Blind subjects implanted with the Argus II retinal prosthesis are able to improve performance in a spatial-motor task
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BACKGROUND/AIMS: To determine to what extent subjects implanted with the Argus II retinal prosthesis can improve performance compared with residual native vision in a spatial-motor task. METHODS: High-contrast square stimuli (5.85 cm sides) were displayed in random locations on a 19″ (48.3 cm) touch screen monitor located 12″ (30.5 cm) in front of the subject. Subjects were instructed to locate and touch the square centre with the system on and then off (40 trials each). The coordinates of the square centre and location touched were recorded. RESULTS: Ninety-six percent (26/27) of subjects showed a significant improvement in accuracy and 93% (25/27) show a significant improvement in repeatability with the system on compared with off (p<0.05, Student t test). A group of five subjects that had both accuracy and repeatability values <250 pixels (7.4 cm) with the system off (ie, using only their residual vision) was significantly more accurate and repeatable than the remainder of the cohort (p<0.01). Of this group, four subjects showed a significant improvement in both accuracy and repeatability with the system on. CONCLUSION: In a study on the largest cohort of visual prosthesis recipients to date, we found that artificial vision augments information from existing vision in a spatial-motor task. Clinical trials registry no NCT00407602.
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Argus II users also improved on object localization and motion discrimination tasks.
“Their performance also improved for object localization and motion discrimination tasks (Ahuja et al. 2011; Barry, Dagnelie, and Argus II Study Group 2012; Dorn et al. 2013; Dagnelie et al. 2017).”
From Sequential epiretinal stimulation improves discrimination in simple shape discrimination tasks only (2022) · cites this paper as Ahuja et al. 2011
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Neural remodeling in retinal degeneration
Marc, R. E., Jones, B. W., Watt, C. B., & Strettoi, E. (2003) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(03)00039-9 · Cited by 871 · see citing works
Preservation of the Inner Retina in Retinitis Pigmentosa
Santos, A. (1997) · Archives of Ophthalmology · doi:10.1001/archopht.1997.01100150513011 · Cited by 644 · see citing works
Pattern electrical stimulation of the human retina
Humayun, M. S., de Juan, E., Weiland, J. D., Dagnelie, G., Katona, S., Greenberg, R. J., & Suzuki, S. (1999) · Vision Research · doi:10.1016/s0042-6989(99)00052-8 · Cited by 593 · see citing works
Self-citationRizzo, J. F., Wyatt, J., Loewenstein, J., Kelly, S., & Shire, D. (2003) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.02-0817 · Cited by 478 · see citing works
Stone, J. L. (1992) · Archives of Ophthalmology · doi:10.1001/archopht.1992.01080230134038 · Cited by 471 · see citing works
Retinal remodeling during retinal degeneration
Jones, B. W., & Marc, R. E. (2005) · Experimental Eye Research · doi:10.1016/j.exer.2005.03.006 · Cited by 430 · see citing works
Perceptual thresholds and electrode impedance in three retinal prosthesis subjects
Mahadevappa, M., Weiland, J. D., Yanai, D., Fine, I., Greenberg, R. J., & Humayun, M. S. (2005) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2005.848687 · Cited by 187 · see citing works
Self-citationVision Following Extended Congenital Blindness
Ostrovsky, Y., Andalman, A. S., & Sinha, P. (2006) · Psychological Science · doi:10.1111/j.1467-9280.2006.01827.x · Cited by 155 · see citing works
