Cited by 258Immune cells in cancerPhagocytosis and Immune RegulationAtherosclerosis and Cardiovascular Diseases

Lung macrophages serve as obligatory intermediate between blood monocytes and alveolar macrophages

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Landsman, Limor, Jung, Steffen·2007·The Journal of Immunology

Abstract

Alveolar macrophages are a unique type of mononuclear phagocytes that populate the external surface of the lung cavity. Early studies have suggested that alveolar macrophages originate from tissue-resident, local precursors, whereas others reported their derivation from blood-borne cells. However, the role of circulating monocytes as precursors of alveolar macrophages was never directly tested. In this study, we show through the combined use of conditional cell ablation and adoptive cell transfer that alveolar macrophages originate in vivo from blood monocytes. Interestingly, this process requires an obligate intermediate stage, the differentiation of blood monocytes into parenchymal lung macrophages, which subsequently migrate into the alveolar space. We also provide direct evidence for the ability of both lung and alveolar macrophages to proliferate.

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Crossref · 10.4049/jimmunol.179.6.3488

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Authors
Landsman, L., & Jung, S.
Affiliations
Weizmann Institute of Science (IL)
Venue
The Journal of Immunology
Published
2007-09
Volume
179
Issue
6
Pages
3488-3494
ISSN
  • 0022-1767 (ISSN-L)
  • 1550-6606
OpenAlex
W2170851221
Cited by
258
References
51
Citations by year
2026: 6 · 2025: 4 · 2024: 11 · 2023: 8 · 2022: 23 · 2021: 6 · 2020: 10 · 2019: 10 · 2018: 17 · 2017: 11 · 2016: 27 · 2015: 11 · 2014: 23 · 2013: 20 · 2012: 18
FWCI
4.56
Type
journal article
Language
en
Open access
Locations
  • The Journal of Immunology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
  • Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
  • Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Keywords
alveolar macrophages, lung macrophages, blood monocytes, monocyte-to-macrophage differentiation, monocyte-derived macrophages, macrophage proliferation, adoptive cell transfer
MeSH terms
Animals, Cell Differentiation, Cell Movement, Diphtheria Toxin, Growth Inhibitors, Lung, Mice, Inbred C57BL, Mice, Mutant Strains, Mice, Transgenic, Monocytes, Stem Cells, Bone Marrow Transplantation, Macrophages, Alveolar, Adoptive Transfer, Cell Proliferation, Mice

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