Spatial resolution and perception of patterns mediated by a subretinal 16-electrode array in patients blinded by hereditary retinal dystrophies
Abstract
PURPOSE: The perception of 11 persons blinded by hereditary retinal degeneration elicited by a subretinally implanted 16-electrode array used for light-independent direct stimulation of the retina is described. This device is part of the Tübingen retina implant, which also employs a light-sensitive, multiphotodiode array (MPDA). The ability to reliably recognize complex spatial percepts was investigated. METHODS: Eleven blind volunteers received implants and participated in standardized psychophysical tests investigating the size and shape of perceptions elicited by single-electrode activation, multiple-electrode activation, and activation of compound patterns such as simplified letters. RESULTS: Visual percepts were elicited reliably in 8 of 11 patients. On single-electrode activation, percepts were generally described as round spots of light of distinguishable localization in the visual field. On activation of a pattern of electrodes, percepts matched that pattern when electrodes were activated sequentially. Patterns such as horizontal or vertical bars were identified reliably; the most recent participant was able to recognize simplified letters presented on the 16-electrode array. The smallest distance between sites of concurrent retinal stimulation still yielding discernible spots of light was assessed to be 280 μm, corresponding to a logMAR of 1.78. CONCLUSIONS: Subretinal electric stimulation can yield reliable, predictable percepts. Patterned perception is feasible, enabling blind persons to recognize shapes and discriminate different letters. Stimulation paradigms must be optimized, to further increase spatial resolution, demanding a better understanding of physical and biological effects of single versus repetitive stimulation (ClinicalTrials.gov number, NCT00515814).
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Patients might still experience arcuate and linear phosphenes when high current amplitudes are used, most probably due to direct RGC activation.
“However, patients might still experience arcuate and linear phosphenes when high current amplitudes are used [140], most probably due to direct RGC activation.”
From Advances in visual prostheses: engineering and biological challenges (2022) · cites this paper as [140]
Cites
(1966) · Medical Entomology and Zoology · Cited by 10,293 · see citing works
Visual perception in a blind subject with a chronic microelectronic retinal prosthesis
Humayun, M. S., Weiland, J. D., Fujii, G. Y., Greenberg, R., Williamson, R., Little, J., Mech, B., Cimmarusti, V., Van Boemel, G., Dagnelie, G., et al. (2003) · Vision Research · doi:10.1016/s0042-6989(03)00457-7 · Cited by 856 · see citing works
Subretinal electronic chips allow blind patients to read letters and combine them to words
Zrenner, E., Bartz-Schmidt, K. U., Benav, H., Besch, D., Bruckmann, A., Gabel, V.-P., Gekeler, F., Greppmaier, U., Harscher, A., Kibbel, S., et al. (2011) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2010.1747 · Cited by 819 · see citing works
Self-citationWill Retinal Implants Restore Vision?
Zrenner, E. (2002) · Science · doi:10.1126/science.1067996 · Cited by 726 · see citing works
Self-citationPreservation of the Inner Retina in Retinitis Pigmentosa
Santos, A. (1997) · Archives of Ophthalmology · doi:10.1001/archopht.1997.01100150513011 · Cited by 644 · see citing works
The Artificial Silicon Retina Microchip for the Treatment of VisionLoss From Retinitis Pigmentosa
Chow, A. Y. (2004) · Archives of Ophthalmology · doi:10.1001/archopht.122.4.460 · Cited by 512 · see citing works
Stone, J. L. (1992) · Archives of Ophthalmology · doi:10.1001/archopht.1992.01080230134038 · Cited by 471 · see citing works
Retinal remodeling during retinal degeneration
Jones, B. W., & Marc, R. E. (2005) · Experimental Eye Research · doi:10.1016/j.exer.2005.03.006 · Cited by 430 · see citing works
Design of a high-resolution optoelectronic retinal prosthesis
Palanker, D., Vankov, A., Huie, P., & Baccus, S. A. (2005) · Journal of Neural Engineering · doi:10.1088/1741-2560/2/1/012 · Cited by 330 · see citing works
Can subretinal microphotodiodes successfully replace degenerated photoreceptors?
