Franceschi, Claudio

Interleukin-6 gene alleles affect the risk of Alzheimer's disease and levels of the cytokine in blood and brain

Licastro, F., Grimaldi, L. M. E., Bonafè, M., Martina, C., Olivieri, F., Cavallone, L., Giovanietti, S., Masliah, E., & Franceschi, C. (2003) · Neurobiology of Aging

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 182

Massive Load of Functional Effector CD4+ and CD8+ T Cells against Cytomegalovirus in Very Old Subjects

Vescovini, R., Biasini, C., Fagnoni, F. F., Telera, A. R., Zanlari, L., Pedrazzoni, M., Bucci, L., Monti, D., Medici, M. C., Chezzi, C., et al. (2007) · The Journal of Immunology

Cytomegalovirus and herpesvirus researchT-cell and B-cell Immunology

Cited by 173

Mediterranean-Style Diet Improves Systolic Blood Pressure and Arterial Stiffness in Older Adults: Results of a 1-Year European Multi-Center Trial

Jennings, A., Berendsen, A. M., de Groot, L. C. P. G. M., Feskens, E. J. M., Brzozowska, A., Sicinska, E., Pietruszka, B., Meunier, N., Caumon, E., Malpuech-Brugère, C., et al. (2019) · Hypertension

Nutritional Studies and DietCardiovascular Health and Disease Prevention

Cited by 172

Chemokines, sTNF-Rs and sCD30 serum levels in healthy aged people and centenarians

Gerli, R., Monti, D., Bistoni, O., M. Mazzone, A., Peri, G., Cossarizza, A., Di Gioacchino, M., E. F. Cesarotti, M., Doni, A., Mantovani, A., et al. (2001) · Mechanisms of Ageing and Development

Genetics, Aging, and Longevity in Model OrganismsCytokine Signaling Pathways and Interactions

Cited by 162

Biomarkers of immunosenescence within an evolutionary perspective: the challenge of heterogeneity and the role of antigenic load

Franceschi, C., Valensin, S., Fagnoni, F., Barbi, C., & Bonafè, M. (1999) · Experimental Gerontology

T-cell and B-cell ImmunologyGenetics, Aging, and Longevity in Model Organisms

Cited by 154

New advances in CMV and immunosenescence

Sansoni, P., Vescovini, R., Fagnoni, F. F., Akbar, A., Arens, R., Chiu, Y.-L., Čičin-Šain, L., Dechanet-Merville, J., Derhovanessian, E., Ferrando-Martinez, S., et al. (2014) · Experimental Gerontology

Cytomegalovirus and herpesvirus researchImmune responses and vaccinations

Cited by 150

Age-related DNA methylation changes are sex-specific: a comprehensive assessment

Yusipov, I., Bacalini, M. G., Kalyakulina, A., Krivonosov, M., Pirazzini, C., Gensous, N., Ravaioli, F., Milazzo, M., Giuliani, C., Vedunova, M., et al. (2020) · Aging

Epigenetics and DNA MethylationGenetics, Aging, and Longevity in Model Organisms

Cited by 148

What accounts for the wide variation in life span of genetically identical organisms reared in a constant environment?

Kirkwood, T. B. L., Feder, M., Finch, C. E., Franceschi, C., Globerson, A., Klingenberg, C. P., LaMarco, K., Omholt, S., & Westendorp, R. G. J. (2005) · Mechanisms of Ageing and Development

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 144

Proteomics in aging research: A roadmap to clinical, translational research

Moaddel, R., Ubaida‐Mohien, C., Tanaka, T., Lyashkov, A., Basisty, N., Schilling, B., Semba, R. D., Franceschi, C., Gorospe, M., & Ferrucci, L. (2021) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsAdvanced Proteomics Techniques and Applications

Cited by 139

Thymic output and functionality of the IL‐7/IL‐7 receptor system in centenarians: implications for the neolymphogenesis at the limit of human life

Nasi, M., Troiano, L., Lugli, E., Pinti, M., Ferraresi, R., Monterastelli, E., Mussi, C., Salvioli, G., Franceschi, C., & Cossarizza, A. (2006) · Aging Cell

T-cell and B-cell ImmunologyHematopoietic Stem Cell Transplantation

Cited by 127

Age- and glycemia-related miR-126-3p levels in plasma and endothelial cells

Olivieri, F., Bonafè, M., Spazzafumo, L., Gobbi, M., Prattichizzo, F., Recchioni, R., Marcheselli, F., Sala, L. L., Galeazzi, R., Rippo, M. R., et al. (2014) · Aging

MicroRNA in disease regulationTelomeres, Telomerase, and Senescence

Cited by 118

Associations between Pro- and Anti-Inflammatory Gastro-Intestinal Microbiota, Diet, and Cognitive Functioning in Dutch Healthy Older Adults: The NU-AGE Study

van Soest, A. P. M., Hermes, G. D. A., Berendsen, A. A. M., van de Rest, O., Zoetendal, E. G., Fuentes, S., Santoro, A., Franceschi, C., de Groot, L. C. P. G. M., & de Vos, W. M. (2020) · Nutrients

