GABA interneurons are the cellular trigger for ketamine's rapid antidepressant actions
Open accessAbstract
A single subanesthetic dose of ketamine, an NMDA receptor (NMDAR) antagonist, produces rapid and sustained antidepressant actions in depressed patients, addressing a major unmet need for the treatment of mood disorders. Ketamine produces a rapid increase in extracellular glutamate and synaptic formation in the prefrontal cortex, but the initial cellular trigger that initiates this increase and ketamine's behavioral actions has not been identified. To address this question, we used a combination of viral shRNA and conditional mutation to produce cell-specific knockdown or deletion of a key NMDAR subunit, GluN2B, implicated in the actions of ketamine. The results demonstrated that the antidepressant actions of ketamine were blocked by GluN2B-NMDAR knockdown on GABA (Gad1) interneurons, as well as subtypes expressing somatostatin (Sst) or parvalbumin (Pvalb), but not glutamate principle neurons in the medial prefrontal cortex (mPFC). Further analysis of GABA subtypes showed that cell-specific knockdown or deletion of GluN2B in Sst interneurons blocked or occluded the antidepressant actions of ketamine and revealed sex-specific differences that are associated with excitatory postsynaptic currents on mPFC principle neurons. These findings demonstrate that GluN2B-NMDARs on GABA interneurons are the initial cellular trigger for the rapid antidepressant actions of ketamine and show sex-specific adaptive mechanisms to GluN2B modulation.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The behavioral effect of GluN2B loss corresponded to disinhibition of layer 5 mPFC pyramidal neurons, with inhibition of GABA signaling strengthening pyramidal neuron activity.
“This behavioral effect corresponded to a disinhibition of layer 5 mPFC pyramidal neurons whereby inhibition of GABA signaling strengthened pyramidal neuron activity.”
From Mechanisms of ketamine and its metabolites as antidepressants (2022) · cites this paper as Gerhard et al., 2020
The Discussion reports that GluN2B knockdown or deletion in Sst interneurons increased excitatory currents in layer V mPFC pyramidal neurons and was associated with antidepressant-like behavior in male mice. It identifies this as disinhibition, but says the electrophysiological association was not observed in females; the claim omits that limitation. The indexed passages provide a section label but no page number. (LLM, conf=0.86)
Experimental — accuracy not yet measuredThe genetic manipulation alone reduced immobility relative to controls to a point where ketamine could not elicit a further reduction.
“The genetic manipulation alone appeared to reduce immobility relative to controls to a point where ketamine could not elicit a further reduction.”
From Mechanisms of ketamine and its metabolites as antidepressants (2022) · cites this paper as Gerhard et al., 2020
The results section reports that GluN2B knockdown in Gad1 interneurons reduced baseline immobility relative to controls and that ketamine produced no further reduction. But the Discussion (p. 1345) reports that another antidepressant reduced immobility in the manipulated mice, ruling out a floor effect. Thus the paper supports the observed lack of further ketamine response, not the suggestion that immobility had fallen to a point where no further reduction was possible. (LLM, conf=0.90)
Experimental — accuracy not yet measuredLoss of GluN2B in medial prefrontal cortex GABAergic interneurons, specifically those expressing somatostatin and parvalbumin, occluded ketamine's antidepressant-like effects in the mouse forced swim test.
“using a genetic knockdown approach in mice found that loss of GluN2B in medial PFC (mPFC GABAergic interneurons, and specifically in those expressing somatostatin (SST) and parvalbumin (PV), occluded the antidepressant-like effects of ketamine in the forced swim test (Gerhard et al., 2020).”
From Mechanisms of ketamine and its metabolites as antidepressants (2022) · cites this paper as Gerhard et al., 2020
Knockdown or deletion of ketamine-sensitive NMDARs from somatostatin- or parvalbumin-expressing interneurons alters baseline forced swim test and other behaviors.
“Furthermore, knock-down and deletion of critical ketaminesensitive NMDARs from either somatostatin-or parvalbuminexpressing interneurons alters baseline behaviors in the FST and other tasks and eliminates the ability of ketamine to change these behaviors in unstressed mice [210].”
From Plasticity of synapses and reward circuit function in the genesis and treatment of depression (2023) · cites this paper as [210]
Deletion of ketamine-sensitive NMDARs from these interneurons eliminates ketamine's ability to change behaviors in unstressed mice.
“Furthermore, knock-down and deletion of critical ketaminesensitive NMDARs from either somatostatin-or parvalbuminexpressing interneurons alters baseline behaviors in the FST and other tasks and eliminates the ability of ketamine to change these behaviors in unstressed mice [210].”
From Plasticity of synapses and reward circuit function in the genesis and treatment of depression (2023) · cites this paper as [210]
Ketamine acutely inhibits interneuron discharge in the prefrontal cortex and reduces spontaneous IPSCs in pyramidal cells.
“As in the hippocampus, ketamine inhibits the discharge of interneurons in the PFC and reduces spontaneous IPSCs in pyramidal cells acutely [210], while restoring inhibition at later timepoints corresponding to its behavioral actions [211].”