Zrenner, E., Stett, A., Weiss, S., Aramant, R. B., Guenther, E., Köhler, K., Miliczek, K.-D., Seiler, M. J., & Haemmerle, H. (1999) · Vision Research · doi:10.1016/s0042-6989(98)00312-5 · Cited by 290 · see citing works
Self-citationElectrical multisite stimulation of the isolated chicken retina
Stett, A., Barth, W., Weiss, S., Haemmerle, H., & Zrenner, E. (2000) · Vision Research · doi:10.1016/s0042-6989(00)00005-5 · Cited by 259 · see citing works
Self-citationVisual Performance Using a Retinal Prosthesis in Three Subjects With Retinitis Pigmentosa
Yanai, D., Weiland, J. D., Mahadevappa, M., Greenberg, R. J., Fine, I., & Humayun, M. S. (2007) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2007.01.027 · Cited by 233 · see citing works
The Development of Subretinal Microphotodiodes for Replacement of Degenerated Photoreceptors
Zrenner, E., Miliczek, K.-D., Gabel, V. P., Graf, H., Guenther, E., Haemmerle, H., Hoefflinger, B., Köhler, K., Nisch, W., Schubert, M. B., et al. (2009) · Ophthalmic Research · doi:10.1159/000268025 · Cited by 214 · see citing works
Self-citationFactors affecting perceptual thresholds in epiretinal prostheses
de Balthasar, C., Patel, S., Roy, A., Freda, R., Greenwald, S., Horsager, A., Mahadevappa, M., Yanai, D., McMahon, M. J., Humayun, M. S., et al. (2008) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.07-0696 · Cited by 204 · see citing works
Rizzo, J. F., Wyatt, J. L., Humayun, M. S., de Juan, E., Liu, W., Chow, A. Y., Eckmiller, R., Zrenner, E., Yagi, T., & Abrams, G. W. (2001) · Ophthalmology · doi:10.1016/s0161-6420(00)00430-9 · Cited by 152 · see citing works
Self-citationFujikado, T., Morimoto, T., Kanda, H., Kusaka, S., Nakauchi, K., Ozawa, M., Matsushita, K., Sakaguchi, H., Ikuno, Y., Kamei, M., et al. (2007) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-007-0563-z · Cited by 147 · see citing works
Optoelectronic retinal prosthesis: system design and performance
Loudin, J., Simanovskii, D. M., Vijayraghavan, K., Sramek, C., Butterwick, A., Huie, P., McLean, G. Y., & Palanker, D. (2007) · Journal of Neural Engineering · doi:10.1088/1741-2560/4/1/s09 · Cited by 130 · see citing works
Responses of ganglion cells to repetitive electrical stimulation of the retina
Jensen, R. J., & Rizzo, J. F. (2007) · Journal of Neural Engineering · doi:10.1088/1741-2560/4/1/s01 · Cited by 121 · see citing works
Besch, D., Sachs, H., Szurman, P., Gülicher, D., Wilke, R. G. H., Reinert, S., Zrenner, E., Bartz‐Schmidt, K. U., & Gekeler, F. (2008) · British Journal of Ophthalmology · doi:10.1136/bjo.2007.131961 · Cited by 115 · see citing works
Self-citationElectric crosstalk impairs spatial resolution of multi-electrode arrays in retinal implants
Wilke, R. G. H., Moghadam, G. K., Lovell, N. H., Suaning, G. J., & Dokos, S. (2011) · Journal of Neural Engineering · doi:10.1088/1741-2560/8/4/046016 · Cited by 110 · see citing works
Self-citationRetinal prostheses: current challenges and future outlook
Winter, J. O., Cogan, S. F., & Rizzo, J. F. (2007) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856207781494403 · Cited by 109 · see citing works
Predicting visual sensitivity in retinal prosthesis patients
Horsager, A., Greenwald, S. H., Weiland, J. D., Humayun, M. S., Greenberg, R. J., McMahon, M. J., Boynton, G. M., & Fine, I. (2009) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.08-2595 · Cited by 107 · see citing works
Visual performance in emmetropia and low myopia after correction of high-order aberrations
Rossi, E. A., Weiser, P., Tarrant, J., & Roorda, A. (2007) · Journal of Vision · doi:10.1167/7.8.14 · Cited by 96 · see citing works
Brightness as a Function of Current Amplitude in Human Retinal Electrical Stimulation
Greenwald, S. H., Horsager, A., Humayun, M. S., Greenberg, R. J., McMahon, M. J., & Fine, I. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-2897 · Cited by 95 · see citing works
Spatiotemporal Interactions in Retinal Prosthesis Subjects
Horsager, A., Greenberg, R. J., & Fine, I. (2010) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.09-3746 · Cited by 95 · see citing works
Visual resolution with retinal implants estimated from recordings in cat visual cortex
Eckhorn, R., Wilms, M., Schanze, T., Eger, M., Hesse, L., Eysel, U. T., Kisvárday, Z. F., Zrenner, E., Gekeler, F., Schwahn, H., et al. (2006) · Vision Research · doi:10.1016/j.visres.2006.01.034 · Cited by 94 · see citing works
Self-citationCortical Activation Via an Implanted Wireless Retinal Prosthesis
Walter, P., ́rday, Z. ́. F. K., Görtz, M., Alteheld, N., Rößler, G., Stieglitz, T., & Eysel, U. T. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.04-0924 · Cited by 92 · see citing works
Biocompatibility of Materials Implanted into the Subretinal Space of Yucatan Pigs
Montezuma, S. R., Loewenstein, J. I., Scholz, C., & Rizzo, J. F. (2006) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.06-0106 · Cited by 84 · see citing works
Gekeler, F., Messias, A. M. V., Ottinger, M., Bartz‐Schmidt, K. U., & Zrenner, E. (2006) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.06-0459 · Cited by 83 · see citing works