Feasibility Study of a Retinal Prosthesis
Caspi, A. (2009) · Archives of Ophthalmology · doi:10.1001/archophthalmol.2009.20 · Cited by 149 · see citing works
Self-citationAnIn VitroModel of a Retinal Prosthesis
Ahuja, A. K., Behrend, M. R., Kuroda, M., Humayun, M. S., & Weiland, J. D. (2008) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2008.919126 · Cited by 111 · see citing works
Self-citationSekirnjak, C., Hulse, C., Jepson, L. H., Hottowy, P., Sher, A., Dąbrowski, W., Litke, A. M., & Chichilnisky, E. J. (2009) · Journal of Neurophysiology · doi:10.1152/jn.00663.2009 · Cited by 98 · see citing works
RETINAL EXCITATION AND INHIBITION FROM DIRECT ELECTRICAL STIMULATION
Crapper, D. R., & Noell, W. K. (1963) · Journal of Neurophysiology · doi:10.1152/jn.1963.26.6.924 · Cited by 82 · see citing works
Carlson, S., Hyvärinen, L., & Raninen, A. (1986) · British Journal of Ophthalmology · doi:10.1136/bjo.70.8.607 · Cited by 36 · see citing works
Jensen, R. J., Ziv, O. R., Rizzo, J. F., Scribner, D. A., & Johnson, L. (2009) · Experimental Eye Research · doi:10.1016/j.exer.2009.08.015 · Cited by 17 · see citing works
Feasibility Study of a Retinal Prosthesis: Spatial Vision With a 16-Electrode Implant
VANDER, J. F. (2010) · Yearbook of Ophthalmology · doi:10.1016/s0084-392x(09)79189-0 · Cited by 10 · see citing works
An in vitro model of a retinal prosthesis
Ahuja, A. (2015) · University of Southern California Digital Library · doi:10.25549/usctheses-m450 · Cited by 8 · see citing works
Self-citationCarlson, M. R. (1987) · Survey of Ophthalmology · doi:10.1016/0039-6257(87)90113-5 · Cited by 3 · see citing works
Electrical Stimulation of the Retina in a 3-Dimensional Interface
Behrend, M. R., Ahuja, A., Humayun, M. S., Chow, R. H.-P., & Weiland, J. D. (2009) · Investigative Ophthalmology & Visual Science · Cited by 2 · see citing works
Self-citation
Flagged first, then by citations
1 of the 19 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Yuk, H., Lu, B., & Zhao, X. (2018) · Chemical Society Reviews · doi:10.1039/c8cs00595h · Cited by 2,124 · see citing works
Revealing neuronal function through microelectrode array recordings
Obien, M. E. J., Deligkaris, K., Bullmann, T., Bakkum, D. J., & Frey, U. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00423 · Cited by 705 · see citing works
Photovoltaic retinal prosthesis with high pixel density
Mathieson, K., Loudin, J., Goetz, G. A., Huie, P., Wang, L., Kamins, T. I., Galambos, L., Smith, R., Harris, J. S., Sher, A., et al. (2012) · Nature Photonics · doi:10.1038/nphoton.2012.104 · Cited by 460 · see citing works
da Cruz, L., Coley, B. F., Dorn, J., Merlini, F., Filley, E., Christopher, P., Chen, F. K., Wuyyuru, V., Sahel, J., Stanga, P., et al. (2013) · British Journal of Ophthalmology · doi:10.1136/bjophthalmol-2012-301525 · Cited by 359 · see citing works
Self-citationFive-year safety and performance results from the argus II retinal prosthesis system clinical trial.
da Cruz, L., Dorn, J. D., Humayun, M. S., Dagnelie, G., Handa, J., Barale, P.-O., Sahel, J.-A., Stanga, P. E., Hafezi, F., Safran, A. B., et al. (2016) · Ophthalmology · doi:10.1016/j.ophtha.2016.06.049 · Cited by 359 · see citing works
Self-citationThe Argus® II Retinal Prosthesis System
Luo, Y. H.-L., & da Cruz, L. (2016) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2015.09.003 · Cited by 351 · see citing works
A polymer optoelectronic interface restores light sensitivity in blind rat retinas
Ghezzi, D., Antognazza, M. R., Maccarone, R., Bellani, S., Lanzarini, E., Martino, N., Mete, M., Pertile, G., Bisti, S., Lanzani, G., et al. (2013) · Nature Photonics · doi:10.1038/nphoton.2013.34 · Cited by 327 · see citing works
