Most cited biochemistry, genetics and molecular biology papers
- Verified
Immunomodulatory agents lenalidomide and pomalidomide co‐stimulate Tcells by inducing degradation of Tcell repressors Ikaros and Aiolos via modulation of the E 3 ubiquitin ligase complex CRL 4 CRBN
Gandhi, A. K., Kang, J., Havens, C. G., Conklin, T., Ning, Y., Wu, L., Ito, T., Ando, H., Waldman, M. F., Thakurta, A., et al. (2014) · British Journal of Haematology
Protein Degradation and InhibitorsUbiquitin and proteasome pathways
Cited by 619
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Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cells
Glass, C. K., & Saijo, K. (2010) · Nature Reviews Immunology
Nuclear Receptors and SignalingEstrogen and related hormone effects
Cited by 619
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Bacteroides vulgatus and Bacteroides dorei Reduce Gut Microbial Lipopolysaccharide Production and Inhibit Atherosclerosis
Yoshida, N., Emoto, T., Yamashita, T., Watanabe, H., Hayashi, T., Tabata, T., Hoshi, N., Hatano, N., Ozawa, G., Sasaki, N., et al. (2018) · Circulation
Gut microbiota and healthOral microbiology and periodontitis research
Cited by 619
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Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1.
Gomis-R¨th, F.-X., Maskos, K., Betz, M., Bergner, A., Huber, R., Suzuki, K., Yoshida, N., Nagase, H., Brew, K., Bourenkov, G. P., et al. (1997) · Nature
Protease and Inhibitor MechanismsBlood Coagulation and Thrombosis Mechanisms
Cited by 619
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Hypoxic Radiosensitization: Adored and Ignored
Overgaard, J. (2007) · Journal of Clinical Oncology
Cancer, Hypoxia, and MetabolismRadiation Therapy and Dosimetry
Cited by 619
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A survey on filter techniques for feature selection in gene expression microarray analysis
Lazar, C., Taminau, J., Meganck, S., Steenhoff, D., Coletta, A., Molter, C., de Schaetzen, V., Duque, R., Bersini, H., & Nowe, A. (2012) · IEEE/ACM Transactions on Computational Biology and Bioinformatics
Gene expression and cancer classificationBioinformatics and Genomic Networks
Cited by 619
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The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18
Le Douarin, B., Zechel, C., Garnier, J. M., Lutz, Y., Tora, L., Pierrat, P., Heery, D., Gronemeyer, H., Chambon, P., & Losson, R. (1995) · The EMBO Journal
Estrogen and related hormone effectsNuclear Receptors and Signaling
Cited by 619
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The BCL2 Family: Key Mediators of the Apoptotic Response to Targeted Anticancer Therapeutics
Hata, A. N., Engelman, J. A., & Faber, A. C. (2015) · Cancer Discovery
Cell death mechanisms and regulationCancer-related Molecular Pathways
Cited by 619
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Should we standardize the 1,700-year-old fecal microbiota transplantation?
Zhang, F., Luo, W., Shi, Y., Fan, Z., & Ji, G. (2012) · American Journal of Gastroenterology
Gut microbiota and healthInflammatory Bowel Disease
Cited by 619
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Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming
Varoqueaux, F., Sigler, A., Rhee, J.-S., Brose, N., Enk, C., Reim, K., & Rosenmund, C. (2002) · Proceedings of the National Academy of Sciences
Cellular transport and secretionNeuroscience and Neuropharmacology Research
Cited by 619
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Metabolic modulation of tumours with engineered bacteria for immunotherapy
Canale, F. P., Basso, C., Antonini, G., Perotti, M., Li, N., Sokolovska, A., Neumann, J., James, M. J., Geiger, S., Jin, W., et al. (2021) · Nature
Bacterial Cancer TherapyCancer Immunotherapy and Biomarkers
Cited by 619
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Meta-analysis of the diagnostic and clinical utility of genome and exome sequencing and chromosomal microarray in children with suspected genetic diseases
Clark, M. M., Stark, Z., Farnaes, L., Tan, T. Y., White, S. M., Dimmock, D., & Kingsmore, S. F. (2018) · npj Genomic Medicine
Genomics and Rare DiseasesPrenatal Screening and Diagnostics
Cited by 619
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Immunocytochemical localization of galactosyltransferase in HeLa cells: codistribution with thiamine pyrophosphatase in trans-Golgi cisternae.