Self-citationRetinal Neurostimulator for a Multifocal Vision Prosthesis
Wong, Y. T., Dommel, N., Preston, P., Hallum, L. E., Lehmann, T., Lovell, N. H., & Suaning, G. J. (2007) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2007.903958 · Cited by 79 · see citing works
A method and technical equipment for an acute human trial to evaluate retinal implant technology
Hornig, R., Laube, T., Walter, P., Velikay‐Parel, M., Bornfeld, N., Feucht, M., Akguel, H., Rößler, G., Alteheld, N., Notarp, D. L., et al. (2005) · Journal of Neural Engineering · doi:10.1088/1741-2560/2/1/014 · Cited by 77 · see citing works
Gekeler, F., Szurman, P., Grisanti, S., Weiler, U., Claus, R., Greiner, T.-O., Völker, M., Köhler, K., Zrenner, E., & Bartz‐Schmidt, K. U. (2006) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-006-0339-x · Cited by 75 · see citing works
Self-citationZhou, J., Woo, S. J., Park, S. I., Kim, E., Seo, J.-M., Chung, H., & Kim, S. J. (2008) · BioMed Research International · doi:10.1155/2008/547428 · Cited by 74 · see citing works
Retinal prosthesis phosphene shape analysis
Nanduri, D., Humayun, M. S., Greenberg, R. J., McMahon, M. J., & Weiland, J. D. (2008) · 2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society · doi:10.1109/iembs.2008.4649524 · Cited by 74 · see citing works
Long-term survival of retinal cell cultures on retinal implant materials
Guenther, E., Tröger, B., Schlosshauer, B., & Zrenner, E. (1999) · Vision Research · doi:10.1016/s0042-6989(99)00128-5 · Cited by 71 · see citing works
Self-citationLong-term stimulation by active epiretinal implants in normal and RCD1 dogs
Güven, D., Weiland, J. D., Fujii, G. Y., Mech, B. V., Mahadevappa, M., Greenberg, R. J., Roizenblatt, R., Qiu, G., LABREE, L. D., Wang, X., et al. (2005) · Journal of Neural Engineering · doi:10.1088/1741-2560/2/1/009 · Cited by 71 · see citing works
Basic Quantitative Assessment of Visual Performance in Patients with Very Low Vision
Bach, M., Wilke, M., Wilhelm, B., Zrenner, E., & Wilke, R. G. H. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-3512 · Cited by 70 · see citing works
Self-citationDeMarco, P. J., Yarbrough, G. L., Yee, C. W., McLean, G. Y., Sagdullaev, B. T., Ball, S. L., & McCall, M. A. (2007) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.06-0811 · Cited by 64 · see citing works
Zrenner, E. (2002) · Ophthalmologica · doi:10.1159/000064650 · Cited by 60 · see citing works
Self-citationStett, A., Mai, A., & Herrmann, T. (2007) · Journal of Neural Engineering · doi:10.1088/1741-2560/4/1/s02 · Cited by 59 · see citing works
Self-citationSchanze, T., Hesse, L., Lau, C., Greve, N., Haberer, W., Kammer, S., Doerge, T., Rentzos, A., & Stieglitz, T. (2007) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2007.895866 · Cited by 57 · see citing works
Intraocular epiretinal prosthesis to restore vision in blind humans
Mokwa, W., Goertz, M., Koch, C., Krisch, I., Trieu, H. K., & Walter, P. (2008) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/iembs.2008.4650530 · Cited by 56 · see citing works
High Dynamic Range CMOS Imager Technologies for Biomedical Applications
Graf, H., Harendt, C., Engelhardt, T., Scherjon, C., Warkentin, K., Richter, H. H., & Burghartz, J. N. (2009) · IEEE Journal of Solid-State Circuits · doi:10.1109/jssc.2008.2007437 · Cited by 55 · see citing works
Experimental implantation of epiretinal retina implants (EPI-RET) with an IOL-type receiver unit
Gerding, H., Benner, F. P., & Taneri, S. (2007) · Journal of Neural Engineering · doi:10.1088/1741-2560/4/1/s06 · Cited by 44 · see citing works
Artificial sight : basic research, biomedical engineering, and clinical advances
Humayun, M. S., Weiland, J. D., Chader, G. J., & Greenbaum, E. (2007) · CERN Document Server (European Organization for Nuclear Research) · doi:10.1007/978-0-387-49331-2 · Cited by 42 · see citing works
Sachs, H. G., Schanze, T., Brunner, U., Sailer, H., & Wiesenack, C. (2005) · Journal of Neural Engineering · doi:10.1088/1741-2560/2/1/008 · Cited by 36 · see citing works
Self-citationThe development of a multichannel electrode array for retinal prostheses
Terasawa, Y., Tashiro, H., Uehara, A., Saitoh, T., Ozawa, M., Tokuda, T., & Ohta, J. (2006) · Journal of Artificial Organs · doi:10.1007/s10047-006-0352-1 · Cited by 31 · see citing works
Sachs, H. G., Gekeler, F., Schwahn, H., Jakob, W., Köhler, M., Schulmeyer, F. J., Marienhagen, J., Brunner, U., & Framme, C. (2005) · European Journal of Ophthalmology · doi:10.1177/112067210501500413 · Cited by 31 · see citing works
Self-citationSachs, H. G., Gekeler, F., Schwahn, H., et al. (2005) · PubMed · doi:10.5301/ejo.2008.3051 · Cited by 30 · see citing works
Self-citationStatus of the feline retina 5 years after subretinal implantation
Pardue, M. T., Ball, S. L., Phillips, M. J., Faulkner, A. E., Walker, T. A., Chow, A. Y., & Peachey, N. S. (2006) · The Journal of Rehabilitation Research and Development · doi:10.1682/jrrd.2005.07.0118 · Cited by 28 · see citing works
Alteheld, N., Roessler, G. F., & Walter, P. (2007) · Springer eBooks · doi:10.1007/978-3-211-33081-4_56 · Cited by 25 · see citing works
