A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages
Abstract
SIR2 genes control life span in model organisms, playing a central role in evolutionarily conserved pathways of aging and longevity. We wanted to verify whether similar effects may act in humans too. First, we searched for variability in the human sirtuin 3 gene (SIRT3) and discovered a VNTR polymorphism (72-bp repeat core) in intron 5. The alleles differed both for the number of repeats and for presence/absence of potential regulatory sites. Second, by transient transfection experiments, we demonstrated that the VNTR region has an allele-specific enhancer activity. Third, by analyzing allele frequencies as a function of age in a sample of 945 individuals (20-106 years), we found that the allele completely lacking enhancer activity is virtually absent in males older than 90 years. Thus the underexpression of a human sirtuin gene seems to be detrimental for longevity as it occurs in model organisms.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The tumor suppressing contributions of SirT3 could partially explain why a polymorphism in intron 5 of human SirT3 associated with higher SirT3 expression is associated with increased longevity.
“The tumor suppressing contributions of SirT3 could partially explain why a polymorphism in a variable number tandem repeat regions within intron 5 of the human SirT3 gene, which results in higher than normal expression of SirT3, is associated with increased longevity in humans (Rose et al., 2003; Bellizzi et al., 2005).”
From SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production (2011) · cites this paper as Bellizzi et al., 2005
Cites
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
Imai, S.-I., Armstrong, C. M., Kaeberlein, M., & Guarente, L. (2000) · Nature · doi:10.1038/35001622 · Cited by 3,510 · see citing works
hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase
Vaziri, H., Dessain, S. K., Eaton, E. N., Imai, S., Frye, R. A., Pandita, T. K., Guarente, L., & Weinberg, R. A. (2001) · Cell · doi:10.1016/s0092-8674(01)00527-x · Cited by 2,653 · see citing works
Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
Murphy, C. T., McCarroll, S. A., Bargmann, C. I., Fraser, A., Kamath, R. S., Ahringer, J., Li, H., & Kenyon, C. (2003) · Nature · doi:10.1038/nature01789 · Cited by 2,280 · see citing works
Kaeberlein, M., McVey, M., & Guarente, L. (1999) · Genes & Development · doi:10.1101/gad.13.19.2570 · Cited by 2,253 · cited 1× · see citing works
“In model organisms the expression levels of SIR2 modulate life span [9–11].”
BackgroundNegative Control of p53 by Sir2α Promotes Cell Survival under Stress
Luo, J., Nikolaev, A. Y., Imai, S.-I., Chen, D., Su, F., Shiloh, A., Guarente, L., & Gu, W. (2001) · Cell · doi:10.1016/s0092-8674(01)00524-4 · Cited by 2,081 · see citing works
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
Tissenbaum, H. A., & Guarente, L. (2001) · Nature · doi:10.1038/35065638 · Cited by 1,918 · see citing works
Genetic pathways that regulate ageing in model organisms
Guarente, L., & Kenyon, C. J. (2000) · Nature · doi:10.1038/35041700 · Cited by 1,337 · see citing works
Use of Unlinked Genetic Markers to Detect Population Stratification in Association Studies
Pritchard, J. K., & Rosenberg, N. A. (1999) · The American Journal of Human Genetics · doi:10.1086/302449 · Cited by 1,198 · see citing works
Frye, R. A. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0897 · Cited by 809 · see citing works
Sir2 links chromatin silencing, metabolism, and agingPreprint
Guarente, L. (2000) · Genes & Development · doi:10.1101/gad.14.9.1021 · Cited by 718 · see citing works
Smith, J. S., Brachmann, C. B., Celic, I., Kenna, M. A., Muhammad, S., Starai, V. J., Avalos, J. L., Escalante-Semerena, J. C., Grubmeyer, C., Wolberger, C., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.12.6658 · Cited by 718 · see citing works
Schwer, B., North, B. J., Frye, R. A., Ott, M., & Verdin, E. M. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200205057 · Cited by 599 · see citing works
The GATA family (vertebrates and invertebrates)
Patient, R. K., & McGhee, J. D. (2002) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(02)00319-2 · Cited by 597 · see citing works
SIRT3, a human SIR2 homologue, is an NAD- dependent deacetylase localized to mitochondria
Onyango, P. O., Celic, I., McCaffery, J. M., Boeke, J. D., & Feinberg, A. P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.222538099 · Cited by 573 · see citing works
Mechanisms of aging: public or private?
