Stress-activated Protein Kinases (JNK and p38/HOG) Are Essential for Vascular Endothelial Growth Factor mRNA Stability

Pagès, Gilles; Berra, Edurne; Milanini, Julie; Levy, Andrew P.; Pouysségur, Jacques

doi:10.1074/jbc.m002104200

Stress-activated Protein Kinases (JNK and p38/HOG) Are Essential for Vascular Endothelial Growth Factor mRNA Stability

Stability of the vascular endothelial growth factor (VEGF) mRNA is tightly regulated through its 3′-untranslated region (3′-UTR). Here, we demonstrate that VEGF mRNA levels are increased by anisomycin, a strong activator of stress-activated protein kinases. Hence, VEGF mRNA induction is inhibited…