Heneka, Michael T.

Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes

Scheiblich, H., Dansokho, C., Mercan, D., Schmidt, S. V., Bousset, L., Wischhof, L., Eikens, F., Odainic, A., Spitzer, J., Griep, A., et al. (2021) · Cell

Neuroinflammation and Neurodegeneration MechanismsParkinson's Disease Mechanisms and Treatments

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Distinct and Non-Redundant Roles of Microglia and Myeloid Subsets in Mouse Models of Alzheimer's Disease

Mildner, A., Schlevogt, B., Kierdorf, K., Böttcher, C., Erny, D., Kummer, M. P., Quinn, M., Brück, W., Bechmann, I., Heneka, M. T., et al. (2011) · The Journal of Neuroscience

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 351

Systemic inflammation impairs microglial Aβ clearance through NLRP3 inflammasome

Tejera, D., Mercan, D., Sanchez‐Caro, J. M., Hanan, M., Greenberg, D., Soreq, H., Latz, E., Golenbock, D., & Heneka, M. T. (2019) · The EMBO Journal

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 351

Nitration of Tyrosine 10 Critically Enhances Amyloid β Aggregation and Plaque Formation

Kummer, M. P., Hermes, M., Delekarte, A., Hammerschmidt, T., Kumar, S., Terwel, D., Walter, J., Pape, H.-C., König, S., Roeber, S., et al. (2011) · Neuron

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 336

PPARγ/RXRα-Induced and CD36-Mediated Microglial Amyloid-β Phagocytosis Results in Cognitive Improvement in Amyloid Precursor Protein/Presenilin 1 Mice

Yamanaka, M., Ishikawa, T., Griep, A., Axt, D., Kummer, M. P., & Heneka, M. T. (2012) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 326

Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

de Rojas, I., Moreno-Grau, S., Tesi, N., Grenier-Boley, B., Andrade, V., Jansen, I. E., Pedersen, N. L., Stringa, N., Zettergren, A., Hernández, I., et al. (2021) · Nature Communications

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 324

Innate Immunity and Neurodegeneration

Labzin, L. I., Heneka, M. T., & Latz, E. (2018) · Annual Review of Medicine

Neuroinflammation and Neurodegeneration MechanismsInflammasome and immune disorders

Cited by 319

PPARs in the brain

HENEKA, M., & LANDRETH, G. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Peroxisome Proliferator-Activated ReceptorsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 317

Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice

Heneka, M. T., Sastre, M., Dumitrescu-Ozimek, L., Dewachter, I., Walter, J., Klockgether, T., & Van Leuven, F. (2005) · Journal of Neuroinflammation

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 309

Locus Ceruleus Degeneration Promotes Alzheimer Pathogenesis in Amyloid Precursor Protein 23 Transgenic Mice

Heneka, M. T., Ramanathan, M., Jacobs, A. H., Dumitrescu-Ozimek, L., Bilkei-Gorzo, A., Debeir, T., Sastre, M., Galldiks, N., Zimmer, A., Hoehn, M., et al. (2006) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 305

Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum

Jansen, W. J., Janssen, O., Tijms, B. M., Vos, S. J. B., Ossenkoppele, R., Visser, P. J., Amyloid Biomarker Study Group, Aarsland, D., Alcolea, D., Altomare, D., et al. (2022) · JAMA Neurology

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 290

Glucose metabolism, gray matter structure, and memory decline in subjective memory impairment

Scheef, L., Spottke, A., Daerr, M., Joe, A., Striepens, N., Kölsch, H., Popp, J., Daamen, M., Gorris, D., Heneka, M. T., et al. (2012) · Neurology

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 277

CD8+ T-cells infiltrate Alzheimer’s disease brains and regulate neuronal- and synapse-related gene expression in APP-PS1 transgenic mice

Unger, M. S., Li, E., Scharnagl, L., Poupardin, R., Altendorfer, B., Mrowetz, H., Hutter-Paier, B., Weiger, T. M., Heneka, M. T., Attems, J., et al. (2020) · Brain, Behavior, and Immunity