Bhowmick, A., & Hazarika, S. M. (2017) · Journal on Multimodal User Interfaces · doi:10.1007/s12193-016-0235-6 · Cited by 276 · see citing works
Long-Term Results from an Epiretinal Prosthesis to Restore Sight to the Blind
Ho, A. C., Humayun, M. S., Dorn, J. D., da Cruz, L., Dagnelie, G., Handa, J. T., Barale, P. O., Sahel, J., Stanga, P. E., Hafezi, F., et al. (2015) · Ophthalmology · doi:10.1016/j.ophtha.2015.04.032 · Cited by 262 · see citing works
Self-citationPhotochemical Restoration of Visual Responses in Blind Mice
Polosukhina, A., Litt, J., Tochitsky, I., Nemargut, J. P., Sychev, Y., Kouchkovsky, I. D., Huang, T., Borges, K., Trauner, D. H., Gelder, R. N. V., et al. (2012) · Neuron · doi:10.1016/j.neuron.2012.05.022 · Cited by 238 · see citing works
Maidenbaum, S., Abboud, S., & Amedi, A. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.11.007 · Cited by 230 · see citing works
Advances in retinal prosthesis systems
Bloch, E., Luo, Y., & da Cruz, L. (2019) · Therapeutic Advances in Ophthalmology · doi:10.1177/2515841418817501 · Cited by 201 · see citing works
Retinal Prostheses: Current Clinical Results and Future Needs
Weiland, J. D., Cho, A. K., & Humayun, M. S. (2011) · Ophthalmology · doi:10.1016/j.ophtha.2011.08.042 · Cited by 196 · see citing works
Self-citationPersistent remodeling and neurodegeneration in late-stage retinal degeneration
Pfeiffer, R. L., Marc, R. E., & Jones, B. W. (2019) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2019.07.004 · Cited by 178 · see citing works
Microscopic magnetic stimulation of neural tissue
Bonmassar, G., Lee, S. W., Freeman, D. K., Polášek, M., Fried, S. I., & Gale, J. T. (2012) · Nature Communications · doi:10.1038/ncomms1914 · Cited by 180 · see citing works
Polymer integration for packaging of implantable sensors
Qin, Y., Howlader, M. M. R., Deen, M. J., Haddara, Y. M., & Selvaganapathy, P. R. (2014) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2014.05.063 · Cited by 163 · see citing works
Nanduri, D., Fine, I., Horsager, A., Boynton, G. M., Humayun, M. S., Greenberg, R. J., & Weiland, J. D. (2012) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.11-8401 · Cited by 163 · see citing works
Self-citationPhotovoltaic retinal prosthesis: implant fabrication and performance
Wang, L., Mathieson, K., Kamins, T. I., Loudin, J., Galambos, L., Goetz, G. A., Sher, A., Mandel, Y., Huie, P., Lavinsky, D., et al. (2012) · Journal of Neural Engineering · doi:10.1088/1741-2560/9/4/046014 · Cited by 142 · see citing works
Kremláček, J., Kreegipuu, K., Tales, A., Astikainen, P., Põldver, N., Näätänen, R., & Stefanics, G. (2016) · Cortex · doi:10.1016/j.cortex.2016.03.017 · Cited by 138 · see citing works
Translating the Brain-Machine Interface
Thakor, N. V. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3007303 · Cited by 128 · see citing works
Brain Machine Interfaces for Vision Restoration: The Current State of Cortical Visual Prosthetics
Niketeghad, S., & Pouratian, N. (2018) · Neurotherapeutics · doi:10.1007/s13311-018-0660-1 · Cited by 128 · see citing works
Eickenscheidt, M., Jenkner, M., Thewes, R., Fromherz, P., & Zeck, G. M. (2012) · Journal of Neurophysiology · doi:10.1152/jn.00909.2011 · Cited by 118 · see citing works
Temporal properties of visual perception on electrical stimulation of the retina
Pérez Fornos, A., Sommerhalder, J., da Cruz, L., Sahel, J. A., Mohand-Said, S., Hafezi, F., & Pelizzone, M. (2012) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.11-9344 · Cited by 113 · see citing works
Optogenetic approaches to vision restoration
