Case-Control Studies of Motor Neuron Disease: Association With Mechanical Injuries
Abstract
Two case-control studies of motor neuron disease that involved 712 cases and 158 cases, respectively, showed that (1) mechanical injuries were two to three times more frequent in both sexes, heralding amyotrophic lateral sclerosis, progressive bulbar paralysis, and progressive muscular atrophy; (2) the head, neck, spine, and the extremities were more often traumatized; (3) traumatized parts were not correlated with the initial manifestation of the disease; and (4) more males were traumatized, but males still predominated among uninjured cases. These results suggested that mechanical injuries were not the cause, but probably one of the risk factors of the disease. No association was observed with smoking, drinking, residence, home space, drinking water, animals, experience as a war prisoner, stay on Guam, parental consanguinity, measles, polio, mumps, tuberculosis, rheumatism, prothesis of the total teeth, shell splinters retained in the body, occupational exposures to radiations, chemicals, or gases, atomic bombings, electric injuries, surgical operations, and occupations.
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Head injuries have previously been associated with ALS risk.
“and head injuries (14;20–22).”
From Association of ALS with head injury, cigarette smoking and APOE genotypes (2010) · cites this paper as [20]
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TDP-43 proteinopathy and motor neuron disease in chronic traumatic encephalopathy
McKee, A. C., Gavett, B. E., Stern, R. A., Nowinski, C. J., Cantu, R. C., Kowall, N. W., Perl, D. P., Hedley-Whyte, E. T., Price, B., Sullivan, C., et al. (2010) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181ee7d85 · Cited by 659 · see citing works
Head Injury and Amyotrophic Lateral Sclerosis
Chen, H., Richard, M., Sandler, D. P., Umbach, D. M., & Kamel, F. (2007) · American Journal of Epidemiology · doi:10.1093/aje/kwm153 · Cited by 279 · see citing works
Association of ALS with head injury, cigarette smoking and APOE genotypes
Schmidt, S., Kwee, L. C., Allen, K. D., & Oddone, E. Z. (2010) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2010.01.011 · Cited by 117 · see citing works
Trauma and amyotrophic lateral sclerosis: a case–control study from a population‐based registry
Pupillo, E., Messina, P., Logroscino, G., Zoccolella, S., Chiò, A., Calvo, A., Corbo, M., Lunetta, C., Micheli, A., Millul, A., et al. (2012) · European Journal of Neurology · doi:10.1111/j.1468-1331.2012.03723.x · Cited by 78 · see citing works
Turner, M. R., Abisgold, J., Yeates, D. G. R., Talbot, K., & Goldacre, M. J. (2010) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2009.10.010 · Cited by 55 · see citing works
Longstreth, W. T., Nelson, L. M., Koepsell, T. D., & Van Belle, G. (1991) · Medical Hypotheses · doi:10.1016/0306-9877(91)90183-y · Cited by 51 · see citing works
Severe head injury and amyotrophic lateral sclerosis
Peters, T. L., Fang, F., Weibull, C. E., Sandler, D. P., Kamel, F., & Ye, W. (2013) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.3109/21678421.2012.754043 · Cited by 45 · see citing works
Head Injury and Amyotrophic Lateral Sclerosis: A Meta-Analysis
Liu, G., Ou, S., Cui, H., Li, X., Yin, Z., Gu, D., & Wang, Z. (2021) · Neuroepidemiology · doi:10.1159/000510987 · Cited by 41 · see citing works
Watanabe, Y., & Watanabe, T. (2017) · European Journal of Epidemiology · doi:10.1007/s10654-017-0327-y · Cited by 27 · see citing works
- Authors
- Kondo, K.
- Venue
- Archives of Neurology
- Publisher
- American Medical Association (AMA)
- Published
- 1981-04-01
- Volume
- 38
- Issue
- 4
- Pages
- 220
- ISSN
- 0003-9942
- Cited by
- 79
- References
- 0
- Language
- en
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