From Plasticity of synapses and reward circuit function in the genesis and treatment of depression (2023) · cites this paper as [210]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The mouse brain in stereotaxic coordinates
Konsman, J. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(03)00088-x · Cited by 16,796 · see citing works
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,501 · see citing works
Antidepressant effects of ketamine in depressed patients
Berman, R. M., Cappiello, A., Anand, A., Oren, D. A., Heninger, G. R., Charney, D. S., & Krystal, J. H. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00230-9 · Cited by 3,856 · see citing works
Interneurons of the neocortical inhibitory system
Markram, H., Toledo-Rodriguez, M., Wang, Y., Gupta, A., Silberberg, G., & Wu, C. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1519 · Cited by 2,954 · see citing works
mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists
Li, N., Lee, B., Liu, R.-J., Banasr, M., Dwyer, J. M., Iwata, M., Li, X.-Y., Aghajanian, G., & Duman, R. S. (2010) · Science · doi:10.1126/science.1190287 · Cited by 2,881 · see citing works
Self-citationRational siRNA design for RNA interference
Reynolds, A., Leake, D., Boese, Q., Scaringe, S., Marshall, W. S., & Khvorova, A. (2004) · Nature Biotechnology · doi:10.1038/nbt936 · Cited by 2,094 · see citing works
GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits
Tremblay, R., Lee, S., & Rudy, B. (2016) · Neuron · doi:10.1016/j.neuron.2016.06.033 · Cited by 2,033 · see citing works
NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses
Autry, A. E., Adachi, M., Nosyreva, E., Na, E. S., Los, M. F., Cheng, P.-F., Kavalali, E. T., & Monteggia, L. M. (2011) · Nature · doi:10.1038/nature10130 · Cited by 1,926 · see citing works
Moghaddam, B., Adams, B., Verma, A., & Daly, D. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02921.1997 · Cited by 1,793 · see citing works
Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants
Duman, R. S., Aghajanian, G. K., Sanacora, G., & Krystal, J. H. (2016) · Nature Medicine · doi:10.1038/nm.4050 · Cited by 1,750 · see citing works
Self-citationAdult mouse cortical cell taxonomy revealed by single cell transcriptomics
Tasic, B., Menon, V., Nguyen, T. N., Kim, T. K., Jarsky, T., Yao, Z., Levi, B., Gray, L. T., Sorensen, S. A., Dolbeare, T., et al. (2016) · Nature Neuroscience · doi:10.1038/nn.4216 · Cited by 1,714 · see citing works
Homayoun, H., & Moghaddam, B. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2213-07.2007 · Cited by 1,231 · see citing works
Maeng, S., Zarate, C. A., Du, J., Schloesser, R. J., McCammon, J., Chen, G., & Manji, H. K. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.05.028 · Cited by 1,103 · see citing works
Li, N., Liu, R.-J., Dwyer, J. M., Banasr, M., Lee, B., Son, H., Li, X.-Y., Aghajanian, G., & Duman, R. S. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.12.015 · Cited by 1,082 · see citing works
Self-citationDuman, R. S., Sanacora, G., & Krystal, J. H. (2019) · Neuron · doi:10.1016/j.neuron.2019.03.013 · Cited by 1,026 · see citing works
Self-citationNew insights into the classification and nomenclature of cortical GABAergic interneurons
DeFelipe, J., López-Cruz, P. L., Benavides-Piccione, R., Bielza, C., Larrañaga, P., Anderson, S., Burkhalter, A., Cauli, B., Fairén, A., Feldmeyer, D., et al. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3444 · Cited by 833 · see citing works
Cre-lox-regulated conditional RNA interference from transgenes
Ventura, A., Meissner, A., Dillon, C. P., McManus, M. T., Sharp, P. A., Parijs, L. V., Jaenisch, R., & Jacks, T. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403954101 · Cited by 623 · see citing works
Preskorn, S., Baker, B., Kolluri, S., Menniti, F. S., Krams, M., & Landen, J. W. (2008) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e31818a6cea · Cited by 522 · see citing works
Wang, Y., Toledo‐Rodriguez, M., Gupta, A., Wu, C., Silberberg, G., Luo, J., & Markram, H. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.073353 · Cited by 491 · see citing works
Unique functional properties of somatostatin-expressing GABAergic neurons in mouse barrel cortex
Gentet, L. J., Kremer, Y., Taniguchi, H., Huang, Z. J., Staiger, J. F., & Petersen, C. C. H. (2012) · Nature Neuroscience · doi:10.1038/nn.3051 · Cited by 438 · see citing works
Miller, O. H., Yang, L., Wang, C.-C., Hargroder, E. A., Zhang, Y., Delpire, E., & Hall, B. J. (2014) · eLife · doi:10.7554/elife.03581 · Cited by 358 · see citing works
Self-citationBrigman, J. L., Wright, T., Talani, G., Prasad-Mulcare, S., Jinde, S., Seabold, G. K., Mathur, P., Davis, M. I., Bock, R., Gustin, R. M., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.0640-10.2010 · Cited by 339 · see citing works
