Microglial activation in a neuroinflammational animal model of schizophrenia – a pilot study

Juckel, Georg; Manitz, Marie Pierre; Brüne, Martin; Friebe, Astrid; Heneka, Michael T.; Wolf, Rainer J.

doi:10.1016/j.schres.2011.06.018

Cited by 165Neuroinflammation and Neurodegeneration MechanismsTryptophan and brain disordersSchizophrenia research and treatment

Microglial activation in a neuroinflammational animal model of schizophrenia – a pilot study

Juckel, Georg, Manitz, Marie Pierre, Brüne, Martin, Friebe, Astrid, Heneka, Michael T., Wolf, Rainer J.·2011·Schizophrenia Research

DOI 10.1016/j.schres.2011.06.018

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Abstract

Inflammatory and immunological processes interfering with brain development are discussed as one cause of schizophrenia. Various signs of overactivation of the immune system were often found in this disease. Based on post-mortem analysis showing an increased number of activated microglial cells in patients with schizophrenia, it can be hypothesized that these cells contribute to disease pathogenesis and may actively be involved in gray matter loss observed in such patients. In the present study, PolyI:C incubation of pregnant dams was used as animal model of schizophrenia, and the number and shape of microglia were assessed in the offspring in the early phase of this disease, using fluorescence immunostaining (Iba1). Descendants of mice exposed to PolyI:C at embryonic day 9 showed higher number of microglial cells in the hippocampus and striatum, but not in the frontal cortex at postnatal day 30, which is similarly to adolescence in man, as compared to those exposed to saline. Furthermore, offspring microglia from PolyI:C treated mothers were morphologically characterized by a reduced arborization indicative for a status of higher activation compared to the offspring microglia from vehicle treated mice. This study supports the hypothesis that maternal infection during embryogenesis contributes to microglial activation in the offspring, which may therefore represent a contributing factor to the pathogenesis of schizophrenia and underlines the need for new pharmacological treatment options in this regard.

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Schizophrenia neuropathology has been reported to be closely associated with cytokines and microglial activation.
“In this context, the neuropathology of schizophrenia has been reported to be closely associated with cytokines and microglial activation (Bayer et al., 1999; Brown, 2011; Juckel et al., 2011; Meyer et al., 2009; Monji et al., 2009; Najjar et al., 2013; Radewicz et al., 2000; Vuillermot et al., 2010).”
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Authors: Juckel, G., Manitz, M. P., Brüne, M., Friebe, A., Heneka, M. T., & Wolf, R. J.
Affiliations: LWL-Universitätsklinikum Bochum (DE)
University of Bonn (DE)
Corresponding author: Juckel, Georg
ORCID: Juckel, Georg
Manitz, Marie Pierre
Brüne, Martin
Friebe, Astrid
Heneka, Michael T.
Wolf, Rainer J.
Venue: Schizophrenia Research
Publisher: Elsevier BV
Published: 2011-09
Volume: 131
Issue: 1-3
Pages: 96-100
ISSN: 0920-9964 (ISSN-L)
DOI: 10.1016/j.schres.2011.06.018
OpenAlex: W2057476473
Cited by: 165
References: 22
Citations by year: 2026: 6 · 2025: 6 · 2024: 7 · 2023: 8 · 2022: 10 · 2021: 14 · 2020: 14 · 2019: 7 · 2018: 13 · 2017: 10 · 2016: 12 · 2015: 16 · 2014: 14 · 2013: 16 · 2012: 10
FWCI: 7.41
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Schizophrenia Research (publishedVersion)
PubMed (publishedVersion)
Open Repository and Bibliography (University of Luxembourg) (submittedVersion)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords: microglial activation, schizophrenia
MeSH terms: Animals, Animals, Newborn, Calcium-Binding Proteins, Disease Models, Animal, Encephalitis, Female, Hippocampus, Leukocytes, Male, Mice, Inbred BALB C, Microfilament Proteins, Pilot Projects, Poly I-C, Pregnancy, Prenatal Exposure Delayed Effects, Schizophrenia, Microglia, CD11b Antigen, Calgranulin B, Mice

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Microglial activation in a neuroinflammational animal model of schizophrenia – a pilot study

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