McCormick, Frank

KRAS G13D sensitivity to neurofibromin-mediated GTP hydrolysis

Rabara, D., Tran, T. H., Dharmaiah, S., Stephens, R. M., McCormick, F., Simanshu, D. K., & Holderfield, M. (2019) · Proceedings of the National Academy of Sciences

Protein Kinase Regulation and GTPase SignalingNeurofibromatosis and Schwannoma Cases

Cited by 128

MAP kinase and autophagy pathways cooperate to maintain RAS mutant cancer cell survival

Lee, C.-S., Lee, L. C., Yuan, T. L., Chakka, S., Fellmann, C., Lowe, S. W., Caplen, N. J., McCormick, F., & Luo, J. (2019) · Proceedings of the National Academy of Sciences

Protein Kinase Regulation and GTPase SignalingMelanoma and MAPK Pathways

Cited by 126

Epithelial-to-Mesenchymal Transition Rewires the Molecular Path to PI3K-Dependent Proliferation

Salt, M. B., Bandyopadhyay, S., & McCormick, F. (2014) · Cancer Discovery

Cancer Cells and MetastasisPI3K/AKT/mTOR signaling in cancer

Cited by 124

Ras‐related proteins in signal transduction and growth control

McCormick, F. (1995) · Molecular Reproduction and Development

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 115

Development of siRNA Payloads to Target KRAS -Mutant Cancer

Yuan, T. L., Fellmann, C., Lee, C.-S., Ritchie, C. D., Thapar, V., Lee, L. C., Hsu, D. J., Grace, D., Carver, J. O., Zuber, J., et al. (2014) · Cancer Discovery

RNA Interference and Gene DeliveryRNA Research and Splicing

Cited by 113

K-Ras protein as a drug target

McCormick, F. (2016) · Journal of Molecular Medicine

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 105

SHOC2–MRAS–PP1 complex positively regulates RAF activity and contributes to Noonan syndrome pathogenesis

Young, L. C., Hartig, N., Boned del Río, I., Sari, S., Ringham-Terry, B., Wainwright, J. R., Jones, G. G., McCormick, F., & Rodriguez-Viciana, P. (2018) · Proceedings of the National Academy of Sciences

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

Cited by 98

The small molecule BI-2852 induces a nonfunctional dimer of KRAS

Tran, T. H., Alexander, P., Dharmaiah, S., Agamasu, C., Nissley, D. V., McCormick, F., Esposito, D., Simanshu, D. K., Stephen, A. G., & Balius, T. E. (2020) · Proceedings of the National Academy of Sciences

Protein Kinase Regulation and GTPase SignalingReceptor Mechanisms and Signaling

Cited by 65

MDMX inhibits the p300/CBP-mediated acetylation of p53

Sabbatini, P., & McCormick, F. (2002) · DNA and Cell Biology

Cancer-related Molecular PathwaysHeat shock proteins research

Cited by 62

Sticking it to KRAS: Covalent Inhibitors Enter the Clinic

McCormick, F. (2020) · Cancer Cell

Protein Kinase Regulation and GTPase SignalingMelanoma and MAPK Pathways

Cited by 56

More to the RAS Story: KRAS G12C Inhibition, Resistance Mechanisms, and Moving Beyond KRAS G12C

Lietman, C. D., Johnson, M. L., McCormick, F., & Lindsay, C. R. (2022) · American Society of Clinical Oncology Educational Book

Protein Kinase Regulation and GTPase SignalingMelanoma and MAPK Pathways

Cited by 44

Feasibility of using NF1-GRD and AAV for gene replacement therapy in NF1-associated tumors

Bai, R.-Y., Esposito, D., Tam, A. J., McCormick, F., Riggins, G. J., Wade Clapp, D., & Staedtke, V. (2019) · Gene Therapy

Virus-based gene therapy researchNeurofibromatosis and Schwannoma Cases

Cited by 38

Inhibition of MET Signaling with Ficlatuzumab in Combination with Chemotherapy in Refractory AML: Clinical Outcomes and High-Dimensional Analysis

Wang, V. E., Blaser, B. W., Patel, R. K., Behbehani, G. K., Rao, A. A., Durbin-Johnson, B., Jiang, T., Logan, A. C., Settles, M., Mannis, G. N., et al. (2021) · Blood Cancer Discovery

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

Cited by 11

Abstract RF02-02: BBO-10203, a first-in-class, orally bioavailable, selective covalent small molecule that inhibits RAS-driven PI3Kalpha activity without affecting glucose metabolism

Beltran, P., Dhirendra, S., Xu, R., Chen, M., Czyzyk, D., Donovan, S., Feng, S., Feng, C., Fu, L., Lightstone, F., et al. (2024) · Cancer Research

PI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase Signaling

Cited by 6

Killing Tumors by Keeping Ras and PI3′ Kinase Apart

Yuan, T. L., & McCormick, F. (2013) · Cancer Cell

PI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase Signaling

Cited by 5