Partridge, L., & Gems, D. (2002) · Nature Reviews Genetics · doi:10.1038/nrg753 · Cited by 510 · see citing works
Barbieri, M., Bonafè, M., Franceschi, C., & Paolisso, G. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00296.2003 · Cited by 456 · see citing works
Self-citationRose, G., Dato, S., Altomare, K., Bellizzi, D., Garasto, S., Greco, V, Passarino, G., Feraco, E., Mari, V, Barbi, C., et al. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(03)00209-2 · Cited by 282 · see citing works
Self-citationRemacle, J., Kraft, H., Lerchner, W., Wuytens, G., Collart, C., Verschueren, K., Smith, J. C., & Huylebroeck, D. (1999) · The EMBO Journal · doi:10.1093/emboj/18.18.5073 · Cited by 276 · see citing works
Do men and women follow different trajectories to reach extreme longevity?
Franceschi, C., Motta, L., Valensin, S., Rapisarda, R., Franzone, A., Berardelli, M., Motta, M., Monti, D., Bonafè, M., Ferrucci, L., et al. (2000) · Aging Clinical and Experimental Research · doi:10.1007/bf03339894 · Cited by 256 · see citing works
Self-citationIvanova, R. (1998) · Human Molecular Genetics · doi:10.1093/hmg/7.2.187 · Cited by 102 · see citing works
Tan, Q., BENEDICTIS, G. D., Yashin, A. I., Bonafè, M., DeLuca, M., Valensin, S., Vaupel, J. W., & Franceschi, C. (2001) · Biogerontology · doi:10.1023/a:1011557022985 · Cited by 48 · see citing works
Self-citationLuca, M. D., Rose, G., Bonafè, M., Garasto, S., Greco, V., Weir, B. S., Franceschi, C., & BENEDICTIS, G. D. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00146-2 · Cited by 42 · see citing works
Self-citationThe variability of the mitochondrial genome in human aging: a key for life and death?
Rose, G., Passarino, G., Franceschi, C., & BENEDICTIS, G. D. (2002) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(02)00042-0 · Cited by 40 · see citing works
Self-citationPartridge, L., & Gems, D. (2002) · Nature · doi:10.1038/418921a · Cited by 34 · see citing works
Between Scylla and Charybdis: p53 links tumor suppression and aging
Campisi, J. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00006-4 · Cited by 33 · see citing works
Hasty, P. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00294-9 · Cited by 27 · see citing works
Flagged first, then by citations
1 of the 27 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release
Zorov, D. B., Juhaszova, M., & Sollott, S. J. (2014) · Physiological Reviews · doi:10.1152/physrev.00026.2013 · Cited by 5,383 · see citing works
Mammalian Sirtuins: Biological Insights and Disease Relevance
Haigis, M. C., & Sinclair, D. A. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092250 · Cited by 2,085 · see citing works
Sirtuins in mammals: insights into their biological function
Michán, S., & Sinclair, D. A. (2007) · Biochemical Journal · doi:10.1042/bj20070140 · Cited by 1,719 · see citing works
Mammalian sirtuins—emerging roles in physiology, aging, and calorie restriction
Haigis, M. C., & Guarente, L. P. (2006) · Genes & Development · doi:10.1101/gad.1467506 · Cited by 1,295 · see citing works
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation
Lombard, D. B., Alt, F. W., Cheng, H.-L., Bunkenborg, J., Streeper, R. S., Mostoslavsky, R., Kim, J., Yancopoulos, G., Valenzuela, D., Murphy, A., et al. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01636-07 · Cited by 1,216 · see citing works
Sundaresan, N. R., Gupta, M., Gene, K., Rajamohan, S. B., Isbatan, A., & Gupta, M. P. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39162 · Cited by 996 · see citing works
The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways
Houtkooper, R. H., Cantó, C., Wanders, R. J., & Auwerx, J. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0026 · Cited by 899 · see citing works
