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Reduced Capacity but Spared Precision and Maintenance of Working Memory Representations in Schizophrenia
Open accessAbstract
CONTEXT: Working memory deficits are considered a core feature of schizophrenia. Several recent integrative articles have offered mechanistic computational and neurobiological models of the origins of this cognitive deficit. OBJECTIVE: To test predictions of these models using a new experimental paradigm from the basic science literature that makes it possible to determine whether patients with schizophrenia show (1) deficits in working memory storage capacity, (2) deficits in the precision of working memory representations, and (3) an amplification of these deficits as the retention interval increases. DESIGN: Case-control design. All subjects performed a color working memory test in which they were asked to recall 3 or 4 items after a 1- or 4-second delay. All subjects also received a standard measure of intelligence and the Matrics Consensus Cognitive Battery. SETTING: A tertiary care research outpatient clinic. Patients A total of 31 clinically stable patients with a DSM-IV diagnosis of schizophrenia or schizoaffective disorder and 26 healthy volunteers participated. The 2 groups were similar in age, sex, and ethnicity distribution. MAIN OUTCOME MEASURES: (1) The number of items stored in working memory and (2) the precision of the working memory representations. RESULTS: Patients showed a clear reduction in the number of items stored in working memory. Patients did not differ from controls in the precision of their working memory representations. There was no evidence of delay-related amplification of impairment in either capacity or precision. CONCLUSIONS: Patients do not show the type of imprecision or delay-dependent amplification of impairment that is predicted on the basis of current models of the neurobiology of schizophrenia. The models need to be revised to account for a pure reduction in the number of items that patients are able to store in working memory.
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“There is evidence that WM capacity is impaired in schizophrenia (Gold et al. 2010).”
From Linking microcircuit dysfunction to cognitive impairment: Effects of disinhibition associated with schizophrenia in a cortical working memory model (2014) · cites this paper as Gold et al. 2010
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Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
The Brief Psychiatric Rating Scale.
Overall, J. E., & Gorham, D. R. (1962) · Psychological Reports · doi:10.2466/pr0.1962.10.3.799 · Cited by 11,090
Wechsler Abbreviated Scale of Intelligence
Dumont, R., Willis, J. O., Veizel, K., & Zibulsky, J. (2014) · Wiley eBooks · doi:10.1002/9781118660584.ese2519 · Cited by 5,546
Psychological Assessment Resources
Abidin, R. R. (1995) · Medical Entomology and Zoology · Cited by 3,141
Scale for the Assessment of Negative Symptoms (SANS)*
(1989) · The British Journal of Psychiatry · doi:10.1192/s0007125000291502 · Cited by 2,710
The Dopamine Hypothesis of Schizophrenia: Version III--The Final Common Pathway
Howes, O. D., & Kapur, S. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp006 · Cited by 2,693
Tutorial on maximum likelihood estimation
Myung, I. J. (2003) · Journal of Mathematical Psychology · doi:10.1016/s0022-2496(02)00028-7 · Cited by 1,802
Discrete fixed-resolution representations in visual working memory
Zhang, W., & Luck, S. J. (2008) · Nature · doi:10.1038/nature06860 · Cited by 1,624
Self-citationAlvarez, G. A., & Cavanagh, P. (2004) · Psychological Science · doi:10.1111/j.0963-7214.2004.01502006.x · Cited by 1,330
Diagnostic and Statistical Manual of Mental Disorders
(2018) · Sage eBooks · doi:10.4135/9781506326139.n198 · Cited by 1,244
Storage of features, conjunctions, and objects in visual working memory.
Vogel, E. K., Woodman, G. F., & Luck, S. J. (2001) · Journal of Experimental Psychology Human Perception & Performance · doi:10.1037//0096-1523.27.1.92 · Cited by 1,194
Self-citationLisman, J. E., Coyle, J. T., Green, R. W., Javitt, D. C., Benes, F. M., Heckers, S., & Grace, A. A. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.02.005 · Cited by 1,010
Dissociable neural mechanisms supporting visual short-term memory for objects
Xu, Y., & Chun, M. M. (2005) · Nature · doi:10.1038/nature04262 · Cited by 974
Schizophrenics Show Spatial Working Memory Deficits
Park, S. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820120063009 · Cited by 953
Working Memory Impairments in Schizophrenia: A Meta-Analysis.