Gut microbiota and healthNutritional Studies and Diet

Cited by 118

Long-term immune-endocrine effects of bereavement: Relationships with anxiety levels and mood

Gerra, G., Monti, D., Panerai, A. E., Sacerdote, P., Anderlini, R., Avanzini, P., Zaimovic, A., Brambilla, F., & Franceschi, C. (2003) · Psychiatry Research

Stress Responses and CortisolGrief, Bereavement, and Mental Health

Cited by 116

Diverse Effect of Inflammatory Markers on Insulin Resistance and Insulin‐Resistance Syndrome in the Elderly

Abbatecola, A. M., Ferrucci, L., Grella, R., Bandinelli, S., Bonafè, M., Barbieri, M., Corsi, A. M., Lauretani, F., Franceschi, C., & Paolisso, G. (2004) · Journal of the American Geriatrics Society

Adipokines, Inflammation, and Metabolic DiseasesDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 116

Are Nutrition-Related Knowledge and Attitudes Reflected in Lifestyle and Health Among Elderly People? A Study Across Five European Countries

Jeruszka-Bielak, M., Kollajtis-Dolowy, A., Santoro, A., Ostan, R., Berendsen, A. A. M., Jennings, A., Meunier, N., Marseglia, A., Caumon, E., Gillings, R., et al. (2018) · Frontiers in Physiology

Nutrition and Health in AgingNutrition, Health and Food Behavior

Cited by 110

A public health perspective of aging: do hyper-inflammatory syndromes such as COVID-19, SARS, ARDS, cytokine storm syndrome, and post-ICU syndrome accelerate short- and long-term inflammaging?

Bektas, A., Schurman, S. H., Franceschi, C., & Ferrucci, L. (2020) · Immunity & Ageing

COVID-19 Clinical Research StudiesLong-Term Effects of COVID-19

Cited by 102

Systemic Age-Associated DNA Hypermethylation of ELOVL2 Gene: In Vivo and In Vitro Evidences of a Cell Replication Process

Bacalini, M. G., Deelen, J., Pirazzini, C., De Cecco, M., Giuliani, C., Lanzarini, C., Ravaioli, F., Marasco, E., van Heemst, D., Suchiman, H. E. D., et al. (2017) · The Journals of Gerontology: Series A

Epigenetics and DNA MethylationTelomeres, Telomerase, and Senescence

Cited by 100

The evolution of the adipose tissue: A neglected enigma

Ottaviani, E., Malagoli, D., & Franceschi, C. (2011) · General and Comparative Endocrinology

Adipose Tissue and MetabolismLipid metabolism and biosynthesis

Cited by 100

The role of low-grade inflammation and metabolic flexibility in aging and nutritional modulation thereof: a systems biology approach

Calçada, D., Vianello, D., Giampieri, E., Sala, C., Castellani, G., de Graaf, A., Kremer, B., van Ommen, B., Feskens, E., Santoro, A., et al. (2014) · Mechanisms of Ageing and Development

Genetics, Aging, and Longevity in Model OrganismsAdipokines, Inflammation, and Metabolic Diseases

Cited by 97

Genetics of human longevity within an eco-evolutionary nature-nurture framework

Giuliani, C., Garagnani, P., & Franceschi, C. (2018) · Circulation Research

Genetics, Aging, and Longevity in Model OrganismsGenetic Associations and Epidemiology

Cited by 92

Low circulating IGF-I bioactivity is associated with human longevity: findings in centenarians’ offspring

Vitale, G., Brugts, M. P., Ogliari, G., Castaldi, D., Fatti, L. M., Varewijck, A. J., Lamberts, S. W., Monti, D., Bucci, L., Cevenini, E., et al. (2012) · Aging

Growth Hormone and Insulin-like Growth FactorsGenetics, Aging, and Longevity in Model Organisms

Cited by 90

Mitochondria hyperfusion and elevated autophagic activity are key mechanisms for cellular bioenergetic preservation in centenarians

Sgarbi, G., Matarrese, P., Pinti, M., Lanzarini, C., Ascione, B., Gibellini, L., Dika, E., Patrizi, A., Tommasino, C., Capri, M., et al. (2014) · Aging

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

Cited by 90

The hormetic and hermetic role of IL-6

Forcina, L., Franceschi, C., & Musarò, A. (2022) · Ageing Research Reviews

Cytokine Signaling Pathways and InteractionsExercise and Physiological Responses

Cited by 85

Anti-Inflammatory Effect of Ubiquinol-10 on Young and Senescent Endothelial Cells via MiR-146a Modulation

Olivieri, F., Lazzarini, R., Babini, L., Prattichizzo, F., Rippo, M. R., Tiano, L., Di Nuzzo, S., Graciotti, L., Festa, R., Brugè, F., et al. (2013) · Free Radical Biology and Medicine

Coenzyme Q10 studies and effectsTelomeres, Telomerase, and Senescence

Cited by 84