Roth, J., & Berger, E. G. (1982) · The Journal of cell biology
Glycosylation and Glycoproteins ResearchCellular transport and secretion
Cited by 619
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Molecular Characterization and Pattern of Tissue Expression of the Gene for Neutrophil Gelatinase-Associated Lipocalin from Humans
Cowland, J. B., & Borregaard, N. (1997) · Genomics
S100 Proteins and AnnexinsNeutrophil, Myeloperoxidase and Oxidative Mechanisms
Cited by 619
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Advanced transfection with Lipofectamine 2000 reagent: Primary neurons, siRNA, and high-throughput applications
Dalby, B. (2004) · Methods
RNA Interference and Gene DeliveryMolecular Biology Techniques and Applications
Cited by 619
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The active synthesis of phosphatidylcholine is required for very low density lipoprotein secretion from rat hepatocytes.
Yao, Z. M., & Vance, D. E. (1988) · Journal of Biological Chemistry
Lipid metabolism and biosynthesisCholesterol and Lipid Metabolism
Cited by 618
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MMseqs2 desktop and local web server app for fast, interactive sequence searches
Mirdita, M., Steinegger, M., & Söding, J. (2019) · Bioinformatics
Genomics and Phylogenetic StudiesAlgorithms and Data Compression
Cited by 618
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Heterogeneous aging across multiple organ systems and prediction of chronic disease and mortality
Tian, Y. E., Cropley, V., Maier, A. B., Lautenschlager, N. T., Breakspear, M., & Zalesky, A. (2023) · Nature Medicine
Genetics, Aging, and Longevity in Model OrganismsDementia and Cognitive Impairment Research
Cited by 618
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Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity
Maurer, T., Garrenton, L. S., Oh, A., Pitts, K., Anderson, D. J., Skelton, N. J., Fauber, B. P., Pan, B., Malek, S., Stokoe, D., et al. (2012) · Proceedings of the National Academy of Sciences
Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases
Cited by 618
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Complete genomic and epigenetic maps of human centromeres
Altemose, N., Logsdon, G. A., Bzikadze, A. V., Sidhwani, P., Langley, S. A., Caldas, G. V., Hoyt, S. J., Uralsky, L., Ryabov, F. D., Shew, C. J., et al. (2022) · Science
Chromosomal and Genetic VariationsGenomic variations and chromosomal abnormalities
Cited by 618
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Structural basis for androgen specificity and oestrogen synthesis in human aromatase
Ghosh, D., Griswold, J., Erman, M., & Pangborn, W. (2009) · Nature
Estrogen and related hormone effectsMetal-Catalyzed Oxygenation Mechanisms
Cited by 618
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Recovery of ethanol-induced Akkermansia muciniphila depletion ameliorates alcoholic liver disease
Grander, C., Adolph, T. E., Wieser, V., Lowe, P., Wrzosek, L., Gyongyosi, B., Ward, D. V., Grabherr, F., Gerner, R. R., Pfister, A., et al. (2018) · Gut
Gut microbiota and healthAlcohol Consumption and Health Effects
Cited by 618
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Modular PROTAC design for the degradation of oncogenic BCR-ABL
Lai, A. C., Toure, M., Hellerschmied, D., Salami, J., Jaime‐Figueroa, S., Ko, E., Hines, J., & Crews, C. M. (2016) · Angewandte Chemie International Edition
Protein Degradation and InhibitorsChemical Synthesis and Analysis
Cited by 618
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Norepinephrine-stimulated hypertrophy of cultured rat myocardial cells is an alpha-1 adrenergic response
Simpson, P. (1983) · Journal of Clinical Investigation
Receptor Mechanisms and SignalingCardiac Fibrosis and Remodeling
Cited by 618
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