Physiological and pathological cardiac hypertrophy
Shimizu, I., & Minamino, T. (2016) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2016.06.001 · Cited by 892 · see citing works
Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases
Hallows, W. C., Lee, S., & Denu, J. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604392103 · Cited by 792 · see citing works
Redox regulation of FoxO transcription factors
Klotz, L.-O., Sánchez-Ramos, C., Prieto-Arroyo, I., Urbánek, P., Steinbrenner, H., & Monsalve, M. (2015) · Redox Biology · doi:10.1016/j.redox.2015.06.019 · Cited by 747 · see citing works
Kong, X., Wang, R., Xue, Y., Liu, X., Zhang, H., Chen, Y., Fang, F., & Chang, Y. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011707 · Cited by 718 · see citing works
Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism
Nogueiras, R., Habegger, K. M., Chaudhary, N., Finan, B., Banks, A. S., Dietrich, M. O., Horváth, T. L., Sinclair, D. A., Pfluger, P. T., & Tschöp, M. H. (2012) · Physiological Reviews · doi:10.1152/physrev.00022.2011 · Cited by 712 · see citing works
Variable tandem repeats accelerate evolution of coding and regulatory sequences
Gemayel, R., Vinces, M. D., Legendre, M., & Verstrepen, K. J. (2010) · Annual Review of Genetics · doi:10.1146/annurev-genet-072610-155046 · Cited by 633 · see citing works
Sundaresan, N. R., Samant, S. A., Pillai, V. B., Rajamohan, S. B., & Gupta, M. P. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00426-08 · Cited by 542 · see citing works
Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5
Schlicker, C., Gertz, M., Papatheodorou, P., Kachholz, B., Becker, C. F. W., & Steegborn, C. (2008) · Journal of Molecular Biology · doi:10.1016/j.jmb.2008.07.048 · Cited by 531 · see citing works
Soranzo, N., Spector, T. D., Mangino, M., Kuehnel, B., Rendon, A., Teumer, A., Willenborg, C., Wright, B. J., Chen, L., Li, M., et al. (2009) · Nature Genetics · doi:10.1038/ng.467 · Cited by 520 · see citing works
The quest for genetic determinants of human longevity: challenges and insights
Christensen, K., Johnson, T. E., & Vaupel, J. W. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1871 · Cited by 489 · see citing works
Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1α in skeletal muscle
Palacios, O. M., Carmona, J. J., Michan, S., Chen, K. Y., Manabe, Y., III, J. L. W., Goodyear, L. J., & Tong, Q. (2009) · Aging · doi:10.18632/aging.100075 · Cited by 487 · see citing works
Sirtuin Functions in Health and Disease
Yamamoto, H., Schoonjans, K., & Auwerx, J. (2007) · Molecular Endocrinology · doi:10.1210/me.2007-0079 · Cited by 480 · see citing works
Scher, M. B., Vaquero, A., & Reinberg, D. (2007) · Genes & Development · doi:10.1101/gad.1527307 · Cited by 476 · see citing works
Sirtuins, a promising target in slowing down the ageing process
Grabowska, W., Sikora, E., & Bielak-Zmijewska, A. (2017) · Biogerontology · doi:10.1007/s10522-017-9685-9 · Cited by 470 · see citing works
Jing, E., Emanuelli, B., Hirschey, M. D., Boucher, J., Lee, K. Y., Lombard, D., Verdin, E. M., & Kahn, C. R. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1111308108 · Cited by 469 · see citing works
Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3
Pillai, V. B., Samant, S. A., Sundaresan, N. R., Raghuraman, H., Kim, G. H., Bonner, M. Y., Arbiser, J. L., Walker, D. I., Jones, D. P., Gius, D. R., et al. (2015) · Nature Communications · doi:10.1038/ncomms7656 · Cited by 453 · see citing works
SIRT3 Deacetylates and Activates OPA1 To Regulate Mitochondrial Dynamics during Stress
