Duman, Ronald S.

GABA interneurons are the cellular trigger for ketamine's rapid antidepressant actions

Gerhard, D. M., Pothula, S., Liu, R.-J., Wu, M., Li, X.-Y., Girgenti, M. J., Taylor, S. R., Duman, C. H., Delpire, E., Picciotto, M., et al. (2020) · Journal of Clinical Investigation

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 345

Role of BDNF in the Pathophysiology and Treatment of Depression: Activity-Dependent Effects Distinguish Rapid-Acting Antidepressants

Duman, R. S., Deyama, S., & Fogaça, M. V. (2021) · European Journal of Neuroscience

Treatment of Major DepressionNerve injury and regeneration

Cited by 321

Inhibition of cAMP response element-binding protein or dynorphin in the nucleus accumbens produces an antidepressant-like effect

Newton, S. S., Thome, J., Wallace, T. L., Shirayama, Y., Schlesinger, L., Sakai, N., Chen, J., Neve, R., Nestler, E. J., & Duman, R. S. (2002) · The Journal of Neuroscience

Treatment of Major DepressionNeurotransmitter Receptor Influence on Behavior

Cited by 313

Altered expression of synapse and glutamate related genes in post-mortem hippocampus of depressed subjects

Duric, V., Banasr, M., Stockmeier, C. A., Simen, A. A., Newton, S. S., Overholser, J. C., Jurjus, G. J., Dieter, L., & Duman, R. S. (2013) · International Journal of Neuropsychopharmacology

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 304

Stress-Induced Neuronal Colony Stimulating Factor 1 Provokes Microglia-Mediated Neuronal Remodeling and Depressive-like Behavior

Wohleb, E. S., Terwilliger, R., Duman, C. H., & Duman, R. S. (2018) · Biological Psychiatry

Neuroinflammation and Neurodegeneration MechanismsStress Responses and Cortisol

Cited by 288

Regionally specific regulation of ERK MAP kinase in a model of antidepressant-sensitive chronic depression

Gourley, S. L., Wu, F. J., Kiraly, D. D., Ploski, J. E., Kedves, A. T., Duman, R. S., & Taylor, J. R. (2008) · Biological Psychiatry

Treatment of Major DepressionStress Responses and Cortisol

Cited by 287

REDD1 is essential for stress-induced synaptic loss and depressive behavior

Ota, K. T., Liu, R.-J., Voleti, B., Maldonado-Aviles, J. G., Duric, V., Iwata, M., Dutheil, S., Duman, C., Boikess, S., Lewis, D. A., et al. (2014) · Nature Medicine

Treatment of Major DepressionStress Responses and Cortisol

Cited by 267

Optogenetic stimulation of infralimbic PFC reproduces ketamine’s rapid and sustained antidepressant actions

Fuchikami, M., Thomas, A., Liu, R., Wohleb, E. S., Land, B. B., DiLeone, R. J., Aghajanian, G. K., & Duman, R. S. (2015) · Proceedings of the National Academy of Sciences

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 265

Scopolamine Rapidly Increases Mammalian Target of Rapamycin Complex 1 Signaling, Synaptogenesis, and Antidepressant Behavioral Responses

Voleti, B., Navarria, A., Liu, R.-J., Banasr, M., Li, N., Terwilliger, R., Sanacora, G., Eid, T., Aghajanian, G., & Duman, R. S. (2013) · Biological Psychiatry

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 264

Spine synapse remodeling in the pathophysiology and treatment of depression

Duman, C. H., & Duman, R. S. (2015) · Neuroscience Letters

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 257

GSK-3 inhibition potentiates the synaptogenic and antidepressant-like effects of subthreshold doses of ketamine

Liu, R.-J., Fuchikami, M., Dwyer, J. M., Lepack, A. E., Duman, R. S., & Aghajanian, G. K. (2013) · Neuropsychopharmacology

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 256

Pathophysiology of depression and innovative treatments: remodeling glutamatergic synaptic connections

Duman, R. S. (2014) · Dialogues in Clinical Neuroscience

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 249

Chronic Cocaine Treatment Decreases Levels of the G Protein Subunits Giα and Goα in Discrete Regions of Rat Brain

Nestler, E. J., Terwilliger, R. Z., Walker, J. R., Sevarino, K. A., & Duman, R. S. (1990) · Journal of Neurochemistry

Neurotransmitter Receptor Influence on BehaviorReceptor Mechanisms and Signaling

Cited by 232

The neurobiology of depression, ketamine and rapid-acting antidepressants: Is it glutamate inhibition or activation?

