The Hemoglobin A1c Level as a Progressive Risk Factor for Cardiovascular Death, Hospitalization for Heart Failure, or Death in Patients With Chronic Heart Failure: An Analysis of the Candesartan in Heart Failure: Assessment of Reduction in Mortality and Morbidity (CHARM) Program
Abstract
BACKGROUND: A progressive relationship between hemoglobin A(1c) (HbA(1c)) levels and cardiovascular (CV) events has been observed in persons with and without diabetes. To our knowledge, the nature of such a relationship in patients with symptomatic chronic heart failure (HF) has not been studied. METHODS: A total of 2412 participants (907 with prior diabetes) in the Candesartan in Heart failure: Assessment of Reduction in Mortality and Morbidity (CHARM) program with at least 1 HbA(1c) level were followed up for a median of 34 months. The incidence of the primary outcome (CV death or HF hospitalization), CV death, and total mortality was calculated according to eighths of the usual HbA(1c) level ranging from 5.8% or less to greater than 8.6%. Adjusted and unadjusted hazard ratios per 1% rise in HbA(1c) levels were also calculated. RESULTS: A total of 99.6% of eligible participants were followed up until they developed an outcome or the study finished. The risk of the primary composite outcome, CV death, hospitalization for worsening HF, and total mortality rose progressively with higher levels of usual HbA(1c) (P for trend <.001). After age and sex were adjusted for, hazards of these outcomes per 1% higher HbA(1c) level were 1.25 (95% confidence interval [CI ], 1.20-1.31), 1.24 (95% CI, 1.17-1.31), 1.25 (95% CI, 1.19-1.31), and 1.22 (95% CI, 1.16-1.29), respectively. This relationship was evident in patients with and without diabetes and with reduced or preserved ejection fraction and persisted after adjustment for diabetes, other risk factors, and allocation to candesartan. CONCLUSION: In diabetic and nondiabetic patients with symptomatic chronic HF, the HbA(1c) level is an independent progressive risk factor for CV death, hospitalization for HF, and total mortality.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the CHARM trial, high HbA1c was associated with increased all-cause and cardiovascular mortality in patients with T2DM and both HFrEF and HFpEF.
“In the CHARM trial, high HbA 1c was associated with increased all-cause and CV mortality in patients with T2DM and both HFrEF and HFpEF.104”
From Type 2 diabetes mellitus and heart failure: A position statement from the Heart Failure Association of the European Society of Cardiology (2018) · cites this paper as [104]
A 1% increase in HbA1c was associated with an increased hazard ratio of 1.1 for cardiovascular mortality.
“A 1% increase in HbA 1c was associated with an increased HR of 1.1 for CV mortality.104”
From Type 2 diabetes mellitus and heart failure: A position statement from the Heart Failure Association of the European Society of Cardiology (2018) · cites this paper as [104]
Cites
Biochemistry and molecular cell biology of diabetic complications
Brownlee, M. (2001) · Nature · doi:10.1038/414813a · Cited by 9,107 · see citing works
Stratton, I. M. (2000) · BMJ · doi:10.1136/bmj.321.7258.405 · Cited by 9,059 · see citing works
The Pathobiology of Diabetic Complications
Brownlee, M. (2005) · Diabetes · doi:10.2337/diabetes.54.6.1615 · Cited by 5,339 · see citing works
Yusuf, S., Pfeffer, M. A., Swedberg, K., Granger, C. B., Held, P., McMurray, J. J., Michelson, E. L., Olofsson, B., & Östergren, J. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14285-7 · Cited by 2,994 · see citing works
McMurray, J. J., Östergren, J., Swedberg, K., Granger, C. B., Held, P., Michelson, E. L., Olofsson, B., Yusuf, S., & Pfeffer, M. A. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14283-3 · Cited by 2,604 · see citing works
Pfeffer, M. A., Swedberg, K. B., Granger, C. B., Held, P., McMurray, J. J. V., Michelson, E. L., Olofsson, B., Östergren, J., & Yusuf, S. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14282-1 · Cited by 1,885 · see citing works
