Church, George M.

Submicrometre geometrically encoded fluorescent barcodes self-assembled from DNA

Lin, C., Jungmann, R., Leifer, A. M., Li, C., Levner, D., Church, G. M., Shih, W. M., & Yin, P. (2012) · Nature Chemistry

Advanced biosensing and bioanalysis techniquesAdvanced Fluorescence Microscopy Techniques

Cited by 302

Rates, distribution and implications of postzygotic mosaic mutations in autism spectrum disorder

Lim, E. T., Uddin, M., De Rubeis, S., Chan, Y., Kamumbu, A. S., Zhang, X., D'Gama, A. M., Kim, S. N., Hill, R. S., Goldberg, A. P., et al. (2017) · Nature Neuroscience

Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental Disorders

Cited by 299

Enzymatic DNA synthesis for digital information storage.

Lee, H. H., Kalhor, R., Goela, N., Bolot, J., & Church, G. M. (2018) · Nature Communications

DNA and Biological ComputingAdvanced biosensing and bioanalysis techniques

Cited by 265

Realizing the potential of synthetic biology

Church, G. M., Elowitz, M. B., Smolke, C. D., Voigt, C. A., & Weiss, R. (2014) · Nature Reviews Molecular Cell Biology

Gene Regulatory Network AnalysisMicrobial Metabolic Engineering and Bioproduction

Cited by 226

REST and neural gene network dysregulation in iPSC models of Alzheimer’s disease

Meyer, K., Feldman, H. M., Lu, T., Drake, D., Lim, E. T., Ling, K.-H., Bishop, N. A., Pan, Y., Seo, J., Lin, Y.-T., et al. (2019) · Cell Reports

Alzheimer's disease research and treatmentsPluripotent Stem Cells Research

Cited by 216

Engineering adeno-associated viral vectors to evade innate immune and inflammatory responses

Chan, Y. K., Wang, S. K., Chu, C. J., Copland, D. A., Letizia, A. J., Costa Verdera, H., Chiang, J. J., Sethi, M., Wang, M. K., Neidermyer, W. J., et al. (2021) · Science Translational Medicine

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 215

Enhancing CRISPR-Cas9 gRNA efficiency prediction by data integration and deep learning

Xiang, X., Corsi, G. I., Anthon, C., Qu, K., Pan, X., Liang, X., Han, P., Dong, Z., Liu, L., Zhong, J., et al. (2021) · Nature Communications

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 209

Computational discovery of sense-antisense transcription in the human and mouse genomes

Shendure, J., & Church, G. M. (2002) · Genome Biology

Cancer-related molecular mechanisms researchRNA Research and Splicing

Cited by 191

Orthogonally induced differentiation of stem cells for the programmatic patterning of vascularized organoids and bioprinted tissues

Skylar-Scott, M. A., Huang, J. Y., Lu, A., Ng, A. H. M., Duenki, T., Liu, S., Nam, L. L., Damaraju, S., Church, G. M., & Lewis, J. A. (2022) · Nature Biomedical Engineering

Pluripotent Stem Cells Research3D Printing in Biomedical Research

Cited by 160

Genome editing assessment using CRISPR Genome Analyzer (CRISPR-GA)

Güell, M., Yang, L., & Church, G. M. (2014) · Bioinformatics

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 142

Deciphering the functions and regulation of brain-enriched A-to-I RNA editing

Li, J. B., & Church, G. M. (2013) · Nature Neuroscience

RNA regulation and diseaseRNA Research and Splicing

Cited by 141

Confronting risks of mirror life

Adamala, K. P., Agashe, D., Belkaid, Y., Bittencourt, D. M. D. C., Cai, Y., Chang, M. W., Chen, I. A., Church, G. M., Cooper, V. S., Davis, M. M., et al. (2024) · Science

Space Science and Extraterrestrial LifeOrigins and Evolution of Life

Cited by 125

Inter-homologue repair in fertilized human eggs?