Samant, S. A., Zhang, H. J., Hong, Z., Pillai, V. B., Sundaresan, N. R., Wolfgeher, D., Archer, S. L., Chan, D. C., & Gupta, M. P. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.01483-13 · Cited by 446 · see citing works
Bell, E. L., Emerling, B. M., Ricoult, S. J. H., & Guarente, L. (2011) · Oncogene · doi:10.1038/onc.2011.37 · Cited by 440 · see citing works
Energy intake and exercise as determinants of brain health and vulnerability to injury and disease
Mattson, M. P. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.08.012 · Cited by 434 · see citing works
Pillai, V. B., Sundaresan, N. R., Kim, G. H., Gupta, M., Rajamohan, S. B., Pillai, J. B., Samant, S. A., Ravindra, P. A., Isbatan, A., & Gupta, M. P. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.077271 · Cited by 420 · see citing works
Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction
Hallows, W. C., Yu, W., Smith, B. C., Devires, M. K., Ellinger, J. J., Someya, S., Shortreed, M. R., Prolla, T., Markley, J. L., Smith, L. M., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.01.002 · Cited by 389 · see citing works
Are sirtuins viable targets for improving healthspan and lifespan?
Baur, J. A., Ungvari, Z. I., Minor, R. K., Couteur, D. G. L., & de Cabo, R. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3738 · Cited by 389 · see citing works
Seven sirtuins for seven deadly diseases ofaging
Morris, B. J. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.10.525 · Cited by 380 · see citing works
Dikalova, A., Pandey, A. K., Xiao, L., Arslanbaeva, L. R., Sidorova, T. N., Lopez, M. G., Billings, F. T., Verdin, E. M., Auwerx, J. H., Harrison, D. G., et al. (2019) · Circulation Research · doi:10.1161/circresaha.119.315767 · Cited by 374 · see citing works
Sirtuin activators and inhibitors
Villalba, J. M., & Alcain, F. J. (2012) · BioFactors · doi:10.1002/biof.1032 · Cited by 353 · see citing works
Resveratrol—A boon for treating Alzheimer's disease?
Anekonda, T. S. (2006) · Brain Research Reviews · doi:10.1016/j.brainresrev.2006.04.004 · Cited by 341 · see citing works
Cardiac Aging: From Molecular Mechanisms to Significance in Human Health and Disease
Dai, D.-F., Chen, T., Johnson, S. C., Szeto, H., & Rabinovitch, P. S. (2012) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.4179 · Cited by 334 · see citing works
Forever young: SIRT3 a shield against mitochondrial meltdown, aging, and neurodegeneration
Kincaid, B., & Bossy‐Wetzel, E. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00048 · Cited by 314 · see citing works
Wang, C., Wu, S., Wu, Y., & Wei, Y. (2013) · Experimental Biology and Medicine · doi:10.1177/1535370213493069 · Cited by 315 · see citing works
Ansari, A., Rahman, M. S., Saha, S. K., Saikot, F. K., Deep, A., & Kim, K. (2016) · Aging Cell · doi:10.1111/acel.12538 · Cited by 307 · see citing works
Role of PGC-1α Signaling in Skeletal Muscle Health and Disease
Kang, C., & Li Ji, L. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06738.x · Cited by 291 · see citing works
Sirtuins and Type 2 Diabetes: Role in Inflammation, Oxidative Stress, and Mitochondrial Function
Kitada, M., Ogura, Y., Monno, I., & Koya, D. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00187 · Cited by 289 · see citing works
Sirtuins: guardians of mammalian healthspan
Giblin, W., Skinner, M. E., & Lombard, D. B. (2014) · Trends in Genetics · doi:10.1016/j.tig.2014.04.007 · Cited by 280 · see citing works
Regulation of Akt Signaling by Sirtuins
Pillai, V. B., Sundaresan, N. R., & Gupta, M. P. (2014) · Circulation Research · doi:10.1161/circresaha.113.300536 · Cited by 260 · see citing works
Sirtuins and Their Roles in Brain Aging and Neurodegenerative Disorders