Self-citationConstantinidis, C., & Goldman-Rakic, P. (2002) · Journal of Neurophysiology · doi:10.1152/jn.00188.2002 · Cited by 337 · see citing works
Rao, S. G., Williams, G. V., & Goldman, P. S. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.81.4.1903 · Cited by 335 · see citing works
A CamKIIα iCre BAC allows brain‐specific gene inactivation
Casanova, E., Fehsenfeld, S., Mantamadiotis, T., Lemberger, T., Greiner, E. F., Stewart, A. F., & Schütz, G. (2001) · genesis · doi:10.1002/gene.1078 · Cited by 293 · see citing works
Emerging treatment mechanisms for depression: focus on glutamate and synaptic plasticity
Gerhard, D. M., Wohleb, E. S., & Duman, R. S. (2016) · Drug Discovery Today · doi:10.1016/j.drudis.2016.01.016 · Cited by 287 · see citing works
Self-citationREDD1 is essential for stress-induced synaptic loss and depressive behavior
Ota, K. T., Liu, R.-J., Voleti, B., Maldonado-Aviles, J. G., Duric, V., Iwata, M., Dutheil, S., Duman, C., Boikess, S., Lewis, D. A., et al. (2014) · Nature Medicine · doi:10.1038/nm.3513 · Cited by 267 · see citing works
Self-citationFuchikami, M., Thomas, A., Liu, R., Wohleb, E. S., Land, B. B., DiLeone, R. J., Aghajanian, G. K., & Duman, R. S. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1414728112 · Cited by 265 · see citing works
Self-citationSex differences in glutamate receptor gene expression in major depression and suicide
Gray, A. L., Hyde, T. M., Deep-Soboslay, A., Kleinman, J. E., & Sodhi, M. S. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.91 · Cited by 250 · see citing works
Hare, B. D., Shinohara, R., Liu, R. J., Pothula, S., DiLeone, R. J., & Duman, R. S. (2019) · Nature Communications · doi:10.1038/s41467-018-08168-9 · Cited by 217 · see citing works
Self-citationHalliwell, R. F., Peters, J. A., & Lambert, J. J. (1989) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1989.tb11841.x · Cited by 215 · see citing works
GABAergic and glutamatergic efferents of the mouse ventral tegmental area
Taylor, S. R., Badurek, S., Dileone, R., Nashmi, R., Minichiello, L., & Picciotto, M. R. (2014) · The Journal of Comparative Neurology · doi:10.1002/cne.23603 · Cited by 209 · see citing works
Self-citationFuchs, T., Jefferson, S. J., Hooper, A., Yee, P.-H., Maguire, J., & Luscher, B. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.188 · Cited by 204 · see citing works
Widman, A. J., & McMahon, L. L. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1718883115 · Cited by 204 · see citing works
Miller, O. H., Moran, J. T., & Hall, B. J. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.07.028 · Cited by 200 · see citing works
The Female Urine Sniffing Test: A Novel Approach for Assessing Reward-Seeking Behavior in Rodents
Malkesman, O., Scattoni, M. L., Paredes, D., Tragon, T. R., Pearson, B. L., Shaltiel, G., Chen, G., Crawley, J. N., & Manji, H. K. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.10.018 · Cited by 197 · see citing works
A Critical Role for GluN2B-Containing NMDA Receptors in Cortical Development and Function
Wang, C.-C., Held, R. G., Chang, S.-C., Yang, L., Delpire, E., Ghosh, A., & Hall, B. J. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.023 · Cited by 180 · see citing works
Self-citationSomatostatin, neuronal vulnerability and behavioral emotionality
Lin, L., & Sibille, E. L. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.184 · Cited by 178 · see citing works
Antidepressant Effects of Fibroblast Growth Factor-2 in Behavioral and Cellular Models of Depression
Elsayed, M., Banasr, M., Duric, V., Fournier, N. M., Licznerski, P., & Duman, R. S. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.03.003 · Cited by 169 · see citing works
Self-citationMurray, A., Wołoszynowska-Fraser, M. U., Ansel-Bollepalli, L., Marshall-Phelps, K. L., Foggetti, A., Crouch, B., Riedel, G., & Wulff, P. (2015) · Scientific Reports · doi:10.1038/srep16778 · Cited by 165 · see citing works
Povysheva, N. V., González‐Burgos, G., Zaitsev, A. V., Kröner, S., Barrionuevo, G., Lewis, D. A., & Krimer, L. S. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhj002 · Cited by 145 · see citing works
GABA interneurons mediate the rapid antidepressant-like effects of scopolamine
Wohleb, E. S., Wu, M., Gerhard, D. M., Taylor, S. R., Picciotto, M. R., Alreja, M., & Duman, R. S. (2016) · Journal of Clinical Investigation · doi:10.1172/jci85033 · Cited by 144 · see citing works
Self-citationSmith, C. C., Vedder, L. C., & McMahon, L. L. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.06.003 · Cited by 129 · see citing works
Distinct Firing Patterns of Neuronal Subtypes in Cortical Synchronized Activities
Kawaguchi, Y. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07261.2001 · Cited by 123 · see citing works
Hartvig, P., Valtysson, J., Lindner, K., Kristensen, J. D., Karlsten, R., Gustafsson, L. L., Persson, J., Svensson, J. O., Øye, I., Antoni, G., et al. (1995) · Clinical Pharmacology & Therapeutics · doi:10.1016/0009-9236(95)90194-9 · Cited by 120 · see citing works