Lee, J., & Park, S. (2005) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.114.4.599 · Cited by 770
Visual Working Memory Represents a Fixed Number of Items Regardless of Complexity
Awh, E., Barton, B., & Vogel, E. K. (2007) · Psychological Science · doi:10.1111/j.1467-9280.2007.01949.x · Cited by 696
Manoach, D. S. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(02)00294-3 · Cited by 693
Complexity of Prefrontal Cortical Dysfunction in Schizophrenia: More Than Up or Down
Callicott, J. H., Mattay, V. S., Verchinski, B. A., Marenco, S., Egan, M. F., & Weinberger, D. R. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.12.2209 · Cited by 673
Reliability and validity of a depression rating scale for schizophrenics
Addington, D., Addington, J., Maticka-Tyndale, E., & Joyce, J. (1992) · Schizophrenia Research · doi:10.1016/0920-9964(92)90003-n · Cited by 651
Unsworth, N., & Engle, R. W. (2007) · Psychological Bulletin · doi:10.1037/0033-2909.133.6.1038 · Cited by 597
Durstewitz, D., & Seamans, J. K. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.015 · Cited by 586
Wide Range Achievement Test 3 (wrat3)
Snelbaker, A. J., Wilkinson, G. S., Robertson, G. J., & Glutting, J. J. (2001) · Springer eBooks · doi:10.1007/978-1-4615-1185-4_13 · Cited by 546
Hashimoto, T., Arion, D., Unger, T., Maldonado-Avilés, J. G., Morris, H. M., Volk, D. W., Mirnics, K., & Lewis, D. A. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002011 · Cited by 490
The cognitive neuroscience of schizophrenia.
Barch, D. M. (2005) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.1.102803.143959 · Cited by 437
Computational models of schizophrenia and dopamine modulation in the prefrontal cortex
Rolls, E. T., Loh, M., Deco, G., & Winterer, G. (2008) · Nature reviews. Neuroscience · doi:10.1038/nrn2462 · Cited by 396
TODD, J. J., & Marois, R. (2005) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/cabn.5.2.144 · Cited by 363
Sudden Death and Gradual Decay in Visual Working Memory
Zhang, W., & Luck, S. J. (2009) · Psychological Science · doi:10.1111/j.1467-9280.2009.02322.x · Cited by 341
Self-citationIndividual differences in working memory
Jarrold, C., & Towse, J. N. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.07.002 · Cited by 336
Arion, D., Unger, T. L., Lewis, D. A., Levitt, P. R., & Mirnics, K. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.12.021 · Cited by 331
Prefrontal DA Transmission at D1 Receptors and the Pathology of Schizophrenia
Abi‐Dargham, A., & Moore, H. M. (2003) · The Neuroscientist · doi:10.1177/1073858403252674 · Cited by 279
Tan, H.-Y., Callicott, J. H., & Weinberger, D. R. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhm069 · Cited by 266
Kolluri, N., Sun, Z., Sampson, A. R., & Lewis, D. A. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.6.1200 · Cited by 241
Visual Perceptual and Working Memory Impairments in Schizophrenia
Tek, C., Gold, J. M., Blaxton, T. A., Wilk, C. M., McMahon, R. P., & Buchanan, R. W. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.2.146 · Cited by 213
Self-citationDiscrete Fixed-Resolution Representations in Visual Working Memory
Zhang, W., & Luck, S. J. (2007) · PsycEXTRA Dataset · doi:10.1037/e527342012-120 · Cited by 183
Self-citationComplex span tasks, simple span tasks, and cognitive abilities: A reanalysis of key studies
Colom, R., Rebollo, I., Abad, F. J., & Shih, P. C. (2006) · Memory & Cognition · doi:10.3758/bf03193395 · Cited by 181
Auditory Sensory Dysfunction in Schizophrenia
Rabinowicz, E. F., Silipo, G. S., GOLDMAN, R. S., & Javitt, D. C. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.12.1149 · Cited by 173
Intact attentional control of working memory encoding in schizophrenia.
Gold, J., Fuller, R., Robinson, B. M., McMahon, R., Braun, E. L., & Luck, S. (2006) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.115.4.658 · Cited by 148
Self-citationLuck, S. J. (2007) · Scholarpedia · doi:10.4249/scholarpedia.3328 · Cited by 125
Self-citationRisk factors for schizophrenia — All roads lead to dopamine
Forti, M. D., Lappin, J., & Murray, R. M. (2007) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2007.02.005 · Cited by 116
Working memory for visual features and conjunctions in schizophrenia.