(2010) · Lecture Notes in Computer Science · doi:10.1007/978-3-642-17537-4 · Cited by 23 · see citing works
Testing Visual Functions in Patients with Visual Prostheses
Wilke, R. G. H., Bach, M., Wilhelm, B., Durst, W., Trauzettel‐Klosinski, S., & Zrenner, E. (2007) · Springer eBooks · doi:10.1007/978-0-387-49331-2_5 · Cited by 21 · see citing works
Self-citationAlteheld, N., Roessler, G. F., Vobig, M. A., & Walter, P. (2004) · Biomedizinische Technik/Biomedical Engineering · doi:10.1515/bmt.2004.020 · Cited by 19 · see citing works
Pardue, M. T., Phillips, M. J., Hanzlicek, B., Yin, H., Chow, A. Y., & Ball, S. L. (2007) · Springer eBooks · doi:10.1007/0-387-32442-9_45 · Cited by 17 · see citing works
Wilke, R. G. H., Moghaddam, G. K., Dokos, S., Suaning, G. J., & Lovell, N. H. (2010) · Lecture notes in computer science · doi:10.1007/978-3-642-17537-4_18 · Cited by 11 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Retinal stimulation strategies to restore vision: fundamentals and systems
Yue, L., Weiland, J. D., Roska, B., & Humayun, M. S. (2016) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2016.05.002 · Cited by 272 · see citing works
An update on retinal prostheses
Ayton, L. N., Barnes, N., Dagnelie, G., Fujikado, T., Goetz, G., Hornig, R., Jones, B. W., Muqit, M. M. K., Rathbun, D. L., Stingl, K., et al. (2020) · Clinical Neurophysiology · doi:10.1016/j.clinph.2019.11.029 · Cited by 223 · see citing works
Retinal implants: a systematic review: Table 1
Chuang, A., Margo, C. E., & Greenberg, P. B. (2014) · British Journal of Ophthalmology · doi:10.1136/bjophthalmol-2013-303708 · Cited by 192 · see citing works
The functional performance of the Argus II retinal prosthesis
Stronks, H. C., & Dagnelie, G. (2014) · Expert Review of Medical Devices · doi:10.1586/17434440.2014.862494 · Cited by 189 · see citing works
Weiland, J. D., & Humayun, M. S. (2014) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2014.2314733 · Cited by 186 · see citing works
Visual prostheses for the blind
Shepherd, R. K., Shivdasani, M. N., Nayagam, D. A. X., Williams, C. E., & Blamey, P. J. (2013) · Trends in biotechnology · doi:10.1016/j.tibtech.2013.07.001 · Cited by 181 · see citing works
Microscopic magnetic stimulation of neural tissue
Bonmassar, G., Lee, S. W., Freeman, D. K., Polášek, M., Fried, S. I., & Gale, J. T. (2012) · Nature Communications · doi:10.1038/ncomms1914 · Cited by 180 · see citing works
Dorn, J. D., Ahuja, A. K., Caspi, A., da Cruz, L., Dagnelie, G., Sahel, J.-A., Greenberg, R. J., McMahon, M. J., & Argus II Study Group, F. T. (2013) · JAMA Ophthalmology · doi:10.1001/2013.jamaophthalmol.221 · Cited by 177 · see citing works
A model of ganglion axon pathways accounts for percepts elicited by retinal implants
Beyeler, M., Nanduri, D., Weiland, J. D., Rokem, A., Boynton, G. M., & Fine, I. (2019) · Scientific Reports · doi:10.1038/s41598-019-45416-4 · Cited by 143 · see citing works
Flexible ultrasound-induced retinal stimulating piezo-arrays for biomimetic visual prostheses
Jiang, L., Lu, G., Zeng, Y., Sun, Y., Kang, H., Burford, J. L., Gong, C., Humayun, M. S., Chen, Y., & Zhou, Q. (2022) · Nature Communications · doi:10.1038/s41467-022-31599-4 · Cited by 154 · see citing works
Electronic retinal implants and artificial vision: journey and present
Mills, J. O., Jalil, A., & Stanga, P. E. (2017) · Eye · doi:10.1038/eye.2017.65 · Cited by 133 · see citing works
Usher syndrome (sensorineural deafness and retinitis pigmentosa)
Bonnet, C., & El-Amraoui, A. (2011) · Current Opinion in Neurology · doi:10.1097/wco.0b013e32834ef8b2 · Cited by 134 · see citing works
Mandel, Y., Goetz, G. A., Lavinsky, D., Huie, P., Mathieson, K., Wang, L., Kamins, T. I., Galambos, L., Manivanh, R. V., Harris, J. S., et al. (2013) · Nature Communications · doi:10.1038/ncomms2980 · Cited by 131 · see citing works
Gauvain, G., Akolkar, H., Chaffiol, A., Arcizet, F., Khoei, M. A., Desrosiers, M., Jaillard, C., Caplette, R., Marre, O., Bertin, S., et al. (2021) · Communications Biology · doi:10.1038/s42003-020-01594-w · Cited by 131 · see citing works
Cideciyan, A. V., Świder, M., Alemán, T. S., Feuer, W. J., Schwartz, S., Russell, R. C., Steinberg, J. D., Stone, E. M., & Jacobson, S. G. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-8415 · Cited by 119 · see citing works
Electric crosstalk impairs spatial resolution of multi-electrode arrays in retinal implants
Wilke, R. G. H., Moghadam, G. K., Lovell, N. H., Suaning, G. J., & Dokos, S. (2011) · Journal of Neural Engineering · doi:10.1088/1741-2560/8/4/046016 · Cited by 110 · see citing works
Self-citationSpatially patterned electrical stimulation to enhance resolution of retinal prostheses
Jepson, L. H., Hottowy, P., Mathieson, K., Gunning, D. E., Dąbrowski, W., Litke, A. M., & Chichilnisky, E. J. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.2882-13.2014 · Cited by 103 · see citing works
Choroidal thickness profiles in retinitis pigmentosa
Ayton, L. N., Guymer, R. H., & Luu, C. D. (2012) · Clinical and Experimental Ophthalmology · doi:10.1111/j.1442-9071.2012.02867.x · Cited by 98 · see citing works