Perova, Z., Delevich, K. M., & Li, B. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2670-14.2015 · Cited by 116 · see citing works
Sex Differences in Psychiatric Disease: A Focus on the Glutamate System
Wickens, M. M., Bangasser, D. A., & Briand, L. A. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00197 · Cited by 114 · see citing works
Seney, M. L., Tripp, A. C., McCune, S., Lewis, D. A., & Sibille, E. L. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.10.005 · Cited by 95 · see citing works
Ghosal, S., Duman, C. H., Liu, R.-J., Wu, M., Terwilliger, R., Girgenti, M. J., Wohleb, E., Fogaca, M. V., Teichman, E. M., Hare, B., et al. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104669 · Cited by 89 · see citing works
Self-citationWang, Y., Ma, Y.-C., Hu, J., Cheng, W.-W., Jiang, H., Zhang, X., Li, M. D., Ren, J., & Li, X.-B. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.06.008 · Cited by 83 · see citing works
Self-citationNg, L. H. L., Huang, Y., Han, L., Chang, R. C.-C., Chan, Y. S., & Lai, C. S. W. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0321-5 · Cited by 82 · see citing works
Pozzi, L., Dorocic, I. P., Wang, X., Carlén, M., & Meletis, K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0083879 · Cited by 74 · see citing works
Freeman, M. P., Papakostas, G. I., Hoeppner, B. B., Mazzone, E., Judge, H., Cusin, C., Mathew, S. J., Sanacora, G., Iosifescu, D. V., DeBattista, C., et al. (2019) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2019.01.010 · Cited by 70 · see citing works
Synaptic Regulation of a Thalamocortical Circuit Controls Depression-Related Behavior
Miller, O. H., Bruns, A., Ammar, I. B., Mueggler, T., & Hall, B. J. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.08.002 · Cited by 69 · see citing works
Regulation of the Mouse Medial Prefrontal Cortical Synapses by Endogenous Estradiol
Galvin, C., & Ninan, I. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.56 · Cited by 68 · see citing works
Rapid-Acting Antidepressants: Mechanistic Insights and Future Directions
Gerhard, D. M., & Duman, R. S. (2018) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-018-0139-8 · Cited by 52 · see citing works
Self-citationZhou, F., Chen, H.-X., & Roper, S. N. (2009) · Journal of Neurophysiology · doi:10.1152/jn.00557.2009 · Cited by 50 · see citing works
Macbeth, A. H., Edds, J. S., & Young, W. S. (2009) · Nature Protocols · doi:10.1038/nprot.2009.141 · Cited by 46 · see citing works
Potapenko, E. S., Biancardi, V. C., Florschutz, R. M., Ryu, P. D., & Stern, J. E. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00218.2011 · Cited by 43 · see citing works
Park, L., Furey, M., Nugent, A. C., Farmer, C., Ellis, J., Szczepanik, J. E., Lener, M. S., & Zarate, C. A. (2018) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy051 · Cited by 37 · see citing works
Dopaminergic modulation of basal ganglia output through coupled excitation–inhibition
Budzillo, A., Duffy, A., Miller, K. E., Fairhall, A. L., & Perkel, D. J. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1611146114 · Cited by 35 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Gerhard DM, Duman RS. Rapid-acting antide- pressants: mechanistic insights and future direc- tions. Curr Behav Neurosci Rep. 2018;5(1):36-47.
Cited by
Sorted by citations
Prefrontal cortex and depression
Pizzagalli, D. A., & Roberts, A. C. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01101-7 · Cited by 644 · see citing works
Brain-Derived Neurotrophic Factor Signaling in Depression and Antidepressant Action
Castrén, E., & Monteggia, L. M. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.05.008 · Cited by 540 · see citing works
Neuroplasticity as a convergent mechanism of ketamine and classical psychedelics
Aleksandrova, L. R., & Phillips, A. G. (2021) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2021.08.003 · Cited by 276 · see citing works
Ketamine and rapid antidepressant action: New treatments and novel synaptic signaling mechanisms
Krystal, J. H., Kavalali, E. T., & Monteggia, L. M. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-023-01629-w · Cited by 262 · see citing works
Ketamine: A tale of two enantiomers
Jelen, L. A., Young, A. H., & Stone, J. M. (2020) · Journal of Psychopharmacology · doi:10.1177/0269881120959644 · Cited by 253 · see citing works
Prévot, T. D., & Sibille, E. L. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0727-3 · Cited by 232 · see citing works
Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanisms
Inserra, A., De Gregorio, D., & Gobbi, G. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000056 · Cited by 232 · see citing works
Brain NMDA Receptors in Schizophrenia and Depression
