Jung, Steffen

Novel Hexb-based tools for studying microglia in the CNS

Masuda, T., Amann, L., Sankowski, R., Staszewski, O., Lenz, M., d´Errico, P., Snaidero, N., Costa Jordão, M. J., Böttcher, C., Kierdorf, K., et al. (2020) · Nature Immunology

Neuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms

Cited by 317

Microglia, seen from the CX3CR1 angle

Wolf, Y., Yona, S., Kim, K.-W., & Jung, S. (2013) · Frontiers in Cellular Neuroscience

Neuroinflammation and Neurodegeneration MechanismsChemokine receptors and signaling

Cited by 316

Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer’s disease

De Schepper, S., Ge, J. Z., Sierksma, A., Crowley, G., Ferreira, L. S. S., Garceau, D., Toomey, C. E., Sokolova, D., Rueda-Carrasco, J., Shin, S.-H., et al. (2023) · Nature Neuroscience

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 295

The chemokine KC, but not monocyte chemoattractant protein-1, triggers monocyte arrest on early atherosclerotic endothelium

Huo, Y., Weber, C., Forlow, S. B., Sperandio, M., Thatte, J., Mack, M., Jung, S., Littman, D. R., & Ley, K. (2001) · Journal of Clinical Investigation

Atherosclerosis and Cardiovascular DiseasesChemokine receptors and signaling

Cited by 266

Lung macrophages serve as obligatory intermediate between blood monocytes and alveolar macrophages

Landsman, L., & Jung, S. (2007) · The Journal of Immunology

Immune cells in cancerPhagocytosis and Immune Regulation

Cited by 258

A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation

Voet, S., Mc Guire, C., Hagemeyer, N., Martens, A., Schroeder, A., Wieghofer, P., Daems, C., Staszewski, O., Vande Walle, L., Jordao, M. J. C., et al. (2018) · Nature Communications

Neuroinflammation and Neurodegeneration MechanismsInflammasome and immune disorders

Cited by 227

Re-evaluating microglia expression profiles using RiboTag and cell isolation strategies

Haimon, Z., Volaski, A., Orthgiess, J., Boura-Halfon, S., Varol, D., Shemer, A., Yona, S., Zuckerman, B., David, E., Chappell-Maor, L., et al. (2018) · Nature Immunology

Single-cell and spatial transcriptomicsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 209

Methyl-CpG Binding Protein 2 Regulates Microglia and Macrophage Gene Expression in Response to Inflammatory Stimuli

Cronk, J. C., Derecki, N. C., Ji, E., Xu, Y., Lampano, A. E., Smirnov, I., Baker, W., Norris, G. T., Marin, I., Coddington, N., et al. (2015) · Immunity

Genetics and Neurodevelopmental DisordersNeuroinflammation and Neurodegeneration Mechanisms

Cited by 199

Dendritic Cells Ameliorate Autoimmunity in the CNS by Controlling the Homeostasis of PD-1 Receptor+ Regulatory T Cells

Yogev, N., Frommer, F., Lukas, D., Kautz-Neu, K., Karram, K., Ielo, D., von Stebut, E., Probst, H.-C., van den Broek, M., Riethmacher, D., et al. (2012) · Immunity

T-cell and B-cell ImmunologyImmunotherapy and Immune Responses

Cited by 197

Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction

Konishi, H., Okamoto, T., Hara, Y., Komine, O., Tamada, H., Maeda, M., Osako, F., Kobayashi, M., Nishiyama, A., Kataoka, Y., et al. (2020) · The EMBO Journal

Neuroinflammation and Neurodegeneration MechanismsPhagocytosis and Immune Regulation

Cited by 179

A Binary Cre Transgenic Approach Dissects Microglia and CNS Border-Associated Macrophages

Kim, J.-S., Kolesnikov, M., Peled-Hajaj, S., Scheyltjens, I., Xia, Y., Trzebanski, S., Haimon, Z., Shemer, A., Lubart, A., Van Hove, H., et al. (2021) · Immunity

Neuroinflammation and Neurodegeneration MechanismsBarrier Structure and Function Studies

Cited by 176

Interleukin-10 Prevents Pathological Microglia Hyperactivation following Peripheral Endotoxin Challenge