A review and update on the current status of retinal prostheses (bionic eye)
Luo, Y. H.-L., & da Cruz, L. (2014) · British Medical Bulletin · doi:10.1093/bmb/ldu002 · Cited by 89 · see citing works
Lorach, H., Goetz, G. A., Mandel, Y., Lei, X., Kamins, T. I., Mathieson, K., Huie, P., Dalal, R., Harris, J. S., & Palanker, D. (2014) · Vision Research · doi:10.1016/j.visres.2014.09.007 · Cited by 78 · see citing works
Cicione, R., Shivdasani, M. N., Fallon, J. B., Luu, C. D., Allen, P. J., Rathbone, G. D., Shepherd, R. K., & Williams, C. E. (2012) · Journal of Neural Engineering · doi:10.1088/1741-2560/9/3/036009 · Cited by 79 · see citing works
Functional Outcome in Subretinal Electronic Implants Depends on Foveal Eccentricity
Štingl, K., Bartz‐Schmidt, K. U., Gekeler, F., Kusnyerik, Á., Sachs, H. G., & Zrenner, E. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.13-12835 · Cited by 73 · see citing works
Self-citationAyton, L. N., Rizzo, J. F., Bailey, I. L., Colenbrander, A., Dagnelie, G., Geruschat, D. R., Hessburg, P. C., McCarthy, C. D., Petoe, M. A., Rubin, G. S., et al. (2020) · Translational Vision Science & Technology · doi:10.1167/tvst.9.8.25 · Cited by 75 · see citing works
Novel interfaces for light directed neuronal stimulation: advances and challenges
Bareket, L., & Hanein, Y. (2014) · International Journal of Nanomedicine · doi:10.2147/ijn.s51193 · Cited by 71 · see citing works
Attaining higher resolution visual prosthetics: a review of the factors and limitations
Eiber, C. D., Lovell, N. H., & Suaning, G. J. (2013) · Journal of Neural Engineering · doi:10.1088/1741-2560/10/1/011002 · Cited by 71 · see citing works
Acute electrical stimulation of the human retina with an epiretinal electrode array
Keserü, M., Feucht, M., Bornfeld, N., Laube, T., Walter, P., Rößler, G., Velikay‐Parel, M., Hornig, R., & Richard, G. W. (2011) · Acta Ophthalmologica · doi:10.1111/j.1755-3768.2011.02288.x · Cited by 69 · see citing works
Im, M., & Fried, S. I. (2016) · Journal of Neural Engineering · doi:10.1088/1741-2560/13/2/025002 · Cited by 65 · see citing works
The appearance of phosphenes elicited using a suprachoroidal retinal prosthesis
Sinclair, N. C., Shivdasani, M. N., Perera, T., Gillespie, L. N., McDermott, H. J., Ayton, L. N., Blamey, P. J., & for the Bionic Vision Australia Consortium (2016) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.15-18991 · Cited by 60 · see citing works
Electric stimulus duration alters network-mediated responses depending on retinal ganglion cell type
Im, M., Werginz, P., & Fried, S. I. (2018) · Journal of Neural Engineering · doi:10.1088/1741-2552/aaadc1 · Cited by 58 · see citing works
Eleftheriou, C. G., Zimmermann, J. B., Kjeldsen, H. D., David‐Pur, M., Hanein, Y., & Sernagor, E. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.10.018 · Cited by 57 · see citing works
Saunders, A. L., Williams, C. E., Heriot, W. J., Briggs, R., Yeoh, J., Nayagam, D. A. X., McCombe, M. F., Villalobos, J., Burns, O., Luu, C. D., et al. (2013) · Clinical and Experimental Ophthalmology · doi:10.1111/ceo.12287 · Cited by 56 · see citing works
Fine, I., & Boynton, G. M. (2015) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2014.0208 · Cited by 55 · see citing works
Yang, R., Zhao, P., Wang, L., Feng, C., Chen, P., Wang, Z., Zhang, Y., Shen, M., Shi, K., Weng, S.-J., et al. (2023) · Nature Biomedical Engineering · doi:10.1038/s41551-023-01137-8 · Cited by 53 · see citing works
Neural stimulation for visual rehabilitation: Advances and challenges
Lorach, H., Marre, O., Sahel, J., Benosman, R. B., & Picaud, S. A. (2012) · Journal of Physiology-Paris · doi:10.1016/j.jphysparis.2012.10.003 · Cited by 51 · see citing works
Mobility and low contrast trip hazard avoidance using augmented depth
McCarthy, C., Walker, J. G., Lieby, P., Scott, A., & Barnes, N. (2015) · Journal of Neural Engineering · doi:10.1088/1741-2560/12/1/016003 · Cited by 49 · see citing works
Damiani, D., Novelli, E., Mazzoni, F., & Strettoi, E. (2011) · The Journal of Comparative Neurology · doi:10.1002/cne.22802 · Cited by 49 · see citing works
Retinal prostheses: Clinical results and future challenges
Picaud, S. A., & Sahel, J. (2014) · Comptes Rendus Biologies · doi:10.1016/j.crvi.2014.01.001 · Cited by 48 · see citing works
Advances in visual prostheses: engineering and biological challenges
Borda, E., & Ghezzi, D. (2022) · Progress in Biomedical Engineering · doi:10.1088/2516-1091/ac812c · Cited by 44 · see citing works
Shivdasani, M. N., Fallon, J. B., Luu, C. D., Cicione, R., Allen, P. J., Morley, J. W., & Williams, C. E. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-9434 · Cited by 42 · see citing works
Flexible Microinterventional Sensors for Advanced Biosignal Monitoring
Liu, Y., Fan, P., Pan, Y., & Ping, J. F. (2025) · Chemical Reviews · doi:10.1021/acs.chemrev.5c00115 · Cited by 40 · see citing works
High-amplitude electrical stimulation can reduce elicited neuronal activity in visual prosthesis