Adell, A. (2020) · Biomolecules · doi:10.3390/biom10060947 · Cited by 218 · see citing works
Ketamine disinhibits dendrites and enhances calcium signals in prefrontal dendritic spines
Ali, F., Gerhard, D. M., Sweasy, K., Pothula, S., Pittenger, C., Duman, R. S., & Kwan, A. C. (2020) · Nature Communications · doi:10.1038/s41467-019-13809-8 · Cited by 196 · see citing works
Self-citationThe stressed synapse 2.0: pathophysiological mechanisms in stress-related neuropsychiatric disorders
Sanacora, G., Yan, Z., & Popoli, M. (2022) · Nature Reviews Neuroscience · doi:10.1038/s41583-021-00540-x · Cited by 197 · see citing works
Mechanisms of ketamine and its metabolites as antidepressants
Hess, E. M., Riggs, L. M., Michaelides, M., & Gould, T. D. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114892 · Cited by 169 · see citing works
Antidepressant actions of ketamine engage cell-specific translation via eIF4E
Aguilar-Valles, A., De Gregorio, D., Matta-Camacho, E., Eslamizade, M. J., Khlaifia, A., Skaleka, A., Lopez-Canul, M., Torres-Berrio, A., Bermudez, S., Rurak, G. M., et al. (2021) · Nature · doi:10.1038/s41586-020-03047-0 · Cited by 144 · see citing works
A non-hallucinogenic LSD analog with therapeutic potential for mood disorders
Lewis, V., Bonniwell, E. M., Lanham, J. K., Ghaffari, A., Sheshbaradaran, H., Cao, A. B., Calkins, M. M., Bautista-Carro, M. A., Arsenault, E., Telfer, A., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112203 · Cited by 138 · see citing works
Lin, S., Huang, L., Luo, Z.-C., Li, X., Jin, S., Du, Z., Wu, D., Xiong, W., Huang, L., Luo, Z.-Y., et al. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.02.014 · Cited by 130 · see citing works
Self-citationDavoudian, P. A., Shao, L.-X., & Kwan, A. C. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.2c00637 · Cited by 128 · see citing works
Fogaça, M. V., Wu, M., Li, C., Li, X.-Y., Picciotto, M. R., & Duman, R. S. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-00916-y · Cited by 129 · see citing works
Self-citationThe molecular pathophysiology of depression and the new therapeutics
Tian, H., Hu, Z., Xu, J., & Wang, C. (2022) · MedComm · doi:10.1002/mco2.156 · Cited by 122 · see citing works
The Role of Parvalbumin Interneurons in Neurotransmitter Balance and Neurological Disease
Nahar, L., Delacroix, B. M., & Nam, H. W. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.679960 · Cited by 118 · see citing works
Ketamine: Mechanisms and Relevance to Treatment of Depression
Kim, J., Suzuki, K., Kavalali, E. T., & Monteggia, L. M. (2023) · Annual Review of Medicine · doi:10.1146/annurev-med-051322-120608 · Cited by 124 · see citing works
A Dendrite-Focused Framework for Understanding the Actions of Ketamine and Psychedelics
Savalia, N. K., Shao, L.-X., & Kwan, A. C. (2021) · Trends in Neurosciences · doi:10.1016/j.tins.2020.11.008 · Cited by 104 · see citing works
Wojtas, A., Bysiek, A., Wawrzczak‐Bargieła, A., Szych, Z., Majcher‐Maślanka, I., Herian, M., Maćkowiak, M., & Gołembiowska, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126713 · Cited by 106 · see citing works
Synaptic Mechanisms Regulating Mood State Transitions in Depression
Parekh, P. K., Johnson, S. B., & Liston, C. (2022) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-110920-040422 · Cited by 101 · see citing works
Kadriu, B., Greenwald, M., Henter, I. D., Gilbert, J. R., Kraus, C., Park, L. T., & Zarate, C. A. (2021) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyaa087 · Cited by 99 · see citing works
Cultural Differences and Information Technology Acceptance
Zakour, A. B. (2004) · Cited by 101 · see citing works
Brain region–specific action of ketamine as a rapid antidepressant
Chen, M., Ma, S., Liu, H., Dong, Y., Tang, J., Ni, Z., Tan, Y. J., Duan, C.-C., Li, H., Huang, H., et al. (2024) · Science · doi:10.1126/science.ado7010 · Cited by 103 · see citing works
Jelen, L. A., & Stone, J. M. (2021) · International Review of Psychiatry · doi:10.1080/09540261.2020.1854194 · Cited by 102 · see citing works
A Synaptic Locus for TrkB Signaling Underlying Ketamine Rapid Antidepressant Action
Lin, P.-Y., Ma, Z. Z., Mahgoub, M., Kavalali, E. T., & Monteggia, L. M. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109513 · Cited by 99 · see citing works
Ketamine triggers a switch in excitatory neuronal activity across neocortex
Cichon, J., Wasilczuk, A. Z., Looger, L. L., Contreras, D., Kelz, M. B., & Proekt, A. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01203-5 · Cited by 87 · see citing works
Cell-type specific modulation of NMDA receptors triggers antidepressant actions
Pothula, S., KATO, T., Liu, R.-J., Wu, M., Gerhard, D. M., Shinohara, R., Sliby, A., Chowdhury, G. M. I., Behar, K. L., Sanacora, G., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0796-3 · Cited by 81 · see citing works
Self-citationKetamine: Neuroprotective or Neurotoxic?
