Giaccia, Amato J.

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

Levental, K. R., Yu, H., Kass, L., Lakins, J. N., Egeblad, M., Erler, J. T., Fong, S. F. T., Csiszar, K., Giaccia, A., Weninger, W., et al. (2009) · Cell

Cellular Mechanics and InteractionsCell Adhesion Molecules Research

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Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

Graeber, T. G., Osmanian, C., Jacks, T., Housman, D. E., Koch, C. J., Lowe, S. W., & Giaccia, A. J. (1996) · Nature

Cell death mechanisms and regulationCancer, Hypoxia, and Metabolism

Cited by 2,300

Pre-metastatic niches: organ-specific homes for metastases

Peinado, H., Zhang, H., Matei, I. R., Costa-Silva, B., Hoshino, A., Rodrigues, G., Psaila, B., Kaplan, R. N., Bromberg, J. F., Kang, Y., et al. (2017) · Nature Reviews Cancer

Cancer Cells and MetastasisMechanisms of cancer metastasis

Cited by 1,889

Hypoxic control of metastasis

Rankin, E. B., & Giaccia, A. J. (2016) · Science

Cancer, Hypoxia, and MetabolismMechanisms of cancer metastasis

Cited by 1,340

Lysyl oxidase is essential for hypoxia-induced metastasis

Erler, J. T., Bennewith, K. L., Nicolau, M., Dornhöfer, N., Kong, C., Le, Q.-T., Chi, J.-T. A., Jeffrey, S. S., & Giaccia, A. J. (2006) · Nature

Cancer, Hypoxia, and MetabolismMechanisms of cancer metastasis

Cited by 1,309

Hypoxia-Induced Lysyl Oxidase Is a Critical Mediator of Bone Marrow Cell Recruitment to Form the Premetastatic Niche

Erler, J. T., Bennewith, K. L., Cox, T. R., Lang, G., Bird, D., Koong, A., Le, Q.-T., & Giaccia, A. J. (2009) · Cancer Cell

Cancer Cells and MetastasisImmune cells in cancer

Cited by 1,231

Regulation of Hypoxia-Inducible Factor 1α Expression and Function by the Mammalian Target of Rapamycin

Hudson, C. C., Liu, M., Chiang, G. G., Otterness, D. M., Loomis, D. C., Kaper, F., Giaccia, A. J., & Abraham, R. T. (2002) · Molecular and Cellular Biology

Cancer, Hypoxia, and MetabolismPI3K/AKT/mTOR signaling in cancer

Cited by 1,186

Loss of PTEN facilitates HIF-1-mediated gene expression

Zundel, W., Schindler, C., Haas-Kogan, D., Koong, A., Kaper, F., Chen, E., Gottschalk, A. R., Ryan, H. E., Johnson, R. S., Jefferson, A. B., et al. (2000) · Genes & Development

Cancer, Hypoxia, and MetabolismPI3K/AKT/mTOR signaling in cancer

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The role of hypoxia-inducible factors in tumorigenesis

Rankin, E. B., & Giaccia, A. J. (2008) · Cell Death & Differentiation

Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in Cancer

Cited by 806

HIF-1 as a target for drug development

Giaccia, A., Siim, B. G., & Johnson, R. S. (2003) · Nature Reviews Drug Discovery

Cancer, Hypoxia, and MetabolismErythropoietin and Anemia Treatment

Cited by 631

JunD Reduces Tumor Angiogenesis by Protecting Cells from Oxidative Stress

Gerald, D., Berra, E., Frapart, Y. M., Chan, D. A., Giaccia, A. J., Mansuy, D., Pouysségur, J., Yaniv, M., & Mechta-Grigoriou, F. (2004) · Cell

Angiogenesis and VEGF in CancerCancer, Hypoxia, and Metabolism

Cited by 588

The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease

Giaccia, A. J., Simon, M. C., & Johnson, R. (2004) · Genes & Development

Cancer, Hypoxia, and MetabolismRedox biology and oxidative stress

Cited by 380

Regulation of the Histone Demethylase JMJD1A by Hypoxia-Inducible Factor 1α Enhances Hypoxic Gene Expression and Tumor Growth