Jęśko, H. M., Wencel, P. L., Strosznajder, R. P., & Strosznajder, J. B. (2016) · Neurochemical Research · doi:10.1007/s11064-016-2110-y · Cited by 262 · see citing works
Sirtuins, Cell Senescence, and Vascular Aging
Kida, Y., & Goligorsky, M. S. (2015) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2015.11.022 · Cited by 255 · see citing works
SIRT3, a pivotal actor in mitochondrial functions: metabolism, cell death and aging
Giralt, A., & Villarroya, F. (2012) · Biochemical Journal · doi:10.1042/bj20120030 · Cited by 253 · see citing works
Mitochondrial sirtuins, metabolism, and aging
Ji, Z., Liu, G., & Qu, J. T. (2021) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2021.11.005 · Cited by 246 · see citing works
The sirtuin family’s role in aging and age-associated pathologies
Hall, J. A., Dominy, J. E., Lee, Y., & Puigserver, P. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64094 · Cited by 235 · see citing works
The SirT3 Divining Rod Points to Oxidative Stress
Bell, E. L., & Guarente, L. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.05.008 · Cited by 232 · see citing works
Sirtuins, epigenetics and longevity
Wątroba, M., Dudek, I., Skoda, M., Stangret, A., Rzodkiewicz, P., & Szukiewicz, D. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.08.001 · Cited by 222 · see citing works
SIRT3 regulates progression and development of diseases of aging
McDonnell, E., Peterson, B. S., Bomze, H. M., & Hirschey, M. D. (2015) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2015.06.001 · Cited by 217 · see citing works
Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer
Alhazzazi, T. Y., Kamarajan, P., Joo, N., Huang, J., Verdin, E., D'Silva, N. J., & Kapila, Y. L. (2011) · Cancer · doi:10.1002/cncr.25676 · Cited by 208 · see citing works
Metabolic networks of longevity
Houtkooper, R. H., Williams, R. W., & Auwerx, J. (2010) · Cell · doi:10.1016/j.cell.2010.06.029 · Cited by 217 · see citing works
Crystal Structures of Human SIRT3 Displaying Substrate-induced Conformational Changes
Jin, L., Wei, W., Jiang, Y., Peng, H., Cai, J., Mao, C., Dai, H., Choy, W., Bemis, J. E., Jirousek, M. R., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.014928 · Cited by 208 · see citing works
Giralt, A., Hondares, E., Villena, J. A., Ribas, F., Díaz-Delfín, J., Giralt, M., Iglesias, R., & Villarroya, F. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.202390 · Cited by 210 · see citing works
Sundaresan, N. R., Bindu, S., Pillai, V. B., Samant, S. A., Pan, Y., Huang, J.-Y., Gupta, M., Nagalingam, R. S., Wolfgeher, D. J., Verdin, E. M., et al. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.00586-15 · Cited by 206 · see citing works
Sirtuins, Aging, and MetabolismPreprint
Guarente, L. (2011) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2011.76.010629 · Cited by 204 · see citing works
Sirtuins' modulation of autophagy
Ng, F., & Tang, B. L. (2013) · Journal of Cellular Physiology · doi:10.1002/jcp.24399 · Cited by 194 · see citing works
Lunetta, K. L., D’Agostino, R. B., Karasik, D., Benjamin, E. J., Guo, C., Govindaraju, R., Kiel, D. P., Kelly‐Hayes, M., Massaro, J. M., Pencina, M. J., et al. (2007) · BMC Medical Genetics · doi:10.1186/1471-2350-8-s1-s13 · Cited by 193 · see citing works
SIRT3 Functions in the Nucleus in the Control of Stress-Related Gene Expression
Iwahara, T., Bonasio, R., Narendra, V. K., & Reinberg, D. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.00822-12 · Cited by 192 · see citing works
Chen, T., Li, J., Liu, J., Li, N., Wang, S., Liu, H., Zeng, M., Zhang, Y., & Bu, P. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00454.2014 · Cited by 178 · see citing works
Human longevity: Genetics or Lifestyle? It takes two to tango
