Cited by 62Cancer-related Molecular PathwaysHeat shock proteins researchUbiquitin and proteasome pathways

MDMX inhibits the p300/CBP-mediated acetylation of p53

Sabbatini, Peter, McCormick, Frank·2002·DNA and Cell Biology

Abstract

The p300/CBP-mediated acetylation of p53 significantly potentiates p53-mediated transactivation and growth inhibition. MDM2 inhibits the acetylation of p53 by p300/CBP through a mechanism that requires a stable p53-MDM2 interaction and that is sensitive to the deacetylase inhibitor, TSA. MDMX is an MDM2-like protein that shares with MDM2 the ability to interact with p53 and, in turn, inhibit p53-mediated transcription. It was therefore of interest to determine if MDMX could also inhibit the acetylation of p53 by p300/CBP. We demonstrate that MDMX dramatically inhibits the acetylation of p53 induced by both endogenous and ectopically expressed p300/CBP. We also demonstrate that the p53-binding domain of MDMX is required for the MDMX-mediated inhibition of p53 acetylation. Our results indicate that MDMX shares with MDM2 the ability to regulate a potentially important post-translational modification of p53. These results may have important biologic implications with respect to the MDMX-mediated regulation of p53 activity during development.

Integrity signals

Registry

Crossref · 10.1089/104454902320219077

Cites

49 of 49 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Mdm2 and Mdmx bind many other proteins, including proteins involved in development, morphogenesis, and tumorigenesis.

    “However, both Mdm2 and Mdmx interact with many other proteins, including those involved in development, morphogenesis and tumorigenesis (Table 2; [81–92]).”

    From The p53 orchestra: Mdm2 and Mdmx set the tone (2010) · cites this paper as [84]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Sabbatini, P., & McCormick, F.
Affiliations
University of California, San Francisco (US)
Venue
DNA and Cell Biology
Published
2002-07
Volume
21
Issue
7
Pages
519-525
ISSN
  • 1044-5498 (ISSN-L)
  • 1557-7430
OpenAlex
W1983939040
Cited by
62
References
49
Citations by year
2026: 1 · 2024: 1 · 2022: 1 · 2021: 3 · 2020: 1 · 2018: 4 · 2017: 3 · 2016: 6 · 2015: 3 · 2014: 4 · 2012: 3
FWCI
1.77
Type
journal article
Language
en
Open access
closed
Locations
  • DNA and Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Keywords
MDMX, P300, CBP, p53 acetylation, p53-MDM2 interaction, p53 transactivation, histone deacetylase inhibition, trichostatin A, p53-binding domain
MeSH terms
Acetylation, Animals, Binding Sites, Cell Line, DNA-Binding Proteins, Humans, Models, Biological, Nuclear Proteins, Protein Processing, Post-Translational, Proto-Oncogene Proteins, Recombinant Proteins, Transfection, Trans-Activators, Tumor Suppressor Protein p53, Protein Serine-Threonine Kinases, Protein Structure, Tertiary, Mice, Knockout, E1A-Associated p300 Protein, Mice, Proto-Oncogene Proteins c-mdm2, DNA-Activated Protein Kinase

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review