Orkin, Stuart H.

Hematopoiesis: An Evolving Paradigm for Stem Cell Biology

Orkin, S. H., & Zon, L. I. (2008) · Cell

Hematopoietic Stem Cell TransplantationMesenchymal stem cell research

Cited by 2,570

A comparative encyclopedia of DNA elements in the mouse genome

Yue, F., Cheng, Y., Breschi, A., Vierstra, J., Wu, W., Ryba, T., Sandstrom, R., Ma, Z., Davis, C., Pope, B. D., et al. (2014) · Nature

Genomics and Chromatin DynamicsChromosomal and Genetic Variations

Cited by 1,781

Mapping the Mouse Cell Atlas by Microwell-Seq

Han, X., Wang, R., Zhou, Y., Fei, L., Sun, H., Lai, S., Saadatpour, A., Zhou, Z., Chen, H., Ye, F., et al. (2018) · Cell

Single-cell and spatial transcriptomicsGenomics and Phylogenetic Studies

Cited by 1,597

Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1

Pevny, L., Simon, M. C., Robertson, E., Klein, W. H., Tsai, S.-F., D'Agati, V., Orkin, S. H., & Costantini, F. (1991) · Nature

Hemoglobinopathies and Related DisordersHematopoietic Stem Cell Transplantation

Cited by 1,308

EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency

Shen, X., Liu, Y., Hsu, Y.-J., Fujiwara, Y., Kim, J., Mao, X., Yuan, G.-C., & Orkin, S. H. (2008) · Molecular Cell

Epigenetics and DNA MethylationPluripotent Stem Cells Research

Cited by 1,021

Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL

Shivdasani, R. A., Mayer, E. L., & Orkin, S. H. (1995) · Nature

Hematopoietic Stem Cell TransplantationT-cell and Retrovirus Studies

Cited by 938

Mouse model of x-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production

Pollock, J. D., Williams, D. A., Gifford, M. A. C., Li, L. L., Du, X., Fisherman, J., Orkin, S. H., Doerschuk, C. M., & Dinauer, M. C. (1995) · Nature Genetics

Neutrophil, Myeloperoxidase and Oxidative MechanismsImmunodeficiency and Autoimmune Disorders

Cited by 921

Human Fetal Hemoglobin Expression Is Regulated by the Developmental Stage-Specific Repressor BCL11A

Sankaran, V. G., Menne, T. F., Xu, J., Akie, T. E., Lettre, G., Van Handel, B., Mikkola, H. K. A., Hirschhorn, J. N., Cantor, A. B., & Orkin, S. H. (2008) · Science

Hemoglobinopathies and Related DisordersHemoglobin structure and function

Cited by 919

BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis

Canver, M. C., Smith, E. C., Sher, F., Pinello, L., Sanjana, N. E., Shalem, O., Chen, D. D., Schupp, P. G., Vinjamur, D. S., Garcia, S. P., et al. (2015) · Nature

Hemoglobinopathies and Related DisordersCRISPR and Genetic Engineering

Cited by 886

Cloning the gene for an inherited human disorder—chronic granulomatous disease—On the basis of its chromosomal location

Royer-Pokora, B., Kunkel, L. M., Monaco, A. P., Goff, S. C., Newburger, P. E., Baehner, R. L., Cole, F. S., Curnutte, J. T., & Orkin, S. H. (1986) · Nature

Neutrophil, Myeloperoxidase and Oxidative MechanismsImmunodeficiency and Autoimmune Disorders

Cited by 833

Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression

Neumann, C. A., Krause, D. S., Carman, C. V., Das, S., Dubey, D. P., Abraham, J. L., Bronson, R. T., Fujiwara, Y., Orkin, S. H., & Van Etten, R. A. (2003) · Nature

Redox biology and oxidative stressAntioxidant Activity and Oxidative Stress

Cited by 801

Endogenous oncogenic K-rasG12D stimulates proliferation and widespread neoplastic and developmental defects

Tuveson, D. A., Shaw, A. T., Willis, N. A., Silver, D. P., Jackson, E. L., Chang, S., Mercer, K. L., Grochow, R., Hock, H., Crowley, D., et al. (2004) · Cancer Cell

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 798

Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1.