Barriga‐Rivera, A., Guo, T., Yang, C.-Y., Abed, A. A., Dokos, S., Lovell, N. H., Morley, J. W., & Suaning, G. J. (2017) · Scientific Reports · doi:10.1038/srep42682 · Cited by 40 · see citing works
1225-Channel Neuromorphic Retinal-Prosthesis SoC With Localized Temperature-Regulation
Park, J. H., Tan, J. S. Y., Wu, H., Dong, Y., & Yoo, J. (2020) · IEEE Transactions on Biomedical Circuits and Systems · doi:10.1109/tbcas.2020.3036091 · Cited by 39 · see citing works
Shivdasani, M. N., Sinclair, N. C., Gillespie, L. N., Petoe, M. A., Titchener, S. A., Fallon, J. B., Perera, T., Pardinas-Diaz, D., Barnes, N. M., Blamey, P. J., et al. (2017) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.16-21311 · Cited by 38 · see citing works
Habib, A. G., Cameron, M. A., Suaning, G. J., Lovell, N. H., & Morley, J. W. (2013) · Journal of Neural Engineering · doi:10.1088/1741-2560/10/3/036013 · Cited by 38 · see citing works
Suppression of Subthalamic Nucleus Activity by Micromagnetic Stimulation
Lee, S.-W., & Fried, S. (2014) · IEEE transactions on neural systems and rehabilitation engineering · doi:10.1109/tnsre.2014.2348415 · Cited by 31 · see citing works
Irons, J. L., Gradden, T., Zhang, A., He, X., Barnes, N. M., Scott, A. F., & McKone, E. (2017) · Vision Research · doi:10.1016/j.visres.2017.06.002 · Cited by 35 · see citing works
Progress in artificial vision through suprachoroidal retinal implants
Bareket, L., Barriga‐Rivera, A., Zapf, M. P., Lovell, N. H., & Suaning, G. J. (2017) · Journal of Neural Engineering · doi:10.1088/1741-2552/aa6cbb · Cited by 34 · see citing works
Opie, N. L., Greferath, U., Vessey, K. A., Burkitt, A. N., Hamish Meffin, A., Grayden, D. B., & Fletcher, E. L. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-10600 · Cited by 33 · see citing works
Retinal Prosthetic Approaches to Enhance Visual Perception for Blind Patients
Shim, S., Eom, K., Jeong, J., & Kim, S. J. (2020) · Micromachines · doi:10.3390/mi11050535 · Cited by 34 · see citing works
Lu, Y., Yan, Y., Chai, X., Ren, Q., Chen, Y., & Li, L. (2013) · Journal of Neural Engineering · doi:10.1088/1741-2560/10/3/036022 · Cited by 32 · see citing works
Spencer, T. C., Fallon, J. B., Thien, P. C., & Shivdasani, M. N. (2016) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.16-19325 · Cited by 31 · see citing works
Creating virtual electrodes with 2D current steering
Spencer, T. C., Fallon, J. B., & Shivdasani, M. N. (2018) · Journal of Neural Engineering · doi:10.1088/1741-2552/aab1b8 · Cited by 31 · see citing works
Gekeler, K., Bartz‐Schmidt, K. U., Sachs, H. G., MacLaren, R. E., Štingl, K., Zrenner, E., & Gekeler, F. (2018) · Current Opinion in Ophthalmology · doi:10.1097/icu.0000000000000467 · Cited by 31 · see citing works
Self-citationMicro/Nano Technologies for High-Density Retinal Implant
Zeng, Q., Zhao, S., Yang, H., Zhang, Y., & Wu, T. (2019) · Micromachines · doi:10.3390/mi10060419 · Cited by 31 · see citing works
Photochemistry of Organic Retinal Prostheses
Manfredi, G., Colombo, E., Barsotti, J., Benfenati, F., & Lanzani, G. (2019) · Annual Review of Physical Chemistry · doi:10.1146/annurev-physchem-042018-052445 · Cited by 29 · see citing works
Argus II retinal prosthesis system: An update
Rachitskaya, A. V., & Yuan, A. (2016) · Ophthalmic Genetics · doi:10.3109/13816810.2015.1130152 · Cited by 28 · see citing works
Clinical applications of choroidal imaging technologies
Chhablani, J. K., & Barteselli, G. (2015) · Indian Journal of Ophthalmology · doi:10.4103/0301-4738.159861 · Cited by 27 · see citing works
A simulation of current focusing and steering with penetrating optic nerve electrodes
Li, M., Yan, Y., Wang, Q., Zhao, H., Chai, X., Sui, X., Ren, Q., & Li, L. (2013) · Journal of Neural Engineering · doi:10.1088/1741-2560/10/6/066007 · Cited by 26 · see citing works
Optogenetics, visual prosthesis and electrostimulation for retinal dystrophies
Garg, S. J., & Federman, J. L. (2013) · Current Opinion in Ophthalmology · doi:10.1097/icu.0b013e328363829b · Cited by 27 · see citing works
Nuzzi, R., & Tridico, F. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00494 · Cited by 27 · see citing works
Yang, C. Y., Tsai, D., Guo, T., Dokos, S., Suaning, G. J., Morley, J. W., & Lovell, N. H. (2018) · Journal of Neural Engineering · doi:10.1088/1741-2552/aac315 · Cited by 25 · see citing works
Neural Responses to Multielectrode Stimulation of Healthy and Degenerate Retina
Halupka, K. J., Abbott, C. J., Wong, Y. T., Cloherty, S. L., Grayden, D. B., Burkitt, A. N., Sergeev, E. N., Luu, C. D., Brandli, A. A., Allen, P. J., et al. (2017) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.16-21290 · Cited by 24 · see citing works
Performance optimization of current focusing and virtual electrode strategies in retinal implants
Moghaddam, G. K., Lovell, N. H., Wilke, R. G. H., Suaning, G. J., & Dokos, S. (2014) · Computer Methods and Programs in Biomedicine · doi:10.1016/j.cmpb.2014.06.012 · Cited by 24 · see citing works
Self-citationLee, S., Jung, S. W., Ahn, J., Yoo, H. J., Oh, S. J., & Cho, D. (2014) · Journal of Micromechanics and Microengineering · doi:10.1088/0960-1317/24/7/075018 · Cited by 23 · see citing works