Simunovic, M. P., Shen, W., Lin, J. Y., Protti, D. A., Lisowski, L., & Gillies, M. C. (2018) · Experimental Eye Research · doi:10.1016/j.exer.2018.09.003 · Cited by 111 · see citing works
Chenais, N. A. L., Airaghi Leccardi, M. J. I., & Ghezzi, D. (2021) · Communications Materials · doi:10.1038/s43246-021-00133-2 · Cited by 110 · see citing works
Regenerative and restorative medicine for eye disease
Gelder, R. N. V., Chiang, M. F., Dyer, M. A., Greenwell, T. N., Levin, L. A., Wong, R., & Svendsen, C. N. (2022) · Nature Medicine · doi:10.1038/s41591-022-01862-8 · Cited by 110 · see citing works
Retinitis Pigmentosa and Allied Disorders
Gregory-Evans, K., Pennesi, M. E., & Weleber, R. G. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4557-0737-9.00040-0 · Cited by 112 · see citing works
Cell-based therapeutic strategies for replacement and preservation in retinal degenerative diseases
Jones, M. K., Lü, B., Girman, S., & Wang, S. (2017) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2017.01.004 · Cited by 110 · see citing works
Differential responses to high-frequency electrical stimulation in ON and OFF retinal ganglion cells
Twyford, P., Cai, C., & Fried, S. I. (2014) · Journal of Neural Engineering · doi:10.1088/1741-2560/11/2/025001 · Cited by 103 · see citing works
Electronic approaches to restoration of sight
Goetz, G. A., & Palanker, D. (2016) · Reports on Progress in Physics · doi:10.1088/0034-4885/79/9/096701 · Cited by 99 · see citing works
Choroidal thickness profiles in retinitis pigmentosa
Ayton, L. N., Guymer, R. H., & Luu, C. D. (2012) · Clinical and Experimental Ophthalmology · doi:10.1111/j.1442-9071.2012.02867.x · Cited by 98 · see citing works
A review and update on the current status of retinal prostheses (bionic eye)
Luo, Y. H.-L., & da Cruz, L. (2014) · British Medical Bulletin · doi:10.1093/bmb/ldu002 · Cited by 89 · see citing works
Activation of ganglion cells and axon bundles using epiretinal electrical stimulation
Grosberg, L. E., Ganesan, K., Goetz, G. A., Madugula, S. S., Bhaskhar, N., Fan, V., Li, P., Hottowy, P., Dabrowski, W., Sher, A., et al. (2017) · Journal of Neurophysiology · doi:10.1152/jn.00750.2016 · Cited by 70 · see citing works
Erickson-Davis, C., & Korzybska, H. (2021) · PLoS ONE · doi:10.1371/journal.pone.0229189 · Cited by 83 · see citing works
The Argus™ II retinal prosthesis: Factors affecting patient selection for implantation
Ahuja, A., & Behrend, M. R. (2013) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2013.01.002 · Cited by 82 · see citing works
Self-citationAdvances in auditory prostheses
Shannon, R. V. (2011) · Current Opinion in Neurology · doi:10.1097/wco.0b013e32834ef878 · Cited by 81 · see citing works
Ong, J. M., & da Cruz, L. (2011) · Clinical and Experimental Ophthalmology · doi:10.1111/j.1442-9071.2011.02590.x · Cited by 79 · see citing works
The brain as a flexible task machine
Reich, L., Maidenbaum, S., & Amedi, A. (2011) · Current Opinion in Neurology · doi:10.1097/wco.0b013e32834ed723 · Cited by 79 · see citing works
Bionic vision: system architectures – a review
Guenther, T., Lovell, N. H., & Suaning, G. J. (2011) · Expert Review of Medical Devices · doi:10.1586/erd.11.58 · Cited by 76 · see citing works
Retinitis Pigmentosa: Review of Current Treatment
Wang, A. L., Knight, D. K., Vu, T.-T. T., & Mehta, M. C. (2018) · International Ophthalmology Clinics · doi:10.1097/iio.0000000000000256 · Cited by 73 · see citing works
Encoding visual information in retinal ganglion cells with prosthetic stimulation
Freeman, D. K., Rizzo, J. F., & Fried, S. I. (2011) · Journal of Neural Engineering · doi:10.1088/1741-2560/8/3/035005 · Cited by 71 · see citing works