Granger, C. B., McMurray, J. J., Yusuf, S., Held, P., Michelson, E. L., Olofsson, B., Östergren, J., Pfeffer, M. A., & Swedberg, K. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14284-5 · Cited by 1,686 · see citing works
Coutinho, M., Gerstein, H. C., Wang, Y., & Yusuf, S. (1999) · Diabetes Care · doi:10.2337/diacare.22.2.233 · Cited by 1,685 · see citing works
Self-citationMeta-analysis: glycosylated hemoglobin and cardiovascular disease in diabetes mellitus
Selvin, E., Marinopoulos, S., Berkenblit, G., Rami, T., Brancati, F. L., Powe, N. R., & Golden, S. H. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-141-6-200409210-00007 · Cited by 1,657 · see citing works
McMurray, J. J. V., Östergren, J., Swedberg, K. B., Granger, C. B., Held, P., Michelson, E. L., Olofsson, B., Yusuf, S., & Pfeffer (2003) · The Lancet · Cited by 1,043 · see citing works
Khaw, K.-T., Wareham, N., Bingham, S., Luben, R., Welch, A., & Day, N. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-141-6-200409210-00006 · Cited by 974 · see citing works
Renal Function as a Predictor of Outcome in a Broad Spectrum of Patients With Heart Failure
Hillege, H. L., Nitsch, D., Pfeffer, M. A., Swedberg, K., McMurray, J. J. V., Yusuf, S., Granger, C. B., Michelson, E. L., Östergren, J., Cornel, J. H., et al. (2006) · Circulation · doi:10.1161/circulationaha.105.580506 · Cited by 945 · see citing works
Booth, G. L., Kapral, M. K., Fung, K., & Tu, J. V. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68967-8 · Cited by 783 · see citing works
The DECODE Study Group, & on behalf of the European Diabetes Epidemiology Group (2003) · Diabetes Care · doi:10.2337/diacare.26.3.688 · Cited by 516 · see citing works
Blood glucose and risk of cardiovascular disease in the Asia Pacific region.
Asia Pacific Cohort Studies Collaboration (2004) · Diabetes Care · doi:10.2337/diacare.27.12.2836 · Cited by 302 · see citing works
Glycemic Control and Coronary Heart Disease Risk in Persons With and Without Diabetes
Selvin, E., Coresh, J., Golden, S. H., Brancati, F. L., Folsom, A. R., & Steffes, M. W. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.16.1910 · Cited by 285 · see citing works
Gerstein, H. C., Pogue, J., Mann, J. F. E., Lonn, E., Dagenais, G. R., McQueen, M., Yusuf, S., & HOPE investigators (2005) · Diabetologia · doi:10.1007/s00125-005-1858-4 · Cited by 262 · see citing works
Self-citationHbA1c and Peripheral Arterial Disease in Diabetes
Selvin, E., Wattanakit, K., Steffes, M. W., Coresh, J., & Sharrett, A. R. (2006) · Diabetes Care · doi:10.2337/diacare.29.04.06.dc05-2018 · Cited by 184 · see citing works
Relation between blood glucose and coronary mortality over 33 years in the Whitehall Study
Brunner, E. J., Shipley, M. J., Witte, D. R., Fuller, J. H., & Marmot, M. G. (2006) · Diabetes Care · doi:10.2337/diacare.29.01.06.dc05-1405 · Cited by 166 · see citing works
Selvin, E., Coresh, J., Shahar, E., Zhang, L., Steffes, M. W., & Sharrett, A. R. (2005) · The Lancet Neurology · doi:10.1016/s1474-4422(05)70227-1 · Cited by 146 · see citing works
Khaw, K., Wareham, N. J., Bingham, S. A., & Luben, R. (2004) · ACC Current Journal Review · doi:10.1016/j.accreview.2004.11.074 · Cited by 94 · see citing works
Glycosylated Hemoglobin: Finally Ready for Prime Time as a Cardiovascular Risk Factor
Gerstein, H. C. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-141-6-200409210-00014 · Cited by 68 · see citing works
Self-citationGerstein, H. C., & Rosenstock, J. (2005) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2004.11.002 · Cited by 23 · see citing works
Self-citationRelation Between Blood Glucose and Coronary Mortality Over 33 Years in the Whitehall Study
Brunner, E. J. (2006) · Diabetes Care · doi:10.2337/diacare.29.1.26 · Cited by 18 · see citing works
Prevention of Cardiovascular Outcomes in Type 2 Diabetes Mellitus: Trials on the Horizon
Buse, J. B., & Rosenstock, J. (2005) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2004.11.003 · Cited by 16 · see citing works
