Cited by 177Neuroscience and Neural EngineeringTactile and Sensory InteractionsRetinal Development and Disorders

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The Detection of Motion by Blind Subjects With the Epiretinal 60-Electrode (Argus II) Retinal Prosthesis

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Dorn, Jessy D., Ahuja, Ashish K., Caspi, Avi, da Cruz, Lyndon, Dagnelie, Gislin, Sahel, Jose-Alain, Greenberg, Robert J., McMahon, Matthew J., Argus II Study Group, for the·2013·JAMA Ophthalmology

DOI 10.1001/2013.jamaophthalmol.221PMC PMC3924899

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Abstract

OBJECTIVE: To investigate the ability of 28 blind subjects implanted with a 60-electrode Argus II (Second Sight Medical Products Inc) retinal prosthesis system to detect the direction of a moving object. METHODS: Blind subjects (bare light perception or worse in both eyes) with retinitis pigmentosa were implanted with the Argus II prosthesis as part of a phase 1/2 feasibility study at multiple clinical sites worldwide. The experiment measured their ability to detect the direction of motion of a high-contrast moving bar on a flatscreen monitor in 3 conditions: with the prosthesis system on and a 1-to-1 mapping of spatial information, with the system off, and with the system on but with randomly scrambled spatial information. RESULTS: Fifteen subjects (54%) were able to perform the task significantly better with their prosthesis system than they were with their residual vision, 2 subjects had significantly better performance with their residual vision, and no difference was found for 11 subjects. Of the 15 better-performing subjects, 11 were available for follow-up testing, and 10 of them had significantly better performance with normal rather than with scrambled spatial information. CONCLUSIONS: This work demonstrates that blind subjects implanted with the Argus II retinal prosthesis were able to perform a motion detection task they could not do with their native vision, confirming that electrical stimulation of the retina provides spatial information from synchronized activation of multiple electrodes. TRIAL REGISTRATION: clinicaltrials.gov Identifier:NCT00407602

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Authors: Dorn, J. D., Ahuja, A. K., Caspi, A., da Cruz, L., Dagnelie, G., Sahel, J.-A., Greenberg, R. J., McMahon, M. J., & Argus II Study Group, F. T.
Affiliations: Second Sight Medical Products (US)
University of Southern California (US)
Corresponding author: Dorn, Jessy D.
ORCID: Dorn, Jessy D.
Caspi, Avi
Dagnelie, Gislin
Venue: JAMA Ophthalmology
Publisher: American Medical Association (AMA)
Published: 2013-02-01
Volume: 131
Issue: 2
Pages: 183
ISSN: 2168-6165 (ISSN-L)
DOI: 10.1001/2013.jamaophthalmol.221
PMC: PMC3924899
OpenAlex: W2024323852
Cited by: 177
References: 12
Citations by year: 2026: 10 · 2025: 8 · 2024: 5 · 2023: 3 · 2022: 7 · 2021: 16 · 2020: 16 · 2019: 14 · 2018: 16 · 2017: 17 · 2016: 22 · 2015: 13 · 2014: 20 · 2013: 9
FWCI: 5.53
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: JAMA Ophthalmology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
UCL Discovery (University College London) (submittedVersion)
Funders: National Eye Institute (R24EY012893, EY012893, R01EY012893, R01EY021220)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
Keywords: Argus II, retinal prosthesis, motion direction detection, retinitis pigmentosa, blindness, spatial mapping, visual prosthesis
MeSH terms: Adult, Aged, Blindness, Electrodes, Implanted, Electric Stimulation Therapy, Feasibility Studies, Female, Humans, Male, Microelectrodes, Middle Aged, Motion Perception, Perceptual Disorders, Retina, Retinitis Pigmentosa, Sensory Thresholds, Treatment Outcome, Prosthesis Implantation, Visual Prosthesis

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The Detection of Motion by Blind Subjects With the Epiretinal 60-Electrode (Argus II) Retinal Prosthesis

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