Novel interfaces for light directed neuronal stimulation: advances and challenges
Bareket, L., & Hanein, Y. (2014) · International Journal of Nanomedicine · doi:10.2147/ijn.s51193 · Cited by 71 · see citing works
The Argus® II retinal prosthesis system: An overview
Zhou, D. D., Dorn, J. D., & Greenberg, R. J. (2013) · IEEE International Conference on Multimedia and Expo workshops · doi:10.1109/icmew.2013.6618428 · Cited by 70 · see citing works
Self-citationDagnelie, G. (2011) · Current Opinion in Neurology · doi:10.1097/wco.0b013e32834f02c3 · Cited by 70 · see citing works
Self-citationTherapeutic Challenges to Retinitis Pigmentosa: From Neuroprotection to Gene Therapy
Sahni, J., Angi, M., Irigoyen, C., Angi, M., Semeraro, F., Romano, M., Parmeggiani, F., & Parmeggiani, F. (2011) · Current Genomics · doi:10.2174/138920211795860062 · Cited by 69 · see citing works
Acute electrical stimulation of the human retina with an epiretinal electrode array
Keserü, M., Feucht, M., Bornfeld, N., Laube, T., Walter, P., Rößler, G., Velikay‐Parel, M., Hornig, R., & Richard, G. W. (2011) · Acta Ophthalmologica · doi:10.1111/j.1755-3768.2011.02288.x · Cited by 69 · see citing works
Neuroprotective Strategies for the Treatment of Inherited Photoreceptor Degeneration
Trifunović, D., Sahaboglu, A., Kaur, J., Mencl, S., Zrenner, E., Ueffing, M., Arango‐González, B., & Paquet‐Durand, F. (2012) · Current Molecular Medicine · doi:10.2174/156652412800620048 · Cited by 67 · see citing works
Ten-Year Follow-up of a Blind Patient Chronically Implanted with Epiretinal Prosthesis Argus I
Lan, Y., Falabella, P., Christopher, P., Wuyyuru, V., Dorn, J. D., Schor, P., Greenberg, R. J., Weiland, J. D., & Humayun, M. S. (2015) · Ophthalmology · doi:10.1016/j.ophtha.2015.08.008 · Cited by 67 · see citing works
Self-citationNaor, O., Hertzberg, Y., Zemel, E., Kimmel, E., & Shoham, S. (2012) · Journal of Neural Engineering · doi:10.1088/1741-2560/9/2/026006 · Cited by 66 · see citing works
SiC protective coating for photovoltaic retinal prosthesis
Lei, X., Kane, S. R., Cogan, S. F., Lorach, H., Galambos, L., Huie, P., Mathieson, K., Kamins, T. I., Harris, J. S., & Palanker, D. (2016) · Journal of Neural Engineering · doi:10.1088/1741-2560/13/4/046016 · Cited by 64 · see citing works
Im, M., & Fried, S. I. (2016) · Journal of Neural Engineering · doi:10.1088/1741-2560/13/2/025002 · Cited by 65 · see citing works
A Second-Generation (44-Channel) Suprachoroidal Retinal Prosthesis: Interim Clinical Trial Results
Petoe, M. A., Titchener, S. A., Kolic, M., Kentler, W. G., Abbott, C. J., Nayagam, D. A. X., Baglin, E. K., Kvansakul, J., Barnes, N., Walker, J. G., et al. (2021) · Translational Vision Science & Technology · doi:10.1167/tvst.10.10.12 · Cited by 63 · see citing works
Gu, W., Luo, J., & Liu, J. (2019) · Social Networks · doi:10.1016/j.socnet.2018.11.002 · Cited by 61 · see citing works
Weiss, J. N., & Levy, S. (2018) · Stem Cell Investigation · doi:10.21037/sci.2018.04.02 · Cited by 59 · see citing works
New Vision for Visual Prostheses
Farnum, A., & Pelled, G. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00036 · Cited by 58 · see citing works
Performance of visually guided tasks using simulated prosthetic vision and saliency-based cues
Parikh, N., Itti, L., Humayun, M., & Weiland, J. (2013) · Journal of Neural Engineering · doi:10.1088/1741-2560/10/2/026017 · Cited by 54 · see citing works
Self-citationNau, A. C., Bach, M., & Fisher, C. (2013) · Translational Vision Science & Technology · doi:10.1167/tvst.2.3.1 · Cited by 54 · see citing works
Singer, M. A., Herro, A. M., Probandarwalla, S. S., Pollard, J., Amir, A., Herro, & Singer (2011) · Clinical ophthalmology · doi:10.2147/opth.s15028 · Cited by 51 · see citing works