Prevention of cardiovascular outcomes in type 2 diabetes mellitus: trials on the horizon
Buse, J. B., & Rosenstock, J. (2005) · Cardiology Clinics · doi:10.1016/j.ccl.2004.11.004 · Cited by 2 · see citing works
Reddy, K. S. (2002) · Elsevier eBooks · doi:10.1016/b978-012153654-1/50012-x · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
McDonagh, T. A., Metra, M., Adamo, M., Gardner, R. S., Baumbach, A., Böhm, M., Burri, H., Butler, J., Čelutkienė, J., Chioncel, O. D., et al. (2021) · PubMed · doi:10.1093/eurheartj/ehab670 · Cited by 19,618 · see citing works
2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure
Ponikowski, P., Voors, A. A., Anker, S. D., Bueno, H., Cleland, J. G. F., Coats, A. J. S., Falk, V., González-Juanatey, J. R., Harjola, V.-P., Jankowska, E. A., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw128 · Cited by 11,429 · see citing works
2016 ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure
Ponikowski, P., Voors, A. A., Anker, S. D., Bueno, H., Cleland, J. G. F., Coats, A. J. S., Falk, V., González-Juanatey, J. R., Harjola, V.-P., Jankowska, E. A., et al. (2016) · European Journal of Heart Failure · doi:10.1002/ejhf.592 · Cited by 5,866 · see citing works
Glycated hemoglobin, diabetes, and cardiovascular risk in nondiabetic adults
Selvin, E., Steffes, M. W., Zhu, H., Matsushita, K., Wagenknecht, L., Pankow, J., Coresh, J., & Brancati, F. L. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0908359 · Cited by 1,544 · see citing works
Long-term effects of intensive glucose lowering on cardiovascular outcomes
The ACCORD Study Group (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1006524 · Cited by 1,035 · see citing works
Vascular Inflammation and Oxidative Stress: Major Triggers for Cardiovascular Disease
Steven, S., Frenis, K., Oelze, M. W., Kalinovic, S., Kuntić, M., Jiménez, M. T. B., Vujačić-Mirski, K., Helmstädter, J., Kröller‐Schön, S., Münzel, T. F., et al. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/7092151 · Cited by 729 · see citing works
Seferović, P. M., Petrie, M. C., Filippatos, G. S., Anker, S. D., Rosano, G., Bauersachs, J., Paulus, W. J., Komajda, M., Cosentino, F., de Boer, R. A., et al. (2018) · European Journal of Heart Failure · doi:10.1002/ejhf.1170 · Cited by 708 · see citing works
Bozkurt, B., Aguilar, D. A., Deswal, A. M., Dunbar, S. B., Francis, G. S., Horwich, T. B., Jessup, M. L., Kosiborod, M., Pritchett, A. M., Ramasubbu, K., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000450 · Cited by 532 · see citing works
Seferović, J. P., Claggett, B. L., Seidelmann, S. B., Seely, E. W., Packer, M., Zile, M. R., Rouleau, J. L., Swedberg, K. B., Lefkowitz, M. P., Shi, V. C., et al. (2017) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(17)30087-6 · Cited by 352 · see citing works
Kristensen, S. L., Preiss, D., Jhund, P. S., Squire, I., Cardoso, J. S., Merkely, B., Martinez, F., Starling, R. C., Desai, A. S., Lefkowitz, M. P., et al. (2016) · Circulation Heart Failure · doi:10.1161/circheartfailure.115.002560 · Cited by 359 · see citing works
Albuminuria in chronic heart failure: prevalence and prognostic importance
Jackson, C. E., Solomon, S. D., Gerstein, H. C., Zetterstrand, S., Olofsson, B., Michelson, E. L., Granger, C. B., Swedberg, K. B., Pfeffer, M. A., Yusuf, S., et al. (2009) · The Lancet · doi:10.1016/s0140-6736(09)61378-7 · Cited by 308 · see citing works
Self-citationGiamouzis, G., Kalogeropoulos, A. P., Georgiopoulou, V. V., Laskar, S. R., Smith, A. L., Dunbar, S. B., Triposkiadis, F. K., & Butler, J. (2010) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2010.08.010 · Cited by 282 · see citing works
Relationship of Hemoglobin A1C and Mortality in Heart Failure Patients With Diabetes
Aguilar, D. A., Bozkurt, B., Ramasubbu, K., & Deswal, A. M. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.04.049 · Cited by 217 · see citing works
