Orkin, Stuart H.

Isolation and characterization of the cDNA encoding BKLF/TEF-2, a major CACCC-box-binding protein in erythroid cells and selected other cells

Crossley, M., Whitelaw, E., Perkins, A., Williams, G., Fujiwara, Y., & Orkin, S. H. (1996) · Molecular and Cellular Biology

Kruppel-like factors researchGenomics and Chromatin Dynamics

Cited by 222

Activation of the erythropoietin receptor promoter by transcription factor GATA-1.

Zon, L. I., Youssoufian, H., Mather, C., Lodish, H. F., & Orkin, S. H. (1991) · Proceedings of the National Academy of Sciences

Erythropoietin and Anemia TreatmentHemoglobinopathies and Related Disorders

Cited by 221

Genetic treatment of a molecular disorder: gene therapy approaches to sickle cell disease

Hoban, M. D., Orkin, S. H., & Bauer, D. E. (2016) · Blood

Hemoglobinopathies and Related DisordersVirus-based gene therapy research

Cited by 194

Hematopoietic development: a balancing act

Cantor, A. B., & Orkin, S. H. (2001) · Current Opinion in Genetics & Development

Hematopoietic Stem Cell TransplantationHemoglobinopathies and Related Disorders

Cited by 191

Self-Association of the Erythroid Transcription Factor GATA-1 Mediated by Its Zinc Finger Domains

Crossley, M., Merika, M., & Orkin, S. H. (1995) · Molecular and Cellular Biology

Hemoglobinopathies and Related DisordersGenomics and Chromatin Dynamics

Cited by 183

Reawakening fetal hemoglobin: prospects for new therapies for the β-globin disorders

Bauer, D. E., Kamran, S. C., & Orkin, S. H. (2012) · Blood

Hemoglobinopathies and Related DisordersHemoglobin structure and function

Cited by 177

Differential roles of Sall4 isoforms in embryonic stem cell pluripotency

Rao, S., Zhen, S., Roumiantsev, S., McDonald, L. T., Yuan, G.-C., & Orkin, S. H. (2010) · Molecular and Cellular Biology

Pluripotent Stem Cells ResearchDevelopmental Biology and Gene Regulation

Cited by 173

Lineage-specific BCL11A knockdown circumvents toxicities and reverses sickle phenotype.

Brendel, C., Guda, S., Renella, R., Bauer, D. E., Canver, M. C., Kim, Y.-J., Heeney, M. M., Klatt, D., Fogel, J., Milsom, M. D., et al. (2016) · Journal of Clinical Investigation

Hemoglobinopathies and Related DisordersVirus-based gene therapy research

Cited by 167

Sustained PU.1 Levels Balance Cell-Cycle Regulators to Prevent Exhaustion of Adult Hematopoietic Stem Cells

Staber, P. B., Zhang, P., Ye, M., Welner, R. S., Nombela-Arrieta, C., Bach, C., Kerenyi, M., Bartholdy, B. A., Zhang, H., Alberich-Jordà, M., et al. (2013) · Molecular Cell

Hematopoietic Stem Cell TransplantationGenomics and Chromatin Dynamics

Cited by 158

Scl Represses Cardiomyogenesis in Prospective Hemogenic Endothelium and Endocardium

Van Handel, B., Montel-Hagen, A., Sasidharan, R., Nakano, H., Ferrari, R., Boogerd, C. J., Schredelseker, J., Wang, Y., Hunter, S., Org, T., et al. (2012) · Cell

Congenital heart defects researchDevelopmental Biology and Gene Regulation

Cited by 154

The C-Terminal Zinc Finger of GATA-1 or GATA-2 Is Sufficient To Induce Megakaryocytic Differentiation of an Early Myeloid Cell Line

Visvader, J. E., Crossley, M., Hill, J., Orkin, S. H., & Adams, J. M. (1995) · Molecular and Cellular Biology

Platelet Disorders and TreatmentsGenomics and Chromatin Dynamics

Cited by 151

The Polycomb-Dependent Epigenome Controls β Cell Dysfunction, Dedifferentiation, and Diabetes

Lu, T. T.-H., Heyne, S., Dror, E., Casas, E., Leonhardt, L., Boenke, T., Yang, C.-H., Sagar, Arrigoni, L., Dalgaard, K., et al. (2018) · Cell Metabolism

