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Cited by 926Immune cells in cancerCancer, Hypoxia, and MetabolismT-cell and B-cell Immunology

Metabolic regulation of immune responses

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Ganeshan, Kirthana, Chawla, Ajay·2014·Annual Review of Immunology
DOI 10.1146/annurev-immunol-032713-120236PMC PMC5800786
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Abstract

The immune system defends against pathogens and maintains tissue homeostasis for the life of the organism. These diverse functions are bioenergetically expensive, requiring precise control of cellular metabolic pathways. Although initial observations in this area were made almost a century ago, studies over the past decade have elucidated the molecular basis for how extracellular signals control the uptake and catabolism of nutrients in quiescent and activated immune cells. Collectively, these studies have revealed that the metabolic pathways of oxidative metabolism, glycolysis, and glutaminolysis preferentially fuel the cell fate decisions and effector functions of immune cells. Here, we discuss these findings and provide a general framework for understanding how metabolism fuels and regulates the maturation of immune responses. A better understanding of the metabolic checkpoints that control these transitions might provide new insights for modulating immunity in infection, cancer, or inflammatory disorders.

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  • Treatment with LPS in macrophages, dendritic and microglia cells provokes a metabolic shift from oxidative phosphorylation (OXPHOS) towards aerobic glycolysis, a process required to quickly supply high energy demands of the inflammatory response.

    “Treatment with LPS in macrophages, dendritic and microglia cells provokes a metabolic shift from oxidative phosphorylation (OXPHOS) towards aerobic glycolysis, a process required to quickly supply high energy demands of the inflammatory response (Galván-Peña and O'Neill, 2014),(Ruiz-García et al., 2011), (Ganeshan and Chawla, 2014),(Orihuela et al., 2016).”

    From TET2 Regulates the Neuroinflammatory Response in Microglia (2019) · cites this paper as Ganeshan and Chawla, 2014

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Authors
Ganeshan, K., & Chawla, A.
Affiliations
  • Cardiovascular Research Institute,
  • University of California, San Francisco (US)
ORCID
Chawla, Ajay
Venue
Annual Review of Immunology
Publisher
Annual Reviews
Published
2014-03-21
Volume
32
Issue
1
Pages
609-634
ISSN
  • 0732-0582 (ISSN-L)
  • 1545-3278
DOI
10.1146/annurev-immunol-032713-120236
PMC
PMC5800786
OpenAlex
W2147263332
Cited by
926
References
27
Citations by year
2026: 72 · 2025: 92 · 2024: 106 · 2023: 110 · 2022: 106 · 2021: 107 · 2020: 102 · 2019: 71 · 2018: 48 · 2017: 45 · 2016: 34 · 2015: 28 · 2014: 5
FWCI
3.64
Type
journal article
Language
en
Open access
Locations
  • Annual Review of Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • American Heart Association
  • Larry L. Hillblom Foundation
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute (HL076746, R01HL076746)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK081405, R01DK081405, DK-094641, R01DK101064, R01DK076760, R01DK094641)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (DP1AR064158)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords
immune cell metabolism, oxidative metabolism, glycolysis, glutaminolysis, immune cell activation, cell fate determination, effector function, metabolic checkpoint, infection, tumor immunology, inflammation
MeSH terms
Animals, Humans, Immune System, Immunity, Immunity, Innate, Metabolic Networks and Pathways, Adaptive Immunity

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