Seferovic, P. M., Coats, A. J. S., Ponikowski, P. P., Filippatos, G. S., Huelsmann, M., Jhund, P. S., Polovina, M. M., Michel Komajda, N., Seferović, J. P., Sarı, İ., et al. (2019) · European Journal of Heart Failure · doi:10.1002/ejhf.1673 · Cited by 180 · see citing works
Li, C.-I., Liu, C.-S., Lin, W., Meng, N., Chen, C., Yang, S.-Y., Chen, H.-J., Lin, C., & Li, T. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2462 · Cited by 175 · see citing works
van Melle, J. P., Bot, M., de Jonge, P., de Boer, R. A., van Veldhuisen, D. J., & Whooley, M. A. (2010) · Diabetes Care · doi:10.2337/dc10-0286 · Cited by 159 · see citing works
The Current and Potential Therapeutic Use of Metformin—The Good Old Drug
Drzewoski, J., & Hanefeld, M. (2021) · Pharmaceuticals · doi:10.3390/ph14020122 · Cited by 165 · see citing works
Unrecognized glucose intolerance is common in pulmonary arterial hypertension
Pugh, M. E., Robbins, I. M., Rice, T. W., West, J. D., Newman, J. H., & Hemnes, A. R. (2011) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2011.02.016 · Cited by 154 · see citing works
MacDonald, M. R., Eurich, D. T., Majumdar, S. R., Lewsey, J. D., Bhagra, S., Jhund, P. S., Petrie, M. C., McMurray, J. J. V., Petrie, J. R., & McAlister, F. A. (2010) · Diabetes Care · doi:10.2337/dc09-2227 · Cited by 149 · see citing works
Dauriz, M., Targher, G., Laroche, C., Temporelli, P. L., Ferrari, R., Anker, S., Coats, A., Filippatos, G., Crespo-Leiro, M., Mebazaa, A., et al. (2017) · Diabetes Care · doi:10.2337/dc16-2016 · Cited by 139 · see citing works
Glucagon-like Peptide–1 Analogues for Type 2 Diabetes Mellitus: Current and Emerging Agents
Gallwitz, B. (2011) · Drugs · doi:10.2165/11592810-000000000-00000 · Cited by 142 · see citing works
Metabolic diseases and associated complications: sex and gender matter
Kautzky‐Willer, A., & Handisurya, A. (2009) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2009.02161.x · Cited by 138 · see citing works
Glycated Albumin and Risk of Death and Hospitalizations in Diabetic Dialysis Patients
Freedman, B. I., Andries, L., Shihabi, Z. K., Rocco, M. V., Byers, J. R., Cardona, C. Y., Pickard, M. A., Henderson, D. L., Sadler, M. V., Courchene, L. M., et al. (2011) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.11491210 · Cited by 134 · see citing works
Martin, N., Manoharan, K., Thomas, J., Davies, C., & Lumbers, R. T. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012721.pub2 · Cited by 128 · see citing works
Arnold, L. W., & Wang, Z. (2014) · The Review of Diabetic Studies · doi:10.1900/rds.2014.11.138 · Cited by 126 · see citing works
Yamaji, M., Tsutamoto, T., Kawahara, C., Nishiyama, K., Yamamoto, T., Fujii, M., & Horie, M. (2010) · American Heart Journal · doi:10.1016/j.ahj.2010.04.024 · Cited by 129 · see citing works
Identifying Adults at High Risk for Diabetes and Cardiovascular Disease Using Hemoglobin A1c
Ackermann, R. T., Cheng, Y. J., Williamson, D. F., & Gregg, E. W. (2011) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2010.09.022 · Cited by 111 · see citing works
Mean HbA1c and mortality in diabetic individuals with heart failure: a population cohort study
Elder, D. H. J., Singh, J. S. S., Levin, D., Donnelly, L. A., Choy, A.-M., George, J., Struthers, A. D., Doney, A. S. F., & Lang, C. C. (2016) · European Journal of Heart Failure · doi:10.1002/ejhf.455 · Cited by 109 · see citing works
Predicting myocardial infarction through retinal scans and minimal personal information
Diaz‐Pinto, A., Ravikumar, N., Attar, R., Suinesiaputra, A., Zhao, Y., Levelt, E., Dall’Armellina, E., Lorenzi, M., Chen, Q., Keenan, T. D. L., et al. (2022) · Nature Machine Intelligence · doi:10.1038/s42256-021-00427-7 · Cited by 105 · see citing works
Heart Failure Outcomes in Clinical Trials of Glucose-Lowering Agents in Patients with Diabetes
FITCHETT, D. H., Udell, J. A., & Inzucchi, S. E. (2016) · European Journal of Heart Failure · doi:10.1002/ejhf.633 · Cited by 102 · see citing works