Passarino, G., Rango, F. D., & Montesanto, A. (2016) · Immunity & Ageing · doi:10.1186/s12979-016-0066-z · Cited by 178 · see citing works
Self-citationExercise-induced hormesis and skeletal muscle health
Ji, L. L., Kang, C., & Zhang, Y. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.02.025 · Cited by 176 · see citing works
The role of sirtuins in aging and age-related diseases
Wątroba, M., & Szukiewicz, D. (2015) · Advances in Medical Sciences · doi:10.1016/j.advms.2015.09.003 · Cited by 185 · see citing works
SIRT3 consolidates heterochromatin and counteracts senescence
Diao, Z., Ji, Q., Wu, Z., Zhang, W., Cai, Y., Wang, Z., Hu, J., Liu, Z., Wang, Q., Bi, S., et al. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab161 · Cited by 171 · see citing works
Cardiac ageing: extrinsic and intrinsic factors in cellular renewal and senescence
Gude, N. A., Broughton, K. M., Firouzi, F., & Sussman, M. A. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0061-5 · Cited by 166 · see citing works
Acetylation of Mitochondrial Proteins in the Heart: The Role of SIRT3
Parodi‐Rullán, R. M., Chapa‐Dubocq, X. R., & Javadov, S. A. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01094 · Cited by 168 · see citing works
Where Metabolism Meets Senescence: Focus on Endothelial Cells
Sabbatinelli, J., Prattichizzo, F., Olivieri, F., Procopio, A. D., Rippo, M. R., & Giuliani, A. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01523 · Cited by 168 · see citing works
Sirtuins and their Biological Relevance in Aging and Age-Related Diseases
Zhao, L., Cao, J., Hu, K., He, X., Dou, Y., Tong, T., & Han, L. (2020) · Aging and Disease · doi:10.14336/ad.2019.0820 · Cited by 174 · see citing works
Calorie restriction mimetics: Can you have your cake and eat it, too?
Ingram, D. K., & Roth, G. S. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.11.005 · Cited by 162 · see citing works
NAD<sup>+</sup>metabolism and oxidative stress: the golden nucleotide on a crown of thorns
Massudi, H., Grant, R., Guillemin, G. J., & Braidy, N. (2012) · Redox Report · doi:10.1179/1351000212y.0000000001 · Cited by 158 · see citing works
Mitochondrial SIRT3 and heart disease
Pillai, V. B., Sundaresan, N. R., Jeevanandam, V., & Gupta, M. P. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq250 · Cited by 160 · see citing works
Mitochondrial Sirtuins and Their Relationships with Metabolic Disease and Cancer
Kumar, S., & Lombard, D. B. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.6213 · Cited by 158 · see citing works
Zhang, G., Deng, Y.-J., Xie, Q.-Q., Ren, E., Ma, Z., He, X., Gao, Y., & Kang, X. (2020) · Clinica Chimica Acta · doi:10.1016/j.cca.2020.04.016 · Cited by 157 · see citing works
Bachschmid, M. M., Schildknecht, S., Matsui, R., Zee, R. S., Haeussler, D. J., Cohen, R. A., Pimental, D. R., & van der Loo, B. (2012) · Annals of Medicine · doi:10.3109/07853890.2011.645498 · Cited by 154 · see citing works
Metabolite of SIR2 Reaction Modulates TRPM2 Ion Channel
Grubisha, O., Rafty, L. A., Takanishi, C. L., Xu, X., Tong, L., Perraud, A., Scharenberg, A. M., & Denu, J. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513741200 · Cited by 154 · see citing works
Jin, L., Galonek, H. L., Israelian, K., Choy, W., Morrison, M. C., Xia, Y. X., Wang, X., Xu, Y., Yang, Y., Smith, J. J., et al. (2009) · Protein Science · doi:10.1002/pro.50 · Cited by 153 · see citing works
Neuronal protection by sirtuins in Alzheimer's disease
Anekonda, T. S., & Reddy, P. H. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03492.x · Cited by 150 · see citing works
Mitochondria and aging: A role for the mitochondrial transition pore?