Kusnyerik, Á., Greppmaier, U., Wilke, R. G. H., Gekeler, F., Wilhelm, B., Sachs, H. G., Bartz‐Schmidt, K. U., Klose, U., Štingl, K., Resch, M., et al. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-9409 · Cited by 23 · see citing works
Self-citationFocal damage to macaque photoreceptors produces persistent visual loss
Strazzeri, J. M., Hunter, J. J., Masella, B. D., Yin, L., Fischer, W. S., DiLoreto, D. A., Libby, R. T., Williams, D. R., & Merigan, W. H. (2013) · Experimental Eye Research · doi:10.1016/j.exer.2013.11.001 · Cited by 23 · see citing works
Reading visual braille with a retinal prosthesis
Lauritzen, T. Z., Harris, J., Mohand-Said, S., Sahel, J. A., Dorn, J. D., McClure, K., & Greenberg, R. J. (2012) · Frontiers in Neuroscience · doi:10.3389/fnins.2012.00168 · Cited by 22 · see citing works
Prediction of cortical responses to simultaneous electrical stimulation of the retina
Halupka, K. J., Shivdasani, M. N., Cloherty, S. L., Grayden, D. B., Wong, Y. T., Burkitt, A. N., & Hamish Meffin, A. (2016) · Journal of Neural Engineering · doi:10.1088/1741-2560/14/1/016006 · Cited by 21 · see citing works
Advances in neuroscience, not devices, will determine the effectiveness of visual prostheses
Abbasi, B., & Rizzo, J. F. (2021) · Seminars in Ophthalmology · doi:10.1080/08820538.2021.1887902 · Cited by 19 · see citing works
Probing the functional impact of sub-retinal prosthesis
Roux, S., Matonti, F., Dupont, F., Hoffart, L., Takerkart, S., Picaud, S. A., Pham, P., & Chavane, F. (2016) · eLife · doi:10.7554/elife.12687 · Cited by 19 · see citing works
Retinal Prostheses Development in Retinitis Pigmentosa Patients—Progress and Comparison
Chow, A. Y. (2013) · Asia-Pacific Journal of Ophthalmology · doi:10.1097/apo.0b013e3182a0b4fe · Cited by 19 · see citing works
Khalili Moghadam, G., Wilke, R., Suaning, G. J., Lovell, N. H., & Dokos, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073130 · Cited by 18 · see citing works
Self-citationElectronic restoration of vision in those with photoreceptor degenerations
O'Brien, E. E., Greferath, U., Vessey, K. A., Jobling, A. I., & Fletcher, E. L. (2012) · Clinical and Experimental Optometry · doi:10.1111/j.1444-0938.2012.00783.x · Cited by 18 · see citing works
Villalobos, J., Fallon, J. B., Nayagam, D. A. X., Shivdasani, M. N., Luu, C. D., Allen, P. J., Shepherd, R. K., & Williams, C. E. (2014) · Journal of Neural Engineering · doi:10.1088/1741-2560/11/4/046017 · Cited by 18 · see citing works
Wearable Computer Vision Systems for a Cortical Visual Prosthesis
Li, W. H. (2013) · IEEE International Conference on Computer Vision Workshops · doi:10.1109/iccvw.2013.63 · Cited by 18 · see citing works
Cicione, R., Fallon, J. B., Rathbone, G. D., Williams, C. E., & Shivdasani, M. N. (2014) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.14-14754 · Cited by 17 · see citing works
Choroidal thickness profile in Retinitis Pigmentosa – Correlation with outer retinal structures
Chhablani, J. K., Jonnadula, G. B., Rao, P., Venkata, A., & Jalali, S. (2015) · Saudi Journal of Ophthalmology · doi:10.1016/j.sjopt.2015.09.003 · Cited by 17 · see citing works
Spectral distribution of local field potential responses to electrical stimulation of the retina
Wong, Y. T., Halupka, K., Kameneva, T., Cloherty, S. L., Grayden, D. B., Burkitt, A. N., Meffin, H., & Shivdasani, M. N. (2016) · Journal of Neural Engineering · doi:10.1088/1741-2560/13/3/036003 · Cited by 16 · see citing works
Italiano, M. L., Guo, T., Lovell, N. H., & Tsai, D. (2022) · Journal of Neural Engineering · doi:10.1088/1741-2552/ac72c2 · Cited by 16 · see citing works
Proceedings of the First International Optogenetic Therapies for Vision Symposium
Francis, P. J., Mansfield, B. C., & Rose, S. (2013) · Translational Vision Science & Technology · doi:10.1167/tvst.2.7.4 · Cited by 16 · see citing works
Song, X., Guo, T., Shivdasani, M. N., Dokos, S., Lovell, N. H., Li, X., Qiu, S., Li, T., Zheng, S., & Li, L. (2020) · Journal of Neural Engineering · doi:10.1088/1741-2552/abc3a9 · Cited by 16 · see citing works
Song, X., Qiu, S., Shivdasani, M. N., Zhou, F., Liu, Z., Ma, S., Chai, X., Chen, Y., Cai, X., Guo, T., et al. (2022) · Journal of Neural Engineering · doi:10.1088/1741-2552/ac5b18 · Cited by 16 · see citing works
Watterson, W. J., Montgomery, R. D., & Taylor, R. P. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00277 · Cited by 16 · see citing works
Sequence of visual cortex stimulation affects phosphene brightness in blind subjects
Salas, M. A., Bell, J. S., Niketeghad, S., Oswalt, D. N., Bosking, W. H., Patel, U. K., Dorn, J. D., Yoshor, D., Greenberg, R. J., Bari, A., et al. (2022) · Brain stimulation · doi:10.1016/j.brs.2022.03.008 · Cited by 15 · see citing works
Axonal stimulation affects the linear summation of single-point perception in three Argus II users
Hou, Y., Nanduri, D., Granley, J., Weiland, J. D., & Beyeler, M. (2024) · Journal of Neural Engineering · doi:10.1088/1741-2552/ad31c4 · Cited by 14 · see citing works
Advances in retinal stem cell biology.
