Shackleton, Cedric H. L.

Differential Inhibition of CYP17A1 and CYP21A2 Activities by the P450 Oxidoreductase Mutant A287P

Dhir, V., Ivison, H. E., Krone, N., Shackleton, C. H. L., Doherty, A. J., Stewart, P. M., & Arlt, W. (2007) · Molecular Endocrinology

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 78

GC/MS in recent years has defined the Normal and clinically disordered steroidome: will It Soon Be surpassed by LC/Tandem MS in this role?

Shackleton, C., Pozo, O. J., & Marcos, J. (2018) · Journal of the Endocrine Society

Metabolomics and Mass Spectrometry StudiesMass Spectrometry Techniques and Applications

Cited by 75

Quantitation of cortisol and related 3-oxo-4-ene steroids in urine using gas chromatography/mass spectrometry with stable isotope-labeled internal standards

Palermo, M., Gomez-Sanchez, C., Roitman, E., & Shackleton, C. H. L. (1996) · Steroids

Adrenal Hormones and DisordersAnalytical Chemistry and Chromatography

Cited by 70

Alternative pathway androgen biosynthesis and human fetal female virilization

Reisch, N., Taylor, A. E., Nogueira, E. F., Asby, D. J., Dhir, V., Berry, A., Krone, N., Auchus, R. J., Shackleton, C. H. L., Hanley, N. A., et al. (2019) · Proceedings of the National Academy of Sciences

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 70

Prenatal diagnosis of congenital adrenal hyperplasia caused by P450 oxidoreductase deficiency

Reisch, N., Idkowiak, J., Hughes, B. A., Ivison, H. E., Abdul-Rahman, O. A., Hendon, L. G., Olney, A. H., Nielsen, S., Harrison, R., Blair, E. M., et al. (2013) · The Journal of Clinical Endocrinology & Metabolism

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 67

Pubertal Presentation in Seven Patients with Congenital Adrenal Hyperplasia due to P450 Oxidoreductase Deficiency

Idkowiak, J., O'Riordan, S., Reisch, N., Malunowicz, E. M., Collins, F., Kerstens, M. N., Köhler, B., Graul-Neumann, L. M., Szarras-Czapnik, M., Dattani, M., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 64

Role of a disordered steroid metabolome in the elucidation of sterol and steroid biosynthesis

Shackleton, C. H. L. (2012) · Lipids

Metabolism and Genetic DisordersSteroid Chemistry and Biochemistry

Cited by 61

Familial male pseudohermaphroditism due to 5-alpha-reductase deficiency in a Turkish village

Akgun, S., Ertel, N. H., Imperato-Mcginley, J., Sayli, B. S., & Shackleton, C. (1986) · The American Journal of Medicine

Sexual Differentiation and DisordersUrological Disorders and Treatments

Cited by 57

Identification of 7(8) and 8(9) unsaturated adrenal steroid metabolites produced by patients with 7-dehydrosterol-Δ7-reductase deficiency (Smith–Lemli–Opitz syndrome)

Shackleton, C., Roitman, E., Guo, L.-W., Wilson, W. K., & Porter, F. D. (2002) · The Journal of Steroid Biochemistry and Molecular Biology

Steroid Chemistry and BiochemistryMetabolism and Genetic Disorders

Cited by 56

Human Δ4-3-oxosteroid 5β-reductase (AKR1D1) deficiency and steroid metabolism

Palermo, M., Marazzi, M. G., Hughes, B. A., Stewart, P. M., Clayton, P. T., & Shackleton, C. H. L. (2008) · Steroids

Adrenal Hormones and DisordersSteroid Chemistry and Biochemistry

Cited by 55

Novel H6PDH mutations in two girls with premature adrenarche: ‘apparent’ and ‘true’ CRD can be differentiated by urinary steroid profiling

Lavery, G. G., Idkowiak, J., Sherlock, M., Bujalska, I., Ride, J. P., Saqib, K., Hartmann, M. F., Hughes, B., Wudy, S. A., De Schepper, J., et al. (2013) · European Journal of Endocrinology

Adrenal Hormones and DisordersSexual Differentiation and Disorders

Cited by 50

Metabolism of fetal and neonatal adrenal steroids

Shackleton, C. H. L., Honour, J. W., & Taylor, N. F. (1979) · Journal of Steroid Biochemistry