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 248

Danger-associated molecular patterns in Alzheimer’s disease

Venegas, C., & Heneka, M. T. (2017) · Journal of Leukocyte Biology

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 236

Microglia rescue neurons from aggregate-induced neuronal dysfunction and death through tunneling nanotubes

Scheiblich, H., Eikens, F., Wischhof, L., Opitz, S., Jüngling, K., Cserép, C., Schmidt, S. V., Lambertz, J., Bellande, T., Pósfai, B., et al. (2024) · Neuron

Neuroinflammation and Neurodegeneration MechanismsExtracellular vesicles in disease

Cited by 207

Soluble Aβ oligomers and protofibrils induce NLRP3 inflammasome activation in microglia

Lučiūnaitė, A., McManus, R. M., Jankunec, M., Rácz, I., Dansokho, C., Dalgėdienė, I., Schwartz, S., Brosseron, F., & Heneka, M. T. (2020) · Journal of Neurochemistry

Inflammasome and immune disordersNeuroinflammation and Neurodegeneration Mechanisms

Cited by 192

Cerebral dysfunctions caused by sepsis during ageing

Manabe, T., & Heneka, M. T. (2022) · Nature Reviews Immunology

Intensive Care Unit Cognitive DisordersSepsis Diagnosis and Treatment

Cited by 191

β-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia

Friker, L. L., Scheiblich, H., Hochheiser, I. V., Brinkschulte, R., Riedel, D., Latz, E., Geyer, M., & Heneka, M. T. (2020) · Cell Reports

Inflammasome and immune disordersNeuroinflammation and Neurodegeneration Mechanisms

Cited by 191

Critical Role of Astroglial Apolipoprotein E and Liver X Receptor-α Expression for Microglial Aβ Phagocytosis

Terwel, D., Steffensen, K. R., Verghese, P. B., Kummer, M. P., Gustafsson, J.-Å., Holtzman, D. M., & Heneka, M. T. (2011) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 190

Neuroimmune Connections in Aging and Neurodegenerative Diseases

Scheiblich, H., Trombly, M., Ramirez, A., & Heneka, M. T. (2020) · Trends in Immunology

Neuroinflammation and Neurodegeneration MechanismsTryptophan and brain disorders

Cited by 166

Gray matter atrophy pattern in elderly with subjective memory impairment

Peter, J., Scheef, L., Abdulkadir, A., Boecker, H., Heneka, M., Wagner, M., Koppara, A., Klöppel, S., Jessen, F., & Initiative, A. D. N. (2014) · Alzheimer's & Dementia

Dementia and Cognitive Impairment ResearchCancer-related cognitive impairment studies

Cited by 165

Microglial activation in a neuroinflammational animal model of schizophrenia – a pilot study

Juckel, G., Manitz, M. P., Brüne, M., Friebe, A., Heneka, M. T., & Wolf, R. J. (2011) · Schizophrenia Research

Neuroinflammation and Neurodegeneration MechanismsTryptophan and brain disorders

Cited by 165

Mediterranean Diet, Alzheimer Disease Biomarkers, and Brain Atrophy in Old Age

Ballarini, T., Melo van Lent, D., Brunner, J., Schröder, A., Wolfsgruber, S., Altenstein, S., Brosseron, F., Buerger, K., Dechent, P., Dobisch, L., et al. (2021) · Neurology

Dementia and Cognitive Impairment ResearchNutritional Studies and Diet

Cited by 153

Peroxisome proliferator-activated receptor gamma agonists protect cerebellar granule cells from cytokine-induced apoptotic cell death by inhibition of inducible nitric oxide synthase

Heneka, M. T., L. Feinstein, D., Galea, E., Gleichmann, M., Wüllner, U., & Klockgether, T. (1999) · Journal of Neuroimmunology

Peroxisome Proliferator-Activated ReceptorsNeuroinflammation and Neurodegeneration Mechanisms

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