Simons, Mikael

Microglia states and nomenclature: A field at its crossroads

Paolicelli, R. C., Sierra, A., Stevens, B., Tremblay, M.-E., Aguzzi, A., Ajami, B., Amit, I., Audinat, E., Bechmann, I., Bennett, M., et al. (2022) · Neuron

Neuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms

Cited by 1,973

Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity

Cantuti-Castelvetri, L., Ojha, R., Pedro, L. D., Djannatian, M., Franz, J., Kuivanen, S., van der Meer, F., Kallio, K., Kaya, T., Anastasina, M., et al. (2020) · Science

SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research Studies

Cited by 1,925

Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte–Neuron Communication

Frühbeis, C., Fröhlich, D., Kuo, W. P., Amphornrat, J., Thilemann, S., Saab, A. S., Kirchhoff, F., Möbius, W., Goebbels, S., Nave, K.-A., et al. (2013) · PLoS Biology

Extracellular vesicles in diseaseCellular transport and secretion

Cited by 902

Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis

Fitzner, D., Schnaars, M., van Rossum, D., Krishnamoorthy, G., Dibaj, P., Bakhti, M., Regen, T., Hanisch, U.-K., & Simons, M. (2011) · Journal of Cell Science

Extracellular vesicles in diseaseNeuroinflammation and Neurodegeneration Mechanisms

Cited by 866

Cell type- and brain region-resolved mouse brain proteome

Sharma, K., Schmitt, S., Bergner, C. G., Tyanova, S., Kannaiyan, N., Manrique-Hoyos, N., Kongi, K., Cantuti, L., Hanisch, U.-K., Philips, M.-A., et al. (2015) · Nature Neuroscience

Advanced Proteomics Techniques and ApplicationsSingle-cell and spatial transcriptomics

Cited by 785

Neuroinflammation in Alzheimer disease

Heneka, M. T., van der Flier, W. M., Jessen, F., Hoozemanns, J., Thal, D. R., Boche, D., Brosseron, F., Teunissen, C., Zetterberg, H., Jacobs, A. H., et al. (2025) · Nature Reviews Immunology

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 638

Age-related myelin degradation burdens the clearance function of microglia during aging

Safaiyan, S., Kannaiyan, N., Snaidero, N., Brioschi, S., Biber, K., Yona, S., Edinger, A. L., Jung, S., Rossner, M. J., & Simons, M. (2016) · Nature Neuroscience

Neuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research Studies

Cited by 604

Defective cholesterol clearance limits remyelination in the aged central nervous system

Cantuti-Castelvetri, L., Fitzner, D., Bosch-Queralt, M., Weil, M.-T., Su, M., Sen, P., Ruhwedel, T., Mitkovski, M., Trendelenburg, G., Lütjohann, D., et al. (2018) · Science

Neuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research Studies

Cited by 586

Myelin dysfunction drives amyloid-β deposition in models of Alzheimer’s disease

Depp, C., Sun, T., Sasmita, A. O., Spieth, L., Berghoff, S. A., Nazarenko, T., Overhoff, K., Steixner-Kumar, A. A., Subramanian, S., Arinrad, S., et al. (2023) · Nature

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 493

White matter aging drives microglial diversity

Safaiyan, S., Besson-Girard, S., Kaya, T., Cantuti-Castelvetri, L., Liu, L., Ji, H., Schifferer, M., Gouna, G., Usifo, F., Kannaiyan, N., et al. (2021) · Neuron

Neuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research Studies

Cited by 477

Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region

Schlepckow, K., Monroe, K. M., Kleinberger, G., Cantuti‐Castelvetri, L., Parhizkar, S., Xia, D., Willem, M., Werner, G., Pettkus, N., Brunner, B., et al. (2020) · EMBO Molecular Medicine

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 324

Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis

Berghoff, S. A., Spieth, L., Sun, T., Hosang, L., Schlaphoff, L., Depp, C., Düking, T., Winchenbach, J., Neuber, J., Ewers, D., et al. (2021) · Nature Neuroscience