Panel, M., Ghaleh, B., & Morin, D. (2018) · Aging Cell · doi:10.1111/acel.12793 · Cited by 149 · see citing works
Biological and Potential Therapeutic Roles of Sirtuin Deacetylases
Taylor, D. M., Maxwell, M. M., Luthi‐Carter, R., & Kazantsev, A. G. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8357-y · Cited by 147 · see citing works
Mediators of Physical Activity Protection against ROS-Linked Skeletal Muscle Damage
Meo, S. D., Napolitano, G., & Venditti, P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20123024 · Cited by 146 · see citing works
Human-specific tandem repeat expansion and differential gene expression during primate evolution
Sulovari, A., Li, R., Audano, P. A., Porubskỳ, D., Vollger, M. R., Logsdon, G. A., Warren, W. C., Pollen, A. A., Chaisson, M., Eichler, E. E., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1912175116 · Cited by 131 · see citing works
Angiotensin II blockade: a strategy to slow ageing by protecting mitochondria?
de Cavanagh, E. M. V., Inserra, F., & Ferder, L. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq285 · Cited by 136 · see citing works
Zeng, H., Vaka, V. R., He, X., Booz, G. W., & Chen, J. (2015) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12556 · Cited by 129 · see citing works
Chen, T., Liu, J., Li, N., Wang, S., Liu, H., Li, J., Zhang, Y., & Bu, P. (2015) · PLoS ONE · doi:10.1371/journal.pone.0118909 · Cited by 126 · see citing works
Mitochondrial Sirtuins in the Regulation of Mitochondrial Activity and Metabolic Adaptation
Lombard, D. B., Tishkoff, D. X., & Bao, J. (2011) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-21631-2_8 · Cited by 124 · see citing works
The Role of Mitochondrial DNA in Mediating Alveolar Epithelial Cell Apoptosis and Pulmonary Fibrosis
Kim, S.-J., Cheresh, P., Jablonski, R. P., Williams, D. B., & Kamp, D. W. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160921486 · Cited by 121 · see citing works
Albani, D., Polito, L., & Forloni, G. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1215 · Cited by 122 · see citing works
The Current State of NAD+‐Dependent Histone Deacetylases (Sirtuins) as Novel Therapeutic Targets
Schiedel, M., Robaa, D., Rumpf, T., Sippl, W., & Jung, M. (2017) · Medicinal Research Reviews · doi:10.1002/med.21436 · Cited by 122 · see citing works
The Role of SIRT3 in Exercise and Aging
Zhou, L., Pinho, R. A., Gu, Y., & Radak, Z. O. (2022) · Cells · doi:10.3390/cells11162596 · Cited by 124 · see citing works
Genes encoding longevity: from model organisms to humans
Kuningas, M., Mooijaart, S. P., van Heemst, D., Zwaan, B. J., Slagboom, P. E., & Westendorp, R. G. J. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00366.x · Cited by 115 · see citing works
Mitochondrial sirtuins: Emerging roles in metabolic regulations, energy homeostasis and diseases
Parihar, P., Solanki, I., Mansuri, M. L., & Parihar, M. S. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.12.004 · Cited by 112 · see citing works
Law, I. K. M., Liu, L., Xu, A., Lam, K. S. L., Vanhoutte, P. M., Che, C., Leung, P. T. Y., & Wang, Y. (2009) · PROTEOMICS · doi:10.1002/pmic.200800738 · Cited by 115 · see citing works