Animal coloration research: why it matters
Caro, T., Stoddard, M. C., & Stuart-Fox, D. M. (2017) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2016.0333 · Cited by 52 · see citing works
Chang, Y.-C., Ghaffari, D. H., Chow, R. H.-P., & Weiland, J. D. (2018) · Journal of Neural Engineering · doi:10.1088/1741-2552/aaf92b · Cited by 51 · see citing works
Interphase gap as a means to reduce electrical stimulation thresholds for epiretinal prostheses
Weitz, A. C., Behrend, M. R., Ahuja, A., Christopher, P., Wei, J., Wuyyuru, V., Patel, U. K., Greenberg, R. J., Humayun, M. S., Chow, R. H.-P., et al. (2014) · Journal of Neural Engineering · doi:10.1088/1741-2560/11/1/016007 · Cited by 51 · see citing works
Self-citationWorldwide Argus II implantation: recommendations to optimize patient outcomes
Ghodasra, D. H., Chen, A., Arévalo, J. F., Birch, D. G., Branham, K. E. H., Coley, B., Dagnelie, G., de Juan, E., Devenyi, R. G., Dorn, J. D., et al. (2016) · BMC Ophthalmology · doi:10.1186/s12886-016-0225-1 · Cited by 50 · see citing works
Self-citationPersonalized therapeutic strategies for patients with retinitis pigmentosa
Zheng, A., Li, Y., & Tsang, S. H. (2015) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2015.1006192 · Cited by 49 · see citing works
A System Verification Platform for High-Density Epiretinal Prostheses
Chen, K., Lo, Y., Yang, Z., Weiland, J. D., Humayun, M. S., & Liu, W. (2012) · IEEE Transactions on Biomedical Circuits and Systems · doi:10.1109/tbcas.2012.2200103 · Cited by 48 · see citing works
Self-citationCaspi, A., Roy, A., Wuyyuru, V., Rosendall, P. E., Harper, J. W., Katyal, K. D., Barry, M. P., Dagnelie, G., & Greenberg, R. J. (2018) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.17-22377 · Cited by 47 · see citing works
Self-citationThe Retinal Response to Sinusoidal Electrical Stimulation
Twyford, P., & Fried, S. I. (2015) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2015.2415811 · Cited by 47 · see citing works
Development of a molecular diagnostic test for Retinitis Pigmentosa in the Japanese population
Maeda, A., Yoshida, A., Kawai, K., Arai, Y., Akiba, R., Inaba, A., Takagi, S. T., Fujiki, R., Hirami, Y., Kurimoto, Y., et al. (2018) · Japanese Journal of Ophthalmology · doi:10.1007/s10384-018-0601-x · Cited by 46 · see citing works
Sabbah, N., Authie, C. N., Sanda, N., Mohand-Said, S., Sahel, J.-A., & Safran, A. B. (2014) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.14-15392 · Cited by 45 · see citing works
Brain-Machine Interfaces to Assist the Blind
Ptito, M., Bleau, M., Djerourou, I., Paré, S., Schneider, F. C., & Chebat, D.-R. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2021.638887 · Cited by 45 · see citing works
Optimization of return electrodes in neurostimulating arrays
Flores, T., Goetz, G., Lei, X., & Palanker, D. (2016) · Journal of Neural Engineering · doi:10.1088/1741-2560/13/3/036010 · Cited by 43 · see citing works
Paraskevoudi, N., & Pezaris, J. S. (2019) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2018.00073 · Cited by 39 · see citing works
Luo, Y. H.-L., Zhong, J., & da Cruz, L. (2014) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-014-2912-z · Cited by 39 · see citing works
The response of retinal neurons to high-frequency stimulation
Cai, C., Twyford, P., & Fried, S. (2013) · Journal of Neural Engineering · doi:10.1088/1741-2560/10/3/036009 · Cited by 38 · see citing works
Assessment of MRI issues for the Argus II Retinal Prosthesis
