Church, George M.

A prudent path forward for genomic engineering and germline gene modification

Baltimore, D., Berg, P., Botchan, M., Carroll, D., Charo, R. A., Church, G., Corn, J. E., Daley, G. Q., Doudna, J. A., Fenner, M., et al. (2015) · Science

CRISPR and Genetic EngineeringBiomedical Ethics and Regulation

Cited by 733

Clinical assessment incorporating a personal genome

Ashley, E. A., Butte, A. J., Wheeler, M. T., Chen, R., Klein, T. E., Dewey, F. E., Dudley, J. T., Ormond, K. E., Pavlovic, A., Morgan, A. A., et al. (2010) · The Lancet

Genomics and Rare DiseasesGenetic Associations and Epidemiology

Cited by 674

Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy

Hinson, J. T., Chopra, A., Nafissi, N., Polacheck, W. J., Benson, C. C., Swist, S., Gorham, J., Yang, L., Schafer, S., Sheng, C. C., et al. (2015) · Science

Cardiomyopathy and Myosin StudiesCardiac electrophysiology and arrhythmias

Cited by 638

A Multifunctional AAV-CRISPR-Cas9 and Its Host Response

Chew, W. L., Tabebordbar, M., Cheng, J. K. W., Mali, P., Wu, E. Y., Ng, A. H. M., Zhu, K., Wagers, A. J., & Church, G. M. (2016) · Nature Methods

CRISPR and Genetic EngineeringVirus-based gene therapy research

Cited by 617

Modular epistasis in yeast metabolism

Segrè, D., DeLuna, A., Church, G. M., & Kishony, R. (2005) · Nature Genetics

Bioinformatics and Genomic NetworksMicrobial Metabolic Engineering and Bioproduction

Cited by 575

Causes and effects of N-terminal codon bias in bacterial genes

Goodman, D. B., Church, G. M., & Kosuri, S. (2013) · Science

RNA and protein synthesis mechanismsBacterial Genetics and Biotechnology

Cited by 573

Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform

Rock, J. M., Hopkins, F. F., Chavez, A., Diallo, M., Chase, M. R., Gerrick, E. R., Pritchard, J. R., Church, G. M., Rubin, E. J., Sassetti, C. M., et al. (2017) · Nature Microbiology

CRISPR and Genetic EngineeringBacterial Genetics and Biotechnology

Cited by 538

Fluorescent in situ sequencing (FISSEQ) of RNA for gene expression profiling in intact cells and tissues

Lee, J. H., Daugharthy, E. R., Scheiman, J., Kalhor, R., Ferrante, T. C., Terry, R., Turczyk, B. M., Yang, J. L., Lee, H. S., Aach, J., et al. (2015) · Nature Protocols

Single-cell and spatial transcriptomicsMolecular Biology Techniques and Applications

Cited by 529

Highly multiplexed in situ protein imaging with signal amplification by Immuno-SABER

Saka, S. K., Wang, Y., Kishi, J. Y., Zhu, A., Zeng, Y., Xie, W., Kirli, K., Yapp, C., Cicconet, M., Beliveau, B. J., et al. (2018) · Nature Biotechnology

Advanced biosensing and bioanalysis techniquesAdvanced Fluorescence Microscopy Techniques

Cited by 485

Single-sequence protein structure prediction using language models from deep learning

Chowdhury, R., Bouatta, N., Biswas, S., Rochereau, C., Church, G. M., Sorger, P. K., & AlQuraishi, M. (2021) · Nature Biotechnology

Protein Structure and DynamicsMachine Learning in Bioinformatics

Cited by 455

Single-sequence protein structure prediction using a language model and deep learning

Chowdhury, R., Bouatta, N., Biswas, S., Floristean, C., Kharkar, A., Roy, K., Rochereau, C., Ahdritz, G., Zhang, J., Church, G. M., et al. (2022) · Nature Biotechnology

Protein Structure and DynamicsMachine Learning in Bioinformatics

Cited by 455

Generation of Functional Human Hepatic Endoderm From Human Induced Pluripotent Stem Cells

Sullivan, G. J., Hay, D. C., Park, I.-H., Fletcher, J., Hannoun, Z., Payne, C. M., Dalgetty, D., Black, J. R., Ross, J. A., Samuel, K., et al. (2010) · Hepatology

