Weight Loss in Overweight Adults and the Long-term Risk of Hypertension: The Framingham Study
Abstract
BACKGROUND: Few studies address long-term effects of weight loss on risk of incident hypertension among overweight adults. METHODS: We evaluated weight loss among 623 overweight (body mass index [calculated as weight in kilograms divided by the square of height in meters] >/=25) middle-aged (aged 30-49 years) and 605 overweight older (aged 50-65 years) adults in Framingham, Mass. Subjects were classified first according to amount of weight lost over 4 years: (1) weight changed by less than 1.8 kg (stable weight), (2) lost 1.8 to less than 3.6 kg, (3) lost 3.6 to less than 6.8 kg, and (4) lost 6.8 kg or more. We also classified weight loss according to whether it was sustained during the next 4 years. RESULTS: After adjusting for age, sex, education, baseline body mass index, height, activity, smoking, and alcohol intake, weight loss of 6.8 kg or more led to a 21% to 29% reduction in long-term hypertension risk. After adjusting for cancer or cardiovascular disease occurring during follow-up, weight loss of 6.8 kg or more led to a 28% reduction in risk (relative risk [95% confidence interval], 0.72 [0.49-1.05]) for middle-aged adults and a 37% reduction (0.63 [0.42-0.95]) for older adults. Sustained weight loss led to a 22% reduction in hypertension risk (0.78 [0.60-1.03]) among middle-aged and a 26% reduction (0.74 [0.56-0.97]) in older adults. This risk reduction was strengthened by adjustment for prevalent cancer or cardiovascular disease during follow-up. CONCLUSION: A modest weight loss, particularly when sustained, substantially lowers the long-term risk of hypertension in overweight adults.
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Even modest weight loss increases the likelihood of achieving goal BPs.
“In fact, even modest weight loss increases the likelihood of achieving goal BPs.166”
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- Authors
- Moore, L. L., Visioni, A. J., Qureshi, M. M., Bradlee, M. L., Ellison, R. C., & D’Agostino, R.
- Affiliations
- Boston University (US)
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 2005-06-13
- Volume
- 165
- Issue
- 11
- Pages
- 1298
- ISSN
- 0003-9926 (ISSN-L)
- OpenAlex
- W2053159513
- Cited by
- 116
- References
- 30
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 5 · 2023: 4 · 2022: 4 · 2021: 6 · 2020: 4 · 2019: 5 · 2018: 4 · 2017: 4 · 2016: 2 · 2015: 4 · 2014: 7 · 2013: 4 · 2012: 8
- FWCI
- 5.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (n01hc25195-41-0-1)
- National Heart, Lung, and Blood Institute (N01‐HC25195)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Keywords
- weight loss, overweight, hypertension, sustained weight loss, body mass index, middle-aged adults, older adults, cancer, cardiovascular disease, Framingham Heart Study
- MeSH terms
- Adult, Female, Humans, Hypertension, Male, Massachusetts, Obesity, Risk, Time Factors, Weight Loss, Incidence, Overnutrition
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