Adrenal Hormones and DisordersMetabolism and Genetic Disorders

Cited by 49

Neonatal urinary steroids in Smith-Lemli-Opitz syndrome associated with 7-dehydrocholesterol reductase deficiency

Shackleton, C. (1999) · Steroids

Metabolism and Genetic DisordersCholesterol and Lipid Metabolism

Cited by 48

17α-Hydroxylase deficiency: mineralocorticoid hormone profiles in an affected family

D'Armiento, M., Reda, G., Kater, C., Shackleton, C. H. L., & Biglieri, E. G. (1983) · The Journal of Clinical Endocrinology & Metabolism

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 47

Steroid sulfatase deficiency and androgen activation before and after puberty

Idkowiak, J., Taylor, A. E., Subtil, S., O'Neil, D. M., Vijzelaar, R., Dias, R. P., Amin, R., Barrett, T. G., Shackleton, C. H. L., Kirk, J. M. W., et al. (2016) · The Journal of Clinical Endocrinology & Metabolism

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 42

Gas chromatography/mass spectrometry characterization of corticosteroid metabolism in human immortalized keratinocytes

Slominski, A., Wortsman, J., Foecking, M. F., Shackleton, C., Gomez-Sanchez, C., & Szczesniewski, A. (2002) · Journal of Investigative Dermatology

Adrenal Hormones and DisordersStress Responses and Cortisol

Cited by 41

17-Hydroxylase/C17, 20-lyase (CYP17) is not the enzyme responsible for side-chain cleavage of cortisol and its metabolites

Shackleton, C. H. L., Neres, M. S., Hughes, B. A., Stewart, P. M., & Kater, C. E. (2008) · Steroids

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 39

Identification and measurement of 18-hydroxycorticosterone metabolites by gas chromatography-mass spectrometry

Shackleton, C. H. L., & Honour, J. W. (1977) · Journal of Steroid Biochemistry

Adrenal Hormones and DisordersHormonal Regulation and Hypertension

Cited by 31

Reduction of aldosterone by anaerobic bacteria: origin of urinary 21-deoxy metabolites in man

Bokkenheuser, V. D., Winter, J., Honour, J. W., & Shackleton, C. H. L. (1979) · Journal of Steroid Biochemistry

Steroid Chemistry and BiochemistryGut microbiota and health

Cited by 30

Longitudinal changes in glucocorticoid metabolism are associated with later development of adverse metabolic phenotype

Crowley, R. K., Hughes, B., Gray, J., McCarthy, T., Hughes, S., Shackleton, C. H. L., Crabtree, N., Nightingale, P., Stewart, P. M., & Tomlinson, J. W. (2014) · European Journal of Endocrinology

Hormonal Regulation and HypertensionAdipokines, Inflammation, and Metabolic Diseases

Cited by 26

Diminished 11β-Hydroxysteroid Dehydrogenase Type 2 Activity Is Associated With Decreased Weight and Weight Gain Across the First Year of Life

Rogers, S. L., Hughes, B. A., Jones, C. A., Freedman, L., Smart, K., Taylor, N., Stewart, P. M., Shackleton, C. H. L., Krone, N. P., Blissett, J., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism

Birth, Development, and HealthHormonal Regulation and Hypertension

Cited by 25

Identification of the androstenetriolones and androstenetetrols present in the urine of infants

Shackleton, C. H. L., & Taylor, N. F. (1975) · Journal of Steroid Biochemistry

Steroid Chemistry and BiochemistryHormonal and reproductive studies

Cited by 20

Gas chromatographic and mass spectrometric analysis of urinary acidic metabolites of cortisol

Shackleton, C. H. L., Roitman, E., Monder, C., & Bradlow, H. L. (1980) · Steroids

Analytical Chemistry and ChromatographyAdrenal Hormones and Disorders

Cited by 16

Bacterial formation of aldosterone metabolites

Winter, J., Shackleton, C. H. L., O'rourke, S., & Bokkenheuser, V. D. (1984) · Journal of Steroid Biochemistry

Steroid Chemistry and BiochemistryHormonal Regulation and Hypertension

Cited by 16