Orkin, Stuart H.

Rb Regulates Interactions between Hematopoietic Stem Cells and Their Bone Marrow Microenvironment

Walkley, C. R., Shea, J. M., Sims, N. A., Purton, L. E., & Orkin, S. H. (2007) · Cell

Hematopoietic Stem Cell TransplantationBlood disorders and treatments

Cited by 424

Transcriptional activation and DNA binding by the erythroid factor GF-1/NF-E1/Eryf 1.

Martin, D. I., & Orkin, S. H. (1990) · Genes & Development

Genomics and Chromatin DynamicsHemoglobinopathies and Related Disorders

Cited by 409

The glycoprotein encoded by the X-linked chronic granulomatous disease locus is a component of the neutrophil cytochrome b complex

Dinauer, M. C., Orkin, S. H., Brown, R., Jesaitis, A. J., & Parkos, C. A. (1987) · Nature

Neutrophil, Myeloperoxidase and Oxidative MechanismsImmunodeficiency and Autoimmune Disorders

Cited by 407

Mapping the Mouse Cell Atlas by Microwell-Seq

Han, X., Wang, R., Zhou, Y., Fei, L., Sun, H., Lai, S., Saadatpour, A., Zhou, Z., Chen, H., Ye, F., et al. (2018) · Cell

Single-cell and spatial transcriptomicsGenomics and Phylogenetic Studies

Cited by 384

Intrinsic Requirement for Zinc Finger Transcription Factor Gfi-1 in Neutrophil Differentiation

Hock, H., Hamblen, M. J., Rooke, H. M., Traver, D., Bronson, R. T., Cameron, S., & Orkin, S. H. (2003) · Immunity

Blood disorders and treatmentsNeutrophil, Myeloperoxidase and Oxidative Mechanisms

Cited by 384

Developmental and species-divergent globin switching are driven by BCL11A

Sankaran, V. G., Xu, J., Ragoczy, T., Ippolito, G. C., Walkley, C. R., Maika, S. D., Fujiwara, Y., Ito, M., Groudine, M., Bender, M. A., et al. (2009) · Nature

Hemoglobinopathies and Related DisordersHemoglobin structure and function

Cited by 379

Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin

Masuda, T., Wang, X., Maeda, M., Canver, M. C., Sher, F., Funnell, A. P. W., Fisher, C., Suciu, M., Martyn, G. E., Norton, L. J., et al. (2016) · Science

Hemoglobinopathies and Related DisordersHemoglobin structure and function

Cited by 373

DNA Methyltransferase 1 Is Essential for and Uniquely Regulates Hematopoietic Stem and Progenitor Cells

Trowbridge, J. J., Snow, J. W., Kim, J., & Orkin, S. H. (2009) · Cell Stem Cell

Hematopoietic Stem Cell TransplantationEpigenetics and DNA Methylation

Cited by 373

Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene

Mikkola, H. K. A., Klintman, J., Yang, H., Hock, H., Schlaeger, T. M., Fujiwara, Y., & Orkin, S. H. (2003) · Nature

Hematopoietic Stem Cell TransplantationMesenchymal stem cell research

Cited by 371

PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding

Zhang, P., Zhang, X., Iwama, A., Yu, C., Smith, K. A., Mueller, B. U., Narravula, S., Torbett, B. E., Orkin, S. H., & Tenen, D. G. (2000) · Blood

Genomics and Chromatin DynamicsHemoglobinopathies and Related Disorders

Cited by 368

Consequences of GATA-1 Deficiency in Megakaryocytes and Platelets

Vyas, P., Ault, K., Jackson, C. W., Orkin, S. H., & Shivdasani, R. A. (1999) · Blood

Platelet Disorders and TreatmentsBlood Coagulation and Thrombosis Mechanisms

Cited by 362

Transcriptional silencing of γ-globin by BCL11A involves long-range interactions and cooperation with SOX6

Xu, J., Sankaran, V. G., Ni, M., Menne, T. F., Puram, R. V., Kim, W., & Orkin, S. H. (2010) · Genes & Development