Egli, D., Zuccaro, M. V., Kosicki, M., Church, G. M., Bradley, A., & Jasin, M. (2018) · Nature

CRISPR and Genetic EngineeringDNA Repair Mechanisms

Cited by 111

Harvard Personal Genome Project: lessons from participatory public research

Ball, M. P., Bobe, J. R., Chou, M. F., Clegg, T., Estep, P. W., Lunshof, J. E., Vandewege, W., Zaranek, A. W., & Church, G. M. (2014) · Genome Medicine

Ethics in Clinical ResearchResearch Data Management Practices

Cited by 103

Accurate analysis of genuine CRISPR editing events with ampliCan

Labun, K., Guo, X., Chavez, A., Church, G., Gagnon, J. A., & Valen, E. (2019) · Genome Research

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 84

Single molecule profiling of tau gene expression in Alzheimer’s disease

Conrad, C., Zhu, J., Conrad, C., Schoenfeld, D., Fang, Z., Ingelsson, M., Stamm, S., Church, G., & Hyman, B. T. (2007) · Journal of Neurochemistry

Alzheimer's disease research and treatmentsRNA Research and Splicing

Cited by 68

PAM-flexible genome editing with an engineered chimeric Cas9

Zhao, L., Koseki, S. R. T., Silverstein, R. A., Amrani, N., Peng, C., Kramme, C., Savic, N., Pacesa, M., Rodríguez, T. C., Stan, T., et al. (2023) · Nature Communications

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 59

RETRACTED: New intranasal and injectable gene therapy for healthy life extension

Jaijyan, D. K., Selariu, A., Cruz-Cosme, R., Tong, M., Yang, S., Stefa, A., Kekich, D., Sadoshima, J., Herbig, U., Tang, Q., et al. (2022) · Proceedings of the National Academy of Sciences

Virus-based gene therapy researchTelomeres, Telomerase, and Senescence

Cited by 57

Circumventing cellular immunity by miR142-mediated regulation sufficiently supports rAAV-delivered OVA expression without activating humoral immunity

Xiao, Y., Muhuri, M., Li, S., Qin, W., Xu, G., Luo, L., Li, J., Letizia, A. J., Wang, S. K., Chan, Y. K., et al. (2019) · JCI Insight

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 53

Massively targeted evaluation of therapeutic CRISPR off-targets in cells

Pan, X., Qu, K., Yuan, H., Xiang, X., Anthon, C., Pashkova, L., Liang, X., Han, P., Corsi, G. I., Xu, F., et al. (2022) · Nature Communications

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 42

Rational design of a compact CRISPR-Cas9 activator for AAV-mediated delivery

Vora, S., Cheng, J., Xiao, R., VanDusen, N. J., Quintino, L., Pu, W. T., Vandenberghe, L. H., Chavez, A., & Church, G. (2018) · bioRxiv (Cold Spring Harbor Laboratory)

CRISPR and Genetic EngineeringVirus-based gene therapy research

Cited by 42

Light and carbon: Synthetic biology toward new cyanobacteria-based living biomaterials

Goodchild-Michelman, I. M., Church, G. M., Schubert, M. G., & Tang, T.-C. (2023) · Materials Today Bio

Microbial Metabolic Engineering and BioproductionMicrobial Applications in Construction Materials

Cited by 41

CRISPR/Cas9-Mediated Phage Resistance Is Not Impeded by the DNA Modifications of Phage T4

Yaung, S. J., Esvelt, K. M., & Church, G. M. (2014) · PLoS ONE

CRISPR and Genetic EngineeringBacteriophages and microbial interactions

Cited by 39

Data privacy in the age of personal genomics

Grishin, D., Obbad, K., & Church, G. M. (2019) · Nature Biotechnology

Privacy-Preserving Technologies in DataEthics in Clinical Research

Cited by 38