Metagenomics Study Reveals Changes in Gut Microbiota in Centenarians: A Cohort Study of Hainan Centenarians
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Caenorhabditis Elegans and Probiotics Interactions from a Prolongevity Perspective
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“In the context of ageing, several physiological changes affecting the immune and digestive systems as well as gut microbiota composition lead to a physiological low-grade inflammatory status called, “inflammageing” [18,19], which can be potentially counteracted by probiotic interventions [20].”
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Harnessing the Microbiome to Enhance Cancer Immunotherapy
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Achieving healthy aging through gut microbiota-directed dietary intervention: Focusing on microbial biomarkers and host mechanisms
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Gut microbiota modulation and implications for host health: Dietary strategies to influence the gut–brain axis
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“, 2011), yet the biodiversity is reduced and the stability compromised (Biagi et al., 2013).”
BackgroundInfluential
Interplay of good bacteria and central nervous system: cognitive aspects and mechanistic considerations
Salami, M. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.613120 · Cited by 67 · see citing works
“(2013). Commensal microbiota modulate murine behaviors in a strictly contamination-free environment confirmed by culture-based methods.”
BackgroundInfluential
The Effect of Bifidobacterium animalis ssp. lactis HN019 on Cellular Immune Function in Healthy Elderly Subjects: Systematic Review and Meta-Analysis
Miller, L. E., Lehtoranta, L., & Lehtinen, M. J. (2017) · Nutrients · doi:10.3390/nu9030191 · Cited by 64 · see citing works
“As intestinal bifidobacteria count decreases with age [12,14], it is noteworthy that two different bifidobacteria strains Bi-07 and HN019 were efficacious whereas the lactobacillus strain was not, however, the data is very limited to make any conclusions on the differences in the efficacy on the genera level.”
Background
Modulation of gut microbiota and delayed immunosenescence as a result of syringaresinol consumption in middle-aged mice
Cho, S., Kim, J., Lee, J. H., Sim, J. H., Cho, D.-H., Bae, I., Lee, H., Seol, M. A., Shin, H. M., Kim, T.-J., et al. (2016) · Scientific Reports · doi:10.1038/srep39026 · Cited by 63 · see citing works
A Comprehensive Evaluation of the Impact of Bovine Milk Containing Different Beta-Casein Profiles on Gut Health of Ageing Mice
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“Concerning discriminant families, Enterobacteriaceae and Enterococcaceae were scored in the CTRL group: these families were previously correlated with ageing and increased serum level of pro-inflammatory cytokines [18] and include several genera and species representing opportunistic pathogens, such as Enterococcus fa…”
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Preventing or Reversing Immunosenescence: Can Exercise be an Immunotherapy?
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The Role of the Gastrointestinal Microbiota in Visceral Pain
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“140 In the past decade, a large number of age ‐ related changes in gut microbiota has been noted, 141,142 and these modifications were associated with the interactions between the gut immune system and microbiota.”
Background
Gut Microbiota and Aging
Kashtanova, D. A., Tkacheva, O. N., Strazhesko, I. D., Dudinskaya, Е. N., Kotovskaya, Y. V., Popenko, A., Tyakht, A., & Alexeev, D. G. (2019) · Healthy ageing and longevity · doi:10.1007/978-3-030-24970-0_17 · Cited by 59 · see citing works
Long-term intake of Lactobacillus paracasei KW3110 prevents age-related chronic inflammation and retinal cell loss in physiologically aged mice
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Polyphenols, the new frontiers of prebiotics
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Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection in the Elderly: Long-Term Outcomes and Microbiota Changes
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Impact of human aging and modern lifestyle on gut microbiota
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“Scientific literature reviews have detailed the therapeutic effects of probiotics, prebiotics and their combination (symbiotics) (Toward et al., 2012; Biagi et al., 2013; Lakshminarayanan et al., 2014).”
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Frailty Status in Older Adults Is Related to Alterations in Indoleamine 2,3-Dioxygenase 1 and Guanosine Triphosphate Cyclohydrolase I Enzymatic Pathways.
Marcos-Pérez, D., Sánchez-Flores, M., Maseda, A., Lorenzo-López, L., Millán-Calenti, J., Strasser, B., Gostner, J., Fuchs, D., Pásaro, E., Valdiglesias, V., et al. (2017) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2017.06.021 · Cited by 46 · see citing works
Gut Microbiota Approach—A New Strategy to Treat Parkinson’s Disease
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Acute Sarcopenia: Mechanisms and Management
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Insights into bread melanoidins: fate in the upper digestive tract and impact on the gut microbiota using in vitro systems
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Ageing of the Gut Microbiome and Its Potential Contribution Towards Immunesenescence and Inflammaging
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Can probiotics and prebiotics contribute to healthy ageing?
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Authors: Biagi, E., Candela, M., Turroni, S., Garagnani, P., Franceschi, C., & Brigidi, P.
Affiliations: University of Bologna (IT)
Corresponding author: Brigidi, Patrizia
ORCID: Biagi, Elena
Candela, Marco
Turroni, Silvia
Garagnani, Paolo
Franceschi, Claudio
Brigidi, Patrizia
Venue: Pharmacological Research
Publisher: Elsevier BV
Published: 2013-03
Volume: 69
Issue: 1
Pages: 11-20
ISSN: 1043-6618 (ISSN-L)
DOI: 10.1016/j.phrs.2012.10.005
OpenAlex: W2009128230
Cited by: 276
References: 123
Citations by year: 2026: 11 · 2025: 18 · 2024: 24 · 2023: 9 · 2022: 16 · 2021: 24 · 2020: 27 · 2019: 26 · 2018: 20 · 2017: 26 · 2016: 27 · 2015: 18 · 2014: 22 · 2013: 8
FWCI: 1.40
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Pharmacological Research (publishedVersion)
PubMed (publishedVersion)
Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Keywords: gut microbiota, aging, immunosenescence, longevity, probiotics, prebiotics, older adults, influenza vaccine adjuvants, winter diseases, constipation, Clostridium difficile-associated diarrhea, colonic mucosa, inflammation
MeSH terms: Aging, Animals, Health Status, Humans, Longevity, Gastrointestinal Tract, Metagenome

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Ageing and gut microbes: Perspectives for health maintenance and longevity

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