Chawla, Ajay

Macrophage biology in development, homeostasis and disease

Wynn, T. A., Chawla, A., & Pollard, J. W. (2013) · Nature

Immune cells in cancerPhagocytosis and Immune Regulation

Cited by 4,684

Macrophage-specific PPARγ controls alternative activation and improves insulin resistance

Odegaard, J. I., Ricardo-Gonzalez, R. R., Goforth, M. H., Morel, C. R., Subramanian, V., Mukundan, L., Eagle, A. R., Vats, D., Brombacher, F., Ferrante, A. W., et al. (2007) · Nature

Peroxisome Proliferator-Activated ReceptorsAdipokines, Inflammation, and Metabolic Diseases

Cited by 2,107

Nuclear Receptors and Lipid Physiology: Opening the X-Files

Chawla, A., Repa, J. J., Evans, R. M., & Mangelsdorf, D. J. (2001) · Science

Cholesterol and Lipid MetabolismPeroxisome Proliferator-Activated Receptors

Cited by 2,085

Oxidative metabolism and PGC-1β attenuate macrophage-mediated inflammation

Vats, D., Mukundan, L., Odegaard, J. I., Zhang, L., Smith, K. L., Morel, C. R., Greaves, D. R., Murray, P. J., & Chawla, A. (2006) · Cell Metabolism

Atherosclerosis and Cardiovascular DiseasesImmune cells in cancer

Cited by 1,369

A PPARγ-LXR-ABCA1 Pathway in Macrophages Is Involved in Cholesterol Efflux and Atherogenesis

Chawla, A., Boisvert, W. A., Lee, C.-H., Laffitte, B. A., Barak, Y., Joseph, S. B., Liao, D., Nagy, L., Edwards, P. A., Curtiss, L. K., et al. (2001) · Molecular Cell

Cholesterol and Lipid MetabolismPeroxisome Proliferator-Activated Receptors

Cited by 1,347

Macrophage-mediated inflammation in metabolic disease

Chawla, A., Nguyen, K. D., & Goh, Y. P. S. (2011) · Nature reviews. Immunology

Adipokines, Inflammation, and Metabolic DiseasesImmune cells in cancer

Cited by 1,314

PPAR-γ dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation

Chawla, A., Barak, Y., Nagy, L., Liao, D., Tontonoz, P., & Evans, R. M. (2001) · Nature Medicine

Peroxisome Proliferator-Activated ReceptorsCholesterol and Lipid Metabolism

Cited by 1,069

Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis

Nguyen, K. D., Qiu, Y., Cui, X., Goh, Y. P. S., Mwangi, J., David, T., Mukundan, L., Brombacher, F., Locksley, R. M., & Chawla, A. (2011) · Nature

Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

Cited by 1,038

Metabolic regulation of immune responses

Ganeshan, K., & Chawla, A. (2014) · Annual Review of Immunology

Immune cells in cancerCancer, Hypoxia, and Metabolism

Cited by 926

Type 2 Innate Signals Stimulate Fibro/Adipogenic Progenitors to Facilitate Muscle Regeneration

Heredia, J. E., Mukundan, L., Chen, F. M., Mueller, A. A., Deo, R. C., Locksley, R. M., Rando, T. A., & Chawla, A. (2013) · Cell

Muscle Physiology and DisordersCardiac Fibrosis and Remodeling

Cited by 818

Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin

Mauer, J., Chaurasia, B., Goldau, J., Vogt, M. C., Ruud, J., Nguyen, K. D., Theurich, S., Hausen, A. C., Schmitz, J., Brönneke, H. S., et al. (2014) · Nature Immunology

Adipokines, Inflammation, and Metabolic DiseasesImmune cells in cancer

Cited by 727

Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis

Odegaard, J. I., & Chawla, A. (2013) · Science

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 643

Alternative macrophage activation and metabolism

Odegaard, J. I., & Chawla, A. (2011) · Annual Review of Pathology: Mechanisms of Disease

Adipokines, Inflammation, and Metabolic DiseasesImmune cells in cancer

Cited by 640

Control of Macrophage Activation and Function by PPARs

Chawla, A. (2010) · Circulation Research

Peroxisome Proliferator-Activated ReceptorsAdipokines, Inflammation, and Metabolic Diseases

Cited by 531

PPAR-δ senses and orchestrates clearance of apoptotic cells to promote tolerance

Mukundan, L., Odegaard, J. I., Morel, C. R., Heredia, J. E., Mwangi, J. W., Ricardo-Gonzalez, R. R., Goh, Y. P. S., Eagle, A. R., Dunn, S. E., Awakuni, J. U. H., et al. (2009) · Nature Medicine

Phagocytosis and Immune RegulationPeroxisome Proliferator-Activated Receptors

Cited by 368

PPARδ is a very low-density lipoprotein sensor in macrophages

Chawla, A., Lee, C.-H., Barak, Y., He, W., Rosenfeld, J., Liao, D., Han, J., Kang, H., & Evans, R. M. (2003) · Proceedings of the National Academy of Sciences

Peroxisome Proliferator-Activated ReceptorsCholesterol and Lipid Metabolism

Cited by 305

Energetic Trade-Offs and Hypometabolic States Promote Disease Tolerance

Ganeshan, K., Nikkanen, J., Man, K., Leong, Y. A., Sogawa, Y., Maschek, J. A., Van Ry, T., Chagwedera, D. N., Cox, J. E., & Chawla, A. (2019) · Cell

Immune Response and InflammationThermal Regulation in Medicine

Cited by 286

An evolutionary trade-off between host immunity and metabolism drives fatty liver in male mice

Nikkanen, J., Leong, Y. A., Krause, W. C., Dermadi, D., Maschek, J. A., Van Ry, T., Cox, J. E., Weiss, E. J., Gokcumen, O., Chawla, A., et al. (2022) · Science

Diet, Metabolism, and DiseaseLiver Disease Diagnosis and Treatment

Cited by 77

Sympathetic inputs regulate adaptive thermogenesis in brown adipose tissue through cAMP-Salt inducible kinase axis

Paulo, E., Wu, D., Wang, Y., Zhang, Y., Wu, Y., Swaney, D. L., Soucheray, M., Jimenez-Morales, D., Chawla, A., Krogan, N. J., et al. (2018) · Scientific Reports

Adipose Tissue and MetabolismPeroxisome Proliferator-Activated Receptors

Cited by 59