The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
The Detection of Motion by Blind Subjects With the Epiretinal 60-Electrode (Argus II) Retinal Prosthesis
Open accessAbstract
OBJECTIVE: To investigate the ability of 28 blind subjects implanted with a 60-electrode Argus II (Second Sight Medical Products Inc) retinal prosthesis system to detect the direction of a moving object. METHODS: Blind subjects (bare light perception or worse in both eyes) with retinitis pigmentosa were implanted with the Argus II prosthesis as part of a phase 1/2 feasibility study at multiple clinical sites worldwide. The experiment measured their ability to detect the direction of motion of a high-contrast moving bar on a flatscreen monitor in 3 conditions: with the prosthesis system on and a 1-to-1 mapping of spatial information, with the system off, and with the system on but with randomly scrambled spatial information. RESULTS: Fifteen subjects (54%) were able to perform the task significantly better with their prosthesis system than they were with their residual vision, 2 subjects had significantly better performance with their residual vision, and no difference was found for 11 subjects. Of the 15 better-performing subjects, 11 were available for follow-up testing, and 10 of them had significantly better performance with normal rather than with scrambled spatial information. CONCLUSIONS: This work demonstrates that blind subjects implanted with the Argus II retinal prosthesis were able to perform a motion detection task they could not do with their native vision, confirming that electrical stimulation of the retina provides spatial information from synchronized activation of multiple electrodes. TRIAL REGISTRATION: clinicaltrials.gov Identifier:NCT00407602
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“Their performance also improved for object localization and motion discrimination tasks (Ahuja et al. 2011; Barry, Dagnelie, and Argus II Study Group 2012; Dorn et al. 2013; Dagnelie et al. 2017).”
From Sequential epiretinal stimulation improves discrimination in simple shape discrimination tasks only (2022) · cites this paper as Dorn et al. 2013
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Subretinal electronic chips allow blind patients to read letters and combine them to words
Zrenner, E., Bartz-Schmidt, K. U., Benav, H., Besch, D., Bruckmann, A., Gabel, V.-P., Gekeler, F., Greppmaier, U., Harscher, A., Kibbel, S., et al. (2011) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2010.1747 · Cited by 819
Interim results from the international trial of Second Sight's visual prosthesis
Humayun, M. S., Dorn, J. D., da Cruz, L., Dagnelie, G., Sahel, J.-A., Stanga, P. E., Cideciyan, A. V., Duncan, J. L., Eliott, D., Filley, E., et al. (2012) · Ophthalmology · doi:10.1016/j.ophtha.2011.09.028 · Cited by 700
Self-citationVisual Perception Elicited by Electrical Stimulation of Retina in Blind Humans
Humayun, M. S. (1996) · Archives of Ophthalmology · doi:10.1001/archopht.1996.01100130038006 · Cited by 602
Stone, J. L. (1992) · Archives of Ophthalmology · doi:10.1001/archopht.1992.01080230134038 · Cited by 480
Can subretinal microphotodiodes successfully replace degenerated photoreceptors?
Zrenner, E., Stett, A., Weiss, S., Aramant, R. B., Guenther, E., Köhler, K., Miliczek, K.-D., Seiler, M. J., & Haemmerle, H. (1999) · Vision Research · doi:10.1016/s0042-6989(98)00312-5 · Cited by 290
Visual Performance Using a Retinal Prosthesis in Three Subjects With Retinitis Pigmentosa
Yanai, D., Weiland, J. D., Mahadevappa, M., Greenberg, R. J., Fine, I., & Humayun, M. S. (2007) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2007.01.027 · Cited by 233
Self-citationRoessler, G. F., Laube, T., Brockmann, C., Kirschkamp, T., Mazinani, B. A. E., Goertz, M., Koch, C., Krisch, I., Sellhaus, B., Trieu, H. K., et al. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-2752 · Cited by 161
Wilke, R., Gabel, V.-P., Sachs, H., Bartz Schmidt, K.-U., Gekeler, F., Besch, D., Szurman, P., Stett, A., Wilhelm, B., Peters, T., et al. (2011) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.10-6946 · Cited by 155
Rizzo, J. F., Wyatt, J. L., Humayun, M. S., de Juan, E., Liu, W., Chow, A. Y., Eckmiller, R., Zrenner, E., Yagi, T., & Abrams, G. W. (2001) · Ophthalmology · doi:10.1016/s0161-6420(00)00430-9 · Cited by 152
Feasibility Study of a Retinal Prosthesis
Caspi, A. (2009) · Archives of Ophthalmology · doi:10.1001/archophthalmol.2009.20 · Cited by 149
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Explainable Machine Learning Predictions of Perceptual Sensitivity for Retinal Prostheses
Pogoncheff, G., Hu, Z., Rokem, A., & Beyeler, M. (2023) · doi:10.1101/2023.02.09.23285633 · Cited by 9
“, age at blindness diagnosis, age at implant surgery) from previous studies [3], [11], [12].”
Metadata
- Authors
- Dorn, J. D., Ahuja, A. K., Caspi, A., da Cruz, L., Dagnelie, G., Sahel, J.-A., Greenberg, R. J., McMahon, M. J., & Argus II Study Group, F. T.
- Affiliations
- Second Sight Medical Products (US)
- University of Southern California (US)
- Corresponding author
- Dorn, Jessy D.
- Venue
- JAMA Ophthalmology
- Publisher
- American Medical Association (AMA)
- Published
- 2013-02-01
- Volume
- 131
- Issue
- 2
- Pages
- 183
- ISSN
- 2168-6165 (ISSN-L)
- PMC
- PMC3924899
- OpenAlex
- W2024323852
- Cited by
- 177
- References
- 12
- Citations by year
- 2026: 10 · 2025: 8 · 2024: 5 · 2023: 3 · 2022: 7 · 2021: 16 · 2020: 16 · 2019: 14 · 2018: 16 · 2017: 17 · 2016: 22 · 2015: 13 · 2014: 20 · 2013: 9
- FWCI
- 5.53
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- JAMA Ophthalmology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- National Eye Institute (R24EY012893, EY012893, R01EY012893, R01EY021220)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
- Keywords
- Argus II, retinal prosthesis, motion direction detection, retinitis pigmentosa, blindness, spatial mapping, visual prosthesis
- MeSH terms
- Adult, Aged, Blindness, Electrodes, Implanted, Electric Stimulation Therapy, Feasibility Studies, Female, Humans, Male, Microelectrodes, Middle Aged, Motion Perception, Perceptual Disorders, Retina, Retinitis Pigmentosa, Sensory Thresholds, Treatment Outcome, Prosthesis Implantation, Visual Prosthesis
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