Choudhury, D., Autry, A. E., Tolias, K. F., & Krishnan, V. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.672526 · Cited by 85 · see citing works
Lazarevic, V., Yang, Y., Flais, I., & Svenningsson, P. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01246-3 · Cited by 76 · see citing works
Liu, H., Zhang, X., Shi, P., Yuan, J.-Y., Jia, Q., Pi, C., Chen, T., Xiong, L., Chen, J., Tang, J., et al. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02768-z · Cited by 70 · see citing works
Kang, M. J. Y., Hawken, E., & Vazquez, G. H. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.860882 · Cited by 77 · see citing works
Anxiety and depression: A top‐down, bottom‐up model of circuit function
LeDuke, D. O., Borio, M., Miranda, R. L., & Tye, K. M. (2023) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14997 · Cited by 76 · see citing works
Murray, C. H., Tare, I., Perry, C., Malina, M., Lee, R., & de Wit, H. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05991-9 · Cited by 72 · see citing works
Krystal, J., Kaye, A. P., Jefferson, S., Girgenti, M., Wilkinson, S. T., Sanacora, G., & Esterlis, I. (2023) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.2305772120 · Cited by 69 · see citing works
Self-citationNarrative Review: Low-Dose Ketamine for Pain Management
Riccardi, A., Guarino, M., Serra, S., Spampinato, M. D., Vanni, S., Shiffer, D., Voza, A., Fabbri, A., & Iaco, F. D. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12093256 · Cited by 74 · see citing works
Johnston, J. N., Kadriu, B., Allen, J., Gilbert, J. R., Henter, I. D., & Zarate, C. A. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109422 · Cited by 68 · see citing works
Torrisi, S. A., Lavanco, G., Maurel, O. M., Gulisano, W., Laudani, S., Geraci, F., Grasso, M., Barbagallo, C., Caraci, F., Bucolo, C., et al. (2020) · Neurobiology of Stress · doi:10.1016/j.ynstr.2020.100286 · Cited by 66 · see citing works
Banasr, M., Sanacora, G., & Esterlis, I. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.04.004 · Cited by 65 · see citing works
A unified model of ketamine’s dissociative and psychedelic properties
Marguilho, M., Figueiredo, I., & Castro-Rodrigues, P. (2022) · Journal of Psychopharmacology · doi:10.1177/02698811221140011 · Cited by 65 · see citing works
Rapid-acting antidepressants and the circadian clock
Sato, S., Bunney, B. G., Mendoza-Viveros, L., Bunney, W. E., Borrelli, E., Sassone‐Corsi, P., & Orozco-Solís, R. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01241-w · Cited by 65 · see citing works
GluN2A mediates ketamine-induced rapid antidepressant-like responses
Su, T., Lu, Y., Fu, C., Geng, Y., & Chen, Y. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01436-y · Cited by 63 · see citing works
Bridging Rapid and Sustained Antidepressant Effects of Ketamine
Kim, J.-W., Suzuki, K., Kavalali, E. T., & Monteggia, L. M. (2023) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2023.02.003 · Cited by 59 · see citing works
Singewald, N., Sartori, S. B., Reif, A., & Holmes, A. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109418 · Cited by 61 · see citing works
Lv, S., Yao, K., Zhang, Y., & Zhu, S. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109378 · Cited by 57 · see citing works
Update on GPCR-based targets for the development of novel antidepressants
Mantas, I., Saarinen, M., Xu, Q., & Svenningsson, P. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01040-1 · Cited by 59 · see citing works
Inflammatory Pathogenesis of Post-stroke Depression
Feng, X., Ma, X., Li, J., Zhou, Q., Liu, Y., Song, J., Liu, J., Situ, Q., Wang, L., Zhang, J., et al. (2024) · Aging and Disease · doi:10.14336/ad.2024.0203 · Cited by 61 · see citing works
Levinstein, M. R., Budinich, R. C., Bonaventura, J., Schatzberg, A. F., Zarate, C. A., & Michaelides, M. (2025) · American Journal of Psychiatry · doi:10.1176/appi.ajp.20240378 · Cited by 56 · see citing works
Neurobiology of the rapid-acting antidepressant effects of ketamine: impact and opportunities
Shinohara, R., Aghajanian, G. K., & Abdallah, C. G. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.12.006 · Cited by 54 · see citing works
NMDA Receptors: Distribution, Role, and Insights into Neuropsychiatric Disorders
Beaurain, M., Salabert, A., Payoux, P., Gras, E., & Talmont, F. (2024) · Pharmaceuticals · doi:10.3390/ph17101265 · Cited by 55 · see citing works
Chen, T., Cheng, L., Ma, J., Yuan, J., Pi, C., Xiong, L., Chen, J., Liu, H., Tang, J., Zhong, Y., et al. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106837 · Cited by 55 · see citing works
Single-cell transcriptomic and chromatin dynamics of the human brain in PTSD
Hwang, A., Škarica, M., Xu, S., Coudriet, J. M., Lee, C.-Y., Lin, L., Terwilliger, R. Z., Sliby, A., Wang, J., Nguyen, T. P., et al. (2025) · Nature · doi:10.1038/s41586-025-09083-y · Cited by 57 · see citing works
Self-citationUncovering the Underlying Mechanisms of Ketamine as a Novel Antidepressant
Xu, S., Yao, X., Li, B., Cui, R., Zhu, C., Wang, Y., & Yang, W. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.740996 · Cited by 51 · see citing works
Roussy, M. P., Luna, R., Duong, L., Corrigan, B. W., Gulli, R. A., Nogueira, R., Moreno‐Bote, R., Sachs, A. J., Palaniyappan, L. K., & Martínez-Trujillo, J. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01082-5 · Cited by 49 · see citing works
Targeting metaplasticity mechanisms to promote sustained antidepressant actions