Viczian, A. S. (2013) · Europe PMC (PubMed Central) · Cited by 14 · see citing works
A model of ganglion axon pathways accounts for percepts elicited by retinal implants
Beyeler, M., Nanduri, D., Weiland, J. D., Rokem, A., Boynton, G. M., & Fine, I. (2018) · doi:10.1101/453035 · Cited by 13 · see citing works
The impact of synchronous versus asynchronous electrical stimulation in artificial vision
Moleirinho, S., Whalen, A. J., Fried, S. I., & Pezaris, J. S. (2021) · Journal of Neural Engineering · doi:10.1088/1741-2552/abecf1 · Cited by 14 · see citing works
Establishment of monocular-limited photoreceptor degeneration models in rabbits
Isago, H., Sugano, E., Murayama, N., Tamai, M., & Tomita, H. (2013) · BMC Ophthalmology · doi:10.1186/1471-2415-13-19 · Cited by 12 · see citing works
An overview of vision processing in implantable prosthetic vision
Barnes, N. M. (2013) · Proceedings - International Conference on Image Processing · doi:10.1109/icip.2013.6738315 · Cited by 11 · see citing works
Fluorescein Angiographic Findings in Eyes of Patients with a Subretinal Electronic Implant
Štingl, K., Gekeler, F., Bartz‐Schmidt, K. U., Kögel, A., Zrenner, E., & Gelişken, F. (2013) · Current Eye Research · doi:10.3109/02713683.2013.767349 · Cited by 11 · see citing works
Self-citationJung, S. H., Shin, J., Pi, K., Goo, Y. S., & Cho, D. (2016) · Sensors · doi:10.3390/s16122035 · Cited by 11 · see citing works
Simulating the perceptual effects of electrode–retina distance in prosthetic vision
Avraham, D., & Yitzhak Yitzhaky, B. (2022) · Journal of Neural Engineering · doi:10.1088/1741-2552/ac6f82 · Cited by 10 · see citing works
Augmenting intensity to enhance scene structure in prosthetic vision
McCarthy, C. D., Feng, D. D., & Barnes, N. M. (2013) · IEEE International Conference on Multimedia and Expo workshops · doi:10.1109/icmew.2013.6618430 · Cited by 10 · see citing works
Implantation and Extraction of Penetrating Electrode Arrays in Minipig Retinas
Chen, J., Poulaki, V., Kim, S.-J., Eldred, W. D., Kane, S. R., Gingerich, M. D., Shire, D. B., Jensen, R. J., DeWalt, G. J., Kaplan, H. J., et al. (2020) · Translational Vision Science & Technology · doi:10.1167/tvst.9.5.19 · Cited by 10 · see citing works
Johnen, S., Meißner, F., Krug, M., Baltz, T., Endler, I., Mokwa, W., & Walter, P. (2016) · Journal of Ophthalmology · doi:10.1155/2016/2371021 · Cited by 10 · see citing works
Electrodeless, Non-Invasive Stimulation of Retinal Neurons Using Time-Varying Magnetic Fields
Shin, J. Y., Ahn, J.-H., Pi, K., Goo, Y. S., & Cho, D. (2016) · IEEE Sensors Journal · doi:10.1109/jsen.2016.2565506 · Cited by 9 · see citing works
Embracing the irregular: A patient-specific image processing strategy for visual prostheses
Kiral-Kornek, F. I., Savage, C. O., O'Sullivan-Greene, E., Burkitt, A. N., & Grayden, D. B. (2013) · 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc.2013.6610312 · Cited by 9 · see citing works
Learning a neural response metric for retinal prosthesisPreprint
Shah, N. P., Madugula, S. S., Chichilnisky, E. J., Shlens, J., & Singer, Y. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/226530 · Cited by 9 · see citing works
Restoration of Sight with Electronic Retinal Prostheses
Palanker, D., Weiland, J. D., Rosin, B., & Sahel, J. (2025) · Annual Review of Vision Science · doi:10.1146/annurev-vision-110323-025244 · Cited by 10 · see citing works
- Authors
- Wilke, R., Gabel, V.-P., Sachs, H., Bartz Schmidt, K.-U., Gekeler, F., Besch, D., Szurman, P., Stett, A., Wilhelm, B., Peters, T., Harscher, A., Greppmaier, U., Kibbel, S., Benav, H., Bruckmann, A., Stingl, K., Kusnyerik, A., & Zrenner, E.
- Affiliations
- University of Tübingen (DE)
- University of Regensburg (DE)
- Krankenhaus Dresden-Friedrichstadt (DE)
- From the Centre for Ophthalmology, University of Tübingen, Tübingen, Germany;
- Natural and Medical Sciences Institute (DE)
- the Steinbeis Transfer Centre Eyetrial, Centre for Ophthalmology, Tübingen, Germany;
- Retina Implant AG, Reutlingen, Germany; and
- From the Centre for Ophthalmology, University of Tübingen, Tübingen, Germany; the 8Department of Ophthalmology, Semmelweis University, Budapest, Hungary.
- ORCID
- Venue
- Investigative Opthalmology & Visual Science
- Published
- 2011-07-30
- Volume
- 52
- Issue
- 8
- Pages
- 5995
- ISSN
- 0146-0404 (ISSN-L)
- 1552-5783
- OpenAlex
- W2051509380
- Cited by
- 155
- References
- 55
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 2 · 2023: 2 · 2022: 8 · 2021: 6 · 2020: 7 · 2019: 5 · 2018: 9 · 2017: 13 · 2016: 18 · 2015: 10 · 2014: 22 · 2013: 25 · 2012: 13
- FWCI
- 8.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Investigative Ophthalmology & Visual Science (publishedVersion)
- PubMed (publishedVersion)
- University of Regensburg Publication Server (University of Regensburg) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Keywords
- retinal prosthesis, inherited retinal degeneration, visual perception, spatial resolution, pattern recognition, letter recognition, electrode spacing, blind patients
- MeSH terms
- Adult, Blindness, Electrodes, Implanted, Humans, Male, Middle Aged, Motion Perception, Orientation, Pattern Recognition, Visual, Prosthesis Design, Psychophysics, Space Perception, Prosthesis Implantation, Visual Prosthesis, Retinal Dystrophies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
