Simons, Mikael

Loss of Myelin Basic Protein Function Triggers Myelin Breakdown in Models of Demyelinating Diseases

Weil, M.-T., Möbius, W., Winkler, A., Ruhwedel, T., Wrzos, C., Romanelli, E., Bennett, J. L., Enz, L., Goebels, N., Nave, K.-A., et al. (2016) · Cell Reports

Multiple Sclerosis Research StudiesPeripheral Neuropathies and Disorders

Cited by 142

Myelin basic protein‐dependent plasma membrane reorganization in the formation of myelin

Fitzner, D., Schneider, A., Kippert, A., Möbius, W., Willig, K. I., Hell, S. W., Bunt, G., Gaus, K., & Simons, M. (2006) · The EMBO Journal

Lipid Membrane Structure and BehaviorNeurogenesis and neuroplasticity mechanisms

Cited by 135

White matter aging and its impact on brain function

Groh, J., & Simons, M. (2025) · Neuron

Cerebrovascular and genetic disordersAdvanced Neuroimaging Techniques and Applications

Cited by 124

Phosphatidylinositol 4,5-Bisphosphate-Dependent Interaction of Myelin Basic Protein with the Plasma Membrane in Oligodendroglial Cells and Its Rapid Perturbation by Elevated Calcium

Nawaz, S., Kippert, A., Saab, A. S., Werner, H. B., Lang, T., Nave, K.-A., & Simons, M. (2009) · The Journal of Neuroscience

Lipid Membrane Structure and BehaviorCellular transport and secretion

Cited by 116

Late motor decline after accomplished remyelination: Impact for progressive multiple sclerosis

Manrique‐Hoyos, N., Jürgens, T., Grønborg, M., Kreutzfeldt, M., Schedensack, M., Kuhlmann, T., Schrick, C., Brück, W., Urlaub, H., Simons, M., et al. (2012) · Annals of Neurology

Multiple Sclerosis Research StudiesPeripheral Neuropathies and Disorders

Cited by 107

Apolipoprotein E aggregation in microglia initiates Alzheimer’s disease pathology by seeding β-amyloidosis

Kaji, S., Berghoff, S. A., Spieth, L., Schlaphoff, L., Sasmita, A. O., Vitale, S., Büschgens, L., Kedia, S., Zirngibl, M., Nazarenko, T., et al. (2024) · Immunity

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 104

Diet-dependent regulation of TGFβ impairs reparative innate immune responses after demyelination

Bosch-Queralt, M., Cantuti-Castelvetri, L., Damkou, A., Schifferer, M., Schlepckow, K., Alexopoulos, I., Lütjohann, D., Klose, C., Vaculčiaková, L., Masuda, T., et al. (2021) · Nature Metabolism

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 88

An optimized quantitative proteomics method establishes the cell type‐resolved mouse brain secretome

Tüshaus, J., Müller, S. A., Kataka, E. S., Zaucha, J., Sebastian Monasor, L., Su, M., Güner, G., Jocher, G., Tahirovic, S., Frishman, D., et al. (2020) · The EMBO Journal

Advanced Proteomics Techniques and ApplicationsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 88

Oligodendrocytes in Alzheimer’s disease pathophysiology

Kedia, S., & Simons, M. (2025) · Nature Neuroscience

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 86

Spatial Transcriptomics-correlated Electron Microscopy maps transcriptional and ultrastructural responses to brain injury

Androvic, P., Schifferer, M., Perez Anderson, K., Cantuti-Castelvetri, L., Jiang, H., Ji, H., Liu, L., Gouna, G., Berghoff, S. A., Besson-Girard, S., et al. (2023) · Nature Communications

Single-cell and spatial transcriptomicsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 67

Erythropoietin Attenuates Neurological and Histological Consequences of Toxic Demyelination in Mice

Hagemeyer, N., Boretius, S., Ott, C., von Streitberg, A., Welpinghus, H., Sperling, S., Frahm, J., Simons, M., Ghezzi, P., & Ehrenreich, H. (2012) · Molecular Medicine

Multiple Sclerosis Research StudiesErythropoietin and Anemia Treatment

Cited by 44

Parental origin of transgene modulates amyloid-β plaque burden in the 5xFAD mouse model of Alzheimer’s disease

Sasmita, A. O., Ong, E. C., Nazarenko, T., Mao, S., Komarek, L., Thalmann, M., Hantakova, V., Spieth, L., Berghoff, S. A., Barr, H. J., et al. (2025) · Neuron

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 42

Individual regional associations between Aβ-, tau- and neurodegeneration (ATN) with microglial activation in patients with primary and secondary tauopathies

Finze, A., Biechele, G., Rauchmann, B.-S., Franzmeier, N., Palleis, C., Katzdobler, S., Weidinger, E., Guersel, S., Schuster, S., Harris, S., et al. (2023) · Molecular Psychiatry

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 40

Microglia-mediated demyelination protects against CD8+ T cell-driven axon degeneration in mice carrying PLP defects

Groh, J., Abdelwahab, T., Kattimani, Y., Hörner, M., Loserth, S., Gudi, V., Adalbert, R., Imdahl, F., Saliba, A.-E., Coleman, M., et al. (2023) · Nature Communications

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 39

TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism

Feiten, A. F., Dahm, K., Schlepckow, K., van Lengerich, B., Suh, J. H., Reifschneider, A., Wefers, B., Bartos, L. M., Wind-Mark, K., de Weerd, L., et al. (2026) · Nature Communications

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 39

Myeloid cell–specific loss of NPC1 in mice recapitulates microgliosis and neurodegeneration in patients with Niemann-Pick type C disease

Dinkel, L., Hummel, S., Zenatti, V., Malara, M., Tillmann, Y., Colombo, A., Monasor, L. S., Suh, J. H., Logan, T., Roth, S., et al. (2024) · Science Translational Medicine

Lysosomal Storage Disorders ResearchNeuroinflammation and Neurodegeneration Mechanisms

Cited by 22

BCAS1-positive oligodendrocytes enable efficient cortical remyelination in multiple sclerosis

Bergner, C. G., van der Meer, F., Franz, J., Vakrakou, A., Würfel, T., Nessler, S., Schäfer, L., Nau-Gietz, C., Winkler, A., Lagumersindez-Denis, N., et al. (2025) · Brain

Multiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanisms

Cited by 16

Correction of dysregulated lipid metabolism normalizes gene expression in oligodendrocytes and prolongs lifespan in female poly-GA C9orf72 mice

Rezaei, A., Kocsis-Jutka, V., Gunes, Z. I., Zeng, Q., Kislinger, G., Bauernschmitt, F., Isilgan, H. B., Parisi, L. R., Kaya, T., Franzenburg, S., et al. (2025) · Nature Communications

Amyotrophic Lateral Sclerosis ResearchAlzheimer's disease research and treatments

Cited by 14

Apolipoprotein E aggregation in microglia initiates Alzheimer’s disease pathology by seeding β-amyloidosis

Kaji, S., Berghoff, S. A., Spieth, L., Schlaphoff, L., Sasmita, A. O., Vitale, S., Büschgens, L., Kedia, S., Zirngibl, M., Nazarenko, T., et al. (2025) · Immunity

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 7