CHARM Investigators and Committees, Kristensen, S. L., Jhund, P. S., Lee, M. M. Y., Køber, L., Solomon, S. D., Granger, C. B., Yusuf, S., Pfeffer, M. A., Swedberg, K., et al. (2017) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-017-6754-x · Cited by 83 · see citing works
SGLT2-inhibitors are effective and safe in the elderly: the SOLD study
Lunati, M. E., Cimino, V., Gandolfi, A., Trevisan, M., Montefusco, L., Pastore, I., Pace, C., Betella, N., Favacchio, G., Bulgheroni, M., et al. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106396 · Cited by 77 · see citing works
Preiss, D., Zetterstrand, S., McMurray, J. J. V., Östergren, J., Michelson, E. L., Granger, C. B., Yusuf, S., Swedberg, K., Pfeffer, M. A., Gerstein, H. C., et al. (2009) · Diabetes Care · doi:10.2337/dc08-1709 · Cited by 76 · see citing works
Self-citationAndersson, C., Gaal, L. V., Caterson, I. D., Weeke, P. E., James, W. P. T., Couthino, W., Finer, N., Sharma, A. M., Maggioni, A. P., & Torp-Pedersen, C. T. (2012) · Diabetologia · doi:10.1007/s00125-012-2584-3 · Cited by 76 · see citing works
Lawson, C. A., Jones, P. W., Teece, L., Dunbar, S. B., Seferovic, P. M., Khunti, K. K., Mamas, M. A., & Kadam, U. T. (2017) · JACC Heart Failure · doi:10.1016/j.jchf.2017.08.020 · Cited by 75 · see citing works
Kongwatcharapong, J., Dilokthornsakul, P., Nathisuwan, S., Phrommintikul, A., & Chaiyakunapruk, N. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.02.146 · Cited by 72 · see citing works
Dauriz, M., Targher, G., Temporelli, P. L., Lucci, D., Gonzini, L., Nicolosi, G. L., Marchioli, R., Tognoni, G., Latini, R., Cosmi, F., et al. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.116.005156 · Cited by 70 · see citing works
Cardiac Insulin Resistance in Heart Failure: The Role of Mitochondrial Dynamics
Saotome, M., Ikoma, T., Hasan, P., & Maekawa, Y. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20143552 · Cited by 70 · see citing works
Rushton, C. A., Satchithananda, D. K., Jones, P. W., & Kadam, U. T. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.05.180 · Cited by 69 · see citing works
Yoda, K., Inaba, M., Hamamoto, K., Yoda, M., Tsuda, A., Mori, K., Imanishi, Y., Emoto, M., & Yamada, S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122521 · Cited by 68 · see citing works
Recent HbA1c Values and Mortality Risk in Type 2 Diabetes. Population-Based Case-Control Study
Nicholas, J. M., Charlton, J., Dregan, A., & Gulliford, M. C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068008 · Cited by 68 · see citing works
Gómez-Arbeláez, D., Alvarado-Jurado, L., Ayala-Castillo, M., Forero-Naranjo, L., Camacho, P. A., & López-Jaramillo, P. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i17.1337 · Cited by 58 · see citing works
An, X., Yu, D., Zhang, R., Zhu, J., Du, R., Shi, Y., & Xiong, X. (2012) · Cardiovascular Diabetology · doi:10.1186/1475-2840-11-71 · Cited by 62 · see citing works
Martin, N., Manoharan, K., Davies, C., & Lumbers, R. T. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012721.pub3 · Cited by 64 · see citing works
Prevalence and Prognostic Implications of Pre-Diabetic State in Patients With Heart Failure
Matsue, Y., Suzuki, M., Nakamura, R. A., Abe, M., Ono, M., Yoshida, S., Seya, M., Iwatsuka, R., Mizukami, A., Setoguchi, M., et al. (2011) · Circulation Journal · doi:10.1253/circj.cj-11-0754 · Cited by 61 · see citing works
Goode, K. M., John, J., Rigby, A. S., Kilpatrick, E. S., Atkin, S. L., Bragadeesh, T., Clark, A. L., & Cleland, J. G. F. (2009) · Heart · doi:10.1136/hrt.2008.156646 · Cited by 58 · see citing works
Gerstein, H. C., Islam, S., Anand, S. S., Almahmeed, W. A., Damasceno, A. A. M., Dans, A., Lang, C. C., Luna, M. A., McQueen, M., Rangarajan, S., et al. (2010) · Diabetologia · doi:10.1007/s00125-010-1871-0 · Cited by 59 · see citing works
Self-citationDungan, K. M., Binkley, P. F., Nagaraja, H. N., Schuster, D., & Osei, K. (2010) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.1155 · Cited by 57 · see citing works