Weiland, J. D., Faraji, B., Greenberg, R. J., Humayun, M. S., & Shellock, F. G. (2012) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2011.12.005 · Cited by 38 · see citing works
Self-citationFacial identification in very low-resolution images simulating prosthetic vision
Chang, M. H., Kim, H.-S., Shin, J., & Park, K. S. (2012) · Journal of Neural Engineering · doi:10.1088/1741-2560/9/4/046012 · Cited by 38 · see citing works
The Argus II prosthesis facilitates reaching and grasping tasks: a case series
Kotecha, A., Zhong, J., Stewart, D., & da Cruz, L. (2014) · BMC Ophthalmology · doi:10.1186/1471-2415-14-71 · Cited by 38 · see citing works
Noninvasive Ultrasound Retinal Stimulation for Vision Restoration at High Spatiotemporal Resolution
Qian, X., Lu, G., Thomas, B. B., Li, R., Chen, X., Shung, K. K., Humayun, M. S., & Zhou, Q. (2022) · BME Frontiers · doi:10.34133/2022/9829316 · Cited by 37 · see citing works
Self-citationBuilding the bionic eye: an emerging reality and opportunity
Merabet, L. B. (2011) · Progress in brain research · doi:10.1016/b978-0-444-53355-5.00001-4 · Cited by 37 · see citing works
Suppression of Subthalamic Nucleus Activity by Micromagnetic Stimulation
Lee, S.-W., & Fried, S. (2014) · IEEE transactions on neural systems and rehabilitation engineering · doi:10.1109/tnsre.2014.2348415 · Cited by 31 · see citing works
Prosthetic vision: devices, patient outcomes and retinal research
Hadjinicolaou, A. E., Hamish Meffin, A., Maturana, M. I., Cloherty, S. L., & Ibbotson, M. R. (2015) · Clinical and Experimental Optometry · doi:10.1111/cxo.12342 · Cited by 35 · see citing works
Rountree, C. M., Raghunathan, A., Troy, J. B., & Saggere, L. (2017) · Microsystems & Nanoengineering · doi:10.1038/micronano.2017.52 · Cited by 35 · see citing works
Quasi-monopolar electrical stimulation of the retina: a computational modelling study
Abramian, M., Lovell, N. H., Habib, A., Morley, J. W., Suaning, G. J., & Dokos, S. (2014) · Journal of Neural Engineering · doi:10.1088/1741-2560/11/2/025002 · Cited by 35 · see citing works
Progress in artificial vision through suprachoroidal retinal implants
Bareket, L., Barriga‐Rivera, A., Zapf, M. P., Lovell, N. H., & Suaning, G. J. (2017) · Journal of Neural Engineering · doi:10.1088/1741-2552/aa6cbb · Cited by 34 · see citing works
Opie, N. L., Greferath, U., Vessey, K. A., Burkitt, A. N., Hamish Meffin, A., Grayden, D. B., & Fletcher, E. L. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-10600 · Cited by 33 · see citing works
Retinal Prosthetic Approaches to Enhance Visual Perception for Blind Patients
Shim, S., Eom, K., Jeong, J., & Kim, S. J. (2020) · Micromachines · doi:10.3390/mi11050535 · Cited by 34 · see citing works
Model-based analysis of multiple electrode array stimulation for epiretinal visual prostheses
Mueller, J. K., & Grill, W. M. (2013) · Journal of Neural Engineering · doi:10.1088/1741-2560/10/3/036002 · Cited by 32 · see citing works
The argus ii retinal prosthesis system
Bloch, E., & da Cruz, L. (2020) · Prosthesis · doi:10.5772/intechopen.84947 · Cited by 31 · see citing works
Spencer, T. C., Fallon, J. B., Thien, P. C., & Shivdasani, M. N. (2016) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.16-19325 · Cited by 31 · see citing works
Optical coherence tomography imaging of retinal damage in real time under a stimulus electrode
Cohen, E. D., Agrawal, A., Connors, M., Hansen, B., Charkhkar, H., & Pfefer, J. (2011) · Journal of Neural Engineering · doi:10.1088/1741-2560/8/5/056017 · Cited by 31 · see citing works
Creating virtual electrodes with 2D current steering
Spencer, T. C., Fallon, J. B., & Shivdasani, M. N. (2018) · Journal of Neural Engineering · doi:10.1088/1741-2552/aab1b8 · Cited by 31 · see citing works