Brown, K. A., & Gould, T. D. (2024) · Molecular Psychiatry · doi:10.1038/s41380-023-02397-1 · Cited by 49 · see citing works
Multivariate genome-wide analysis of education, socioeconomic status and brain phenome
Wendt, F. R., Pathak, G. A., Lencz, T., Krystal, J. H., Gelernter, J. E., & Polimanti, R. A. (2020) · Nature Human Behaviour · doi:10.1038/s41562-020-00980-y · Cited by 49 · see citing works
Ketamine’s rapid antidepressant effects are mediated by Ca2+-permeable AMPA receptors
Zaytseva, A., Bouckova, E., Wiles, M. J., Wustrau, M. H., Schmidt, I. G., Mendez-Vazquez, H., Khatri, L., & Kim, S. (2023) · eLife · doi:10.7554/elife.86022 · Cited by 48 · see citing works
Huang, C., Wu, Z., Wang, D., Qu, Y., Zhang, J., Jiang, R., Xu, X., Xu, X., Wang, Y., Liu, H., et al. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02288-5 · Cited by 48 · see citing works
The role of the excitation:inhibition functional balance in the mPFC in the onset of antidepressants
Yin, Y., Wang, Y., Liu, W., Yao, J.-Q., Yuan, J., Li, Z.-H., Ran, Y., Zhang, L., & Li, Y. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108573 · Cited by 48 · see citing works
Wang, Y., Zhang, N., Liu, L., Jiang, H., Hu, D., Wang, Z., Chen, N., & Zhang, Y. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.01.024 · Cited by 46 · see citing works
Deyama, S., & Kaneda, K. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109335 · Cited by 46 · see citing works
Duan, W., Peng, K., Qin, H.-M., Li, B.-M., Xu, Y.-X., Wang, D.-J., Yu, L., Wang, H., Hu, J., & Wang, Q. (2023) · British Journal of Anaesthesia · doi:10.1016/j.bja.2023.10.038 · Cited by 47 · see citing works
Dissecting the neurobiology of linguistic disorganisation and impoverishment in schizophrenia
Palaniyappan, L. K. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.08.015 · Cited by 47 · see citing works
P2X2 receptors in pyramidal neurons are critical for regulating vulnerability to chronic stress
Kuang, X., Zhang, C.-Y., Yan, B.-Y., Cai, W.-Z., Lu, C., Xie, L.-J., Li, S.-J., Kong, P., Fan, J., Pan, S.-M., et al. (2022) · Theranostics · doi:10.7150/thno.72144 · Cited by 46 · see citing works
Jiang, C. S., Dileone, R., Pittenger, C., & Duman, R. S. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02796-0 · Cited by 42 · see citing works
Self-citationAntidepressant mechanisms of ketamine: Focus on GABAergic inhibition
Lüscher, B., Feng, M., & Jefferson, S. J. (2020) · Advances in pharmacology · doi:10.1016/bs.apha.2020.03.002 · Cited by 41 · see citing works
GluN2B-containing NMDARs in the mammalian brain: pharmacology, physiology, and pathology
Ge, Y., & Wang, Y. T. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1190324 · Cited by 41 · see citing works
Ketamine: The final frontier or another depressing end?
Sial, O. K., Parise, E. M., Parise, L. F., Gnecco, T., & Bolaños‐Guzmán, C. A. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112508 · Cited by 40 · see citing works
Maksymetz, J., Byun, N. E., Luessen, D. J., Li, B., Barry, R. L., Gore, J. C., Niswender, C. M., Lindsley, C. W., Joffe, M. E., & Conn, P. J. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109950 · Cited by 38 · see citing works
Plasticity of synapses and reward circuit function in the genesis and treatment of depression
Thompson, S. M. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-022-01422-1 · Cited by 40 · see citing works
Gawande, D. Y., Narasimhan, K. K. S., Shelkar, G. P., Pavuluri, R., Stessman, H. A. F., & Dravid, S. M. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.03.020 · Cited by 39 · see citing works
Wu, L., Zhang, T., Chen, K., Lu, C., Liu, X. F., Zhou, J. L., Huang, Y., Yan, H., Chen, Y., Zhang, C. J., et al. (2020) · Phytotherapy Research · doi:10.1002/ptr.6812 · Cited by 40 · see citing works
Lei, L., Zhu, B., Qiao, K., Zhou, Y., Chen, X., Men, J., Yang, L., Wang, Q., Han, J. Z., & Zhou, B. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.153623 · Cited by 40 · see citing works
Adam, E. M., Kowalski, M., Akeju, O., Miller, E. K., Brown, E. N., McCarthy, M. M., & Kopell, N. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2402732121 · Cited by 35 · see citing works
Reversal of Age-Related Neuronal Atrophy by α5-GABAA Receptor Positive Allosteric Modulation
Prévot, T. D., Sumitomo, A., Tomoda, T., Knutson, D. E., Li, G., Mondal, P., Banasr, M., Cook, J. M., & Sibille, E. L. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhaa310 · Cited by 38 · see citing works
Yu, Z., Han, Y., Hu, D., Chen, N., Zhang, Z., Chen, W., Xue, Y.-X., Meng, S., Lü, L., Zhang, W., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01495-w · Cited by 37 · see citing works
Izumi, Y., Hsu, F., Conway, C. R., Nägele, P., Mennerick, S. J., & Zorumski, C. F. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.06.016 · Cited by 35 · see citing works
Hughes, B. W., Siemsen, B. M., Tsvetkov, E., Berto, S., Kumar, J., Cornbrooks, R. G., Akiki, R. M., Cho, J. Y., Carter, J. S., Snyder, K. K., et al. (2023) · eLife · doi:10.7554/elife.75631 · Cited by 34 · see citing works
Recent advances in the study of anesthesia-and analgesia-related mechanisms of S-ketamine
Zhou, J., Peng, G., Liang, W., Chen, Z., Liu, Y., Wang, B., Guo, M., Deng, Y.-L., Jun-ming, Y., Zhong, M., et al. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1228895 · Cited by 39 · see citing works