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 307

Central nervous system myelin: structure, synthesis and assembly

Aggarwal, S., Yurlova, L., & Simons, M. (2011) · Trends in Cell Biology

Multiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanisms

Cited by 301

Assembly of Myelin by Association of Proteolipid Protein with Cholesterol- and Galactosylceramide-Rich Membrane Domains

Simons, M., Krämer, E.-M., Thiele, C., Stoffel, W., & Trotter, J. (2000) · The Journal of Cell Biology

Lipid Membrane Structure and BehaviorSphingolipid Metabolism and Signaling

Cited by 293

Proteome profiling in cerebrospinal fluid reveals novel biomarkers of Alzheimer's disease

Bader, J. M., Geyer, P. E., Müller, J. B., Strauss, M. T., Koch, M., Leypoldt, F., Koertvelyessy, P., Bittner, D., Schipke, C. G., Incesoy, E. I., et al. (2020) · Molecular Systems Biology

Alzheimer's disease research and treatmentsAdvanced Proteomics Techniques and Applications

Cited by 286

BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions

Fard, M. K., van der Meer, F., Sánchez, P., Cantuti-Castelvetri, L., Mandad, S., Jäkel, S., Fornasiero, E. F., Schmitt, S., Ehrlich, M., Starost, L., et al. (2017) · Science Translational Medicine

Multiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanisms

Cited by 249

CD8+ T cells induce interferon-responsive oligodendrocytes and microglia in white matter aging

Kaya, T., Mattugini, N., Liu, L., Ji, H., Cantuti-Castelvetri, L., Wu, J., Schifferer, M., Groh, J., Martini, R., Besson-Girard, S., et al. (2022) · Nature Neuroscience

Neuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research Studies

Cited by 224

TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination

Gouna, G., Klose, C., Bosch-Queralt, M., Liu, L., Gokce, O., Schifferer, M., Cantuti-Castelvetri, L., & Simons, M. (2021) · Journal of Experimental Medicine

Neuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research Studies

Cited by 186

Neuron to glia signaling triggers myelin membrane exocytosis from endosomal storage sites

Trajkovic, K., Dhaunchak, A. S., Goncalves, J. T., Wenzel, D., Schneider, A., Bunt, G., Nave, K.-A., & Simons, M. (2006) · The Journal of Cell Biology

Cellular transport and secretionNeurogenesis and neuroplasticity mechanisms

Cited by 186

CNS remyelination and inflammation: From basic mechanisms to therapeutic opportunities

Franklin, R. J. M., & Simons, M. (2022) · Neuron

Multiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanisms

Cited by 184

Overexpression of the myelin proteolipid protein leads to accumulation of cholesterol and proteolipid protein in endosomes/lysosomes

Simons, M., Krämer, E.-M., Macchi, P., Rathke-Hartlieb, S., Trotter, J., Nave, K.-A., & Schulz, J. B. (2002) · The Journal of Cell Biology

Lysosomal Storage Disorders ResearchCellular transport and secretion

Cited by 168

Pro-inflammatory activation following demyelination is required for myelin clearance and oligodendrogenesis

Cunha, M. I., Su, M., Cantuti-Castelvetri, L., Müller, S. A., Schifferer, M., Djannatian, M., Alexopoulos, I., van der Meer, F., Winkler, A., van Ham, T. J., et al. (2020) · Journal of Experimental Medicine

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 160

Mononuclear phagocytes locally specify and adapt their phenotype in a multiple sclerosis model

Locatelli, G., Theodorou, D., Kendirli, A., Jordão, M. J. C., Staszewski, O., Phulphagar, K., Cantuti-Castelvetri, L., Dagkalis, A., Bessis, A., Simons, M., et al. (2018) · Nature Neuroscience

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 155

Control of oligodendroglial cell number by the miR-17-92 cluster

Budde, H., Schmitt, S., Fitzner, D., Opitz, L., Salinas-Riester, G., & Simons, M. (2010) · Development

Neurogenesis and neuroplasticity mechanismsMicroRNA in disease regulation

Cited by 152