Tomova, G. S., Nimbal, V. C., & Horwich, T. B. (2012) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2012.02.022 · Cited by 56 · see citing works
Dysglycaemia, vasculopenia, and the chronic consequences of diabetes
Gerstein, H. C., & Werstuck, G. H. (2013) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(13)70025-1 · Cited by 56 · see citing works
Self-citationSilbernagel, G., Grammer, T. B., Winkelmann, B. R., Boehm, B. O., & März, W. (2011) · Diabetes Care · doi:10.2337/dc10-2010 · Cited by 51 · see citing works
Zareini, B., Rørth, R., Holt, A., Mogensen, U. M., Selmer, C., Gislason, G., Schou, M., Køber, L., Torp-Pedersen, C., Lamberts, M., et al. (2019) · Cardiovascular Diabetology · doi:10.1186/s12933-019-0883-4 · Cited by 49 · see citing works
Gu, J., Pan, J., Fan, Y.-Q., Zhang, H., Zhang, J., & Wang, C.-Q. (2018) · Cardiovascular Diabetology · doi:10.1186/s12933-018-0739-3 · Cited by 50 · see citing works
Wang, C. C., Wu, C., Tsai, M., Lee, C., Huang, W. C., Chou, H., Huang, J. L., Chi, N., Yen, H., Tzeng, B., et al. (2019) · PubMed Central · doi:10.6515/acs.201905_35(3).20190422a · Cited by 50 · see citing works
Treatment of type 2 diabetes patients with heart conditions
Aktaş, G., Tel, B. M. A., Tel, M. R., & Balci, B. (2023) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2023.2204941 · Cited by 48 · see citing works
Hypertension in Patients with Insulin Resistance: Etiopathogenesis and Management in Children
Tagi, V. M., Mainieri, F., & Chiarelli, F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105814 · Cited by 47 · see citing works
Yokota, S., Tanaka, H., Mochizuki, Y., Soga, F., Yamashita, K., Tanaka, Y., Shono, A., Suzuki, M., Sumimoto, K., Mukai, J., et al. (2019) · Cardiovascular Diabetology · doi:10.1186/s12933-019-0971-5 · Cited by 47 · see citing works
Targher, G., Dauriz, M., Tavazzi, L., Temporelli, P. L., Lucci, D., Urso, R., Lecchi, G., Bellanti, G., Merlo, M., Rossi, A., et al. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.10.207 · Cited by 45 · see citing works
Inzucchi, S. E., Claggett, B. L., Vaduganathan, M., Desai, A. S., Jhund, P. S., de Boer, R. A., Hernandez, A. F., Kosiborod, M., Lam, C. S. P., Martínez, F. A., et al. (2022) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(22)00308-4 · Cited by 47 · see citing works
Ueda, H., Mitsusada, N., Harimoto, K., Miyawaki, M., Yasuga, Y., & Hiraoka, H. (2010) · Cardiology · doi:10.1159/000314331 · Cited by 44 · see citing works
Blecker, S., Park, H., & Katz, S. D. (2016) · BMC Cardiovascular Disorders · doi:10.1186/s12872-016-0275-6 · Cited by 44 · see citing works
SGLT2 Inhibitors in Type 2 Diabetes Mellitus and Heart Failure—A Concise Review
Adamczak, D., Ahmed, N., Tariq, H., Walgamage, M., WALGAMAGE, T., Mohammed, A., Chou, J. T.-T., Kałużna‐Oleksy, M., Lesiak, M., & Straburzyńska‐Migaj, E. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11061470 · Cited by 46 · see citing works
Egstrup, M., Schou, M., Gustafsson, I., Kistorp, C., Hildebrandt, P. R., & Tuxen, C. (2010) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfq216 · Cited by 44 · see citing works
Punthakee, Z., Iglesias, P. P., Alonso‐Coello, P., Gich, I. J., India, I., Málaga, G., Jover, R. D., Gerstein, H. C., & Devereaux, P. J. (2018) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(18)30205-5 · Cited by 42 · see citing works
Self-citationMamas, M. A., Deaton, C., Rutter, M. K., Yuille, M., Williams, S. G., Ray, S. G., New, J. P., Gibson, M., & Neyses, L. (2010) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2010.05.027 · Cited by 42 · see citing works
Impact of Diabetes Mellitus on Outcomes in Patients Supported With Left Ventricular Assist Devices
Asleh, R., Briasoulis, Α., Schettle, S. D., Tchantchaleishvili, V., Pereira, N. L., Edwards, B. S., Clavell, A. L., Maltais, S., Joyce, D. L., Joyce, L. D., et al. (2017) · Circulation Heart Failure · doi:10.1161/circheartfailure.117.004213 · Cited by 41 · see citing works