Zeng, H., He, X., Hou, X., Li, L., & Chen, J. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00821.2013 · Cited by 114 · see citing works
SIRT3 and mitochondrial metabolism in neurodegenerative diseases
Salvatori, I., Valle, C., Ferri, A., & Carrı̀, M. T. (2017) · Neurochemistry International · doi:10.1016/j.neuint.2017.04.012 · Cited by 112 · see citing works
Dato, S., Crocco, P., D’Aquila, P., Rango, F. D., Bellizzi, D., Rose, G., & Passarino, G. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140816443 · Cited by 109 · see citing works
Self-citationImpaired quality control of mitochondria: Aging from a new perspective
Weber, T. A., & Reichert, A. S. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.03.018 · Cited by 110 · see citing works
Monsalve, M., & Olmos, Y. (2011) · Current Drug Targets · doi:10.2174/138945011796150307 · Cited by 112 · see citing works
Aging and the Renin-Angiotensin System
Conti, S., Cassis, P., & Benigni, A. (2012) · Hypertension · doi:10.1161/hypertensionaha.110.155895 · Cited by 107 · see citing works
Successful Aging: From Phenotype to Genotype
Glatt, S. J., Chayavichitsilp, P., Depp, C. A., Schork, N. J., & Jeste, D. V. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.09.015 · Cited by 107 · see citing works
Radak, Z. O., Bori, Z., Koltai, E., Fatouros, I. G., Jamurtas, A. Z., DOUROUDOS, I. I., Terzis, G. D., Nikolaidis, M. G., Chatzinikolaou, A., Sovatzidis, A., et al. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.04.018 · Cited by 109 · see citing works
Kanwal, A., Pillai, V. B., Samant, S. A., Gupta, M., & Gupta, M. P. (2019) · The FASEB Journal · doi:10.1096/fj.201900767r · Cited by 103 · see citing works
- Authors
- Bellizzi, D., Rose, G., Cavalcante, P., Covello, G., Dato, S., De Rango, F., Greco, V., Maggiolini, M., Feraco, E., Mari, V., Franceschi, C., Passarino, G., & De Benedictis, G.
- Affiliations
- University of Calabria (IT)
- Istituto Nazionale di Riposo e Cura per Anziani (IT)
- University of Bologna (IT)
- ORCID
- Venue
- Genomics
- Publisher
- Elsevier BV
- Published
- 2005-02
- Volume
- 85
- Issue
- 2
- Pages
- 258-263
- ISSN
- 0888-7543 (ISSN-L)
- OpenAlex
- W2095106276
- Cited by
- 367
- References
- 27
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 13 · 2023: 11 · 2022: 9 · 2021: 21 · 2020: 16 · 2019: 15 · 2018: 17 · 2017: 20 · 2016: 26 · 2015: 26 · 2014: 21 · 2013: 29 · 2012: 17
- FWCI
- 4.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Genomics (publishedVersion)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Archive of Doctoral Theses and Digital Collections (University of Calabria) (submittedVersion)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- SIRT3, VNTR polymorphism, intron 5, enhancer activity, allele-specific expression, longevity, oldest old, aging, gene expression regulation, repeat number variation
- MeSH terms
- Adult, Aged, Aged, 80 and over, Base Sequence, Enhancer Elements, Genetic, Female, Histone Deacetylases, Humans, Longevity, Male, Middle Aged, Molecular Sequence Data, Polymorphism, Genetic, Minisatellite Repeats, Mitochondrial Proteins, Sirtuins, Sirtuin 3
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review