A Central Role for Hypoxic Signaling in Cartilage, Bone, and Hematopoiesis

Rankin, Erinn B.; Giaccia, Amato J.; Schipani, Ernestina

doi:10.1007/s11914-011-0047-2

Cited by 93Cancer, Hypoxia, and MetabolismBone Metabolism and DiseasesOsteoarthritis Treatment and Mechanisms

A Central Role for Hypoxic Signaling in Cartilage, Bone, and Hematopoiesis

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Rankin, Erinn B., Giaccia, Amato J., Schipani, Ernestina·2011·Current Osteoporosis Reports

DOI 10.1007/s11914-011-0047-2PMC PMC4012534

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Abstract

Hypoxic signaling plays an essential role in maintaining oxygen homeostasis and cell survival. Hypoxia-inducible transcription factors HIF-1 and HIF-2 are central mediators of the cellular response to hypoxia by regulating the expression of genes controlling metabolic adaptation, oxygen delivery, and survival in response to oxygen deprivation. Recent studies have identified an important role for HIF-1 and HIF-2 in the regulation of skeletal development, bone formation, and regeneration, as well as joint formation and homeostasis. In addition, overexpression of HIF-1 and HIF-2 is clinically associated with osteosarcoma and osteoarthritis. Together, these findings implicate hypoxic signaling as a central regulator of bone biology and disease.

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Hypoxic signaling is a central regulator of skeletal biology and disease.
“Together, these findings implicate hypoxic signaling as a central regulator of skeletal biology and disease [32].”
From Arthropod steroid hormone (20-Hydroxyecdysone) suppresses IL-1β- induced catabolic gene expression in cartilage (2015) · cites this paper as [32]

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Passing the baton: the HIF switch
Koh, M. Y., & Powis, G. (2012) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2012.06.004 · Cited by 589 · see citing works
Arthropod steroid hormone (20-Hydroxyecdysone) suppresses IL-1β- induced catabolic gene expression in cartilage
Sheu, S.-Y., Ho, S.-R., Sun, J.-S., Chen, C.-Y., & Ke, C.-J. (2015) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-015-0520-z · Cited by 181 · see citing works
Oxygen Regulation in Development: Lessons from Embryogenesis towards Tissue Engineering
Fathollahipour, S., Patil, P. S., & Leipzig, N. D. (2018) · Cells Tissues Organs · doi:10.1159/000493162 · Cited by 101 · see citing works

Authors: Rankin, E. B., Giaccia, A. J., & Schipani, E.
Affiliations: Harvard University (US)
Stanford Medicine (US)
Corresponding author: Schipani, Ernestina
ORCID: Rankin, Erinn B.
Giaccia, Amato J.
Schipani, Ernestina
Venue: Current Osteoporosis Reports
Publisher: Springer Science and Business Media LLC
Published: 2011-03-01
Volume: 9
Issue: 2
Pages: 46-52
ISSN: 1544-1873 (ISSN-L)
1544-2241
DOI: 10.1007/s11914-011-0047-2
PMC: PMC4012534
OpenAlex: W2053094047
Cited by: 93
References: 74
Citations by year: 2026: 7 · 2025: 5 · 2024: 1 · 2023: 4 · 2022: 5 · 2021: 11 · 2020: 11 · 2019: 7 · 2018: 9 · 2017: 7 · 2016: 3 · 2015: 7 · 2014: 5 · 2013: 5 · 2012: 3
FWCI: 0.32
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Current Osteoporosis Reports (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR048191)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
Keywords: hypoxia signaling, hypoxia-inducible factor, HIF-1, HIF-2, cartilage, bone formation, bone regeneration, skeletal development, joint homeostasis, hematopoiesis, oxygen homeostasis, osteosarcoma, osteoarthritis
MeSH terms: Hypoxia, Bone and Bones, Cartilage, Hematopoiesis, Humans, Osteogenesis, Oxygen, Cell Hypoxia, Hypoxia-Inducible Factor 1

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A Central Role for Hypoxic Signaling in Cartilage, Bone, and Hematopoiesis

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