Gold, J. M., Wilk, C. M., McMahon, R. P., Buchanan, R. W., & Luck, S. J. (2003) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.112.1.61 · Cited by 111
Self-citationJavitt, D. C., Liederman, E., Cienfuegos, A., & Shelley, A. M. (1999) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a033417 · Cited by 101
Lencz, T., Bilder, R. M., Turkel, E., Goldman, R. S., Robinson, D., Kane, J. M., & Lieberman, J. A. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.3.238 · Cited by 89
Tanaka, S. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.08.070 · Cited by 79
Visual working memory represents a fixed number of items regardless of complexity
Awh, E., Barton, B., & Vogel, E. K. (2006) · PsycEXTRA Dataset · doi:10.1037/e527352012-294 · Cited by 79
Luck, S. J. (2008) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195305487.003.0003 · Cited by 79
Self-citationExamining encoding imprecision in spatial working memory in schizophrenia
Badcock, J. C., Badcock, D. R., Read, C., & Jablensky, A. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2007.08.005 · Cited by 48
March, L., Cienfuegos, A., Goldbloom, L. M., Ritter, W., Cowan, N., & Javitt, D. C. (1999) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.108.1.69 · Cited by 41
March, L., Cienfuegos, A., Goldbloom, L. M., et al. (1999) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.108.1.69 · Cited by 34
Research works printed but not linked: 4
- [5]Baddeley AD Working Memory Clarendon Oxford 1986
- [6]Miyake A Shah P Models of Working Memory Cambridge, UK Cambridge University Press 1999
- [31]First MB Spitzer RL Gibbon M Williams JBW Structured Clinical Interview for DSM-IV- Axis I Disorders (SCID-I) Washington, DC American Psychiatric Press 1997
- [48]Vogel EK Woodman GF Luck SJ Storages of features, conjunctions and objects in visual working memory Journal of Experimental Psychology: Human Perception and Performance 2001 27 1 92 114 11248943
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Barch, D. M., & Ceaser, A. E. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.11.015 · Cited by 792
The global cognitive impairment in schizophrenia: consistent over decades and around the world
Schaefer, J., Giangrande, E., Weinberger, D. R., & Dickinson, D. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.07.009 · Cited by 605
Prioritizing Information during Working Memory: Beyond Sustained Internal Attention
Myers, N. E., Stokes, M. G., & Nobre, A. C. (2017) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2017.03.010 · Cited by 453
Bae, G., Olkkonen, M., Allred, S., & Flombaum, J. (2015) · Journal of Experimental Psychology General · doi:10.1037/xge0000076 · Cited by 286
Murray, J. D., Anticevic, A., Gancsos, M., Ichinose, M., Corlett, P. R., Krystal, J. H., & Wang, X.-J. (2014) · Cerebral Cortex · doi:10.1093/cercor/bhs370 · Cited by 255
Metadata
- Authors
- Gold, J. M., Hahn, B., Zhang, W. W., Robinson, B. M., Kappenman, E. S., Beck, V. M., & Luck, S. J.
- Affiliations
- University of Maryland, Baltimore (US)
- University of California, Davis (US)
- ORCID
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 2010-06-01
- Volume
- 67
- Issue
- 6
- Pages
- 570
- ISSN
- 0003-990X (ISSN-L)
- PMC
- PMC2883794
- OpenAlex
- W2105397762
- Cited by
- 144
- References
- 49
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 5 · 2023: 5 · 2022: 7 · 2021: 6 · 2020: 9 · 2019: 13 · 2018: 9 · 2017: 19 · 2016: 6 · 2015: 9 · 2014: 7 · 2013: 16 · 2012: 13
- FWCI
- 9.62
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Archives of General Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Funders
- National Institute of Mental Health (MH065034, R01MH076226, R01MH065034)
- National Center for Research Resources (M01RR016500)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- schizophrenia, working memory, working memory precision, retention interval, schizoaffective disorder, cognitive impairment
- MeSH terms
- Adult, Cognition Disorders, Color Perception, Female, Humans, Male, Memory Disorders, Memory, Short-Term, Models, Neurological, Neuropsychological Tests, Psychotic Disorders, Reaction Time, Retention, Psychology, Schizophrenia, Schizophrenic Psychology, Case-Control Studies, Prefrontal Cortex
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