Shemer, A., Scheyltjens, I., Frumer, G. R., Kim, J.-S., Grozovski, J., Ayanaw, S., Dassa, B., Van Hove, H., Chappell-Maor, L., Boura-Halfon, S., et al. (2020) · Immunity

Neuroinflammation and Neurodegeneration MechanismsImmune Response and Inflammation

Cited by 175

Microglia plasticity during health and disease: An immunological perspective

Shemer, A., Erny, D., Jung, S., & Prinz, M. (2015) · Trends in Immunology

Neuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms

Cited by 168

Microglia contribute to circuit defects in Mecp2 null mice independent of microglia-specific loss of Mecp2 expression

Schafer, D. P., Heller, C. T., Gunner, G., Heller, M., Gordon, C., Hammond, T., Wolf, Y., Jung, S., & Stevens, B. (2016) · eLife

Genetics and Neurodevelopmental DisordersNeuroinflammation and Neurodegeneration Mechanisms

Cited by 147

Cxcl10+ monocytes define a pathogenic subset in the central nervous system during autoimmune neuroinflammation

Giladi, A., Wagner, L. K., Li, H., Dörr, D., Medaglia, C., Paul, F., Shemer, A., Jung, S., Yona, S., Mack, M., et al. (2020) · Nature Immunology

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 130

Microglia: unique and common features with other tissue macrophages

Prinz, M., Tay, T. L., Wolf, Y., & Jung, S. (2014) · Acta Neuropathologica

Neuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms

Cited by 126

Opposing Effects of Membrane-Anchored CX3CL1 on Amyloid and Tau Pathologies via the p38 MAPK Pathway

Lee, S., Xu, G., Jay, T. R., Bhatta, S., Kim, K.-W., Jung, S., Landreth, G. E., Ransohoff, R. M., & Lamb, B. T. (2014) · The Journal of Neuroscience

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 123

TGF‐β signaling through SMAD2/3 induces the quiescent microglial phenotype within the CNS environment

Abutbul, S., Shapiro, J., Szaingurten‐Solodkin, I., Levy, N., Carmy, Y., Baron, R., Jung, S., & Monsonego, A. (2012) · Glia

Neuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms

Cited by 122

An essential role for dendritic cells in human and experimental allergic rhinitis

KleinJan, A., Willart, M., van Rijt, L. S., Braunstahl, G.-J., Leman, K., Jung, S., Hoogsteden, H. C., & Lambrecht, B. N. (2006) · Journal of Allergy and Clinical Immunology

Allergic Rhinitis and SensitizationAsthma and respiratory diseases

Cited by 111

Comparative analysis of CreER transgenic mice for the study of brain macrophages: A case study

Chappell‐Maor, L., Kolesnikov, M., Kim, J., Shemer, A., Haimon, Z., Grozovski, J., Boura‐Halfon, S., Masuda, T., Prinz, M., & Jung, S. (2020) · European Journal of Immunology

Neuroinflammation and Neurodegeneration MechanismsAnimal Genetics and Reproduction

Cited by 70

Clonal hematopoiesis-associated motoric deficits caused by monocyte-derived microglia accumulating in aging mice

Kim, J.-S., Trzebanski, S., Shin, S.-H., Schori, L., Frumer Friedman, G. R., Ilani, N. C., Kadam, A., Vicario, R., Aust, O., Bugaeva, P., et al. (2025) · Cell Reports

Neuroinflammation and Neurodegeneration MechanismsAcute Myeloid Leukemia Research

Cited by 33

Macrophages and monocytes: of tortoises and hares

Jung, S. (2018) · Nature Reviews Immunology

Immune cells in cancerPhagocytosis and Immune Regulation

Cited by 27

Genetically enhancing the expression of chemokine domain of CX3CL1 fails to prevent tau pathology in mouse models of tauopathy

Bemiller, S. M., Maphis, N. M., Formica, S. V., Wilson, G. N., Miller, C. M., Xu, G., Kokiko-Cochran, O. N., Kim, K.-W., Jung, S., Cannon, J. L., et al. (2018) · Journal of Neuroinflammation

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 24