Ugarte, G., Piña, R., Contreras, D., Godoy, F., Rubio, D., Rozas, C., Zeise, M. L., Vidal, R., Escobar, J., & Morales, B. (2023) · Biology · doi:10.3390/biology12091241 · Cited by 32 · see citing works
Fogaça, M. V., Daher, F., & Picciotto, M. R. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-024-02002-1 · Cited by 34 · see citing works
Self-citationPothula, S., Liu, R.-J., Wu, M., Sliby, A., Picciotto, M. R., Banerjee, P., & Duman, R. S. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-00882-7 · Cited by 32 · see citing works
Self-citationSydnor, V. J., Lyall, A. E., Karayumak, S. C., Cheung, J. C., Felicione, J. M., Akeju, O., Shenton, M. E., Deckersbach, T., Ionescu, D. F., Pasternak, O., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-01122-8 · Cited by 32 · see citing works
Okada, M., Kawano, Y., Fukuyama, K., Motomura, E., & Shiroyama, T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21217951 · Cited by 32 · see citing works
Viana, G. S. D. B., do Vale, E. M., de Araujo, A. R. A., Coelho, N. C., Andrade, S. M., da Costa, R. O., de Aquino, P. E. A., de Sousa, C. N. S., Medeiros, I. D. S., Vasconcelos, S. M. M., et al. (2020) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x202010107 · Cited by 30 · see citing works
Benefits of animal models to understand the pathophysiology of depressive disorders
Czéh, B., & Simon, M. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110049 · Cited by 30 · see citing works
S100A10 and its binding partners in depression and antidepressant actions
Chen, M. X., Oh, Y., & Kim, Y. D. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.953066 · Cited by 32 · see citing works
Bernardo, A. M., Lee, P., Marcotte, M. D., Mian, M. Y., Rezvanian, S., Sharmin, D., Kovačević, A., Savić, M. M., Cook, J. M., Sibille, E. L., et al. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01360-y · Cited by 29 · see citing works
Sachdeva, B., Sachdeva, P., Ghosh, S., Ahmad, F., & Sinha, J. K. (2023) · Ibrain · doi:10.1002/ibra.12094 · Cited by 29 · see citing works
Depression and the Glutamate/GABA-Glutamine Cycle
Mamelak, M. (2024) · Current Neuropharmacology · doi:10.2174/1570159x22666240815120244 · Cited by 29 · see citing works
Fogaça, M. V., Wu, M., Li, C., Li, X., Duman, R. S., & Picciotto, M. R. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-023-01583-7 · Cited by 28 · see citing works
Self-citationZhang, Y.-M., Zong, H.-C., Qi, Y.-B., Chang, L.-L., Gao, Y.-N., Zhou, T., Yin, T., Liu, M., Pan, K.-J., Chen, W.-G., et al. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02283-w · Cited by 27 · see citing works
Chaki, S., & Watanabe, M. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109348 · Cited by 28 · see citing works
Hare, B. D., Pothula, S., Dileone, R., & Duman, R. S. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.107947 · Cited by 25 · see citing works
Self-citationLinking depression and neuroinflammation: Crosstalk between glial cells
Yang, X., Wang, H., Wang, Z.-Z., & Chen, N. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177408 · Cited by 26 · see citing works
Sex Differences in the Sustained Effects of Ketamine on Resilience to Chronic Stress
Okine, T., Shepard, R. M., Lemanski, E. A., & Coutellier, L. D. (2020) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.581360 · Cited by 26 · see citing works
Ketamine induces multiple individually distinct whole-brain functional connectivity signatures
Moujaes, F., Ji, J. L., Rahmati, M., Burt, J. B., Schleifer, C. H., Adkinson, B. D., Savić, A., Santamauro, N. P., Tamayo, Z., Diehl, C., et al. (2024) · eLife · doi:10.7554/elife.84173 · Cited by 27 · see citing works
Esketamine as a treatment for paediatric depression: questions of safety and efficacy
Zimmermann, K. S., Richardson, R., & Baker, K. (2020) · The Lancet Psychiatry · doi:10.1016/s2215-0366(19)30521-8 · Cited by 26 · see citing works
An integrative view on the cell-type-specific mechanisms of ketamine's antidepressant actions
Lewis, V., Rurak, G. M., Salmaso, N., & Aguilar‐Valles, A. (2024) · Trends in Neurosciences · doi:10.1016/j.tins.2023.12.004 · Cited by 27 · see citing works
- Authors
- Gerhard, D. M., Pothula, S., Liu, R.-J., Wu, M., Li, X.-Y., Girgenti, M. J., Taylor, S. R., Duman, C. H., Delpire, E., Picciotto, M., Wohleb, E. S., & Duman, R. S.
- Affiliations
- Yale University (US)
- Vanderbilt University (US)
- ORCID
- Venue
- Journal of Clinical Investigation
- Published
- 2020-01-27
- Volume
- 130
- Issue
- 3
- Pages
- 1336-1349
- ISSN
- 0021-9738 (ISSN-L)
- 1558-8238
- PMC
- PMC7269589
- OpenAlex
- W2991582092
- Cited by
- 345
- References
- 61
- Citations by year
- 2026: 37 · 2025: 51 · 2024: 51 · 2023: 61 · 2022: 55 · 2021: 44 · 2020: 43
- FWCI
- 22.01
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH093897, MH105910, MH077681)
- National Institute on Drug Abuse (DA14241)
- National Institute on Alcohol Abuse and Alcoholism (AA013514)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- ketamine, rapid antidepressant effects, GABAergic interneurons, GluN2B, NMDA receptor, somatostatin interneurons, parvalbumin interneurons, medial prefrontal cortex, depression, sex differences, excitatory postsynaptic currents, glutamate release, synaptic plasticity
- MeSH terms
- Animals, Antidepressive Agents, Female, Glutamate Decarboxylase, Interneurons, Ketamine, Male, Mice, Transgenic, Parvalbumins, Sex Characteristics, Somatostatin, Receptors, N-Methyl-D-Aspartate, Mice, Gene Knockout Techniques, GABAergic Neurons
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