Fujiwara, Y., Browne, C. P., Cunniff, K., Goff, S. C., & Orkin, S. H. (1996) · Proceedings of the National Academy of Sciences

Hematopoietic Stem Cell TransplantationHemoglobinopathies and Related Disorders

Cited by 778

Tet1 and Tet2 Regulate 5-Hydroxymethylcytosine Production and Cell Lineage Specification in Mouse Embryonic Stem Cells

Koh, K. P., Yabuuchi, A., Rao, S., Huang, Y., Cunniff, K., Nardone, J., Laiho, A., Tahiliani, M., Sommer, C. A., Mostoslavsky, G., et al. (2011) · Cell Stem Cell

Pluripotent Stem Cells ResearchEpigenetics and DNA Methylation

Cited by 776

FOG, a Multitype Zinc Finger Protein, Acts as a Cofactor for Transcription Factor GATA-1 in Erythroid and Megakaryocytic Differentiation

Tsang, A. P., Visvader, J. E., Turner, C. A., Fujiwara, Y., Yu, C., Weiss, M. J., Crossley, M., & Orkin, S. H. (1997) · Cell

Genomics and Chromatin DynamicsHemoglobinopathies and Related Disorders

Cited by 712

A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis

Gao, Y., Sun, Y., Frank, K. M., Dikkes, P., Fujiwara, Y., Seidl, K. J., Sekiguchi, J. M., Rathbun, G. A., Swat, W., Wang, J., et al. (1998) · Cell

DNA Repair MechanismsNeurogenesis and neuroplasticity mechanisms

Cited by 688

Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of β-thalassemia

Uda, M., Galanello, R., Sanna, S., Lettre, G., Sankaran, V. G., Chen, W., Usala, G., Busonero, F., Maschio, A., Albai, G., et al. (2008) · Proceedings of the National Academy of Sciences

Hemoglobinopathies and Related DisordersGenetic Associations and Epidemiology

Cited by 672

An Erythroid Enhancer of BCL11A Subject to Genetic Variation Determines Fetal Hemoglobin Level

Bauer, D. E., Kamran, S. C., Lessard, S., Xu, J., Fujiwara, Y., Lin, C., Shao, Z., Canver, M. C., Smith, E. C., Pinello, L., et al. (2013) · Science

Hemoglobinopathies and Related DisordersGenomics and Chromatin Dynamics

Cited by 653

Targeted Deletion of a High-Affinity GATA-binding Site in the GATA-1 Promoter Leads to Selective Loss of the Eosinophil Lineage In Vivo

Yu, C., Cantor, A. B., Yang, H., Browne, C., Wells, R. A., Fujiwara, Y., & Orkin, S. H. (2002) · The Journal of Experimental Medicine

Genomics and Chromatin DynamicsAsthma and respiratory diseases

Cited by 600

Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells

Hock, H., Hamblen, M. J., Rooke, H. M., Schindler, J. W., Saleque, S., Fujiwara, Y., & Orkin, S. H. (2004) · Nature

Hematopoietic Stem Cell TransplantationMesenchymal stem cell research

Cited by 541

Novel insights into erythroid development revealed through in vitro differentiation of GATA-1 embryonic stem cells.

Weiss, M. J., Keller, G., & Orkin, S. H. (1994) · Genes & Development

Hematopoietic Stem Cell TransplantationHemoglobinopathies and Related Disorders

Cited by 541

Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma

Perry, J. A., Kiezun, A., Tonzi, P., Van Allen, E. M., Carter, S. L., Baca, S. C., Cowley, G. S., Bhatt, A. S., Rheinbay, E., Pedamallu, C. S., et al. (2014) · Proceedings of the National Academy of Sciences

Sarcoma Diagnosis and TreatmentPI3K/AKT/mTOR signaling in cancer

Cited by 481

Direct promoter repression by BCL11A controls the fetal to adult hemoglobin switch

Liu, N., Hargreaves, V. V., Zhu, Q., Kurland, J. V., Hong, J., Kim, W., Sher, F., Macias-Trevino, C., Rogers, J. M., Kurita, R., et al. (2018) · Cell

Hemoglobinopathies and Related DisordersHemoglobin structure and function

Cited by 478

Functional Synergy and Physical Interactions of the Erythroid Transcription Factor GATA-1 with the Krüppel Family Proteins Sp1 and EKLF

Merika, M., & Orkin, S. H. (1995) · Molecular and Cellular Biology

Kruppel-like factors researchGenomics and Chromatin Dynamics

Cited by 462