Innate Immunity and Neurodegeneration

Labzin, Larisa I.; Heneka, Michael T.; Latz, Eicke

doi:10.1146/annurev-med-050715-104343

Cited by 319Neuroinflammation and Neurodegeneration MechanismsInflammasome and immune disordersNeurological Disease Mechanisms and Treatments

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Innate Immunity and Neurodegeneration

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Labzin, Larisa I., Heneka, Michael T., Latz, Eicke·2018·Annual Review of Medicine

DOI 10.1146/annurev-med-050715-104343

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Abstract

The innate immune system plays diverse roles in health and disease. It represents the first line of defense against infection and is involved in tissue repair, wound healing, and clearance of apoptotic cells and cellular debris. Excessive or nonresolving innate immune activation can lead to systemic or local inflammatory complications and cause or contribute to the development of inflammatory diseases. In the brain, microglia represent the key innate immune cells, which are involved in brain development, brain maturation, and homeostasis. Impaired microglial function, either through aberrant activation or decreased functionality, can occur during aging and during neurodegeneration, and the resulting inflammation is thought to contribute to neurodegenerative diseases. This review highlights recent advances in our understanding of the influence of innate immunity on neurodegenerative disorders such as Alzheimer's disease, amyotrophic lateral sclerosis, Parkinson's disease, and Huntington's disease.

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Authors: Labzin, L. I., Heneka, M. T., & Latz, E.
Affiliations: MRC Laboratory of Molecular Biology (GB)
University of Massachusetts Chan Medical School (US)
ORCID: Labzin, Larisa I.
Heneka, Michael T.
Latz, Eicke
Venue: Annual Review of Medicine
Publisher: Annual Reviews
Published: 2018-01-29
Volume: 69
Issue: 1
Pages: 437-449
ISSN: 0066-4219 (ISSN-L)
1545-326X
DOI: 10.1146/annurev-med-050715-104343
OpenAlex: W2735217968
Cited by: 319
References: 80
Citations by year: 2026: 11 · 2025: 30 · 2024: 37 · 2023: 35 · 2022: 42 · 2021: 53 · 2020: 53 · 2019: 32 · 2018: 26
FWCI: 2.93
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Annual Review of Medicine (publishedVersion)
PubMed (publishedVersion)
Open Repository and Bibliography (University of Luxembourg) (submittedVersion, other-oa)
DZNE Pub (submittedVersion)
Funders: EU Joint Programme – Neurodegenerative Disease Research
Deutsche Forschungsgemeinschaft (SFB1089, SPP-1923)
National Institutes of Health
National Health and Medical Research Council
National Heart, Lung, and Blood Institute (R01HL112661)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords: innate immunity, neurodegeneration, microglia, neuroinflammation, Alzheimer's disease, amyotrophic lateral sclerosis, Parkinson's disease, Huntington's disease, microglial activation, brain homeostasis, aging
MeSH terms: Alzheimer Disease, Amyotrophic Lateral Sclerosis, Humans, Huntington Disease, Immunity, Innate, Inflammation, Parkinson Disease, Microglia, Neurodegenerative Diseases

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