Cited by 371Pancreatic function and diabetesDiabetes Treatment and ManagementNeuropeptides and Animal Physiology

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Entero-Insular Axis

Unger, Roger H.·1969·Archives of Internal Medicine

DOI 10.1001/archinte.1969.00300130043007

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Abstract

Evidence for an entero-insular axis is based upon studies showing that amino acids as well as glucose cause a greater and earlier release of islet cell hormones when administered via the gastrointestinal tract than occurs with comparable elevations in the plasma concentrations of the nutrients given intravenously. The ability of several gastrointestinal hormones to elicit immediate augmentation of insulin and glucagon secretion has been established. Gastrin, secretin, and pancreozymin in dogs all produce an immediate rise of insulin to a peak one minute after injection, but the response to gastrin is quantitatively trivial, while that to secretin is modest. However, pancreozymin elicits substantial release of both insulin and glucagon, and augments the insulinogenic and glucagonogenic effects of amino acids. The physiologic implications of such studies are considered.

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Authors: Unger, R. H.
Corresponding author: Unger, Roger H.
Venue: Archives of Internal Medicine
Publisher: American Medical Association (AMA)
Published: 1969-03-01
Volume: 123
Issue: 3
Pages: 261
ISSN: 0003-9926 (ISSN-L)
DOI: 10.1001/archinte.1969.00300130043007
OpenAlex: W2097717126
Cited by: 371
References: 20
Citations by year: 2025: 4 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 2 · 2019: 4 · 2018: 6 · 2017: 7 · 2016: 7 · 2015: 6 · 2014: 4 · 2013: 5 · 2012: 6
FWCI: 30.57
Type: journal article
Language: en
Open access: closed
Locations: Archives of Internal Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: enteroinsular axis, gut-brain axis, gastrointestinal hormones, insulin secretion, glucagon secretion, amino acids, glucose, gastrin, secretin, cholecystokinin, enteroendocrine cells
MeSH terms: Insulin Secretion, Amino Acids, Animals, Blood Glucose, Cholecystokinin, Dogs, Gastrins, Gastrointestinal Hormones, Glucagon, Glucose, Injections, Intravenous, Insulin, Intestinal Absorption, Pancreas, Secretin

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