Krieg, A. J., Rankin, E. B., Chan, D., Razorenova, O., Fernandez, S., & Giaccia, A. J. (2010) · Molecular and Cellular Biology

Cancer, Hypoxia, and MetabolismEpigenetics and DNA Methylation

Cited by 334

Multiple Factors Affecting Cellular Redox Status and Energy Metabolism Modulate Hypoxia-Inducible Factor Prolyl Hydroxylase Activity In Vivo and In Vitro

Pan, Y., Mansfield, K. D., Bertozzi, C. C., Rudenko, V., Chan, D. A., Giaccia, A. J., & Simon, M. C. (2007) · Molecular and Cellular Biology

Cancer, Hypoxia, and MetabolismMetal-Catalyzed Oxygenation Mechanisms

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Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET

Rankin, E. B., Fuh, K. C., Castellini, L., Viswanathan, K., Finger, E. C., Diep, A. N., LaGory, E. L., Kariolis, M. S., Chan, A., Lindgren, D., et al. (2014) · Proceedings of the National Academy of Sciences

Renal cell carcinoma treatmentCancer, Hypoxia, and Metabolism

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Role of Prolyl Hydroxylation in Oncogenically Stabilized Hypoxia-inducible Factor-1α

Chan, D. A., Sutphin, P. D., Denko, N. C., & Giaccia, A. J. (2002) · Journal of Biological Chemistry

Cancer, Hypoxia, and MetabolismErythropoietin and Anemia Treatment

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AXL Is an Essential Factor and Therapeutic Target for Metastatic Ovarian Cancer

Rankin, E. B., Fuh, K. C., Taylor, T. E., Krieg, A. J., Musser, M., Yuan, J., Wei, K., Kuo, C. J., Longacre, T. A., & Giaccia, A. J. (2010) · Cancer Research

Ovarian cancer diagnosis and treatmentCancer Cells and Metastasis

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Age Decreases Endothelial Progenitor Cell Recruitment Through Decreases in Hypoxia-Inducible Factor 1α Stabilization During Ischemia

Chang, E. I., Loh, S. A., Ceradini, D. J., Chang, E. I., Lin, S.-E., Bastidas, N., Aarabi, S., Chan, D. A., Freedman, M. L., Giaccia, A. J., et al. (2007) · Circulation

Angiogenesis and VEGF in CancerMesenchymal stem cell research

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Hypoxia-inducible Factor-1α Stabilization in Nonhypoxic Conditions: Role of Oxidation and Intracellular Ascorbate Depletion

Pagé, E. L., Chan, D. A., Giaccia, A. J., Levine, M., & Richard, D. E. (2008) · Molecular Biology of the Cell

Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in Cancer

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Hypoxia-inducible Factor-1 Activation in Nonhypoxic Conditions: The Essential Role of Mitochondrial-derived Reactive Oxygen Species

Patten, D. A., Lafleur, V. N., Robitaille, G. A., Chan, D. A., Giaccia, A. J., & Richard, D. E. (2010) · Molecular Biology of the Cell

Cancer, Hypoxia, and MetabolismNitric Oxide and Endothelin Effects

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Dual roles of NRF2 in tumor prevention and progression: Possible implications in cancer treatment

Moon, E. J., & Giaccia, A. (2015) · Free Radical Biology and Medicine

Genomics, phytochemicals, and oxidative stressRedox biology and oxidative stress

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A Central Role for Hypoxic Signaling in Cartilage, Bone, and Hematopoiesis

Rankin, E. B., Giaccia, A. J., & Schipani, E. (2011) · Current Osteoporosis Reports

Cancer, Hypoxia, and MetabolismBone Metabolism and Diseases

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Telomere shortening and metabolic compromise underlie dystrophic cardiomyopathy

Chang, A. C. Y., Ong, S.-G., LaGory, E. L., Kraft, P. E., Giaccia, A. J., Wu, J. C., & Blau, H. M. (2016) · Proceedings of the National Academy of Sciences

Telomeres, Telomerase, and SenescenceMuscle Physiology and Disorders

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HIF gene expression in cancer therapy

Chan, D. A., Krieg, A. J., Turcotte, S., & Giaccia, A. J. (2007) · Methods in Enzymology

Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in Cancer

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