Abdallah, C. G., Sanacora, G., Duman, R. S., & Krystal, J. H. (2018) · Pharmacology & Therapeutics

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 219

Dysregulation of Protein Kinase A Signaling in the Aged Prefrontal Cortex

Ramos, B. P., Birnbaum, S. G., Lindenmayer, I., Newton, S. S., Duman, R. S., & Arnsten, A. F. T. (2003) · Neuron

Neuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

Cited by 218

Optogenetic stimulation of medial prefrontal cortex Drd1 neurons produces rapid and long-lasting antidepressant effects

Hare, B. D., Shinohara, R., Liu, R. J., Pothula, S., DiLeone, R. J., & Duman, R. S. (2019) · Nature Communications

Treatment of Major DepressionNeurotransmitter Receptor Influence on Behavior

Cited by 217

Beta-hydroxybutyrate, an endogenic NLRP3 inflammasome inhibitor, attenuates stress-induced behavioral and inflammatory responses

Yamanashi, T., Iwata, M., Kamiya, N., Tsunetomi, K., Kajitani, N., Wada, N., Iitsuka, T., Yamauchi, T., Miura, A., Pu, S., et al. (2017) · Scientific Reports

Tryptophan and brain disordersTreatment of Major Depression

Cited by 214

NEUROBIOLOGY OF STRESS, DEPRESSION, AND RAPID ACTING ANTIDEPRESSANTS: REMODELING SYNAPTIC CONNECTIONS: Review: Remodeling Synaptic Connections

Duman, R. S. (2014) · Depression and Anxiety

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 213

Neuronal damage and protection in the pathophysiology and treatment of psychiatric illness: stress and depression

Duman, R. S. (2009) · Dialogues in Clinical Neuroscience

Stress Responses and CortisolTreatment of Major Depression

Cited by 210

Depression and sterile inflammation: essential role of danger associated molecular patterns

Franklin, T. C., Xu, C., & Duman, R. S. (2018) · Brain, Behavior, and Immunity

Tryptophan and brain disordersStress Responses and Cortisol

Cited by 204

Cell atrophy and loss in depression: reversal by antidepressant treatment

Banasr, M., Dwyer, J. M., & Duman, R. S. (2011) · Current Opinion in Cell Biology

Treatment of Major DepressionStress Responses and Cortisol

Cited by 201

Transiently increased glutamate cycling in rat PFC is associated with rapid onset of antidepressant-like effects

Chowdhury, G. M. I., Zhang, J., Thomas, M., Banasr, M., Ma, X., Pittman, B., Bristow, L., Schaeffer, E., Duman, R. S., Rothman, D. L., et al. (2017) · Molecular Psychiatry

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 197

Ketamine disinhibits dendrites and enhances calcium signals in prefrontal dendritic spines

Ali, F., Gerhard, D. M., Sweasy, K., Pothula, S., Pittenger, C., Duman, R. S., & Kwan, A. C. (2020) · Nature Communications

Neuroscience and Neuropharmacology ResearchTreatment of Major Depression

Cited by 196

Stressor-specific regulation of distinct brain-derived neurotrophic factor transcripts and cyclic AMP response element-binding protein expression in the postnatal and adult rat hippocampus

Nair, A., Vadodaria, K. C., Banerjee, S. B., Benekareddy, M., Dias, B. G., Duman, R. S., & Vaidya, V. A. (2007) · Neuropsychopharmacology

Stress Responses and CortisolNerve injury and regeneration

Cited by 189