Pluripotent Stem Cells ResearchDrug-Induced Hepatotoxicity and Protection

Cited by 445

Low-N protein engineering with data-efficient deep learning

Biswas, S., Khimulya, G., Alley, E. C., Esvelt, K. M., & Church, G. M. (2021) · Nature Methods

Protein Structure and DynamicsEnzyme Catalysis and Immobilization

Cited by 422

A robust benchmark for detection of germline large deletions and insertions

Zook, J. M., Hansen, N. F., Olson, N. D., Chapman, L., Mullikin, J. C., Xiao, C., Sherry, S., Koren, S., Phillippy, A. M., Boutros, P. C., et al. (2020) · Nature Biotechnology

Genomic variations and chromosomal abnormalitiesGenomics and Phylogenetic Studies

Cited by 418

Composability of regulatory sequences controlling transcription and translation in Escherichia coli

Kosuri, S., Goodman, D. B., Cambray, G., Mutalik, V. K., Gao, Y., Arkin, A. P., Endy, D., & Church, G. M. (2013) · Proceedings of the National Academy of Sciences

Microbial Metabolic Engineering and BioproductionGene Regulatory Network Analysis

Cited by 392

Developmental barcoding of whole mouse via homing CRISPR

Kalhor, R., Kalhor, K., Mejia, L., Leeper, K., Graveline, A., Mali, P., & Church, G. M. (2018) · Science

CRISPR and Genetic EngineeringDevelopmental Biology and Gene Regulation

Cited by 363

CRISPR-Cas Encoding of a Digital Movie into the Genomes of a Population of Living Bacteria

Shipman, S. L., Nivala, J., Macklis, J. D., & Church, G. M. (2017) · Nature

CRISPR and Genetic EngineeringDNA and Biological Computing

Cited by 361

Comprehensive AAV capsid fitness landscape reveals a viral gene and enables machine-guided design

Ogden, P. J., Kelsic, E. D., Sinai, S., & Church, G. M. (2019) · Science

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 356

Regulatory Networks Revealed by Transcriptional Profiling of Damaged Saccharomyces cerevisiae Cells: Rpn4 Links Base Excision Repair with Proteasomes

Jelinsky, S. A., Estep, P., Church, G. M., & Samson, L. D. (2000) · Molecular and Cellular Biology

Fungal and yeast genetics researchDNA Repair Mechanisms

Cited by 335

Forward Error Correction for DNA Data Storage

Blawat, M., Gaedke, K., Hütter, I., Chen, X.-M., Turczyk, B., Inverso, S., Pruitt, B. W., & Church, G. M. (2016) · Procedia Computer Science

DNA and Biological ComputingError Correcting Code Techniques

Cited by 333

A highly annotated whole-genome sequence of a Korean individual

Kim, J.-I., Ju, Y. S., Park, H., Kim, S., Lee, S., Yi, J.-H., Mudge, J., Miller, N. A., Hong, D., Bell, C. J., et al. (2009) · Nature

Genomics and Phylogenetic StudiesGenomic variations and chromosomal abnormalities

Cited by 330

Engineering an allosteric transcription factor to respond to new ligands

Taylor, N. D., Garruss, A. S., Moretti, R., Chan, S., Arbing, M. A., Cascio, D., Rogers, J. K., Isaacs, F. J., Kosuri, S., Baker, D., et al. (2016) · Nature Methods

Gene Regulatory Network AnalysisMicrobial Metabolic Engineering and Bioproduction

Cited by 328

Nucleic acid memory

Zhirnov, V., Zadegan, R. M., Sandhu, G. S., Church, G. M., & Hughes, W. L. (2016) · Nature Materials

DNA and Biological ComputingAdvanced Memory and Neural Computing

Cited by 307

Design and testing of a humanized porcine donor for xenotransplantation

Anand, R. P., Layer, J. V., Heja, D., Hirose, T., Lassiter, G., Firl, D. J., Paragas, V. B., Akkad, A., Chhangawala, S., Colvin, R. B., et al. (2023) · Nature

Xenotransplantation and immune responseAnimal Genetics and Reproduction

Cited by 302