Suzuki, S. S., Sagara, K., Otsuka, T., Matsuno, S., Funada, R., Uejima, T., Oikawa, Y., Yajima, J., Koike, A., Nagashima, K., et al. (2012) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2012.04.049 · Cited by 40 · see citing works
Xu, L., Chan, W. M., Hui, Y.-Q., & Lam, T. (2011) · Diabetic Medicine · doi:10.1111/j.1464-5491.2011.03456.x · Cited by 40 · see citing works
Vest, A. R., Mistak, S. M., Hachamovitch, R., Mountis, M., Moazami, N., & Young, J. B. (2016) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2016.02.010 · Cited by 39 · see citing works
Selection of a mineralocorticoid receptor antagonist for patients with hypertension or heart failure
Iqbal, J., Parviz, Y., Pitt, B., Newell-Price, J. D. C., Al‐Mohammad, A., & Zannad, F. M. (2013) · European Journal of Heart Failure · doi:10.1111/ejhf.31 · Cited by 38 · see citing works
Nasir, S., & Aguilar, D. A. (2012) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2012.08.031 · Cited by 37 · see citing works
SGLT2 inhibition and heart failure—current concepts
da Silva, J. C., Durães, A. R., Abreu, M., Rocha, N. A., & Roever, L. (2018) · Heart Failure Reviews · doi:10.1007/s10741-018-9703-2 · Cited by 37 · see citing works
Dysglycemia and Cardiovascular Risk in the General Population
Gerstein, H. C. (2009) · Circulation · doi:10.1161/circulationaha.108.834408 · Cited by 36 · see citing works
Self-citationAgouridis, A. P., Rizos, C. V., Elisaf, M., & Filippatos, T. D. (2013) · The Review of Diabetic Studies · doi:10.1900/rds.2013.10.171 · Cited by 35 · see citing works
Positive affect, anhedonia, and compliance with self-care in patients with chronic heart failure
Kessing, D., Pelle, A. J. M., Kupper, N. H. M., Szabó, B. M., & Denollet, J. (2014) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2014.08.007 · Cited by 35 · see citing works
Use of SGLT2 Inhibitors in Older Adults: Scientific Evidence and Practical Aspects
da Silva, J. C., Filho, J. D. S. R., Cavalcanti, C. A. J., Martins, A., & Salles, J. E. N. (2020) · Drugs & Aging · doi:10.1007/s40266-020-00757-y · Cited by 35 · see citing works
Predictors of early-stage left ventricular dysfunction in type 2 diabetes: results of DYDA study
Giorda, C. B., Cioffi, G., SIMONE, G. D., Lenarda, A. D., Faggiano, P. M., Latini, R., Lucci, D., Maggioni, A. P., Tarantini, L., Velussi, M., et al. (2011) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1177/1741826710389402 · Cited by 34 · see citing works
Ikeda, N., Iijima, R., Hara, H., Moroi, M., Nakamura, M., & Sugi, K. (2012) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.13722 · Cited by 34 · see citing works
Freel, E. M., Tsorlalis, I. K., Lewsey, J., Latini, R., Maggioni, A. P., Solomon, S., Pitt, B., Connell, J. M. C., & McMurray, J. J. V. (2009) · Heart · doi:10.1136/hrt.2009.173344 · Cited by 33 · see citing works
Yaghoubi, M., Mansell, K. D., Vatanparastc, H., Steeves, M., Zeng, W., & Farag, M. (2017) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2017.09.014 · Cited by 32 · see citing works
Kleinherenbrink, W., Osei, E., den Hertog, H. M., & Zandbergen, A. A. M. (2018) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2018.07.001 · Cited by 31 · see citing works
Htoo, P. T., Tesfaye, H., Schneeweiß, S., Wexler, D. J., Everett, B. M., Glynn, R. J., Kim, S. C., Najafzadeh, M., Koeneman, L., FARSANI, S. F. F., et al. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.37606 · Cited by 31 · see citing works
Schneider, H. J., Wallaschofski, H., Völzke, H., Markus, M. R. P., Dörr, M., Felix, S. B., Nauck, M. A., & Friedrich, N. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033084 · Cited by 30 · see citing works
Tajik, A. A., Dobre, D., Aguilar, D. A., KJEKSHUS, J. K., Zannad, F. M., & Dickstein, K. (2017) · European Journal of Heart Failure · doi:10.1002/ejhf.797 · Cited by 30 · see citing works
Tsutamoto, T., Yamaji, M., Kawahara, C., Nishiyama, K., Fujii, M., Yamamoto, T., & Horie, M. (2009) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfp144 · Cited by 30 · see citing works
