Brain-derived neurotrophic factor as a model system for examining gene by environment interactions across development
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There has been a dramatic rise in gene x environment studies of human behavior over the past decade that have moved the field beyond simple nature versus nurture debates. These studies offer promise in accounting for more variability in behavioral and biological phenotypes than studies that focus on genetic or experiential factors alone. They also provide clues into mechanisms of modifying genetic risk or resilience in neurodevelopmental disorders. Yet, it is rare that these studies consider how these interactions change over the course of development. In this paper, we describe research that focuses on the impact of a polymorphism in a brain-derived neurotrophic factor (BDNF) gene, known to be involved in learning and development. Specifically we present findings that assess the effects of genotypic and environmental loadings on neuroanatomic and behavioral phenotypes across development. The findings illustrate the use of a genetic mouse model that mimics the human polymorphism, to constrain the interpretation of gene-environment interactions across development in humans.
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Some samples of children with institutional care histories show increased internalizing and externalizing behaviors, although previously institutionalized children show fewer such problems than domestically adopted children.
“These regulation difficulties have additionally been evidenced by increased internalizing (Casey, et al., 2009) and externalizing behaviors in some samples of children with a history of institutional care (see meta-analysis in Juffer & van Ijzendoorn, 2005) (although PI children show fewer internalizing and externalizing behavior problems than children adopted domestically).”
From Risk and developmental heterogeneity in previously institutionalized children (2012) · cites this paper as Casey, et al., 2009
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Self-citationHung, P., Wu, K. L. H., Chen, C., Siu, K.-K., Hsin, Y., Wang, L., & Wang, F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22137174 · Cited by 13 · see citing works
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Altered declarative memory in introverted middle-aged adults carrying the BDNF val66met allele
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Contemporary Genetics for Gender Researchers
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- Authors
- Casey, B. J., Glatt, C. E., Tottenham, N., Soliman, F., Bath, K., Amso, D., Altemus, M., Pattwell, S., Jones, R., Levita, L., McEwen, B., Magariños, A. M., Gunnar, M., Thomas, K. M., Mezey, J., Clark, A. G., Hempstead, B. L., & Lee, F. S.
- Affiliations
- Cornell University (US)
- Weill Cornell Medicine (US)
- Rockefeller University (US)
- University of Minnesota (US)
- Corresponding author
- Casey, B.J.
- ORCID
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2009-11
- Volume
- 164
- Issue
- 1
- Pages
- 108-120
- ISSN
- 0306-4522 (ISSN-L)
- PMC
- PMC2760671
- OpenAlex
- W2000196263
- Cited by
- 129
- References
- 119
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 5 · 2020: 6 · 2019: 8 · 2018: 7 · 2017: 11 · 2016: 6 · 2015: 13 · 2014: 13 · 2013: 12 · 2012: 12
- FWCI
- 1.21
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (P50MH079513, R01MH073175, R01MH091864, R01 MH73175)
- National Institute of General Medical Sciences (T32GM007739)
- National Institute of Neurological Disorders and Stroke (R01NS052819)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- brain-derived neurotrophic factor, BDNF gene polymorphism, gene-environment interaction, developmental trajectories, genetic mouse models, behavioral phenotypes, neurodevelopmental disorders, learning and development
- MeSH terms
- Aging, Animals, Brain, Environment, Humans, Human Development, Models, Genetic, Phenotype, Polymorphism, Genetic, Brain-Derived Neurotrophic Factor, Mice
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