Pancreatic function and diabetesEpigenetics and DNA Methylation

Cited by 151

BCL11A deletions result in fetal hemoglobin persistence and neurodevelopmental alterations

Basak, A., Hancarova, M., Ulirsch, J. C., Balci, T. B., Trkova, M., Pelisek, M., Vlckova, M., Muzikova, K., Cermak, J., Trka, J., et al. (2015) · Journal of Clinical Investigation

Hemoglobinopathies and Related DisordersGenetics and Neurodevelopmental Disorders

Cited by 147

Hemoglobin switching’s surprise: the versatile transcription factor BCL11A is a master repressor of fetal hemoglobin.

Bauer, D. E., & Orkin, S. H. (2015) · Current Opinion in Genetics & Development

Hemoglobinopathies and Related DisordersHemoglobin structure and function

Cited by 143

Induction of phagocyte cytochrome b heavy chain gene expression by interferon gamma.

Newburger, P. E., Ezekowitz, R. A., Whitney, C., Wright, J., & Orkin, S. H. (1988) · Proceedings of the National Academy of Sciences

Neutrophil, Myeloperoxidase and Oxidative MechanismsRedox biology and oxidative stress

Cited by 140

Acquired Tissue-Specific Promoter Bivalency Is a Basis for PRC2 Necessity in Adult Cells

Jadhav, U., Nalapareddy, K., Saxena, M., O’Neill, N. K., Pinello, L., Yuan, G.-C., Orkin, S. H., & Shivdasani, R. A. (2016) · Cell

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 139

Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains

Trowbridge, J. J., Sinha, A. U., Zhu, N., Li, M., Armstrong, S. A., & Orkin, S. H. (2012) · Genes & Development

Acute Myeloid Leukemia ResearchEpigenetics and DNA Methylation

Cited by 137

Functional footprinting of regulatory DNA

Vierstra, J., Reik, A., Chang, K.-H., Stehling-Sun, S., Zhou, Y., Hinkley, S. J., Paschon, D. E., Zhang, L., Psatha, N., Bendana, Y. R., et al. (2015) · Nature Methods

Genomics and Chromatin DynamicsCRISPR and Genetic Engineering

Cited by 133

Rb intrinsically promotes erythropoiesis by coupling cell cycle exit with mitochondrial biogenesis

Sankaran, V. G., Orkin, & Walkley, C. R. (2008) · Genes & Development

Erythropoietin and Anemia TreatmentHematopoietic Stem Cell Transplantation

Cited by 133

Emerging genetic therapy for sickle cell disease

Orkin, S. H., & Bauer, D. E. (2019) · Annual Review of Medicine

Hemoglobinopathies and Related DisordersVirus-based gene therapy research

Cited by 119

Recent progress in understanding and manipulating haemoglobin switching for the haemoglobinopathies

Vinjamur, D. S., Bauer, D. E., & Orkin, S. H. (2018) · British Journal of Haematology

Hemoglobinopathies and Related DisordersHemoglobin structure and function

Cited by 114

Control of human hemoglobin switching by LIN28B-mediated regulation of BCL11A translation

Basak, A., Munschauer, M., Lareau, C. A., Montbleau, K. E., Ulirsch, J. C., Hartigan, C. R., Schenone, M., Lian, J., Wang, Y., Huang, Y., et al. (2020) · Nature Genetics

Hemoglobinopathies and Related DisordersRNA Research and Splicing

Cited by 105

The public repository of xenografts enables discovery and randomized phase II-like trials in mice

Townsend, E. C., Murakami, M. A., Christodoulou, A., Christie, A. L., Köster, J., DeSouza, T. A., Morgan, E. A., Kallgren, S. P., Liu, H., Wu, S.-C., et al. (2016) · Cancer Cell

Acute Lymphoblastic Leukemia researchAcute Myeloid Leukemia Research

Cited by 80

Rb is dispensable for self-renewal and multilineage differentiation of adult hematopoietic stem cells

Walkley, C. R., & Orkin, S. H. (2006) · Proceedings of the National Academy of Sciences

Hematopoietic Stem Cell TransplantationMesenchymal stem cell research

Cited by 71