Romero, S. P., Garcia-Egido, A. A., Escobar, M. A., Andrey, J. L., Corzo, R., Perez, V., Garcia-Domiguez, G. J., & Gomez, F. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.03.134 · Cited by 29 · see citing works
Association of comorbid and metabolic factors with optimal control of type 2 diabetes mellitus
Roy, S., Sherman, A., Monari-Sparks, M., Schweiker, O., Jain, N., Sims, E., Breda, M., Byraiah, G., Belecanech, R., Coletta, M. C., et al. (2016) · North American Journal of Medical Sciences · doi:10.4103/1947-2714.175197 · Cited by 28 · see citing works
Wilke, T., Mueller, S., Groth, A., Fuchs, A., Seitz, L., Kienhöfer, J., Maywald, U., Lundershausen, R., & Wehling, M. (2015) · Cardiovascular Diabetology · doi:10.1186/s12933-015-0179-2 · Cited by 27 · see citing works
Filion, K. B., Joseph, L., Boivin, J., Suissa, S., & Brophy, J. M. (2011) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.2165 · Cited by 26 · see citing works
Nicolini, F., Santarpino, G., Gatti, G., Reichart, D., Onorati, F., Faggian, G. G., Dalén, M., Khodabandeh, S., Fischlein, T. J. M., Maselli, D., et al. (2018) · International Journal of Surgery · doi:10.1016/j.ijsu.2018.04.021 · Cited by 26 · see citing works
Li, T., Kardia, S. L. R., Li, C.-I., Chen, C., Liu, C.-S., Yang, S.-Y., Muo, C.-S., Peyser, P. A., & Lin, C. (2015) · Metabolism · doi:10.1016/j.metabol.2015.05.004 · Cited by 26 · see citing works
Shin, S., Claggett, B. L., Pfeffer, M. A., Skali, H., Liu, J., Aguilar, D. A., Díaz, R., Dickstein, K., Gerstein, H. C., Køber, L., et al. (2020) · European Journal of Heart Failure · doi:10.1002/ejhf.1790 · Cited by 26 · see citing works
Self-citationShao, H., Shi, L., & Fonseca, V. A. (2020) · Diabetes Care · doi:10.2337/dc20-0227 · Cited by 25 · see citing works
Britton, K. A., Aggarwal, V., Chen, A. Y., Alexander, K. P., Amsterdam, E. A., Fraulo, E. S., Muntner, P., Thomas, L. E., McGuire, D. K., Wiviott, S. D., et al. (2011) · American Heart Journal · doi:10.1016/j.ahj.2010.12.004 · Cited by 25 · see citing works
Chiang, H.-H., Tseng, F., Wang, C., Chen, C., Chen, Y., See, T.-T., & Chen, H.-F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109501 · Cited by 24 · see citing works
Korol, S., Mottet, F., Perreault, S., Baker, W. L., White, M., & de Denus, S. (2017) · Medicine · doi:10.1097/md.0000000000008719 · Cited by 24 · see citing works
Low HbA1c and mortality: causation and confounding
Rutter, M. K. (2012) · Diabetologia · doi:10.1007/s00125-012-2620-3 · Cited by 24 · see citing works
Kristensen, S. L., Rørth, R., Jhund, P. S., Shen, L., Lee, M. M. Y., Petrie, M. C., Køber, L., & McMurray, J. J. V. (2018) · European Journal of Heart Failure · doi:10.1002/ejhf.1201 · Cited by 24 · see citing works
Šimić, S., Svaguša, T., Prkačin, I., & Bulum, T. (2019) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-019-00460-9 · Cited by 22 · see citing works
- Authors
- Gerstein, H. C.
- Affiliations
- Population Health Research Institute (CA)
- Corresponding author
- Gerstein, Hertzel C.
- ORCID
- Gerstein, Hertzel C.
- Venue
- Archives of Internal Medicine
- Publisher
- American Medical Association (AMA)
- Published
- 2008-08-11
- Volume
- 168
- Issue
- 15
- Pages
- 1699
- ISSN
- 0003-9926 (ISSN-L)
- OpenAlex
- W2164518074
- Cited by
- 217
- References
- 27
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 5 · 2023: 6 · 2022: 17 · 2021: 12 · 2020: 11 · 2019: 10 · 2018: 16 · 2017: 17 · 2016: 20 · 2015: 17 · 2014: 11 · 2013: 7 · 2012: 17
- FWCI
- 10.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- Funders
- AstraZeneca
- Heart and Stroke Foundation of Canada
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- HbA1c, chronic heart failure, cardiovascular mortality, heart failure hospitalization, all-cause mortality, glycemic control, diabetes mellitus, candesartan, risk factors, ejection fraction
- MeSH terms
- Aged, Cardiovascular Diseases, Chronic Disease, Diabetes Mellitus, Female, Follow-Up Studies, Heart Failure, Glycated Hemoglobin, Hospitalization, Humans, Male, Risk Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