Holographic display system for restoration of sight to the blind
Goetz, G. A., Mandel, Y., Manivanh, R. V., Palanker, D., & Čižmár, T. (2013) · Journal of Neural Engineering · doi:10.1088/1741-2560/10/5/056021 · Cited by 31 · see citing works
Jalligampala, A., Sekhar, S., Zrenner, E., & Rathbun, D. L. (2017) · Journal of Neural Engineering · doi:10.1088/1741-2552/14/2/026004 · Cited by 29 · see citing works
Freeman, D. K., Jeng, J. S., Kelly, S. K., Hartveit, E., & Fried, S. I. (2011) · Journal of Neural Engineering · doi:10.1088/1741-2560/8/4/046005 · Cited by 31 · see citing works
Depth and motion cues with phosphene patterns for prosthetic vision
Perez-Yus, A., Bermudez-Cameo, J., Guerrero, J. J., & Lopez-Nicolas, G. (2017) · 2017 IEEE International Conference on Computer Vision Workshops (ICCVW) · doi:10.1109/iccvw.2017.179 · Cited by 24 · see citing works
Argus II retinal prosthesis system: An update
Rachitskaya, A. V., & Yuan, A. (2016) · Ophthalmic Genetics · doi:10.3109/13816810.2015.1130152 · Cited by 28 · see citing works
Esler, T. B., Kerr, R. R., Tahayori, B., Grayden, D. B., Meffin, H., & Burkitt, A. N. (2018) · PLoS ONE · doi:10.1371/journal.pone.0193598 · Cited by 28 · see citing works
3D Diamond Electrode Array for High-Acuity Stimulation in Neural Tissue
Stamp, M. E. M., Tong, W., Ganesan, K., Prawer, S., Ibbotson, M. R., & Garrett, D. J. (2020) · ACS Applied Bio Materials · doi:10.1021/acsabm.9b01165 · Cited by 28 · see citing works
Liu, X., Chen, P., Ding, X., Liu, A., Li, P., Sun, C., & Guan, H. (2022) · Annals of Translational Medicine · doi:10.21037/atm-22-2858 · Cited by 28 · see citing works
Extracellular voltage noise probes the interface between retina and silicon chip
Zeitler, R., Fromherz, P., & Zeck, G. M. (2011) · Applied Physics Letters · doi:10.1063/1.3672224 · Cited by 28 · see citing works
Regenerative nanomedicine and the treatment of degenerative retinal diseases
Zarbin, M. A., Montemagno, C. D., Leary, J. F., & Ritch, R. H. (2011) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.167 · Cited by 28 · see citing works
- Authors
- Ahuja, A. K., Dorn, J. D., Caspi, A., McMahon, M. J., Dagnelie, G., daCruz, L., Stanga, P., Humayun, M. S., Greenberg, R. J., & Argus II Study Group
- Affiliations
- Second Sight Medical Products (US)
- Moorfields Eye Hospital (GB)
- Manchester Royal Eye Hospital (GB)
- Doheny Eye Institute (US)
- Corresponding author
- Ahuja, A. K.
- Venue
- British Journal of Ophthalmology
- Publisher
- BMJ
- Published
- 2010-09-29
- Volume
- 95
- Issue
- 4
- Pages
- 539-543
- ISSN
- 0007-1161 (ISSN-L)
- PMC
- PMC3345188
- OpenAlex
- W2171460754
- Cited by
- 289
- References
- 19
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 7 · 2023: 8 · 2022: 14 · 2021: 15 · 2020: 17 · 2019: 17 · 2018: 25 · 2017: 21 · 2016: 24 · 2015: 20 · 2014: 27 · 2013: 27 · 2012: 26
- FWCI
- 9.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal of Ophthalmology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- National Eye Institute (R01EY012893, 5R01EY12893)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Health Sciences › Health Professions › Occupational Therapy › Assistive Technology in Communication and Mobility
- Keywords
- Argus II retinal prosthesis, retinal prosthesis, visual prosthesis, visual augmentation, blind subjects, residual vision, visual acuity, task accuracy
- MeSH terms
- Adult, Aged, Aged, 80 and over, Blindness, Female, Humans, Male, Middle Aged, Motor Activity, Orientation, Prosthesis Design, Retina, Task Performance and Analysis, Touch, Treatment Outcome, Visual Prosthesis
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