Hemoglobinopathies and Related DisordersGenomics and Chromatin Dynamics

Cited by 361

CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation

Blobel, G. A., Nakajima, T., Eckner, R., Montminy, M., & Orkin, S. H. (1998) · Proceedings of the National Academy of Sciences

Genomics and Chromatin DynamicsHemoglobinopathies and Related Disorders

Cited by 355

Exome sequencing identifies GATA1 mutations resulting in Diamond-Blackfan anemia

Sankaran, V. G., Ghazvinian, R., Do, R., Thiru, P., Vergilio, J.-A., Beggs, A. H., Sieff, C. A., Orkin, S. H., Nathan, D. G., Lander, E. S., et al. (2012) · Journal of Clinical Investigation

Blood disorders and treatmentsGenomics and Rare Diseases

Cited by 342

The switch from fetal to adult hemoglobin.

Sankaran, V. G., & Orkin, S. H. (2013) · Cold Spring Harbor Perspectives in Medicine

Hemoglobinopathies and Related DisordersHemoglobin structure and function

Cited by 333

Functional analysis and in vivo footprinting implicate the erythroid transcription factor GATA-1 as a positive regulator of its own promoter.

Tsai, S. F., Strauss, E., & Orkin, S. H. (1991) · Genes & Development

Genomics and Chromatin DynamicsHemoglobinopathies and Related Disorders

Cited by 327

Correction of Sickle Cell Disease in Adult Mice by Interference with Fetal Hemoglobin Silencing

Xu, J., Peng, C., Sankaran, V. G., Shao, Z., Esrick, E. B., Chong, B. G., Ippolito, G. C., Fujiwara, Y., Ebert, B. L., Tucker, P. W., et al. (2011) · Science

Hemoglobinopathies and Related DisordersHemoglobin structure and function

Cited by 326

Reprogramming Committed Murine Blood Cells to Induced Hematopoietic Stem Cells with Defined Factors

Riddell, J., Gazit, R., Garrison, B. S., Guo, G., Saadatpour, A., Mandal, P. K., Ebina, W., Volchkov, P., Yuan, G.-C., Orkin, S. H., et al. (2014) · Cell

Hematopoietic Stem Cell TransplantationPluripotent Stem Cells Research

Cited by 323

A Human Stem Cell Model of Early Alzheimer’s Disease Pathology in Down Syndrome

Shi, Y., Kirwan, P., Smith, J., MacLean, G., Orkin, S. H., & Livesey, F. J. (2012) · Science Translational Medicine

Alzheimer's disease research and treatmentsPluripotent Stem Cells Research

Cited by 310

Abnormal RNA processing due to the exon mutation of βE-globin gene

Orkin, S. H., Kazazian, H. H., Antonarakis, S. E., Ostrer, H., Goff, S. C., & Sexton, J. P. (1982) · Nature

Hemoglobinopathies and Related DisordersRNA Research and Splicing

Cited by 298

Transcription factor GATA-1 permits survival and maturation of erythroid precursors by preventing apoptosis.

Weiss, M. J., & Orkin, S. H. (1995) · Proceedings of the National Academy of Sciences

Hematopoietic Stem Cell TransplantationHemoglobinopathies and Related Disorders

Cited by 296

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice

Townsend, E. C., Murakami, M. A., Christodoulou, A., Christie, A. L., Köster, J., DeSouza, T. A., Morgan, E. A., Kallgren, S. P., Liu, H., Wu, S.-C., et al. (2016) · Cancer Cell

Acute Lymphoblastic Leukemia researchAcute Myeloid Leukemia Research

Cited by 295

Dissecting super-enhancer hierarchy based on chromatin interactions

Huang, J., Li, K., Cai, W., Liu, X., Zhang, Y., Orkin, S. H., Xu, J., & Yuan, G.-C. (2018) · Nature Communications

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 241

Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A

Xu, J., Bauer, D. E., Kerenyi, M. A., Vo, T. D., Hou, S., Hsu, Y.-J., Yao, H., Trowbridge, J. J., Mandel, G., & Orkin, S. H. (2013) · Proceedings of the National Academy of Sciences

Hemoglobinopathies and Related DisordersHemoglobin structure and function

Cited by 233