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Cited by 355

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Depressive Symptoms and Increased Risk of Stroke Mortality Over a 29-Year Period

Everson, Susan A., Roberts, Robert E., Goldberg, Debbie E., Kaplan, George A.·1998·Archives of Internal Medicine

Abstract

BACKGROUND: Several lines of evidence indicate that depression is importantly associated with cardiovascular disease end points. However, little is known about the role of depression in stroke mortality. METHODS: This study examined the association between depressive symptoms and stroke mortality in a prospective study of behavioral, social, and psychological factors related to health and mortality in a community sample of 6676 initially stroke-free adults (45.8% male; 79.1% white; mean age at baseline, 43.4 years) from Alameda County, California. Depressive symptoms were assessed by the 18-item Human Population Laboratory Depression Scale. Cox proportional hazards regression models were used to evaluate the impact of depressive symptoms after controlling for age, sex, race, and other confounders. RESULTS: A total of 169 stroke deaths occurred during 29 years of follow-up. Reporting 5 or more depressive symptoms at baseline was associated with increased risk of stroke mortality, after adjusting for age, sex, and race (hazard ratio, 1.66; 95% confidence interval, 1.16-2.39; P<.006). This association remained significant after additional adjustments for education, alcohol consumption, smoking, body mass index, hypertension, and diabetes (hazard ratio, 1.54; 95% confidence interval, 1.06-2.22; P<.02). Time-dependent covariate models, which allowed changes in reported depressive symptoms and risk factor levels during follow-up, revealed the same pattern of associations. CONCLUSIONS: This population-based study provides the strongest epidemiological evidence to date for a significant relationship between depressive symptoms and stroke mortality. These results contribute to the growing literature on the adverse health effects of depression.

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Metadata

Authors
Everson, S. A., Roberts, R. E., Goldberg, D. E., & Kaplan, G. A.
Venue
Archives of Internal Medicine
Published
1998-05-25
Volume
158
Issue
10
Pages
1133
ISSN
0003-9926 (ISSN-L)
OpenAlex
W2070434316
Cited by
355
References
7
FWCI
9.40
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Depressive Symptoms and Increased Risk of Stroke Mortality Over a 29-Year Period. https://app.cochat.ai/papers/10.1001/archinte.158.10.1133
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Everson, S. A., Roberts, R. E., Goldberg, D. E., & Kaplan, G. A. (1998). Depressive Symptoms and Increased Risk of Stroke Mortality Over a 29-Year Period. Archives of Internal Medicine. https://doi.org/10.1001/archinte.158.10.1133

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